DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ufd4 and hecw-1

DIOPT Version :9

Sequence 1:NP_609369.1 Gene:Ufd4 / 34378 FlyBaseID:FBgn0032208 Length:2727 Species:Drosophila melanogaster
Sequence 2:NP_001317872.1 Gene:hecw-1 / 175438 WormBaseID:WBGene00009738 Length:1247 Species:Caenorhabditis elegans


Alignment Length:1905 Identity:329/1905 - (17%)
Similarity:581/1905 - (30%) Gaps:768/1905 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   890 REIYNKYFKSAQIIPRGAVAILTDIVKQIELSFEEQHMAPNGNWETTLTDALMKL----SQLIHE 950
            :||:...|.|.||  :.::.|.:..||.|.::|:.|:  |.           :||    |||...
 Worm    25 KEIFQLSFSSNQI--KRSLGIASIPVKSIFVNFDSQY--PK-----------IKLIGESSQLEWV 74

  Fly   951 DGVVSAYEMHSSGLVQALVAVLSVNHWETNSPRCKRNKMQKQRVSVFKKCILEDNVESATNKPRT 1015
            .|:       ..||....|.|..:.|::.   :||.:                 .....|.....
 Worm    75 FGI-------PDGLEYTDVGVYKIGHFKF---QCKTS-----------------GTAFYTEHYDL 112

  Fly  1016 KSTASILIQKLVSVLESTEKLPVYLYDSPCTGYSLQILQKRLRFRLERAECESTLFDRSGRTLKM 1080
            ::...::|:.::|:.:.:..:..||      ...|.:::.      .||.||:.:..:     |:
 Worm   113 ENAMLVVIRYMISIFKCSNSIITYL------SIDLGVIED------SRAICENFVAFK-----KV 160

  Fly  1081 EPLATIGQLSKYLLKMVAKQWYDLDRSTYFYLKKIREHRTATVFTHSFDFDEEGL---LFYIGSN 1142
            |.|:            :.:..|.::|:|             ..|..|||:..:.|   ..:||: 
 Worm   161 ERLS------------IFQTNYGVERNT-------------LNFAQSFDWICDNLEIKNIHIGA- 199

  Fly  1143 AKTCDWVNPAQYGLVQVTSSE-GKTLPYGKLEDILSRDSISLNCHTKDNKKAWFAIDLGVYIIPT 1206
                |.:.|.   :||.|:.| ...|...:.|.:|:.|.|                         
 Worm   200 ----DVLEPK---MVQKTNGEFDIKLCARRFEQVLTMDHI------------------------- 232

  Fly  1207 AYTLRHARGYGRSALRNWLLQGSKDGSTWTTLSTHVDDKSLVEPGSTATWPINCATDDSVWYRHI 1271
              .|:||         :|:.  |:|     .|:..|....|:|         |..|:..:   :.
 Worm   233 --YLQHA---------DWIT--SED-----LLNLDVQTAMLIE---------NNLTEQDL---NA 267

  Fly  1272 RIQQNGRNASGQTHYLSLSGFEIYGRV-----VGVADDIGKSVKEAEAKTRRERRQIRAQLKHMT 1331
            .|:|..|:.|.:..:|.:.|..::.|.     :.|.||..:|:.......||.|..         
 Worm   268 FIKQWLRSDSDKLWWLEVKGKMMFNREEVLKDLDVQDDAYRSLNTRWYVARRSRAN--------- 323

  Fly  1332 TGARVIRGVDWRWEEQDGCAE---GTITGEIHNGWIDVKWDHGVRNSYRMGAEGKYDLKLADCEY 1393
                         ...:|||.   |::..::...|                   .:.:.:.....
 Worm   324 -------------PSGNGCARKKMGSLRPKLTELW-------------------PFKVYIIFGSI 356

  Fly  1394 LSAFDGNQSMGSASTAAKPSEKGGNTLTSRKSSSTPSLPEATEKNQNPEGASNQTVSA------- 1451
            |..|      |.|:.....:.:..:..|.|.|.|...: ..::....|.|..|:.|..       
 Worm   357 LIVF------GPAALNRMITLRRMDVETDRPSGSETGI-FVSKSAVYPFGNKNEVVKVWWNIDKP 414

