DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ufd4 and Hectd1

DIOPT Version :9

Sequence 1:NP_609369.1 Gene:Ufd4 / 34378 FlyBaseID:FBgn0032208 Length:2727 Species:Drosophila melanogaster
Sequence 2:NP_659037.2 Gene:Hectd1 / 207304 MGIID:2384768 Length:2610 Species:Mus musculus


Alignment Length:2907 Identity:1399/2907 - (48%)
Similarity:1794/2907 - (61%) Gaps:477/2907 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MGDVDPETLLEWLSMGQGDERDMQLIALEQLCMLLLMSDNVDRCFESCPPRTFLPALCKIFLDEL 65
            |.||||:||||||.||||||||||||||||||||||||||||||||:|||||||||||||||||.
Mouse     1 MADVDPDTLLEWLQMGQGDERDMQLIALEQLCMLLLMSDNVDRCFETCPPRTFLPALCKIFLDES 65

  Fly    66 APENVLEVTARAITYYLDVSAECTRRIVSIDGAIKAICNHLVVADLSSRTSRDLAEQCIKVLELI 130
            ||:|||||||||||||||||||||||||.:||||||:||.|||.:|::||||||||||:||||||
Mouse    66 APDNVLEVTARAITYYLDVSAECTRRIVGVDGAIKALCNRLVVVELNNRTSRDLAEQCVKVLELI 130

  Fly   131 CTREAGAVFEGGGLNCVLSFIRDCGSQVHKDTLHSAMSVVSRLCTKVEPNTPCIQNCVESLSTLL 195
            ||||:|||||.|||||||:||||.|..||||||||||:||||||.|:||....::.||||||:||
Mouse   131 CTRESGAVFEAGGLNCVLTFIRDSGHLVHKDTLHSAMAVVSRLCGKMEPQDSSLEICVESLSSLL 195

  Fly   196 QHEDPMVSDGALKCFASVADRFTRKWVDPAPLAEYGLTTELLKRLQSVGGNTHSSLTAAGTQPTS 260
            :|||..||||||:||||:||||||:.|||||||::|||.|||.|:.:.||      |.:|  |:|
Mouse   196 KHEDHQVSDGALRCFASLADRFTRRGVDPAPLAKHGLTEELLSRMAAAGG------TVSG--PSS 252

  Fly   261 SSQPAATTNSDAINENVAGTATISNSTKVKSSDAAASPQSISTTISLLSTLCRGSPSITHDILRS 325
            :.:|..:|..   ..:.|..:.:||              .:||.:|||||||||||.:|||:|||
Mouse   253 ACKPGRSTTG---APSAAADSKLSN--------------QVSTIVSLLSTLCRGSPLVTHDLLRS 300

  Fly   326 QLADALERALQGDERCVLDCMRFADLLLLLLFEGRQALNRGSNNPNQGQLAPRPRRNNTNTDRTH 390
            :|.|::|.|||||||||||.||..||||:||||||:||.:.|.. :.|:: |..||.:::.:|:|
Mouse   301 ELPDSIESALQGDERCVLDTMRLVDLLLVLLFEGRKALPKSSAG-STGRI-PGLRRLDSSGERSH 363

  Fly   391 RQLIDCIRSKDSEALREAIESGGIDVNCMDDVGQTLLNWASAFGTLEMVEYLCEKGADVNKGQRS 455
            |||||||||||::||.:||::|..:||.|||||||||||||||||.||||:|||:|||||:||||
Mouse   364 RQLIDCIRSKDTDALIDAIDTGAFEVNFMDDVGQTLLNWASAFGTQEMVEFLCERGADVNRGQRS 428

  Fly   456 SSLHYAACFGRPAIAKILLKFGAYPDLRDEDGKTPLDKARERLDDGHREVAAILQSPGEWMSPDH 520
            ||||||||||||.:||.||:.||.||||||||||||||||||   ||.||.|||||||:||.|  
Mouse   429 SSLHYAACFGRPQVAKTLLRHGANPDLRDEDGKTPLDKARER---GHSEVVAILQSPGDWMCP-- 488

  Fly   521 SLLNK-DGKK--------YTLMEPRGDPEMAPIYLKVLLPIFCRTFLGSMLGSVRRASLALIKKI 576
              :|| |.||        ....||||||||||:|||.|||:|.:||..:||.|:|:||||||:|:
Mouse   489 --VNKGDDKKKKDTNKDEEECNEPRGDPEMAPLYLKRLLPVFAQTFQHTMLPSIRKASLALIRKM 551

