DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ufd4 and Yap1

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	XP_006509915.1	Gene:	Yap1 / 22601	MGIID:	103262	Length:	494	Species:	Mus musculus

Alignment Length:	493	Identity:	95/493 - (19%)
Similarity:	159/493 - (32%)	Gaps:	184/493 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  1227 QGSKDGSTWTTLS-----THVDDKSL----VEPGS-TATWPINCATDDSVWYRHIRIQQNGRNAS 1281
            |.|.|..|...|:     .|....||    |.||: ||:..:                 :|..|:
Mouse    92 QASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTASGVV-----------------SGPAAA 139

  Fly  1282 GQTHYLSLSGFEIYGRVVGVADDIGKSVKEAEAKTRRERRQI--------------RAQLKHMTT 1332
            ....:|..|.|||       .||:........|||...:|..              :|.|..:..
Mouse   140 PAAQHLRQSSFEI-------PDDVPLPAGWEMAKTSSGQRYFLNHNDQTTTWQDPRKAMLSQLNV 197

  Fly  1333 GARVIRGVDWR------------WEE---QDGCAEGTITGEIH--------NGWIDVKWDHGVRN 1374
            .|.....|...            ||:   ||        ||::        ..|:|.:.|.
Mouse   198 PAPASPAVPQTLMNSASGPLPDGWEQAMTQD--------GEVYYINHKNKTTSWLDPRLDP---- 250

  Fly  1375 SYRMGAEGKYDLKLADCEYLSAFDGNQSMGSASTAAKPSEKGGNTLTSRKSSSTPSLPEATEKNQ 1439
              |.|                     ::|....|.:.|.::           ..|..|::.:...
Mouse   251 --RFG---------------------KAMNQRITQSAPVKQ-----------PPPLAPQSPQGGV 281

  Fly  1440 NPEGASNQ---------TVSADNLAWKQTVETIAENVFASAKTQIISNQLAMNTSSSREARAK-- 1493
            ...|:|||         .:..:.|..||      :.:|...:.|.|.|   :|.|::...:.:
Mouse   282 LGGGSSNQQQQIQLQQLQMEKERLRLKQ------QELFRQVRPQAIRN---INPSTANAPKCQEL 337

  Fly  1494 ---------HKESGTNQMHKDNISGPSPLSRELEHISDLSAINNSMPAINS--------SNVSDL 1541
                     .::.||    .:.:|.|. :|:||..::    .|:|.|.:||        |..|.|
Mouse   338 ALRSQLPTLEQDGGT----PNAVSSPG-MSQELRTMT----TNSSDPFLNSGTYHSRDESTDSGL 393

  Fly  1542 ATISENLSLTELSKENICRVLTPSYKPAESVTASQSSSHPDVQSSSPREN-DIKNISNIEENNKM 1605
            :..|.::..|.....|....:......::|...||.|..||...:.|..| |:..:    |.:.|
Mouse   394 SMSSYSIPRTPDDFLNSVDEMDTGDTISQSTLPSQQSRFPDYLEALPGTNVDLGTL----EGDAM 454

  Fly  1606 NANNSVNKISKDLLANLRTSNIAGCPPVTQLSTEALEM 1643
            |..      .::|:.:|:.:          ||:|.|::
Mouse   455 NIE------GEELMPSLQEA----------LSSEILDV 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041	20/80 (25%)
		MIB_HERC2	1333..1389	CDD:310955	13/78 (17%)
		DamX	1576..>1725	CDD:330571	16/69 (23%)
		HECTc	2265..2725	CDD:238033
Yap1	XP_006509915.1	FAM181	<61..>141	CDD:373671	15/65 (23%)
		WW	159..188	CDD:238122	4/28 (14%)
		WW	217..246	CDD:366073	7/36 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900