DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ufd4 and Plekha5

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	NP_647556.1	Gene:	Plekha5 / 246237	RGDID:	621175	Length:	1281	Species:	Rattus norvegicus

Alignment Length:	1452	Identity:	255/1452 - (17%)
Similarity:	448/1452 - (30%)	Gaps:	527/1452 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  1456 WKQTVETIAENVFASAKTQIISNQLAMNTSSSREARAKHKESGTNQMHKDNISGPSPLSRELEHI 1520
            |::..      .|..|:..|..|:        |:...||..:|  |..:||.
  Rat    63 WEEAY------TFEGARYYINHNE--------RKVTCKHPVTG--QPSQDNC------------- 98

  Fly  1521 SDLSAINNSMPAINSSNVSDLATISENLSLTELSKENICRVLTPSYKPAESVTASQSSSHP--DV 1583
              :..:|:...|..:|.......||   .:.|.|..|:               ||..:.||  .|
  Rat    99 --IFVVNDQTVATMTSEEKKERPIS---MINEASNYNM---------------ASDYTVHPMSPV 143

  Fly  1584 QSSSPRENDIKNISNIEENNKMNANNSV-------------NKISKD---LLANLRTSNIAGCPP 1632
            ..:|.....:.|......:.|.|.|..|             .|:.|.   :|::|       |
  Rat   144 GRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQDSTGMKLWKKRWFVLSDL-------C-- 199

  Fly  1633 VTQLSTEALEMIDKMRDGVDMIRNMSNSILSTDTFPVPCTNVPVGGKKTPKAQALINPDNANQKQ 1697
                   .....|:..:|:      ..|||      :|...:.:          |...|:.|:|.
  Rat   200 -------LFYYRDEKEEGI------LGSIL------LPSFQIAM----------LTAEDHINRKY 235

  Fly  1698 IIVTSEE------FPTKSSKKPSVTLKPAQQPNAVLSIVDIKEQPISNENVSVPSQMSISVPNLT 1756
            ....:..      |.|.:.|:..:.:|      |:|....::.:|:..      ...:..|..:|
  Rat   236 AFKAAHPNMRTYYFCTDTGKEMELWMK------AMLDAALVQTEPVKR------ITFNFRVDKIT 288

  Fly  1757 TTSASEVPSTSEVATHTGLLETFAAIARRRTSQGTNIQDNQIMNAEANVNEHGDQNASGSFLGHS 1821
            |.||| ...|:.:..|..|:.. .....::..:.:.|::.:.:.||    .:|.|. .|.....:
  Rat   289 TESAS-TKETNNIPNHRVLIRP-EVQNNQKNKEISKIEEKRALEAE----RYGFQK-DGQDRPLT 346

  Fly  1822 VTSLVKL-ALSSNFHSGLLSTAQS--YPSLSSNNSENIA----------PSNPSNTSAGQQSAST 1873
            ..:.||| :|.|.:.||.....|:  |..::.|||::.|          .|:|:......::...
  Rat   347 KINSVKLNSLPSEYESGPACPPQNIHYRPINVNNSDSKAVNVSLADVRGGSHPNTGPLATEADRV 411

  Fly  1874 INHTLTMSLTSTSSDSEQVSLEDFLESCRAPALLGDLDDEDDMDEDNDEEENEDEYEEVGNTL-- 1936
            |..|.:|.           .||.:::..:...|             .:|......|:.:...:
  Rat   412 IQRTNSMQ-----------QLEQWIKVQKGRGL-------------EEEPRGVISYQTLPRNMPS 452

  Fly  1937 --LQVM---------VSRNLLTFMDDEAMENRLVGVT-------------KRKSWDDEFV----- 1972
              .|::         :.||      .:.....:..||             ||:|..|:.:
  Rat   453 HRAQILARYPEGYRTLPRN------SKTRPESICSVTPSGHEKTGPGAEEKRRSMRDDTMWQLYE 511

  Fly  1973 -LKRQF----------SAL-----------------------IPA-----FDP-RPGRTNVN--- 1994
             .:|||          |.|                       :||     |.| |..|:.|:
  Rat   512 WQQRQFYHKQSTLPRHSCLSSPKAMGKVSDQTMHSIPTSPSHVPAAAYQGFSPQRTYRSEVSSPI 576

  Fly  1995 QTSDLEIS-------------------PLGAELP--KPQQSGGPETIEQPLLGLKLRGPGIGGIP 2038
            |..|:.|.                   |.|..|.  .||...|....|..||.:|||
  Rat   577 QRGDVTIDRRHRPHHPKHVYVPDRRSMPAGLALQAVSPQSLHGRTPEELTLLLIKLR-------- 633

  Fly  2039 EVEIDLSN-TDWTIFRAVQELLQC-SQLNK------------LDKFRKIWEPTYTIVYREVSPEA 2089
            ..:.:||: .:.|:.:.:|..|:. |..|:            ||...|..||..|:|:..:
  Rat   634 RQQAELSSIREHTLAQLMQLKLEAHSPKNEILSHHLQRNTIYLDHQMKENEPIITMVHTMI---- 694

