DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ufd4 and HECW1

DIOPT Version :9

Sequence 1:NP_609369.1 Gene:Ufd4 / 34378 FlyBaseID:FBgn0032208 Length:2727 Species:Drosophila melanogaster
Sequence 2:XP_016867371.1 Gene:HECW1 / 23072 HGNCID:22195 Length:1639 Species:Homo sapiens


Alignment Length:1722 Identity:329/1722 - (19%)
Similarity:546/1722 - (31%) Gaps:596/1722 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  1245 KSLVEPGSTATWPINCATDDSVWYRHIRIQQNGRNASGQTHYLSLSGFEIYGRVVGVADDIGK-S 1308
            |..::||..:.:|   |.......|..:|..|..|...|....|.         |.:..|:.: .
Human   262 KISIQPGKHSIFP---ALPHHGQERRSKIIGNTVNPIWQAEQFSF---------VSLPTDVLEIE 314

  Fly  1309 VKEAEAKTR-----------------RERRQIRAQLKHMTTGARV----IRG-VDWRWEEQDGCA 1351
            ||:..||:|                 .||..|..::...|.|.|:    :.| :.:|:|      
Human   315 VKDKFAKSRPIIKRFLGKLSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFE------ 373

  Fly  1352 EGTITGEIHNGWIDVKWDHGVRNSYRMGAEGKYDLKLADCEYLSAFDGNQSMGSASTAAKP---- 1412
               ||..||.                           ||.|.:|.   :....||.....|    
Human   374 ---ITSSIHP---------------------------ADDEEISL---STEPESAQIQDSPMNNL 405

  Fly  1413 SEKG-GNTLTSRKSSSTPSLPEATEKNQNPEGASNQTVSADNLAWKQTVETIAENVFASAKTQII 1476
            .|.| |...:....||....||...:...|:|..||::.....|.:..|.|.|.:          
Human   406 MESGSGEPRSEAPESSESWKPEQLGEGSVPDGPGNQSIELSRPAEEAAVITEAGD---------- 460

  Fly  1477 SNQLAMNTSSSREARAKHKESGTNQMHKDNISGPSPLSRELEHISDLSAINNSMPAINSSNVSDL 1541
            ...:::....:.|..|        |:.||  ..|:|.:.||....||..             ...
Human   461 QGMVSVGPEGAGELLA--------QVQKD--IQPAPSAEELAEQLDLGE-------------EAS 502

  Fly  1542 ATISENLSLTELSKENICRVLTPSYKPAESVTASQS-SSHPDVQSSSPRENDIKNISNIEENNKM 1605
            |.:.|:......:||          :|.|....:|| :...:.:.....|.|:..:...|...::
Human   503 ALLLEDGEAPASTKE----------EPLEEEATTQSRAGREEEEKEQEEEGDVSTLEQGEGRLQL 557

  Fly  1606 NANNSVNKISKDLLANLRTSNIAGCP-PVTQLST---EALEMIDKMRDGVDMIRNMSNSILSTDT 1666
            .|  ||.:.|:.            |. ||::|.|   .|....:..|.....|..:.:|:.|.. 
Human   558 RA--SVKRKSRP------------CSLPVSELETVIASACGDPETPRTHYIRIHTLLHSMPSAQ- 607

  Fly  1667 FPVPCTNVPVGGKKTPKAQALINPDNANQKQIIVTSEEFPTKSSKKPSVTLKPAQQPNAVLSIVD 1731
                      ||      .|....|.|.::..:..|.|   |.......|:  |..|:|   :.:
Human   608 ----------GG------SAAEEEDGAEEESTLKDSSE---KDGLSEVDTV--AADPSA---LEE 648

  Fly  1732 IKEQPI-SNENVSVPSQMSISVPNLTTTSASE---VPSTSEVATHTGLLETFAAIARRRTSQGTN 1792
            .:|:|. :....:.|.......|:|...:|.:   .|||..                        
Human   649 DREEPEGATPGTAHPGHSGGHFPSLANGAAQDGDTHPSTGS------------------------ 689

  Fly  1793 IQDNQIMNAEANVNEHGDQNASGSFLGHSVTSLVKLALSSNFHSGLLSTAQSYPSLSSNNSENIA 1857
                   .::::..:.||.:..|                       ...:...||..|::..:.:
Human   690 -------ESDSSPRQGGDHSCEG-----------------------CDASCCSPSCYSSSCYSTS 724

  Fly  1858 PSNPSNTSAGQQSASTINHTLTMSLTSTSS-DSEQVSLEDFLESCRAPALLGDLDDEDDMDEDND 1921
            ..:.|..||...|.|..|.....|.|..|| ||.::|......|                 :|::
Human   725 CYSSSCYSASCYSPSCYNGNRFASHTRFSSVDSAKISESTVFSS-----------------QDDE 772

  Fly  1922 EEENEDEYEEVGNTL----LQVMVSRNLLTFMDD------------EAMENRLVGVTKRKSWDDE 1970
            |||| ..:|.|.:::    |....:.....:.|:            |.:|:.:.|.:.|:..:..
Human   773 EEEN-SAFESVPDSMQSPELDPESTNGAGPWQDELAAPSGHVERSPEGLESPVAGPSNRREGECP 836

  Fly  1971 FVLKRQFSALIPAF-----------DPRP----------GRT----NVNQTSDLEISPLGAELP- 2009
            .:...|..:.:|:.           :|.|          ||.    :||:|:..: .|..|..| 
Human   837 ILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARIDSHGRVFYVDHVNRTTTWQ-RPTAAATPD 900