  Fly   577 VQYAYPTVLQSLSETSFSEDAASTSGQNGGNLLIEVIASVLDNEDDGDGHLIVLNIIEEIMCKTQ 641
            :.:.        ||....|...|..|.|....|:|:.|:|||.|||.||||:.|.||.:::.|..
Mouse   552 IHFC--------SEALLKEVCDSDVGHNLPTTLVEITATVLDQEDDDDGHLLALQIIRDLVDKGG 608

  Fly   642 EEFLDHFARLGVFAKVQALMDTDAEELYVQLPGTVEEPAAAQRSSTSVVVAPRPTSDDPMEDAKE 706
            :.|||..|||||.:||.||....:::       ..||.:..::            .|:|.|||||
Mouse   609 DIFLDQLARLGVISKVSALAGPSSDD-------ENEEESKPEK------------EDEPQEDAKE 654

  Fly   707 ILQGKPYHWREWSICRGRDCLYVWSDSVALELSNGSNGWFRFIIDGKLATMYSSGSPENGNDSSE 771
            :.||||||||:|||.|||||||:|||:.|||||||||||||||:||||||||||||||.|:||||
Mouse   655 LQQGKPYHWRDWSIIRGRDCLYIWSDAAALELSNGSNGWFRFILDGKLATMYSSGSPEGGSDSSE 719

  Fly   772 NRGEFLEKLMRARSCVIAGVVSQPILPTASALRLVVGNWVLQSQKTNQLQIHNTEGHQVTVLQDD 836
            :|.||||||.|||..|.....|||||......:|.||||.|...|..::.|||::|.|.|:|::|
Mouse   720 SRSEFLEKLQRARGQVKPSTSSQPILSAPGPTKLTVGNWSLTCLKEGEIAIHNSDGQQATILKED 784

  Fly   837 LPGFIFESNRGTKHTFSAETVLGPDFASGWSTAKKKRNKSKTEGQKFQVRNLSREIYNKYFKSAQ 901
            ||||:|||||||||:|:|||.||.:|.:||:..:.::.|||.|..|.:||.::|::|:.:||:.:
Mouse   785 LPGFVFESNRGTKHSFTAETSLGSEFVTGWTGKRGRKLKSKLEKTKQKVRTMARDLYDDHFKAVE 849

  Fly   902 IIPRGAVAILTDIVKQIELSFE----EQHMAPNGNWETTLTDALMKLSQLIHEDGVVSAYEMHSS 962
            .:|||.|..|.:|..|:|.|:|    .|.:.....|...:..||..|..|:.::..:|.|||.||
Mouse   850 SMPRGVVVTLRNIATQLESSWELHTNRQCIEGENTWRDLMKTALENLIVLLKDENTISPYEMCSS 914

  Fly   963 GLVQALVAVLSVNHWETNSPR-CKRNKMQKQRVSVFKKCILEDNVESATNKPRTKSTASILIQKL 1026
            ||||||:.||: |..:.:..: |.:   ..:|::|||....|.  |...::|     |..||:||
Mouse   915 GLVQALLTVLN-NSIDLDMKQDCSQ---LVERINVFKTAFSES--EDDESRP-----AVALIRKL 968

  Fly  1027 VSVLESTEKLPVYLYDSPCTGYSLQILQKRLRFRLERAECESTLFDRSGRTLKMEPLATIGQLSK 1091
            ::||||.|:||::|||:|.:.|:||||.:|||||||||..|::|.||:||.||||||||:..|.:
Mouse   969 IAVLESIERLPLHLYDTPGSTYNLQILTRRLRFRLERAPGETSLIDRTGRMLKMEPLATVESLEQ 1033

  Fly  1092 YLLKMVAKQWYDLDRSTYFYLKKIREHRTATVFTHSFDFDEEGLLFYIGSNAKTC-DWVNPAQYG 1155
            ||||||||||||.|||::.:::|:||.:. .:|.|..||||.|::::||:||||. :|||||.||
Mouse  1034 YLLKMVAKQWYDFDRSSFVFVRKLREGQN-FIFRHQHDFDENGIIYWIGTNAKTAYEWVNPAAYG 1097

  Fly  1156 LVQVTSSEGKTLPYGKLEDILSRDSISLNCHTKDNKKAWFAIDLGVYIIPTAYTLRHARGYGRSA 1220
            ||.||||||:.||||:||||||||:.:||||:.|:|.|||||||||::||:||||||||||||||
Mouse  1098 LVVVTSSEGRNLPYGRLEDILSRDNSALNCHSNDDKNAWFAIDLGVWVIPSAYTLRHARGYGRSA 1162

