DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ufd4 and hecd-1

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	NP_001368365.1	Gene:	hecd-1 / 177486	WormBaseID:	WBGene00016405	Length:	2650	Species:	Caenorhabditis elegans

Alignment Length:	3004	Identity:	1091/3004 - (36%)
Similarity:	1536/3004 - (51%)	Gaps:	631/3004 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGDVDPETLLEWLSMGQGDERDMQLIALEQLCMLLLMSDNVDRCFESCPPRTFLPALCKIFLDEL 65
            |..:|||||||||..|.|||||:||:|||||||||||:||:||||||||||||:|||||||:||.
Worm     1 MDGIDPETLLEWLQTGIGDERDLQLMALEQLCMLLLMADNIDRCFESCPPRTFIPALCKIFIDET 65

  Fly    66 APENVLEVTARAITYYLDVSAECTRRIVSIDGAIKAICNHLVVADLSSRTSRDLAEQCIKVLELI 130
            ||:|||||||||||||||||.||||||..:|||:||||..|..||:|.|:|:||||||:|:||.:
Worm    66 APDNVLEVTARAITYYLDVSNECTRRITQVDGAVKAICTRLAAADISDRSSKDLAEQCVKLLEHV 130

  Fly   131 CTREAGAVFEGGGLNCVLSFIRDCGSQVHKDTLHSAMSVVSRLCTKVEPNTPCIQNCVESLSTLL 195
            |.||..||::.||:|.:|:.:|..|:||||||:|||||||:|||.|:||..|.:..|.|||..||
Worm   131 CQRETMAVYDAGGINAMLTLVRVHGTQVHKDTMHSAMSVVTRLCGKMEPTDPELGKCAESLGALL 195

  Fly   196 QHEDPMVSDGALKCFASVADRFTRKWVDPAPLAEYGLTTELLKRLQSVGGNTHSSLTAAGTQPTS 260
            :||||.||:.||:|||::.|||.||.:|||.||                  .||:|.
Worm   196 EHEDPKVSESALRCFAALTDRFVRKMMDPAELA------------------MHSNLV-------- 234

  Fly   261 SSQPAATTNSDAINENVAGTATISNSTKVKSSDAAASPQSISTTISLLSTLCRGSPSITHDILRS 325
                          |::......||.   ::|...||...:|..:||:..|||||..||..:|.|
Worm   235 --------------EHLISIMVASND---ENSPTTASANILSIVLSLIGNLCRGSSLITEKVLTS 282

  Fly   326 -QLADALERALQG-DERCVLDCMRFADLLLLLLFEGRQALNRGSNNPNQGQLAPRPRRNNTNTDR 388
             .:...|:..|.. :||.|.|.:||.||||:||.|||.||...|  ...|..|.     .:..:|
Worm   283 PNMITGLKATLTNKEERVVTDGLRFCDLLLVLLCEGRSALPLTS--VVSGDYAA-----GSGAER 340

  Fly   389 THRQLIDCIRSKDSEALREAIESGGIDVNCMDDVGQTLLNWASAFGTLEMVEYLCEKGADVNKGQ 453
            .||||||.||.||..||.:|||||.:|||..|||||:|.|||||||::|||:|||:||:|||||.
Worm   341 VHRQLIDAIRQKDLTALVDAIESGQVDVNFADDVGQSLTNWASAFGSIEMVQYLCDKGSDVNKGH 405

  Fly   454 RSSSLHYAACFGRPAIAKILLKFGAYPDLRDEDGKTPLDKARERLDDGHREVAAILQSPGEWMSP 518
            :|||||||||||||.:.|:||:.||.||||||||||.|||||||.||.|.:||.||:||..:|.
Worm   406 KSSSLHYAACFGRPDVVKLLLQRGANPDLRDEDGKTALDKARERSDDDHNQVANILESPSAFMR- 469

  Fly   519 DHSLLNKDGKKY---------TLMEPR-GDPEMAPIYLKVLLPIFCRTFLGSMLGSVRRASLALI 573
                 ||:..|.         |..:|. .:|.:....|..||||||..|..|:.|||||.||:|:
Worm   470 -----NKEDPKVKASTSKQPGTSTKPELPNPNLVRKVLHQLLPIFCEIFQKSLNGSVRRTSLSLM 529

