DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ufd4 and WWC1

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	XP_011532787.1	Gene:	WWC1 / 23286	HGNCID:	29435	Length:	1185	Species:	Homo sapiens

Alignment Length:	1284	Identity:	226/1284 - (17%)
Similarity:	416/1284 - (32%)	Gaps:	372/1284 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1129 DFDEEGLLFYIGSNAKTCDWVNPAQYGLVQVTSSE--GKTLPYG--------------------- 1170
            |||  |.::||....:|..|::|.......:|.::  ...||.|
Human    17 DFD--GKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYDPQVGDYFIDHNTKTT 79

  Fly  1171 KLED-----------------ILSRDSISLNCHTKDNKKAWFAIDLGVYIIPTAYTLRHARGYGR 1218
            ::||                 :::::::|.      .|:.:......:.:....|...||....:
Human    80 QIEDPRVQWRREQEHMLKDYLVVAQEALSA------QKEIYQVKQQRLELAQQEYQQLHAVWEHK 138

  Fly  1219 SALRNWLLQGSKDGSTWTTLSTHVDDKSLVEPGSTATWPINCATDDSVWYRHIRIQQNGRNASGQ 1283
            ...:..|:.||...|.:       |.:.|....:||...:|....:.|..:| .:|...|
Human   139 LGSQVSLVSGSSSSSKY-------DPEILKAEIATAKSRVNKLKREMVHLQH-ELQFKER----- 190

  Fly  1284 THYLSLSGFEIYGRVVGVADDIGKSVK--EAEAKTR-------------RERRQIRAQLKHMTTG 1333
                   ||:...::.....|...|.|  ||:|..|             :|::.:...|..:..|
Human   191 -------GFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIKSLAMLKDG 248

  Fly  1334 ARVIRGV-DWRWEEQDGCAEGTITGEIHNGWIDVKWDHGVRNSYRMGAEG----KYDLKL----- 1388
            .|..||. ...|.........:.  .:...::||.....:..|:.:.:..    |..|:|
Human   249 FRTDRGSHSDLWSSSSSLESSSF--PLPKQYLDVSSQTDISGSFGINSNNQLAEKVRLRLRYEEA 311

  Fly  1389 ---ADCEYLSAFDGNQSM------GSASTAAKPSEKGGNTLTSRKSS-----STPSLPEATEKNQ 1439
               ..|:...|...|..:      .::|..|:......:.|.|.|.:     |.||.     :|.
Human   312 KRRLSCQCGQATPSNSELTHYQLPQASSKTARHLYLDSHFLFSLKRTTLNLGSVPSC-----RNA 371

  Fly  1440 NPEGASN---QTVSADNLAWKQTVETIAEN-VFASAKTQIISNQLAMNTSSSREARAKHKESGTN 1500
            .....:|   |....|:.||...:::..:. :..:.|.:::.....::.....:...:..|....
Human   372 CLRWIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPRKWTQGEVEQLEMARK 436

  Fly  1501 QMHKD------------------NISGPSPLSRELEHI--------SDLSAINNSMPAINS-SNV 1538
            ::.||                  | |..:.|.||||..        |.|.::::||.:::| |:.
Human   437 RLEKDLQAARDTQSKALTERLKLN-SKRNQLVRELEEATRQVATLHSQLKSLSSSMQSLSSGSSP 500

  Fly  1539 SDLATISENLSLTELSKENICRVLTPSYKPAESVTASQSSS------------HPDVQSSSPREN 1591
            ..|.:...:|..:.|............|.|.|.:.:...|.            .|....::..|:
Human   501 GSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQSKVEFLLLEGATGFRPSGCITTIHED 565

  Fly  1592 DIKNISNIEENNKMNANNSVNKISKDLLA-NLRTSNIAGCPPVTQLSTEALEMIDKMRDGVDMIR 1655
            ::......|...::.|..|::...|.:.: :.|:|..:..||.:.|
Human   566 EVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSSLSSPSPPCSPL------------------- 611

