DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ufd4 and MAGI3

DIOPT Version :9

Sequence 1:NP_609369.1 Gene:Ufd4 / 34378 FlyBaseID:FBgn0032208 Length:2727 Species:Drosophila melanogaster
Sequence 2:NP_001136254.1 Gene:MAGI3 / 260425 HGNCID:29647 Length:1481 Species:Homo sapiens


Alignment Length:1747 Identity:308/1747 - (17%)
Similarity:529/1747 - (30%) Gaps:616/1747 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   711 KPYHWREWSICRGRDCLYVWSDSVALELSNGSNGWFRFIIDGKLATMYSSGSPENGNDSSENRGE 775
            |..||    :.:.::|...|:         |..|.|...|.|                 ...|||
Human     7 KKKHW----LSKVQECAVSWA---------GPPGDFGAEIRG-----------------GAERGE 41

  Fly   776 FLEKLMRARS-------CVIAGVVSQPILPTASALRLVVGNWV--LQSQKTNQLQIHNTEGHQVT 831
            | ..|.|.|.       ||::|....|    ...|..|.|..|  |.::.|..:..|..|..::.
Human    42 F-PYLGRLREEPGGGTCCVVSGKAPSP----GDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLK 101

  Fly   832 VLQDDLPGFIFESNRGTKHTFSAETVLGPDFASGWSTAKKKRNKSKTEGQKFQVRNLSREIY--- 893
            .::   ||.:.  |:..:|..|.:                           ||..::..::.   
Human   102 TVK---PGKVI--NKDLRHYLSLQ---------------------------FQKGSIDHKLQQVI 134

  Fly   894 --NKYFKSAQIIPRGAVAILTDIVKQIELSF--EEQHMAPNGNWETTLTDALMKLSQLIHEDGVV 954
              |.|.::   ||....|.....|..::.:|  .||..|                   :.|.|. 
Human   135 RDNLYLRT---IPCTTRAPRDGEVPGVDYNFISVEQFKA-------------------LEESGA- 176

  Fly   955 SAYEMHSSGLVQALVAVLSVNHWETNSPRCKRNKMQKQRVSVFKKCILEDNVESATNKPRTKSTA 1019
                :..||....       |.:.|..|..:.:..|...|.   :.:.::..::.:.:.||.|  
Human   177 ----LLESGTYDG-------NFYGTPKPPAEPSPFQPDPVD---QVLFDNEFDAESQRKRTTS-- 225

  Fly  1020 SILIQKLVSVLESTE-KLPVYLYDSPCTGYSLQILQKRLRFRLERAECESTLFDRSGRTLKMEPL 1083
                   ||.:|..: .||.                       |..:.:....:.||.....|..
Human   226 -------VSKMERMDSSLPE-----------------------EEEDEDKEAINGSGNAENRERH 260

  Fly  1084 ATIGQLSKYLLKMVAKQWYDLDRSTYFYLKKIREHRTATVFTHSFD--FDEEGLLFYIGSNAKTC 1146
            :.    |...:|.|..  |:...|:..:...:....|......:::  :.:.|::::|..|.||.
Human   261 SE----SSDWMKTVPS--YNQTNSSMDFRNYMMRDETLEPLPKNWEMAYTDTGMIYFIDHNTKTT 319

  Fly  1147 DWVNP--------------------------AQYGLVQVTSSEGKTLPYGKLEDILSR---DSIS 1182
            .|::|                          .|||...|.....||.....:|:...:   ..:.
Human   320 TWLDPRLCKKAKAPEDCEDGELPYGWEKIEDPQYGTYYVDHLNQKTQFENPVEEAKRKKQLGQVE 384

  Fly  1183 LNCHTKDNKKAWFAIDLGVYIIPTAYTLRHARGYGRSALRNWLLQGSKDGST----WTTLSTHVD 1243
            :.....|.:|:.|..|                   .|.|:..|::.|...||    :|.:.....
Human   385 IGSSKPDMEKSHFTRD-------------------PSQLKGVLVRASLKKSTMGFGFTIIGGDRP 430

