DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ufd4 and Magi3

DIOPT Version :9

Sequence 1:NP_609369.1 Gene:Ufd4 / 34378 FlyBaseID:FBgn0032208 Length:2727 Species:Drosophila melanogaster
Sequence 2:NP_620784.3 Gene:Magi3 / 245903 RGDID:621362 Length:1470 Species:Rattus norvegicus


Alignment Length:2013 Identity:347/2013 - (17%)
Similarity:591/2013 - (29%) Gaps:829/2013 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   711 KPYHWREWSICRGRDCLYVWS---DSVALELSNGS-NGWFRFIIDGKLATMYSSGSPENGNDSSE 771
            |..||    :.:.::|...|:   ..:..|:..|: .|.|.::  |:|     ...|..|..:  
  Rat     7 KKKHW----LSKVQECAVSWAGPPGDLGAEIRGGAERGEFPYL--GRL-----RDEPGGGGGT-- 58

  Fly   772 NRGEFLEKLMRARSCVIAGVVSQPILPTASALRLVVGNWV--LQSQKTNQLQIHNTEGHQVTVLQ 834
                         .||::|....|    ...|..|.|..|  |.::.|..:..|..|..::..::
  Rat    59 -------------CCVVSGKAPSP----GDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVK 106

  Fly   835 DDLPGFIFESNRGTKHTFSAETVLGPDFASGWSTAKKKRNKSKTEGQKFQVRNLSREIY-----N 894
               ||.:.  |:..:|..|.:                           ||..::..::.     |
  Rat   107 ---PGKVI--NKDLRHYLSLQ---------------------------FQKGSIDHKLQQVIRDN 139

  Fly   895 KYFKSAQIIPRGAVAILTDIVKQIELSF--EEQHMAPNGNWETTLTDALMKLSQLIHEDGVVSAY 957
            .|.::   ||....|.....|..::.:|  .||..|                   :.|.|.    
  Rat   140 LYLRT---IPCTTRAPRDGEVPGVDYNFISVEQFKA-------------------LEESGA---- 178

  Fly   958 EMHSSGLVQALVAVLSVNHWETNSPRCKRNKMQKQRVSVFKKCILEDNVESATNKPRTKSTASIL 1022
             :..||....       |.:.|..|..:.:..|...|..    :|.|| |..|...|.::|:...
  Rat   179 -LLESGTYDG-------NFYGTPKPPAEPSPFQPDPVDQ----VLFDN-EFDTESQRKRTTSVSK 230

  Fly  1023 IQKLVSVLE---------------STEKLPVYLYDSPC---TGYSLQILQKRLRFR--LERAECE 1067
            ::::.|.|.               |.|...::...|.|   |..|.....:.:.||  :.|.|  
  Rat   231 MERMDSSLPEEEEDEDKEAVNGSGSMETREMHSESSDCWMKTVPSYNQTNRSMDFRNYMMRDE-- 293

  Fly  1068 STLFDRSGRTLKMEPLATIGQLSKYLLKMVAKQWYDLDRSTYFYLKKIREHRTATVFTHSFDFDE 1132
                       .:|||              .|.|                         ...:.:
  Rat   294 -----------NLEPL--------------PKNW-------------------------EMAYTD 308

  Fly  1133 EGLLFYIGSNAKTCDWVNPAQYGLVQVTSS-EGKTLPYG--KLEDILSRDSISLNCHTKDNKKAW 1194
            .|.:::|..|.||..|::|......:.... |...||||  |:||                    
  Rat   309 TGTIYFIDHNTKTTTWLDPRLCKKAKAPEDCEDGELPYGWEKIED-------------------- 353

  Fly  1195 FAIDLGVYIIPTAYTLRHARGYGRSALRNWLLQGSKDGSTWTTLSTHVDDKSLVEPGSTATWPIN 1259
              ...|.|.:                                   .|::.|:..|.      |:.
  Rat   354 --PQYGTYYV-----------------------------------DHLNQKTQFEN------PVE 375

  Fly  1260 CATDDSVWYRHIRIQQNGRNASGQTHYLSLSGFEIYGRVVGVADDIGKSVKEAEAKTRRERRQ-- 1322
            .|.         |.:|.|:   .:||                           .|||..||..  
  Rat   376 EAK---------RKKQIGQ---AETH---------------------------SAKTDVERAHFT 401

  Fly  1323 ----------IRAQLKHMTTG-ARVIRGVDWRWEE--------------QDG-CAEGTITGEIHN 1361
                      :||.||..|.| ...|.|.| |.:|              ||| .|.|.:..:|:.
  Rat   402 RDPSQLKGVLVRASLKKSTMGFGFTIIGGD-RPDEFLQVKNVLKDGPAAQDGKMAPGDVIVDING 465

