DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ufd4 and Plekha7

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	XP_017177675.1	Gene:	Plekha7 / 233765	MGIID:	2445094	Length:	1359	Species:	Mus musculus

Alignment Length:	1646	Identity:	293/1646 - (17%)
Similarity:	489/1646 - (29%)	Gaps:	606/1646 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  1130 FDEEGLLFYIGSNAKTCDWVNP---------AQY--------------------GLVQVTSSEG- 1164
            |.|||..|:|..|.:|..:.:|         ::|                    .:|..||:.|
Mouse    63 FTEEGASFFIDHNQQTTTFRHPVTGQFSSENSEYVLREEPHPHMSKPERNQRPSSMVSETSTAGT 127

  Fly  1165 -----------------KTLPYGKLEDILSRDSISLN--------CHTKDN------KKAWF--- 1195
                             |...:||.:..:.|   :||        .|.:|:      |:.||
Mouse   128 TSTLEAKPGPKIVKSSSKVHSFGKRDQAIRR---NLNVPVVVRGWLHKQDSSGMRLWKRRWFVLA 189

  Fly  1196 -----------------AIDLGVYII-PTAYTLRHARGYGRSALRNWLLQGSKDGSTWTTLSTHV 1242
                             :|.|..|:| |.|...|.:|.|...|:                   |.
Mouse   190 DYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKAV-------------------HT 235

  Fly  1243 DDKSLVEPGSTATWPINCATDDSVWYRHIRIQQNGRNASGQTHYLSLSGFEIYGRVVGVADDIGK 1307
            ..::|:...:||               ..:::.:|.    :|:|.|....|.....|...:...:
Mouse   236 GMRALIYSTTTA---------------GSQMEHSGM----RTYYFSADTLEDMNAWVRAMNQAAQ 281

  Fly  1308 SVKEAEAKTRRE----RRQIRAQLKHMTTGARVIRGVDWRWEEQDGCAEGTITGEIHNGWIDVKW 1368
            .:  :.:..||:    .||...|..|                 .|.|.|....|..|:
Mouse   282 VL--SRSSLRRDVDKVERQAMPQANH-----------------TDACQECGHVGPGHS------- 320

  Fly  1369 DHGVRNSYRMGAEGKYDLKLADCE------YLSAFDGNQSMGSASTAAKPSEK--------GGNT 1419
                |:..|.|.|..|.....:.|      .....:|.:....|.:...|:|:        ||
Mouse   321 ----RDCPRRGYEDSYGFNRREQEEERFRAQRDPLEGRRDRSKARSPYLPAEEDALFVDLPGG-- 379

  Fly  1420 LTSRKSSSTPSLPEATEKNQNPE---GASNQTVSADNLAWKQTVETIAENVFASAKTQIISNQLA 1481
                 .....:.|:..|||..|.   |..|.|                 |.:
Mouse   380 -----PRGQQAQPQRAEKNGVPPYGLGEQNGT-----------------NGY------------- 409

  Fly  1482 MNTSSSREARAKHKESGTNQMHKDNIS------GPS-PLSRELEHISDLSAINNSMPAINSSNVS 1539
            ..|:..|....||.:..|.....::.:      |.| ||.:.|.....      |.|.....|..
Mouse   410 QRTAPPRANPEKHSQRKTGLAQAEHWTKAQKGDGRSLPLDQTLPRQGP------SQPLSFPENYQ 468

  Fly  1540 DLATISENLSLTELSKENICRVLTPSYKPAESVTASQSSSHPDVQSS---SPRENDIKNISNIEE 1601
            .|...:.:||.:...        .|...|::...|...:||..:.|.   :.|:..:..:...::
Mouse   469 SLPKSTRHLSGSSSP--------PPRNLPSDYKYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQ 525

  Fly  1602 NNKMNANNSVNKISKDLLANLRTSNIAGCPPVTQLSTEALEMIDKMRDGVDMIRNMSNSILSTDT 1666
            ..:....:....|.            ||.|..|:..        :.|..:::.|::|
Mouse   526 RQQFRHGSPTAPIG------------AGSPEFTEQG--------RSRSLLEVPRSIS-------- 562

  Fly  1667 FPVPCTNVPVGGKKTPKAQALINPDNANQKQIIVTSEEFPTKSSKKPS--VTLKPAQQPNAV--- 1726
            .|...:::|..|...|                      ||.:....|:  ||:||.:|..:|
Mouse   563 VPPSPSDIPPPGPPRP----------------------FPPRRPHTPAERVTVKPPEQRRSVDIS 605

  Fly  1727 ---------------LSIVDIKEQP---ISNENVSVPSQMSISVPNLT------TTSASEVPSTS 1767
                           .|.||.:..|   .....||.||....|:..|:      ....|::.|..
Mouse   606 LGGSPRKARGHAAKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSLEELSLLLTRLQRHQSKLASVR 670

  Fly  1768 EVAT----HTGLLETFAAIARRRTSQGTNIQ--------DNQIMNAEANVN---EHGDQNASGSF 1817
            ..|.    |..|  ||.|.    .:..|.:|        |.:|.|.|..:|   :...::|.|..
Mouse   671 NFAVGQLLHHYL--TFPAC----QADDTYLQLKKDLEYLDLKIKNNEPLINVLYKVLKKSARGCR 729

  Fly  1818 LGHSVT--------SL-----------VKLALSSNFHSGLLSTAQSYPSLSSNNSENIAPSNPSN 1863
            .|.|:|        ||           |||::.......|........:|..|..:
Mouse   730 PGRSMTGRDLLKDRSLKPMKIAESDIDVKLSIFCEQDRILQDLEDKIRALKENKDQ--------- 785