  Fly   574 KKIVQYAYPTVLQSLSETSFSEDAA---------STSGQNGGNLLIEVIASVLDNEDDGDGHLIV 629
            :|||:.     :..|.:::..:..|         ||....|...|:.|:.||:|.|||.:||..|
Worm   530 RKIVEN-----IGDLRQSAVGDGNAPAAQSARKMSTDVSAGAESLVAVVVSVMDQEDDHEGHEQV 589

  Fly   630 LNIIEEIMCKTQEEFLDHFARLGVFAKVQA----------------------------------- 659
            |.|:|.::.|..|.::....|||||.:|:|
Worm   590 LLILESLLEKDAELWVIELVRLGVFERVEAMAKEPPKGLEEVLNAIHLEGRSRVTPMEIDFENQP 654

  Fly   660 -----------LMDT---------DAEELYVQLPGTVE--EPAAAQRSSTS--VVVAPRPTSDDP 700
                       :|||         |||.  ...|.|:|  :|.::..||::  .:..|:.|:...
Worm   655 SSSTAVPTANDIMDTTVPSSSGGADAES--NSNPSTIEMADPESSTPSSSTQQSISKPKATASST 717

  Fly   701 MEDA--------------------------KEIL-QGKPYHWREWSICRGRDCLYVWSDSVALEL 738
            ...|                          |.:| ||.||.|:||.|.||...|::|||.:.:||
Worm   718 ASSAILQVVSKLSSVASLDKSAAAVDKKPTKTVLSQGTPYRWKEWRIVRGTTSLFIWSDVLLIEL 782

  Fly   739 SNGSNGWFRFIIDGKLATMYSSGSPENGNDSSENRGEFLEKLMR----ARSCVIAGVV-----SQ 794
            ...||||||::.|......:.:|:.......:|...:..:|..|    :|...:.||.     |.
Worm   783 PFQSNGWFRYLADNDSHVQFVTGTASVDQQMTEEEKDNFQKTERREMVSRWNAVKGVFDDDWSSV 847

  Fly   795 PI----LPTAS---ALRLVVGNWVLQSQKTNQLQIHNTE-----GHQVTVL-----QDDLPGFIF 842
            ||    :|:.:   :.:|.|..|.|.|.|:::|||.:..     |...|:|     |||..||:|
Worm   848 PIAVLGIPSNAKKVSQKLEVPAWELWSSKSSELQIKSISSSAPTGQANTMLTTIKIQDDAGGFLF 912

  Fly   843 ESNRGTKHTFSAETVLGPDFASGWST--AKKKRNKSKTEGQKFQVRNLSREIYNKYFKSAQIIPR 905
            |:..|.|.....|..|..||.:|||:  ...::.|.:.:.||.:|:.|:.:::|.:.|.|...||
Worm   913 ETGTGRKTNVMPEHALPSDFHTGWSSHGVSTRKMKFRQDIQKRKVQELAWKLWNDHLKEAHAKPR 977

  Fly   906 GAVAILTDIVKQIELSFEEQHMAPNGNWE------------TTLTDALMKLSQLIHEDGVVSAYE 958
            .|:..|.:..:.||.:.  :|:....|::            .....|:..|.:.|.:|..:|.:|
Worm   978 EALVRLENAARTIESTI--RHVKAQSNFKHRNVKQPRIERVQEYCAAISTLHESIVDDRRLSTFE 1040

  Fly   959 MHSSGLVQALVAVLSVNHWETNSPRCKRNKMQKQRVSVFKKCILEDNVESATNKPR-TKSTA-SI 1021
            ...||:|.||..:||:              |:|          ..|:..|...|.: :|..| |.
Worm  1041 FSVSGIVPALFGLLSM--------------MEK----------FPDSFPSRIFKEQFSKGEALSY 1081

  Fly  1022 LIQKLVSVLESTEKLPVYLYDSP-CTGYSLQILQKRLRFRLE---RAE----CESTLFDRSGRTL 1078
            |..|:|:|||:.||.|.:||||| .:.:.||:|.:|:|.:||   ||:    .:..|.:::|:.:
Worm  1082 LALKIVAVLEANEKFPQHLYDSPGGSSFGLQLLSRRVRTKLEMLPRADGKENNDENLVNKTGKIV 1146

  Fly  1079 KMEPLATIGQLSKYLLKMVAKQWYDLDRSTYFYLKKIREHRT---ATVFTHSFDFDEEGLLFYIG 1140
            |.||||::|.:..||.:||.:||:|.:|:.|.|:|:|:|.:|   :....|..||||.|::::||
Worm  1147 KCEPLASVGAIRAYLHRMVTRQWHDRERANYRYVKEIQELKTKGKSIELRHVSDFDENGVIYWIG 1211

