Protein Alignment Ufd4 and Wwp1

DIOPT Version :9

• Sequence 1: NP_609369.1
• Gene: Ufd4 / 34378
• FlyBaseID: FBgn0032208
• Length: 2727
• Species: Drosophila melanogaster
• Sequence 2: XP_006237992.1
• Gene: Wwp1 / 297930
• RGDID: 1311734
• Length: 968
• Species: Rattus norvegicus
• Alignment Length: 1136
• Identity: 250/1136 - (22%)
• Similarity: 394/1136 - (34%)
• Gaps: 345/1136 - (30%)

  Fly  1672 TNVPVGG--KKTPKAQALINPDNANQKQIIV-----TSEEFPTKSSKKPSVTLKPAQQPNAVL-- 1727
            |.|.|.|  |||.|:.:..||  ...:|:||     |:.||...|..    |||    .:|:|
  Rat    92 TEVIVDGEIKKTAKSSSSSNP--KWDEQLIVNVAPQTTLEFRVWSHH----TLK----ADALLGK 146

  Fly  1728 SIVDIKEQPISNEN--VSVPSQMSISVPNLTTTSASEVPSTSEV-ATHTGLLETFAAIARRRTSQ 1789
            :.||:|:..:::..  ..|..|:.:|:.|     .:.:..|.|: ....||:....|:..|.:|.
  Rat   147 ATVDLKQVLLTHNRKLEKVKEQLKLSLEN-----KNGIVQTGELTVVLDGLVIEPEAVTNRSSSP 206

  Fly  1790 GTNIQDNQIMNAEANVNEHGD-----------QNASGSFLGHSVTSLVKLALSSNFHSGLLSTAQ 1843
            ...||    .|.:| |:|:||           :...|.....|.:::|..:..|:..:| .:|..
  Rat   207 PIEIQ----QNGDA-VHENGDPLTRTTPRLAVEGTIGIDNHVSTSTVVPSSCCSHIVNG-ENTPS 265

  Fly  1844 SYPSLSSNNSENIAP----SNP-SNTSAGQQSASTINHTLTMSLTSTSSDSEQVSLEDFLESCRA 1903
            |.|.:::......||    |.| |:|..|:.|:...:.|..|..:..|.||...|      :|.:
  Rat   266 SPPQVATRPQNTPAPKPLTSEPTSDTVNGESSSVLADSTSAMGTSLPSEDSTSTS------NCTS 324

  Fly  1904 PALLGDLDDEDDMDEDNDEEENED----EYEEVGNTLLQVMVSRNLLTFMDDEAMENRLVGVTKR 1964
            ..:     .|..:.|.....|:.:    ...|||..      :|:|:. .|.::..|
  Rat   325 TTV-----QEPPVQEPPASSEHSECIPSASAEVGPE------ARSLID-PDSDSRNN-------- 369

  Fly  1965 KSWDDEFVLKRQFSALIPAFDPRPGRTNVNQTSDLEISPLGAELPKP--------QQSGGPETIE 2021
                ..|...||....:....|:.|.||.      |..|.|.|..|.        ..:....|.|
  Rat   370 ----SGFDKVRQPEGCVEPLRPQSGNTNT------ESLPSGWEQRKDPHGRTYYVDHNTRTTTWE 424

  Fly  2022 --QPL-LGLKLRGPGIGGIPEVEIDLSNTDW--TIFRAVQELLQC-SQLNKLDKFRKIWEPTYTI 2080
              ||| .|.:.|....|.:..|:.:...|.|  ....:|:...|. ||.|:|..
  Rat   425 RPQPLPPGWERRVDDRGRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQG----------- 478

  Fly  2081 VYREVSPEAQESTCLESEEFPQTPDVSSKSGASTLSPNSPMHIGFNVADNNLCSVDDVLELLTQI 2145
                           ..::|.|....|:...|:...|..|:..|:
  Rat   479 ---------------AMQQFNQRYLYSASMLAAENDPYGPLPPGW-------------------- 508

  Fly  2146 NGLNQSEIDSDVKEHGVSVLSEDLFISKKITNKLQQQIQDPLVLASNALPN-------W-CENLN 2202
                :..:||..:.:.|:            .|....|.:||   .:..|||       | .....
  Rat   509 ----EKRVDSTDRVYFVN------------HNTKTTQWEDP---RTQGLPNEEPLPEGWEIRYTR 554