  Fly  1864 TSAGQQSASTINHTLTMSLTSTSSDSEQVSLEDFLESCRAPALLGDL-DDEDDMDEDNDEEEN-- 1925
                .:|...:.|..|..........|::       :|:...|..|| ....::..::.|.||
Mouse   786 ----LESVLEVLHRQTEQYRDQPQHLEKI-------TCQQRLLQEDLVHIRAELCRESTEMENAW 839

  Fly  1926 ------EDEYEEVGNTLLQVMVSRNLLTFMDDEAMENRLVGVTKRKSWDDEFVL------KRQFS 1978
                  |.:.|::..||.:  ..|....|.:...::..|        |..|.|:      |..:.
Mouse   840 NEYLKLEKDVEQLKQTLQE--QHRRAFFFQEKSQIQKDL--------WRIEDVMAGLSANKENYR 894

  Fly  1979 AL-----------IPAFDPRPGRTNVNQTSDLEISPLGAELPKPQQSGGPET--IEQPLLGLKLR 2030
            .|           :|.| |.|...:::.|..           ||.....|.|  :..||
Mouse   895 VLVGSVKNPERKTVPLF-PHPSVPSLSPTES-----------KPALQPSPPTSPVRTPL------ 941

  Fly  2031 GPGIGGIPEVEIDLSNTDWTIFRAVQELLQCSQLNKLDKFRKIWEPTYTIVYREVSPEAQESTCL 2095
                    ||.:......:..:|.....|           ||:..|..:..  :..|:|::
Mouse   942 --------EVRLFPQLQTYVPYRPHPPQL-----------RKVMSPLQSPT--KAKPQAED---- 981

  Fly  2096 ESEEFPQTPDVSSKSGASTLSPNSPMHIGFNVADNNLCSVDDVLELLTQINGL-NQSEIDSDVKE 2159
            |:...|..|::.|........|..|.              :..:...|.:.|| .||:.....:|
Mouse   982 EAPPRPPLPELYSPEDQPPAVPPLPR--------------EATIIRHTSVRGLKRQSDERKRDRE 1032

  Fly  2160 HGVSVLSEDLFISKKITNKLQQQIQDP-LVLASNALPNWCENLNQSCPFLFPFETRQLYFNCTSF 2223
            .|..| :.||.:      :|:..:.:| |...|..:|.         |.|....:...|......
Mouse  1033 QGQCV-NGDLKV------ELRSYVSEPELASLSGDVPQ---------PSLSLVGSESRYQTLPGR 1081

  Fly  2224 GASRSIVCLQS----------QRDVTVERQRIPIMSPRRDDHEFRIGRLKHERVKVPRNEDLLMW 2278
            |.|.|...||.          :|.:..|........|:........|  .|:|.|:...|.|
Mouse  1082 GLSGSTSRLQQSSTIAPYVTLRRGLNAENSSATFSRPKSALERLYSG--DHQRGKMSAEEQL--- 1141

  Fly  2279 AMQVMKTH-----CNRKSVLEVEFLDEEGTGLGPTLEFYALVAAEIQRSDLCMWLCDDDLGEDTE 2338
              :.||.|     ..||..|.    ..|.|||     ..|...::....||..|..:.:.  |.:
Mouse  1142 --ERMKRHQKALVRERKRTLS----QGEKTGL-----LSARYLSQPLPGDLGSWKREQEF--DLQ 1193

  Fly  2339 NSTQSAEGNSKPVGYYVNRREHGIFPAPLPQNSEICENVLKYFWFFGVFVAKVLQDMRLVDIPLS 2403
            ...::|:|:.|.       :|.|                    |            :::...|:.
Mouse  1194 LLERAAQGDRKD-------KEEG--------------------W------------LKVQATPVM 1219

  Fly  2404 TSFLQLLCHNKVLSRNLQKVISDRRNGDLSVVSEDSDIVETCTKLLRTDSNKSNAFGGILSLENL 2468
            ...|:...::..:||.|.|             .|...|.|...:|   |..:..      |||.|
Mouse  1220 ELDLEPQDYDLDISRELSK-------------PEKVSIPERYVEL---DPEEPP------SLEEL 1262

  Fly  2469 KEIDPTRYQFLQEMQNLLLR------------KQSI-EFDDTISAEKK-----HELINELKLQTQ 2515
            :    .|||..::::|:|.|            :.|: :.|..:..:::     :.|.:|...:::
Mouse  1263 Q----ARYQKAEKIRNILARSSMCNLQPLGQDRNSLADLDSQLQEQERIINISYALASEASKRSK 1323

  Fly  2516 NGLEVSLEDLALTFTYLPSSS 2536
               :|:::.|||.....|.||
Mouse  1324 ---QVAVQQLALLPPKAPLSS 1341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041	27/159 (17%)
		MIB_HERC2	1333..1389	CDD:310955	10/55 (18%)
		DamX	1576..>1725	CDD:330571	24/153 (16%)
		HECTc	2265..2725	CDD:238033	57/295 (19%)
Plekha7	XP_017177675.1	WW	10..39	CDD:366073
		WW	55..84	CDD:366073	8/20 (40%)
		PH_PEPP1_2_3	158..280	CDD:270068	28/162 (17%)
		Smc	<692..>894	CDD:224117	42/231 (18%)
		PHA03247	<903..1009	CDD:223021	26/162 (16%)
		PRK10263	<912..>1118	CDD:236669	49/277 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900