  Fly  1452 DN-LAWKQTVETIAENVFASAKTQIISNQLAMNTSSSREARAKHKESGTNQMHKDNISGPSPLSR 1515
            :| |.|        ..:|.:..:....:|.::.                                
 Worm   415 ENCLDW--------IGLFDNNDSSFYLDQKSLR-------------------------------- 439

  Fly  1516 ELEHISDLSAINNSMPAINSSNV---------SDLATISENLSLTELSKENICR---VLTPSYKP 1568
              :|||.:.....|...:|:|.|         ..|...|||:        .||:   ::....|.
 Worm   440 --QHISPVVFTLTSKNLLNASEVYFGLIDGMTGRLLAKSENV--------EICKSASLVVHEVKK 494

  Fly  1569 AESVTASQSSSHPDVQSSSPRENDIKN-----------------ISNIEENNKMNANNSVNKISK 1616
            .|::....:::|..::....|....||                 ||.:|.:.|:|.::.:     
 Worm   495 PENINVYLNTNHGRIEIPKKRSFSRKNGSFRSSFEFDFDVEDLHISLVENSEKLNFDHFI----- 554

  Fly  1617 DLLANLRTSNIAGCPPVTQLSTEALEMIDKMRDGVDMIRNMSNSILSTDTFPVPCTNVPVGGKKT 1681
                   .||                             .:.|:.:.:.:|              
 Worm   555 -------ASN-----------------------------QLQNNYIQSKSF-------------- 569

  Fly  1682 PKAQALINPDNANQKQIIVTSEEFPTKSSKKPSVTLKPAQQPNAVLSIVDIKEQPISNENVSVPS 1746
                     .:::..:|:.:.|   .|:|||                              |.|.
 Worm   570 ---------SHSHVVEIVFSIE---PKTSKK------------------------------SAPD 592

  Fly  1747 QMSISVPNLTTTSASEVPSTSEVATHTGLLETFAAIARRRTSQGTNIQDNQIMNAEANVNEHGDQ 1811
            .|.|:       |:|:.|..|...|:..        |::|                         
 Worm   593 IMEIA-------SSSQTPPESHWKTYLD--------AKKR------------------------- 617

  Fly  1812 NASGSFLGHSVTSLVKLALSSNFHSGLLSTAQSYPSLSSNNSENIAPSNPSNTSAGQQSASTINH 1876
                .|..:.||.               .|..:.|...:||  :|.|..|.:.....:|||..|.
 Worm   618 ----KFYVNHVTK---------------ETRWTKPDTLNNN--HIEPETPVHKRLSDRSASPRNS 661

  Fly  1877 TLT--MSLTSTSSDSEQVSLEDFLESCRAPALLGDLDDEDDMDEDNDEEENEDEYEEVGNTLLQV 1939
            .:|  .::|..|:...:..|..|.:                          .||::    |.|  
 Worm   662 FITPRRTITVRSAGCPKSDLIQFFQ--------------------------RDEFK----TAL-- 694

  Fly  1940 MVSRNLLTFMDDEAMENRLVGVTKRKSWDDEFVLKRQFSALIPAFDPRPGRTNVNQTSDLEISPL 2004
                    :.:.:||:          .:::..|::.....:....|| |.:.. ||...:....|
 Worm   695 --------YENQDAMQ----------IYNECSVVRHAIHRIQKDLDP-PSKFE-NQPLFVRFVNL 739

  Fly  2005 GAELPKPQQSGGPETIEQPLLGLKLRGPGIGGIPEVEIDLSNTDWTIFRAVQELLQCSQLNKLDK 2069
            .|::.:|..||                                 |          :|..:|....
 Worm   740 FADITQPLPSG---------------------------------W----------ECITMNNRTV 761

  Fly  2070 FRKIWEPTYTIVYREVSPEAQESTCLESEEFPQTPDVSSKSGASTLSPNSPMHIGFNVADNNLCS 2134
            |..               .|.:.|........:....:|:.|.|..|.:|..|.|  ..|:.|.|
 Worm   762 FLN---------------HANKETSFYDPRIRRFETKTSRRGRSVPSRSSTAHKG--KIDHALIS 809