  Fly  1141 SNAKTCD-WVNPAQYGLVQVTSSEGKTLPYGKLEDILSRDSISLNCHTKDNKKAWFAIDLGVYII 1204
            :|.:... |.|||....|::|.|:.:. |:||.||:||||...:||||.|:|.|.|.||||::::
Worm  1212 TNGRAAPLWTNPATVKAVKITCSDTRQ-PFGKPEDLLSRDQNPINCHTSDDKNAHFTIDLGLFVV 1275

  Fly  1205 PTAYTLRHARGYGRSALRNWLLQGSKDGSTWTTLSTHVDDKSLVEPGSTATWPINCATDDSVWYR 1269
            ||:|:|||:|||||||||||:||||.|...|..:..|.|||.|.||||||||.:  ....:..:|
Worm  1276 PTSYSLRHSRGYGRSALRNWMLQGSVDAKRWENVIVHTDDKGLGEPGSTATWHV--GEKGTTAFR 1338

  Fly  1270 HIRIQQNGRNASGQTHYLSLSGFEIYGRVVGVADDI----------------------------- 1305
            ..||.|||:|:||||||||.|||||||.:|.|..:.
Worm  1339 FFRIAQNGKNSSGQTHYLSCSGFEIYGDIVDVVTEAICEDPPKKDSPAGTSSTPGSSSSAALPPL 1403

  Fly  1306 --------------------GKSVKEAEAKTRRERRQIRAQLKHMTTGARVIRGVDWRWEEQDGC 1350
                                |.|::...:..:|.|.:.|...|...:.::|:||.|||||:|||
Worm  1404 TKEQVLEMLPARENNNRLKSGLSLETVTSMLQRSRHRSRGSYKISESKSKVVRGKDWRWEDQDG- 1467

  Fly  1351 AE---GTITGEIHNGWIDVKWDHGVRNSYRMGAEGKYDLKLADCEYLSAFDGNQSMGSASTAAKP 1412
            .|   |.||....:||:||.||:|..||||.||.|.:|::                       :.
Worm  1468 GEGKFGRITSPPESGWVDVTWDNGNANSYRFGANGNFDIE-----------------------RV 1509

  Fly  1413 SEKGGNTLTSRKSSSTP-SLPEATEKNQ---NPEGASNQTVSADNLAWKQTVETIAENVFASAKT 1473
            :..|....|...:|..| |:.||..:|:   .|               |.|....:.:||.::.
Worm  1510 TSTGHRYSTPSLASHVPTSVMEAVRRNRAFYTP---------------KTTGGPPSSSVFGTSS- 1558

  Fly  1474 QIISNQLAMNTSSSREARAKHKESGTNQMHKDNISGPSPLSRELEHISDLSAINNSMPA--INSS 1536
                     :..|||.|                   .|.|||       .:::.|:.||  .:|.
Worm  1559 ---------SAGSSRGA-------------------ASALSR-------FASVKNTTPAGTPSSG 1588

  Fly  1537 NVSDLATISENLSLTELSKENICRVLTPSYKPAESVTASQSSSHPDVQSSSPRENDIKNISNIEE 1601
            ..|..|...:::|.|.|..|.                  |.:|.|.|.|:..
Worm  1589 GSSGGAIGKKSMSTTNLVDER------------------QKTSGPSVASTGQ------------- 1622

  Fly  1602 NNKMNANNSVNKISKDLLANLRTSNIAGCPPVTQLSTEALEMIDKMRDGVDMIRNMSNSI--LST 1664
                                      |......|..|.:||.:        :.|.|.::.  ::.
Worm  1623 --------------------------AASAESLQHQTPSLENL--------LARAMPHAFGRIAE 1653

  Fly  1665 DTFPVPCTNVPVGGKKTPKAQALINPDNAN---------QKQIIVTSEEFPTKSSKKPSVTLKPA 1720
            :..|   .:.|:||:::..|.::.:..::|         |:|....|:..|..|:..||.   |.
Worm  1654 NQEP---EDEPMGGEESDSAASMRSAASSNSQMSMGSSSQQQQQQDSDMTPRDSAGTPST---PR 1712