  Fly  1244 D-----KSLVEPGSTATWPINCATDDSVWYRHIRIQQNGRNASGQTH--------------YLSL 1289
            |     |::::.|.       .|.|..:....:.:..||....|.||              |::|
Human   431 DEFLQVKNVLKDGP-------AAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNL 488

  Fly  1290 S---GFEIYGRVVGVADDIGKSVKEAEAKTRRERRQIRAQLKHMTTGARVIRGVDWR----WEEQ 1347
            :   |:.:       .||....|.:..|.|    ..|..|  .:|.|...:...|::    ..||
Human   489 TLCRGYPL-------PDDSEDPVVDIVAAT----PVINGQ--SLTKGETCMNPQDFKPGAMVLEQ 540

  Fly  1348 DGCAEGTITGEIHNGWIDVKWDHGVRNSYRMGAEGKYDLKLADCEYLSAFDGNQSMGSASTAAKP 1412
            :|.:..|:||:..||..|..     .....|.:.|....:|..   :....|.:..|.|...:..
Human   541 NGKSGHTLTGDGLNGPSDAS-----EQRVSMASSGSSQPELVT---IPLIKGPKGFGFAIADSPT 597

  Fly  1413 SEKGGNTLTSRKSSSTPSLPEATEKNQNPEGASNQTVSADNLAWKQTVETIAE-NVFASAKTQII 1476
            .:|....|.|:..       :..:|....:...:|.|  .||...|.||.:.: .|.|.....|:
Human   598 GQKVKMILDSQWC-------QGLQKGDIIKEIYHQNV--QNLTHLQVVEVLKQFPVGADVPLLIL 653

  Fly  1477 SNQLAMNTSSSREARAKHKESGTNQMHKDNISGPSPLSRELEHISDLSAINNSMPAINSSNVSDL 1541
            .......|.:::....|.:.:|:.:...:.|..|.|...        |.|.:..|.::.|.|   
Human   654 RGGPPSPTKTAKMKTDKKENAGSLEAINEPIPQPMPFPP--------SIIRSGSPKLDPSEV--- 707

  Fly  1542 ATISENLSLTELSKENICRVLTPSYKPAESVTASQSSSH---------PDVQSSSPRENDIKNIS 1597
                      .|..:.:.....|:.|..:.....|.|..         ||   .|.....|..:.
Human   708 ----------YLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGGDGPD---QSIYIGAIIPLG 759

  Fly  1598 NIEENNKMNANNSVNKISKDLLANLRTSNIAGCPPVTQLSTEALEMIDKMRDGVDMIRNMSNSIL 1662
            ..|::.::.|       :.:|:.      |.|.|...:...:.|:::........::..:...|.
Human   760 AAEKDGRLRA-------ADELMC------IDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIF 811

  Fly  1663 STDTFPVPCTNVPVGGKKTPK---AQALINPDNANQKQIIVTSEEFPTKSSKKPSVTLKPA-QQP 1723
            .              |:|.|:   :||.|:..|.:.:             ..:..|..:|| |:|
Human   812 Y--------------GEKQPEDDSSQAFISTQNGSPR-------------LNRAEVPARPAPQEP 849

  Fly  1724 NAVLSIVDIKEQP------ISNENVSVPSQMSISVPNLTTTSASEVPSTSEVATH---------- 1772
            ..|  ::..||..      ::::|...|..:...:..:...|.::.....:|..|          
Human   850 YDV--VLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIV 912

  Fly  1773 -------------TGLLETFAAIARRR---TSQGTN-------IQDNQIMNAEANVNEH--GDQN 1812
                         .|:..|...||...   ...|||       :|...:..::||   |  ||::
Human   913 ELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQAN---HIPGDRS 974

  Fly  1813 ASGSFLGHSVTSLVKLALSSNFH-----SGLLSTAQS--------YP------------SLSSNN 1852
            |....:|..|::..:.:.|.:.|     :.::|...|        ||            ||....
Human   975 ALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSLRGGK 1039

  Fly  1853 SEN-------IAPSNPS----NTSAGQQSASTINHTLTMSLTSTSSDSEQVSLEDFLESCRAPAL 1906
            ..|       :|...|:    ....|.|... ||...|..:|.|.:       .:.:::.....|
Human  1040 EYNMGLFILRLAEDGPAIKDGRIHVGDQIVE-INGEPTQGITHTRA-------IELIQAGGNKVL 1096