  Fly  2090 QESTCLESEEFPQTPDVSSKSGASTLSPNS---------PMHIGFNVADNNLCSVDDVLELLTQI 2145
             |::.|..:.:.|.....:|.....||.:.         |..:..:...:.||..|.|:..|.:
  Rat   695 -ENSALRPQLYQQFLRQKNKISLYCLSQDECRGTLYKYRPEEVDIDAKLSRLCEQDKVVRALEE- 757

  Fly  2146 NGLNQSEIDSDVKEHGVSVLSEDLFISKKITNKLQQQI--QDPLVLASNALPNWCENLNQSCPFL 2208
             .|.|...:....|..:...|:::.::......:|..:  :|.|   .|.|.:.|..|:::
  Rat   758 -KLQQLHKEKYTLEQALLSASQEIEMNADNPAAIQTVVLQRDDL---QNGLLSTCRELSRA---- 814

  Fly  2209 FPFETRQLYFNCTSFGASRSIVCLQSQRDVTVERQRIPIMSPRRDDHEFRIGRLKHERVKVPRNE 2273
                |.:|......:.        :.:.||||.|.::       .|...|:|.::.|...:.|.:
  Rat   815 ----TAELERAWREYD--------KLEYDVTVTRNQM-------QDQLDRLGEVQSESAGIQRAQ 860

  Fly  2274 -DLLMW----AMQVMKTHCNRKSVLE-----------VEFLDEE--------------------- 2301
             ...:|    .|:.:..|..::...|           |::..||
  Rat   861 IQKELWRIQDVMEGLSKHKQQRGSSETGLAGPKPFPAVKYKSEEEEVVPPRPPLPRSYDFTEQPP 925

  Fly  2302 -------------------------------------GTGLGPTLEFY-----ALVAAEIQRSDL 2324
                                                 |:..||....|     ....||:
  Rat   926 IIPPLPSDSSSLLCYSRGPVHLPEEKKSHQVQGYPRNGSHCGPDYRLYKSEPELTTVAEV----- 985

  Fly  2325 CMWLCDDDLGEDTENSTQSAE-----GNSKPVGYYVNRREHGIFPAPLPQNSEICENVLKYFWFF 2384
                 |:..||:.......||     |:..|||..:..:      :|.|::|.|...|.
  Rat   986 -----DESNGEEKSEPASEAEAPVVRGSHFPVGVPLRTK------SPTPESSTIASYVT------ 1033

  Fly  2385 GVFVAKVLQDMRLVDIPLSTSFLQLLC--------------------HNKVLSRNLQKVISDRRN 2429
             :...|.:.::| .:.|.|.  ::.||                    |.:...|..:|.::....
  Rat  1034 -LRKTKKMVELR-TERPRSA--VEQLCLAESTRPRMTVEEQLERIRRHQQACLREKKKGLNVLSA 1094

  Fly  2430 GDLSVVSEDSDIVETCTKLLRTDSNKSNAFGGILSLENLKEIDPTRYQFLQEMQNLLLRKQSIEF 2494
            .|.|.....|.:.::.:::.:|          :...:|.||:|...            |:...:.
  Rat  1095 SDPSPSQSPSSVRDSPSRVPQT----------VRRDDNTKELDAVH------------RENDGKP 1137

  Fly  2495 D-DTISAEKKHELINELKLQTQN-GLEVS-LEDLALTFTYLPSSSIYGYT---------QAELLP 2547
            | ||.:||..|.  .|.:.|:.: |.::. .|.:.....|.| ..:.|.|         |.|.:|
  Rat  1138 DYDTSAAETAHP--EEAEPQSADVGRKLKRTESIFYEMLYTP-EPLNGLTSEEVMAKERQEEQVP 1199

  Fly  2548 NGSSVNVTIDNLEAYCELLMNFILQDGIAQQMKAFSDGFNEVFPLKKLAAFTPSEARMMICGEQF 2612
            .|           |.|.|            |.:|.........|.::..:....|..:..| |..
  Rat  1200 EG-----------AVCSL------------QEEAAMANHQAEGPPEEAESLHEEEEALASC-EPA 1240

  Fly  2613 PHWSREDIISYTEPKLGYNKDS 2634
            |...||:  ..|...|..:.||
  Rat  1241 PETPREN--QTTVKSLSPSPDS 1260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041
		MIB_HERC2	1333..1389	CDD:310955
		DamX	1576..>1725	CDD:330571	28/172 (16%)
		HECTc	2265..2725	CDD:238033	81/486 (17%)
Plekha5	NP_647556.1	WW	13..42	CDD:278809
		WW	59..88	CDD:278809	7/38 (18%)
		PH_PEPP1_2_3	165..268	CDD:270068	24/146 (16%)
		PH	171..267	CDD:278594	22/139 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900