  Fly  1721 QQPNAVLSIVDIKEQPISNENVSVPSQMSISVPNLTTTSASEVPSTSEVATHTGLLETFAAIARR 1785
            ...|..||        :|..:::...|...|........|.|..|..:.......:|
Worm  1713 DDKNQTLS--------VSAPDLAAARQRQASAETDGDADADETNSEDKTVGADDAME-------- 1761

  Fly  1786 RTSQGTNIQDNQIMNAEANVNEHGDQNASGSFLGHSVTSLVKLALSSNFHSGLLS------TAQS 1844
                 .:.::.:.|..|.:.::..|..:|    ..:...||:|.   ....||..      |.:|
Worm  1762 -----EDDEEEETMEDEEDDDDDDDDESS----NENQEKLVELL---GGERGLFDKLKEVITGES 1814

  Fly  1845 YPSLSSNNSENIAPSNPSNTSAGQQSASTIN--HTLTMSLTSTSSDSEQVSLEDFLESCRAPALL 1907
            ....||:..:  |.:|.:....|::......  .:.|..|.....:...|:|.|       ||..
Worm  1815 LSDASSSAKD--ATTNEAQKKGGKKPKKWFKKMSSYTDVLKGLMQNRYPVALLD-------PAAA 1870

  Fly  1908 G-----DLDDED--DMDED--NDEEENEDEY-EEVG---NTLLQVMVSRNLLTFMD--------- 1950
            |     .:||:|  |..||  :|.:..|||. ..:|   ::...::.:|..:|:..
Worm  1871 GIEMDEMMDDDDYYDFSEDGPDDGDSVEDEVAAHLGMPVDSFASMVAARTPITWRQFSELMSGSN 1935

  Fly  1951 -DEAMENRLVGVTKRKSWDDEFVLKRQFSALIPAFDPRPGRTNVNQTSDLEISPLGAELPKPQQS 2014
             :.|...|.|..::...|:|:..:|..|.||||||||||||:|||||.::|:..:..:....:.|
Worm  1936 RERAAMARAVASSRGSPWEDDATVKCTFEALIPAFDPRPGRSNVNQTLEVELPTVVKDFGSTKAS 2000

  Fly  2015 GGPETIEQPLLGLKLRGPGIGGIPEVEIDLSNTDWTIFRAVQEL-LQCSQLNKLDKFRKIWEPTY 2078
            .. :..:...:...||||.:.|:..|.|::::...::||.:|.: ...:...|.|:.|:||||||
Worm  2001 SS-KIDKDDQMRFFLRGPNMSGVDNVTIEMNDDSASLFRYMQIINNSVNWATKSDRSRRIWEPTY 2064

  Fly  2079 TIVYREVSPEAQESTCLESEEFPQTPDVSSKSGASTLSPNSPMHIGFNVADNNLCSVDDVLELLT 2143
            :|.|........|.:.:..|| ..||                            |.|:..||.:.
Worm  2065 SICYCSADQTNVEVSKIPDEE-SSTP----------------------------CQVNQCLETIG 2100

  Fly  2144 QINGLNQSEIDSDVKEHGVSVLSEDLFISKKITNKLQQQIQDPLVLASNALPNWCENLNQSCPFL 2208
            .::.:.|:..::::        :.::|||.|:|.|:.|.:.|.||:|:.:||.||..|....|.|
Worm  2101 LLSRIQQAMPEAEI--------TPNVFISDKLTLKVTQVLSDALVVAARSLPEWCSRLVYKYPCL 2157

  Fly  2209 FPFETRQLYFNCTSFGASRSIVCLQSQRDVTVERQRIPIM-----SPRRDD--HEFRIGRLKHER 2266
            |..|||.:|...|:||.||:||.||.:||..|||.|....     :.|:.|  ||:|:|||:|||
Worm  2158 FTVETRNMYMQATAFGVSRTIVWLQQRRDAAVERARGSAQAGNSSAARQHDRYHEYRVGRLRHER 2222

  Fly  2267 VKVPRNED-LLMWAMQVMKTHCNRKSVLEVEFLDEEGTGLGPTLEFYALVAAEIQRSDLCMWLCD 2330
            |||.|.|: ||..|:::||.|.:||:|||:|:.:|||||||||||||||||||:||..|.:|:||
Worm  2223 VKVTRAEETLLDQAIRLMKFHADRKAVLEIEYTNEEGTGLGPTLEFYALVAAELQRKSLALWVCD 2287

