DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ufd4 and HERC4

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	XP_011537894.1	Gene:	HERC4 / 26091	HGNCID:	24521	Length:	1081	Species:	Homo sapiens

Alignment Length:	914	Identity:	173/914 - (18%)
Similarity:	303/914 - (33%)	Gaps:	334/914 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  1956 NRLVGVTKRKSW-------------DDEFVLKRQFSALIPAFDPRPGRTNVNQTSDLEISPLGAE 2007
            ||....|.:.:|             ::.|.:||.||....:|                     :.
Human   358 NRKSPFTVKGNWYPYNGQCLPDIDSEEYFCVKRIFSGGDQSF---------------------SH 401

  Fly  2008 LPKPQQSGGPE------------TIEQPLLGLKLRGPGIGGIP-EV--EID-------------- 2043
            ...||..|.|:            |:.:.|:...|..|. |..| |:  |||
Human   402 YSSPQNCGPPDDFRCPNPTKQIWTVNEALIQKWLSYPS-GRFPVEIANEIDGTFSSSGCLNGSFL 465

  Fly  2044 -LSNTD----WTIFRAVQELLQCSQLNKLDKFRKIWEPTYTIVYREVSPEAQESTCLESEEFPQ- 2102
             :||.|    .|.|..|.  :..::|    .|.|:.:|.:..:.::|      :..||....|:
Human   466 AVSNDDHYRTGTRFSGVD--MNAARL----LFHKLIQPDHPQISQQV------AASLEKNLIPKL 518

  Fly  2103 ---TPDVSSKSGASTLSPNSPMHIGFNVAD-NNLCSVDDVLELLTQINGLNQSEIDSDVKEHGVS 2163
               .|||.:.....|| |..|:     ::| ||..::  .:...|.:..|.::.:  .|.|:..|
Human   519 TSSLPDVEALRFYLTL-PECPL-----MSDSNNFTTI--AIPFGTALVNLEKAPL--KVLENWWS 573

  Fly  2164 VLSEDLF------------------------------------------ISKKITNKLQQQIQ-- 2184
            ||...||                                          |..::..|:.|.||
Human   574 VLEPPLFLKIVELFKEVVVHLLKLYKIGIPPSERRIFNSFLHTALKVLEILHRVNEKMGQIIQYD 638

  Fly  2185 -------DPLVLASNALPNWCE------NLNQS-----------C--PFLFPFETRQLYFNCTSF 2223
                   ..|:...|...||.:      ::|..           |  ||:|..:.:      |:.
Human   639 KFYIHEVQELIDIRNDYINWVQQQAYGMDVNHGLTELADIPVTICTYPFVFDAQAK------TTL 697

  Fly  2224 GASRSIVCLQSQRDVTVERQRI-----PIMSPRRDDHEFRIGRLKHERVKVPRNEDLLMWAMQVM 2283
            ..:.:::.:|...| ...||.:     |:           |..:....:.|.|.|:::..||:|:
Human   698 LQTDAVLQMQMAID-QAHRQNVSSLFLPV-----------IESVNPCLILVVRRENIVGDAMEVL 750

  Fly  2284 K--THCNRKSVLEVEFLDEEGTGLGPT-LEFYALVAAEI----------QRSDLCMWLCDDDLGE 2335
            :  .:.:.|..|:|.|:.|:....|.. .||:.|:..|:          ......:|..|... |
Human   751 RKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTF-E 814

  Fly  2336 DTENSTQSAEGNSKPVGYYVNRREHGIFPAPLPQNSEICENVLKYFWFFGVFVAKVLQDMRLVDI 2400
            |::                                         .|...||.....:.:..:||:
Human   815 DSD-----------------------------------------LFHLIGVICGLAIYNCTIVDL 838

  Fly  2401 PLSTSFLQLLCHNKVLSRNLQKVISDRRNGDLSVVSEDSDIVETCTKLLRTDSNKSNAFGGILSL 2465
                 ...|..:.|:|.:.                                           .||
Human   839 -----HFPLALYKKLLKKK-------------------------------------------PSL 855

  Fly  2466 ENLKEIDPTRYQFLQEMQNLLLRKQSIEF-DDTISAEKKHELINELKLQTQNGLEVSLEDLALTF 2529
            ::|||:.|...:.:|::         ::: :|.|.                       |...|.|
Human   856 DDLKELMPDVGRSMQQL---------LDYPEDDIE-----------------------ETFCLNF 888

  Fly  2530 TYLPSSSIYGYTQA-ELLPNGSSVNVTIDNLEAYCELLMNFILQDGIAQQMKAFSDGFNEVFPLK 2593
            |....:  :|.|:. ||:.||:...|...|.:.:.:..:::|....:|....||..||::|...|
Human   889 TITVEN--FGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGK 951

  Fly  2594 KLAAFTPSEARMMICGEQFPHWSREDIISYTEPKLGYNKDSPGFQRFVNVLLSMSGDERKAFLQF 2658
            .|..|.|:|.:.|:.|.....|  :::...||.|..|..:.|..:.|..|...:..:::|.||.|
Human   952 VLLLFQPNELQAMVIGNTNYDW--KELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLF 1014

  Fly  2659 TTGCSSLPPGGLANLHPRLTVVRKVDAGVGSYPSVNTCVHYLKLPDYPTEEIMKERLLTA-TKEK 2722
            .||...:|..|:.:|.   .|::....|....|..:||.:.|.||.|..:|.::.:|:.| ...:
Human  1015 LTGSDRIPILGMKSLK---LVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNE 1076

  Fly  2723 GFHL 2726
            ||.|
Human  1077 GFSL 1080

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041
		MIB_HERC2	1333..1389	CDD:310955
		DamX	1576..>1725	CDD:330571
		HECTc	2265..2725	CDD:238033	93/475 (20%)
HERC4	XP_011537894.1	RCC1	2..368	CDD:332518	3/9 (33%)
HERC4	XP_011537894.1	HECTc	733..1079	CDD:238033	93/474 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900