  Fly  1221 LRNWLLQGSKDGSTWTTLSTHVDDKSLVEPGSTATWPINCATDDSVWYRHIRIQQNGRNASGQTH 1285
            ||||:.|.||||..||:|.|||||.||.|||||||||::.|.|:...:||:|::|.|:|||||||
Mouse  1163 LRNWVFQVSKDGQNWTSLYTHVDDCSLNEPGSTATWPLDPAKDEKQGWRHVRLKQMGKNASGQTH 1227

  Fly  1286 YLSLSGFEIYGRVVGVADD-IGKSVKEAEAKTRRERRQIRAQ-LKHMTTGARVIRGVDWRWEEQD 1348
            ||||||||:||.|.||.:| :||:.|||||..||:||.:|:| ||:|..|||||||:||:|.:||
Mouse  1228 YLSLSGFELYGTVNGVCEDQLGKAAKEAEANLRRQRRLVRSQVLKYMVPGARVIRGLDWKWRDQD 1292

  Fly  1349 GC--AEGTITGEIHNGWIDVKWDHGVRNSYRMGAEGKYDLKLADCEYLSAFDGNQSMGSASTAAK 1411
            |.  .|||:|||:|||||||.||.|..||||||||||:|||||     ..:|       ..|.|.
Mouse  1293 GSPQGEGTVTGELHNGWIDVTWDAGGSNSYRMGAEGKFDLKLA-----PGYD-------PDTVAS 1345

  Fly  1412 PSEKGGNTLTSRKSSSTPSLPEATEKNQNPE------GASNQTVSADNLAWKQTVETIAENVFAS 1470
            |     ..::|..|.:|.|. .:..||..|:      |:|::..|:.::.   :|.:.::...||
Mouse  1346 P-----KPVSSTVSGTTQSW-SSLVKNNCPDKTSAAAGSSSRKGSSSSVC---SVASSSDISLAS 1401

  Fly  1471 AKTQIISNQLAMNTSSSREARAKHKESGTNQMHKDNISGPSPLSRELEHISDLSAINN-SMPAIN 1534
            .||:..|           |...:|.......:|              |.|..||:..| ....:.
Mouse  1402 TKTERRS-----------EIVMEHSIVSGADVH--------------EPIVVLSSAENVPQTEVG 1441

  Fly  1535 SSNVSDLATISENLSLTELSKENICRVLTPSYK---PAESVTASQ---SSSHPDVQSSSPRENDI 1593
            ||:.:..:|::     .|...||..|.|.|...   |.||...|.   |.|.|||.|.|      
Mouse  1442 SSSSASTSTLT-----AETGSENAERKLGPDSSVRAPGESSAISMGIVSVSSPDVSSVS------ 1495

  Fly  1594 KNISNIEENNKMNANNSVNKISKDLLANLRTSNIAGCPPVTQLSTEALEMIDKMRDGVDMIRNMS 1658
                                                                             
Mouse  1496 ----------------------------------------------------------------- 1495

  Fly  1659 NSILSTDTFPVPCTNVPVGGKKTPKAQALINPDNANQKQIIVTSEEFPTKSSKKPSVTLKPAQQP 1723
                                       .|.|.:.|:|:         |..||         |...
Mouse  1496 ---------------------------ELTNKEAASQR---------PLSSS---------ASNR 1515

  Fly  1724 NAVLSIVDIKEQPISNENVSVPSQMSISVPNLTTTSASEVPSTSEVATHTGLLETFAAIARRRTS 1788
            .:|.|::          ....|...|.|||||::...|.:.|         .:...|.|||    
Mouse  1516 LSVSSLL----------AAGAPMSSSASVPNLSSRETSSLES---------FVRRVANIAR---- 1557

  Fly  1789 QGTNIQDNQIMNAEANVNEHGDQNASGSFLGHSVTSLVKLALSSNFHSGLLSTAQSYPSLSS-NN 1852
              ||..:|.      |::.....|.:.: ||.:|.|..         :..|..|||:|:|:: ..
Mouse  1558 --TNATNNM------NLSRSSSDNNTNT-LGRNVMSTA---------TSPLMGAQSFPNLTTPGT 1604

  Fly  1853 SENIAPSNPSNTSAGQQSAST--------INHTLTMSLTSTSSDSE-----QVSLEDFLESCRAP 1904
            :..:..|..|.||:...:.:|        :::|||.|||||||:|:     :.||.|||:||||.
Mouse  1605 TSTVTMSTSSVTSSSNVATATTVLSVGQSLSNTLTTSLTSTSSESDTGQEAEYSLYDFLDSCRAS 1669