  Fly  2331 DDLGEDT-------ENSTQSAEGNSKPVGYYVNRREHGIFPAPLPQNSEICENVLKYFWFFGVFV 2388
            ||   ||       |......|| .||:|||| ||..|:||||||..::..:.....|...|||:
Worm  2288 DD---DTHASKSGEEREVDLGEG-KKPIGYYV-RRVGGLFPAPLPPGTDETKRAADMFRVLGVFL 2347

  Fly  2389 AKVLQDMRLVDIPLSTSFLQLLCHNKVLSRNLQKVISDRRNGDLSVVSEDSDIVETCTKLLRTDS 2453
            ||||.|.||||:|||..||:||.|.::              ||                    |:
Worm  2348 AKVLLDGRLVDLPLSRPFLKLLVHPQI--------------GD--------------------DA 2378

  Fly  2454 NKSNAFGGILSLENLKEIDPTRYQFLQEMQNLLLRKQSIEFDDTISAEKKHELINELKLQTQNGL 2518
            ...| ...||||::.:|::|.:..||:|::.|..||:.||.|.:|.:..|...|.||||..: |.
Worm  2379 RGPN-LHKILSLDDFEEVNPVKGSFLKELRALAQRKRLIENDTSIDSNSKRRKIAELKLHIK-GS 2441

  Fly  2519 EVSLEDLALTFTYLPSSSIYGYTQAELLPNGSSVNVTIDNLEAYCELLMNFILQDGIAQQMKAFS 2583
            ...:|||||.||..|.|.::.|.:.||:..||.::|||||:|.|.|....|.|..|||.||:||.
Worm  2442 TCRVEDLALNFTVNPPSKVFQYAEMELVDGGSDIDVTIDNVEQYVEKCEEFYLNTGIAYQMRAFR 2506

  Fly  2584 DGFNEVFPLKKLAAFTPSEARMMICGEQFPHWSREDIISYTEPKLGYNKDSPGFQRFVNVLLSMS 2648
            |||:.||||:.|.|::|.|.:.::.|||.|.|||:||::||||||||.::||||.|||:|:.:::
Worm  2507 DGFDRVFPLRTLRAYSPEEVQRLLSGEQCPEWSRDDILNYTEPKLGYTRESPGFLRFVDVMEALT 2571

  Fly  2649 GDERKAFLQFTTGCSSLPPGGLANLHPRLTVVRKVDAGVGSYPSVNTCVHYLKLPDYPTEEIMKE 2713
            ..|||.||||.|||||||||||||||||||:||||::|.||||||||||||||||:|.:..|::|
Worm  2572 AQERKNFLQFATGCSSLPPGGLANLHPRLTIVRKVESGDGSYPSVNTCVHYLKLPEYSSSAILRE 2636

  Fly  2714 RLLTATKEKGFHLN 2727
            |||||..|||||||
Worm  2637 RLLTAINEKGFHLN 2650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786	17/26 (65%)
		ANK	396..509	CDD:238125	80/112 (71%)
		ANK repeat	422..453	CDD:293786	23/30 (77%)
		ANK repeat	455..484	CDD:293786	21/28 (75%)
		F5_F8_type_C	1173..1298	CDD:329041	76/124 (61%)
		MIB_HERC2	1333..1389	CDD:310955	30/58 (52%)
		DamX	1576..>1725	CDD:330571	26/159 (16%)
		HECTc	2265..2725	CDD:238033	239/467 (51%)
hecd-1	NP_001368365.1	Ank_2	345..436	CDD:403870	64/90 (71%)
		ANK repeat	345..372	CDD:293786	17/26 (65%)
		ANK repeat	374..403	CDD:293786	21/28 (75%)
		PTZ00322	383..>497	CDD:140343	68/119 (57%)
		ANK repeat	405..436	CDD:293786	21/30 (70%)
		F5_F8_type_C	1243..1365	CDD:419973	74/123 (60%)
		MIB_HERC2	1452..1509	CDD:399589	30/80 (38%)
		HECTc	2221..2648	CDD:238033	239/467 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162529
Domainoid	1	1.000	391	1.000	Domainoid score	I401
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9115
Inparanoid	1	1.050	1645	1.000	Inparanoid score	I32
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52632
OrthoDB	1	1.010	-	-		D10145at33208
OrthoFinder	1	1.000	-	-		FOG0006411
OrthoInspector	1	1.000	-	-		oto19149
orthoMCL	1	0.900	-	-		OOG6_107049
Panther	1	1.100	-	-	LDO	PTHR45670
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4675
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.860