  Fly  1656 NMSNSILSTDTFPVPCTNVPVGGKKTPKAQALINPDNANQKQIIVTSEEFPTKSSKKPSVTLKPA 1720
             |::.:|:.|.|   ..::.....:.......::..|:.|::..:   |.|....|:....:..|
Human   612 -MADPLLAGDAF---LNSLEFEDPELSATLCELSLGNSAQERYRL---EEPGTEGKQLGQAVNTA 669

  Fly  1721 QQPNAVLSIVDIKEQPISNENVSVPSQM-SISVPNLTTTSASEVPSTSEVATHTGLLETFAAIAR 1784
            |.....::.|   ...:|:|:|:..|.: ..||..|..:.|:...|....|  .|......|:..
Human   670 QGCGLKVACV---SAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEA--VGATRIQIALKY 729

  Fly  1785 RRTSQGTNIQDNQIMNAEANVNEHGDQ--NASGSFL--GHSVTSLVKL----ALSSNFHSGLLST 1841
            ...::...|...|:.|..|.:.:. ||  |...:.|  ..|.|.|.:.    |..:...:.:...
Human   730 DEKNKQFAILIIQLSNLSALLQQQ-DQKVNIRVAVLPCSESTTCLFRTRPLDASDTLVFNEVFWV 793

  Fly  1842 AQSYPSLSSNNSENIAPSNPSNTSAGQQSASTINHTLTMSLTSTSSD---------SEQVSLEDF 1897
            :.|||:|                           |..|:.:...::|         ..|:||
Human   794 SMSYPAL---------------------------HQKTLRVDVCTTDRSHLEECLGGAQISL--- 828

  Fly  1898 LESCRAPALLGDLDDEDDMDEDNDEEENEDEYEEVGNTLLQVMVSRNLLT--FMDDEAMENRLVG 1960
            .|.||:                  .|.:...|              |||:  ::..::.|.:.||
Human   829 AEVCRS------------------GERSTRWY--------------NLLSYKYLKKQSRELKPVG 861

  Fly  1961 V-------TKRKSWDDEFVLKRQFSALIPAFDPRPGRTNVNQTSDL----EISPLGAELPKPQQS 2014
            |       ....|||.:.|........:.....:.||::.....|.    |.|...|...:.::.
Human   862 VMAPASGPASTVSWDQDAVSALLEQTAVELEKRQEGRSSTQTLEDSWRYEETSENEAVAEEEEEE 926

  Fly  2015 GGPETIEQPLLGLKLRGPGIGGIPEVEIDL-SNTDW-----TIFRAVQELLQCSQLNKLDKFRKI 2073
            ...|..|:.:...| ..|.:.|.|.:::|. :||:.     |:.|              .|.|::
Human   927 VEEEEGEEDVFTEK-ASPDMDGYPALKVDKETNTETPAPSPTVVR--------------PKDRRV 976

  Fly  2074 WEPTYTIVYREVSPEAQESTCLESEEF---PQTPDV----SSKSGASTLSPNSPMHIGFNVADNN 2131
            ..|:.       .|..:.||.:.|:.|   ||:..|    .|.|.:||||...|.      ..|:
Human   977 GTPSQ-------GPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPF------VRNS 1028

  Fly  2132 L-----------------------------CSVDDVLELLTQINGLNQSEIDSDVKEHGVSVLSE 2167
            |                             .|:|  |||..|......|::..:     :|||.|
Human  1029 LERRSVRMKRPSPPPQPSSVKSLRSERLIRTSLD--LELDLQATRTWHSQLTQE-----ISVLKE 1086

  Fly  2168 DLFISKKITNKLQQQIQDPLVLASNALPNWCENLNQSCPFLFPFETRQL 2216
                       |::|::.........||.|.....:....|...|.||:
Human  1087 -----------LKEQLEQAKSHGEKELPQWLREDERFRLLLRMLEKRQM 1124

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041	22/141 (16%)
		MIB_HERC2	1333..1389	CDD:310955	11/68 (16%)
		DamX	1576..>1725	CDD:330571	23/161 (14%)
		HECTc	2265..2725	CDD:238033
WWC1	XP_011532787.1	WW	9..39	CDD:238122	9/23 (39%)
		WW	55..84	CDD:278809	4/28 (14%)
		ALDH-SF	429..>481	CDD:299846	10/52 (19%)
		C2_Kibra	721..844	CDD:176062	28/185 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900