  Fly  2203 QSCPFLFPFETRQLYFNCTSFGASRSIVCLQSQRDVTVERQRIPIMSPRRDDHEFRIGRLK---- 2263
            :...:.....||...|.....|.| |:.  :....:..||           ...:::...:
  Rat   555 EGVRYFVDHNTRTTTFKDPRNGKS-SVT--KGGPQIAYER-----------SFRWKLAHFRYLCQ 605

  Fly  2264 ------HERVKVPRN---EDLLMWAMQVMKTHCNRKSVLEVEFLDEEGTGLGP-TLEFYALVAAE 2318
                  |.::.|.|.   ||.....|.:......|:  |.|.|..|||...|. ..|::.|::.|
  Rat   606 SNALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRR--LYVIFRGEEGLDYGGLAREWFFLLSHE 668

  Fly  2319 IQRSDLCMWLCDDDLGEDTENSTQSAEGNSKPVGYYVNRREH--GIFPAPLPQNSEICENVLKYF 2381
            :.....|::                         .|..:..:  .|.||     |.|..:.|.||
  Rat   669 VLNPMYCLF-------------------------EYAGKNNYCLQINPA-----STINPDHLSYF 703

  Fly  2382 WFFGVFVAKVLQDMRLVDIPLSTSFLQLLCHNKVLSRNLQKVISDRRNGDLSVVSEDSDIVETCT 2446
            .|.|.|:|..|...:.:|...|..|     :.::||:.
  Rat   704 CFIGRFIAMALFHGKFIDTGFSLPF-----YKRMLSKK--------------------------- 736

  Fly  2447 KLLRTDSNKSNAFGGILSLENLKEIDPTRYQFLQEMQNLLLRKQSIEFDDTISAEKKHELINELK 2511
                            |::::|:.||...|..|     :.:|..:||
  Rat   737 ----------------LTIKDLESIDTEFYNSL-----IWIRDNNIE------------------ 762

  Fly  2512 LQTQNGLE----VSLEDLALTFTYLPSSSIYGYTQAELLPNGSSVNVTIDNLEAYCELLMNFILQ 2572
               :.|||    |.:|.|...            |..:|...||::.||.:|.:.|..|:..:...
  Rat   763 ---ECGLEMYFSVDMEILGKV------------TSHDLKLGGSNILVTEENKDEYIGLMTEWRFS 812

  Fly  2573 DGIAQQMKAFSDGFNEVFPLKKLAAFTPSEARMMICGEQ---FPHWSREDIISYTEPKLGYNKDS 2634
            .|:.:|.|||.||||||.||:.|..|...|..:|:||.|   ...|.|..:..:      |.::|
  Rat   813 RGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRH------YTRNS 871

  Fly  2635 PGFQRFVNVLLSMSGDERKAFLQFTTGCSSLPPGGLANL----HPRLTVVRKVDAGVGSY-PSVN 2694
            .....|...:.....:.|...|||.||...||.||.|.|    .|:...:.||  |..:: |..:
  Rat   872 KQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKV--GKDTWLPRSH 934

  Fly  2695 TCVHYLKLPDYPTEEIMKERLLTATKE-KGF 2724
            ||.:.|.||.|.:.|.:||:||.|.:| :||
  Rat   935 TCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 965

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041
		MIB_HERC2	1333..1389	CDD:310955
		DamX	1576..>1725	CDD:330571	20/59 (34%)
		HECTc	2265..2725	CDD:238033	117/479 (24%)
Wwp1	XP_006237992.1	C2_E3_ubiquitin_ligase	67..190	CDD:175988	31/112 (28%)
		PARM	243..>400	CDD:293666	41/193 (21%)
		WW	397..426	CDD:278809	6/28 (21%)
		WW	429..458	CDD:278809	7/28 (25%)
		WW	504..533	CDD:278809	6/64 (9%)
		WW	545..574	CDD:238122	4/28 (14%)
		HECTc	614..966	CDD:238033	117/478 (24%)
		HECTc	637..965	CDD:214523	110/453 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900