  Fly  1907 L------GDLDDEDDMDEDN--------DEEE--------------------------------- 1924
            |      |.:.|..|.|.:|        ||:.                                 
Human  1097 LLLRPGTGLIPDHGDWDINNPSSSNVIYDEQSPLPPSSHFASIFEESHVPVIEESLRVQICEKAE 1161

  Fly  1925 -------------NEDEYEEVGNTLLQVMVS-------------RNLLTFMDDEAMENRLVGVTK 1963
                         ||::.|....:|||..||             :|||      .:||   |||:
Human  1162 ELKDIVPEKKSTLNENQPEIKHQSLLQKNVSKRDPPSSHGHSNKKNLL------KVEN---GVTR 1217

  Fly  1964 RKSWDDEFVLKRQFSALIPAFD---------PRPGRTN-VNQTSDLEISPLGAE----------- 2007
            |         .|..|...||..         |.|.:.| ..:..|..:||...|           
Human  1218 R---------GRSVSPKKPASQHSEEHLDKIPSPLKNNPKRRPRDQSLSPSKGENKSCQVSTRAG 1273

  Fly  2008 --------------LPKPQQ----SGGPETIEQPLLGLKLR------GPGIGGIPE--VEIDLSN 2046
                          .||.||    |..|...|..||..|.|      |.....||:  .:.|:..
Human  1274 SGQDQCRKSRGRSASPKKQQKIEGSKAPSNAEAKLLEGKSRRIAGYTGSNAEQIPDGKEKSDVIR 1338

  Fly  2047 TDWTIFRAVQELLQCSQLNKLDKFRKIWEPTYTIVYREVSPEAQESTCLESEEFPQTPDVSSKSG 2111
            .|             ::.|:|:|            .|..|||.:....:| :..|.  .:::|:.
Human  1339 KD-------------AKQNQLEK------------SRTRSPEKKIKRMVE-KSLPS--KMTNKTT 1375

  Fly  2112 ASTLSPNSPMHIGFNVADNNLCSVDDVLELLTQINGLNQSEIDSDVKEHGVSVLSED 2168
            :..:|.|..   |..|......|.:|.:....|   |::..:..:.:|..||..:||
Human  1376 SKEVSENEK---GKKVTTGETSSSNDKIGENVQ---LSEKRLKQEPEEKVVSNKTED 1426

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ufd4NP_609369.1 ANK repeat 393..420 CDD:293786
ANK 396..509 CDD:238125
ANK repeat 422..453 CDD:293786
ANK repeat 455..484 CDD:293786
F5_F8_type_C 1173..1298 CDD:329041 25/153 (16%)
MIB_HERC2 1333..1389 CDD:310955 13/59 (22%)
DamX 1576..>1725 CDD:330571 26/161 (16%)
HECTc 2265..2725 CDD:238033
MAGI3NP_001136254.1 Interaction with ADRB1 and TGFA. /evidence=ECO:0000250 18..106 26/121 (21%)
PDZ_signaling 24..101 CDD:238492 24/98 (24%)
NK 123..>197 CDD:327404 17/107 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 182..273 20/138 (14%)
WW 294..326 CDD:197736 7/31 (23%)
WW 342..372 CDD:238122 6/29 (21%)
Interaction with PTEN. /evidence=ECO:0000269|PubMed:10748157 410..492 16/88 (18%)
PDZ 413..493 CDD:214570 15/86 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 542..570 8/32 (25%)
PDZ 575..656 CDD:214570 18/92 (20%)
Interaction with ADGRB1. /evidence=ECO:0000269|PubMed:10748157 726..808 13/97 (13%)
PDZ_signaling 726..807 CDD:238492 13/96 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 821..843 5/34 (15%)
PDZ_signaling 849..935 CDD:238492 11/87 (13%)
Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000269|PubMed:10748157, ECO:0000269|PubMed:16904289 851..938 12/88 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 939..976 9/39 (23%)
PDZ_signaling 1022..1100 CDD:238492 14/85 (16%)
Red1 <1132..1461 CDD:311769 67/347 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1170..1481 67/309 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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