  Fly  1905 ALLGDLDDEDDMDE-DNDEEENED------EYEE-----------------------VGNTLLQV 1939
            .||.:|||::|:.| |.:::||||      ||||                       |.:.|.||
Mouse  1670 TLLAELDDDEDLPEPDEEDDENEDDNQEDQEYEEVMILRRPSLQRRAGSRSDVTHHVVTSQLPQV 1734

  Fly  1940 MVSRNLLTFMDDEAMENRLVGVTKRKSWDDEFVLKRQFSALIPAFDPRPGRTNVNQTSDLEISPL 2004
            ..........:.|..|....| .:|::|||::|||||||||:||||||||||||.||:||||.|.
Mouse  1735 PSGAGSRPVGEQEEEEYETKG-GRRRAWDDDYVLKRQFSALVPAFDPRPGRTNVQQTTDLEIPPP 1798

  Fly  2005 GAELPKPQQSGGPETIEQPLLGLKLRGPGIGGIPEVEIDLSNTDWTIFRAVQELLQ--CSQLNKL 2067
            |.  |..:.....|....|.|.|.|:..|:|...|||:.|:|...|||..||:|||  |:...|.
Mouse  1799 GT--PHSELLEEVECTPSPRLALTLKVTGLGTTREVELPLTNFRSTIFYYVQKLLQLSCNGNVKS 1861

  Fly  2068 DKFRKIWEPTYTIVYREVSPEAQEST-----C---------LESEEFPQTPDVS----------- 2107
            ||.|:||||||||:|||:....:|..     |         |.::|.|:...::           
Mouse  1862 DKLRRIWEPTYTIMYREMKDSDKEKENGKMGCWSIEHVEQYLGTDELPKNDLITYLQKNADAAFL 1926

  Fly  2108 --------------------------------SKSGAS-------------TLSPNSPMHIGFNV 2127
                                            :|||.:             .|:...|.....| 
Mouse  1927 RHWKLTGTNKSIRKNRNCSQLIAAYKDFCEHGTKSGLNQGAISSLQSSDILNLTKEQPQAKAGN- 1990

  Fly  2128 ADNNLCSVDDVLELLTQI--------NGLNQSEIDSDVKEHGVSVLSEDLFISKKITNKLQQQIQ 2184
             ..:.|.|:|||:||..:        :.::|.:.|    |........|.|.|||||.|:.|||:
Mouse  1991 -GQSPCGVEDVLQLLRILYIVASDPYSRISQEDGD----EQPQFTFPPDEFTSKKITTKILQQIE 2050

  Fly  2185 DPLVLASNALPNWCENLNQSCPFLFPFETRQLYFNCTSFGASRSIVCLQSQRDVTVERQRIPIMS 2249
            :||.|||.|||:|||.|...||||.|||||||||.||:|||||:||.||::|:.||||.| ...|
Mouse  2051 EPLALASGALPDWCEQLTSKCPFLIPFETRQLYFTCTAFGASRAIVWLQNRREATVERTR-TTSS 2114

  Fly  2250 PRRDD-HEFRIGRLKHERVKVPRNEDLLMWAMQVMKTHCNRKSVLEVEFLDEEGTGLGPTLEFYA 2313
            .|||| .|||:||||||||||||.|.|:.||..||:.|.:||||||||||.||||||||||||||
Mouse  2115 VRRDDPGEFRVGRLKHERVKVPRGESLMEWAENVMQIHADRKSVLEVEFLGEEGTGLGPTLEFYA 2179

  Fly  2314 LVAAEIQRSDLCMWLCDDDLGEDTENSTQSAEGNSKPVGYYVNRREHGIFPAPLPQNSEICENVL 2378
            |||||.||:||..|||||:..:| |:......|..||.|||| :|..|:|.||.||:|:..|.:.
Mouse  2180 LVAAEFQRTDLGTWLCDDNFPDD-ESRHVDLGGGLKPPGYYV-QRSCGLFTAPFPQDSDELERIT 2242

  Fly  2379 KYFWFFGVFVAKVLQDMRLVDIPLSTSFLQLLCHNKVLSRNLQKVISDRRNGD------------ 2431
            |.|.|.|:|:||.:||.||||:|:|..|.:|:|...:.| |:.|:|.:.| ||            
Mouse  2243 KLFHFLGIFLAKCIQDNRLVDLPISKPFFKLMCMGDIKS-NMSKLIYESR-GDRDLHCTESQSEA 2305