  Fly  1362 GWIDVKWDHGVRNSYRMGAEGKYDLKLADCEYLSAFDGNQSMGSASTAAKPSEKGGNTLTSRKSS 1426
            ..:.......|...:::....:| :.|..|...:..|.::.......||.|...|.:........
  Rat   466 NCVLGHTHADVVQMFQLVPVNQY-VNLTLCRGYALPDDSEDPVVDIVAATPVINGQSLAKGEACM 529

  Fly  1427 STPSLP-EATEKNQNPEGASNQTVSADNLAWKQTVETIAENVFASAKTQIISNQLAMNTSSSREA 1490
            ||.... .|...:||  |.|.:.:|:|:|                           ...|.|.|.
  Rat   530 STQDFKLGAMVLDQN--GKSGKLLSSDHL---------------------------NGPSDSNEQ 565

  Fly  1491 RAKHKESGTNQMHKDNI---SGP---------SPLSRELEHISDLS-----AINNSMPAINSSNV 1538
            ||....||::|.....|   .||         ||..::::.|.|..     ...:.:..|...||
  Rat   566 RASLASSGSSQPELVTIPLVKGPKGFGFAIADSPTGQKVKMILDSQWCQGLQKGDIIKEIYHQNV 630

  Fly  1539 SDLATISENLSLTELSKE--------------------NICRVLTPSYKPAESV-TASQSSSHP- 1581
            .:|.    :|.:.|:.|:                    ...::.|.:.:.:.|: |.::.:..| 
  Rat   631 QNLT----HLQVVEVLKQFPVGADVPLLILRGGPCSPTKTAKMKTDTKETSGSLETINEPTPQPM 691

  Fly  1582 -----DVQSSSPR----ENDIKNISNIEENNKMNANNSVNKISKDLLANLRTSN-------IAGC 1630
                 .::|.||:    |..:|: ..:.|:...|        :|||...||...       :.|.
  Rat   692 PFPPSIIRSGSPKLDPSEVYLKS-KTLYEDKPPN--------TKDLDVFLRKQESGFGFRVLGGD 747

  Fly  1631 PPVTQLSTEALEMIDKM-RDGVDMIRNMSNSILSTDTFPVPCTNVPVGGKKTPKAQALINPDNAN 1694
            .|...:...|:..:... :||  .:| .::.::..|       .:||.||              :
  Rat   748 GPDQSIYIGAIIPLGAAEKDG--RLR-AADELMCID-------GIPVKGK--------------S 788

  Fly  1695 QKQIIVTSEEFPTKSSKKPSVTLKPAQQPNAVLSIVDIKEQPISNENVSVPSQMSISVPNLTTTS 1759
            .||::    :..|.:::...|.|...::      |...::||   |:.|         |...:.|
  Rat   789 HKQVL----DLMTTAARNGHVLLTVRRK------IFYGEKQP---EDES---------PQAFSQS 831

  Fly  1760 ASEVPSTSEVATHTGLLETFAAIARRRTSQGTNIQDNQIMNAEA--------------------- 1803
            .|...:.:|:.|.:...|::..|.:|:.::|...   .|:.:::                     
  Rat   832 GSPRLNRTELPTRSAPQESYDVILQRKENEGFGF---VILTSKSKPPPGVIPHKIGRVIDGSPAD 893

  Fly  1804 -----NVNEHGDQNASGSFLGHSVTSLVKLALSSNFHSGLLSTAQSYPSLSSNNSENIAPSNPSN 1863
                 .|.:|.......|.:..|..::|:|...:.....|...|:         .|:..|  ||.
  Rat   894 RCGRLKVGDHISAVNGQSIVDLSHDNIVQLIKDAGVTVTLTVVAE---------EEHHGP--PSG 947

  Fly  1864 TSAGQQSASTINHTLTMSLTSTSSDSEQVSLEDFLESCRAPALLGDLDDEDDMDEDNDEEENEDE 1928
            |::.:||.: :.|.......:|....::.:||.                                
  Rat   948 TNSARQSPA-LQHRPMGQAQATHIPGDRTALEG-------------------------------- 979

  Fly  1929 YEEVGNTLLQVMVSRNLLTFMDDEAMENRLVGVTKRKSWDDEFVLKRQFSALIPAFDPRPGRTNV 1993
              |||..:..                       :.|.||.|...|.:..:|:|.....|..::..
  Rat   980 --EVGKDVCS-----------------------SYRHSWSDHKHLAQPDTAVISVVGSRHSQSLG 1019

  Fly  1994 NQTSDLEISPLG--------------------AELPKPQQSG----GPETIE---QPLLG----- 2026
            ....:||..|.|                    ||.....:.|    |.:.:|   :|..|     
  Rat  1020 CYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTR 1084