  Fly  2010 ----------------------------KPQQSGGPETIEQPLLGLKLRGPGIGGIPEVEIDLSN 2046
                                        :.::..|.::.||...|   .|.|.|...|.|...|:
Human   901 GMRRSGSIQQMEQLNRRYQNIQRTIATERSEEDSGSQSCEQAPAG---GGGGGGSDSEAESSQSS 962

  Fly  2047 TDW--------TIFRAVQELLQCSQLNKLDKFRKIWEPT-YTIVYREVSPEA--QESTCLES--- 2097
            .|.        ...:.:..|||...:    ||  |..|. :|:::...|...  ..||||:.   
Human   963 LDLRREGSLSPVNSQKITLLLQSPAV----KF--ITNPEFFTVLHANYSAYRVFTSSTCLKHMIL 1021

  Fly  2098 ---------EEFPQTPD-------------------------------VSSKSGAST-LSPNSPM 2121
                     |.:....|                               |...|.|:| :.|..|:
Human  1022 KVRRDARNFERYQHNRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPL 1086

  Fly  2122 HIGFNVADNNLCSVDDVLELLTQINGLNQSEIDSDVKEHGVSVLSEDLFISKKITNKLQQQIQ-D 2185
            ..|  ...|:|..    .:.|.::...:..|.....:..|.|:|:..   ...:...::.|.| :
Human  1087 QNG--RLPNHLTH----RQHLQRLRSYSAGEASEVSRNRGASLLARP---GHSLVAAIRSQHQHE 1142

  Fly  2186 PLVLASN-------ALPNWCENLNQSCPFLFPFET--RQLYF------------NCT-------- 2221
            .|.||.|       ..||..|.|.:..|.|....|  .::::            :|.        
Human  1143 SLPLAYNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLS 1207

  Fly  2222 --------------------SFGASRSIVCLQSQRDVTVERQRIPIMSPRRDDHEFRI------- 2259
                                || :.|...|...|....::|......||.|.|.|.::       
Human  1208 LFEEEIMSYVPLQAAFHPGYSF-SPRCSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYRKL 1271

  Fly  2260 ---------GRLKHERVKVPRNEDLLMWAMQVMKTHCNR---KSVLEVEFLDEEGTGL-GPTLEF 2311
                     |::|    .:.|.:.||......:..:..:   ::.|.|.|:.|||... ||:.||
Human  1272 EAKGFGQGPGKIK----LIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREF 1332

  Fly  2312 YALVAAEIQRSDLCMWLCDDDLGEDTENSTQSAEGNSKPVGYYVNRREHGIFPAPLPQNSEICEN 2376
            :.|::.|:.....       .|.|.:.|.|.:.:  ..|:..:|                   ||
Human  1333 FFLLSQELFNPYY-------GLFEYSANDTYTVQ--ISPMSAFV-------------------EN 1369

  Fly  2377 VLKYFWFFGVFVAKVLQDMRLVDI----PLSTSFLQLLCHNKVLSRNLQKVISDRRNGDLSVVSE 2437
            .|::|.|.|..:...|....|:|.    |...:.|:|.|                   |||    
Human  1370 HLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPC-------------------DLS---- 1411

  Fly  2438 DSDIVETCTKLLRTDSNKSNAFGGILSLENLKEIDPTRYQFLQEMQNLLLRKQSIEFDDTISAEK 2502
                                         :|:.:|...:|.||.|:           |:.|:   
Human  1412 -----------------------------DLEYLDEEFHQSLQWMK-----------DNNIT--- 1433

  Fly  2503 KHELINELKLQTQNGLEVSLEDLALTFTYLPSSSIYG-YTQAELLPNGSSVNVTIDNLEAYCELL 2566
                                :.|.||||.  :..::| .|:.||...|::..||..|.:.|.|.:
Human  1434 --------------------DILDLTFTV--NEEVFGQVTERELKSGGANTQVTEKNKKEYIERM 1476

  Fly  2567 MNFILQDGIAQQMKAFSDGFNEVFPLKKLAAFTPSEARMMICGE---QFPHWSREDIISYTEPKL 2628
            :.:.::.|:.||.:|...||.||...:.::.|...|..::|.|.   ....|...     ||.:.
Human  1477 VKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNN-----TEYRG 1536

  Fly  2629 GYNKDSPGFQRFVNVLLSMSGDERKAFLQFTTGCSSLPPGGLANLHP----RLTVVRKVDAGVGS 2689
            ||:......:.|...:...:.::|...|||.||.||:|..|.|.|..    |...:.|. ..:.|
Human  1537 GYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKW-GKITS 1600

  Fly  2690 YPSVNTCVHYLKLPDYPTEEIMKERLLTATKE 2721
            .|..:||.:.|.||.||:..::.|:||||.:|
Human  1601 LPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEE 1632

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ufd4NP_609369.1 ANK repeat 393..420 CDD:293786
ANK 396..509 CDD:238125
ANK repeat 422..453 CDD:293786
ANK repeat 455..484 CDD:293786
F5_F8_type_C 1173..1298 CDD:329041 11/52 (21%)
MIB_HERC2 1333..1389 CDD:310955 9/60 (15%)
DamX 1576..>1725 CDD:330571 30/153 (20%)
HECTc 2265..2725 CDD:238033 107/473 (23%)
HECW1XP_016867371.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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