  Fly  2432 --------LSVVSEDSDIVETCTKLLRTDSNKSNA-FGGILSLENLKEIDPTRYQFLQEMQNLLL 2487
                    |||.|.:.|  .....:|.....|..| |.|||:.|:.:.::|.|.:||:|:::|.:
Mouse  2306 STEEGHDSLSVGSFEED--SKSEFILDPPKPKPPAWFNGILTWEDFELVNPHRARFLKEIKDLAI 2368

  Fly  2488 RKQSIEFDDTISAEKKHELINELKLQTQNGL--EVSLEDLALTFTYLPSSSIYGYTQAELLPNGS 2550
            :::.|..:.::|.::|:..:.||.|:..:|.  .:|:|||.|.|.:.|||.|||:|..:|.|:|.
Mouse  2369 KRRQILGNKSLSEDEKNTKLQELVLRNPSGSGPPLSIEDLGLNFQFCPSSRIYGFTAVDLKPSGE 2433

  Fly  2551 SVNVTIDNLEAYCELLMNFILQDGIAQQMKAFSDGFNEVFPLKKLAAFTPSEARMMICGEQFPHW 2615
            ...:|:||.|.|.:|:.:|.:..||.:||:||.||||:|||::||::|:..|.:|::||.|.|.|
Mouse  2434 DEMITMDNAEEYVDLMFDFCMHTGIQKQMEAFRDGFNKVFPMEKLSSFSHEEVQMILCGNQSPSW 2498

  Fly  2616 SREDIISYTEPKLGYNKDSPGFQRFVNVLLSMSGDERKAFLQFTTGCSSLPPGGLANLHPRLTVV 2680
            :.||||:||||||||.:|||||.|||.||..||.||||||||||||||:||||||||||||||||
Mouse  2499 AAEDIINYTEPKLGYTRDSPGFLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVV 2563

  Fly  2681 RKVDAGVGSYPSVNTCVHYLKLPDYPTEEIMKERLLTATKEKGFHLN 2727
            |||||...|||||||||||||||:|.:||||:||||.||.|||||||
Mouse  2564 RKVDATDASYPSVNTCVHYLKLPEYSSEEIMRERLLAATMEKGFHLN 2610

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ufd4NP_609369.1 ANK repeat 393..420 CDD:293786 16/26 (62%)
ANK 396..509 CDD:238125 87/112 (78%)
ANK repeat 422..453 CDD:293786 26/30 (87%)
ANK repeat 455..484 CDD:293786 22/28 (79%)
F5_F8_type_C 1173..1298 CDD:329041 90/124 (73%)
MIB_HERC2 1333..1389 CDD:310955 42/57 (74%)
DamX 1576..>1725 CDD:330571 15/151 (10%)
HECTc 2265..2725 CDD:238033 255/482 (53%)
Hectd1NP_659037.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 247..268 5/25 (20%)
Ank_2 366..457 CDD:289560 70/90 (78%)
ANK repeat 366..393 CDD:293786 16/26 (62%)
ANK 369..479 CDD:238125 87/112 (78%)
ANK 1. /evidence=ECO:0000255 395..424 25/28 (89%)
ANK repeat 396..426 CDD:293786 25/29 (86%)
ANK 2. /evidence=ECO:0000255 426..455 22/28 (79%)
ANK repeat 428..457 CDD:293786 22/28 (79%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 450..469 17/18 (94%)
ANK 3. /evidence=ECO:0000255 459..491 26/38 (68%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 489..513 8/23 (35%)
ANK 4. /evidence=ECO:0000255 579..612 15/32 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 627..657 10/48 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 707..748 27/40 (68%)
F5_F8_type_C 1107..1240 CDD:304887 95/132 (72%)
MIB_HERC2 1277..1335 CDD:284184 42/57 (74%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1343..1389 12/51 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1433..1475 11/46 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1592..1611 5/18 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1674..1756 21/82 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1777..1801 19/25 (76%)
K-box. /evidence=ECO:0000250 2029..2103 47/73 (64%)
HECTc 2131..2608 CDD:238033 255/482 (53%)
HECTc 2155..2607 CDD:214523 240/457 (53%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2297..2318 3/20 (15%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167842637
Domainoid 1 1.000 620 1.000 Domainoid score I179
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H9115
Inparanoid 1 1.050 2198 1.000 Inparanoid score I39
Isobase 1 0.950 - 0 Normalized mean entropy S5221
OMA 1 1.010 - - QHG52632
OrthoDB 1 1.010 - - D10145at33208
OrthoFinder 1 1.000 - - FOG0006411
OrthoInspector 1 1.000 - - oto92346
orthoMCL 1 0.900 - - OOG6_107049
Panther 1 1.100 - - LDO PTHR45670
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3704
SonicParanoid 1 1.000 - - X4675
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1615.890

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