  Fly  2027 ------------LKLRGPGIGGIPEVEIDLSNTDWTIFRAVQELLQCSQLNKLDKFRKIWEPTYT 2079
                        |.|..||.|.||:      :.||.|:                           
  Rat  1085 AIELIQAGGNKVLLLLRPGTGLIPD------HGDWDIY--------------------------- 1116

  Fly  2080 IVYREVSPEAQESTCLESEEFPQTPDVSSKSGASTLSPNSPMHIGFNVADNNLCSV--------- 2135
                  ||.:  |..:..|:.|..|  ||.|.|:....:.|      |.:::|..|         
  Rat  1117 ------SPSS--SNVIYDEQPPPLP--SSHSAATFEESHVP------VTEDSLIRVQTCEKAEEL 1165

  Fly  2136 -DDVLELLTQINGLNQSEID-SDVKEHGVSVLSEDLFISKKITNKLQQQIQDPLVLASNALPNWC 2198
             |.|.|..:.:|| :|.|:. ..|:::          :|||          ||    |.:..:..
  Rat  1166 KDTVQEKKSTLNG-SQPEMKYQSVQKN----------VSKK----------DP----SRSHGHGD 1205

  Fly  2199 ENLNQSCPFLFPFETRQLYFNCTSFGASRSIVCLQSQRDVTVERQRIPIMSPRRDDHEFRIGRLK 2263
            :||.                              :.:..||   :|....||::.     :.|..
  Rat  1206 KNLP------------------------------KGENGVT---RRGRSASPKKS-----VNRHS 1232

  Fly  2264 HERV-KVPR---------NEDLLMWAMQVMKTHCNRKSVLEVEFLDEEGTGLGPTLEFYALVAAE 2318
            .|.: |:||         :.|         ::...||...:.:...:.|:|..|           
  Rat  1233 EEHLEKIPRPLRSDPKGKSRD---------RSLSPRKGENKGQVTIKAGSGQDP----------- 1277

  Fly  2319 IQRSDLCMWLCDDDLGEDTE---------NSTQSAEGNSKPVGYYVNRREHGI---FPAPLPQNS 2371
                      |..|.|..:.         ||..:.||.....|   :||..|:   .|..||:..
  Rat  1278 ----------CRKDRGRSSSPRKQQKIGGNSLSNTEGKLSEAG---SRRAAGLSSDSPEQLPEGK 1329

  Fly  2372 EICENVLKYFWFFGVFVAKVLQDMRLVDI---------PLSTSFLQLLCHNKVLSRNLQKVISDR 2427
            |..          ||    ..:|::|..:         ..|:...:....:|..|....:|:|::
  Rat  1330 EKS----------GV----SRKDLKLSQLGKNRTRSPEKRSSKVDEASLPSKKTSDTASRVVSEK 1380

  Fly  2428 RNGDLSVVSEDS-----DIVETCTKLLR---------------TDSNKSNAFGGILSLENLKE 2470
            ..|......|.|     :.|:|..|.|.               ||..|..|.|...|...:|:
  Rat  1381 EKGRKPGTGERSRDKTGESVQTSAKPLTQEAGEKMALSKASEVTDRGKERAGGAPESSSPVKK 1443

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ufd4NP_609369.1 ANK repeat 393..420 CDD:293786
ANK 396..509 CDD:238125
ANK repeat 422..453 CDD:293786
ANK repeat 455..484 CDD:293786
F5_F8_type_C 1173..1298 CDD:329041 14/124 (11%)
MIB_HERC2 1333..1389 CDD:310955 14/71 (20%)
DamX 1576..>1725 CDD:330571 29/166 (17%)
HECTc 2265..2725 CDD:238033 48/257 (19%)
Magi3NP_620784.3 Interaction with ADRB1 and TGFA. /evidence=ECO:0000269|PubMed:16316992 18..108 22/118 (19%)
PDZ_signaling 24..103 CDD:238492 20/104 (19%)
NK 125..>199 CDD:418433 17/107 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 184..266 16/93 (17%)
HUL4 <211..>373 CDD:227354 44/277 (16%)
WW 299..329 CDD:238122 9/54 (17%)
WW 345..375 CDD:238122 12/92 (13%)
Interaction with PTEN. /evidence=ECO:0000250 413..495 20/83 (24%)
PDZ 416..496 CDD:214570 19/81 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 550..575 10/51 (20%)
PDZ 578..659 CDD:214570 14/84 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 665..700 4/34 (12%)
PDZ 729..812 CDD:214570 18/110 (16%)
Interaction with ADGRB1. /evidence=ECO:0000250 729..811 18/109 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 818..847 9/40 (23%)
PDZ_signaling 851..936 CDD:238492 11/87 (13%)
Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000250 852..939 12/98 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 939..976 9/39 (23%)
PDZ_signaling 1023..1101 CDD:238492 13/77 (17%)
PTZ00112 1115..>1405 CDD:240274 76/442 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1124..1146 7/23 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1167..1470 70/387 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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