  Fly  2135 VDDVLELLTQINGLNQSEIDSD----VKEHG---VSVLSEDLFISKKITNKLQQQIQDPLVLASN 2192
            ..:.|..:.|.|....:|..|.    ::..|   |:.|:.||.|:..::           :|.||
 Worm   810 KCEDLRKIAQDNFPQIAERISKKLMLIERFGGLAVASLANDLDITLALS-----------MLDSN 863

  Fly  2193 A--LPNWCENLNQSCPFLFPFETRQLYFNCTSFGASRSIVCLQSQRDVTVERQRIPIMSPRRDDH 2255
            .  |....:|:..   |....:..:|       |...|.:|.:..||                  
 Worm   864 TEKLAGEGDNIKM---FYEDMKKEKL-------GKGPSRLCWKVSRD------------------ 900

  Fly  2256 EFRIGRLKHERVKVPRNEDLLMWAMQVMKTHCNRKSVLEVEFLDEEGTGLGP-TLEFYALVAAEI 2319
                 ||..:..::..|.|..     |:|     ||.|.:.|..|.....|. :.||:.|::.|:
 Worm   901 -----RLLDDAFRIILNVDPF-----VLK-----KSRLHIRFEGELALDYGGLSREFFILLSREL 950

  Fly  2320 QRSDLCMWLCDDDLGEDTENSTQSAEGNSKPVGYYVNRREHGIFPAPLPQNSEICENVLKYFWFF 2384
            ..               .:|.....|||.    |::..|..|            ||...:..|. 
 Worm   951 FH---------------PKNGYFEYEGND----YHLQLRPRG------------CETEKEKKWL- 983

  Fly  2385 GVFVAKVLQDMRLVDIPLSTSFLQLLCHNKVLSRNLQKVISDRRNGDLSVVSEDSDIVETCTKLL 2449
                                    :|| .:||:              |:|       :..|    
 Worm   984 ------------------------ILC-GRVLA--------------LAV-------IHRC---- 998

  Fly  2450 RTDSNKSNAFGGILSLENLKEIDPTRYQFLQEMQNLLL--RKQSIEFDDTISAEKKHELINELKL 2512
            ..|...:|.|                |:.||:....|:  ::...||         ::.:|.|  
 Worm   999 YIDVFFTNVF----------------YKSLQKRPVTLMDFKESDAEF---------YKSMNWL-- 1036

  Fly  2513 QTQNGLEVSLEDLALTFTYLPSSSIYG-YTQAELLPNGSSVNVTIDNLEAYCELLMNFILQDGIA 2576
                 ||..:.||.::|.|  ||.:.| ..:.||:|.|.|..||..|...:.:|:.......|:.
 Worm  1037 -----LENDVVDLEMSFVY--SSMVNGKLAEQELVPGGESQMVTEANKAEFIDLMCQKKAIRGVE 1094

  Fly  2577 QQMKAFSDGFNEVFPLKKLAAFTPSEARMMICGE---QFPHWSREDIISYTEPKLGYNKDSPGFQ 2638
            :.::.....||::.....|.:...|:.:.::.|.   ....|....|.     |.||:......:
 Worm  1095 KPLEILLTSFNQILNDNLLNSLESSDLKRILSGSLELDLNDWRTNTIY-----KGGYSDCHIVVE 1154

  Fly  2639 RFVNVLLSMSGDERKAFLQFTTGCSSLPPGGLANLH-----PRLTVVRKVDAGVGSYPSVNTCVH 2698
            .|..|:.:|:..||...|.|.||.||:|..|.:.|.     .:..:.:..||  .|:|..:||.:
 Worm  1155 WFWEVIETMTNQERFDLLLFVTGSSSVPFEGFSALRGNEEISKFCIEKWGDA--TSFPRAHTCFN 1217

  Fly  2699 YLKLPDYPTEEIMKERLLTA 2718
            .|:||.|.|::.:|.:|..|
 Worm  1218 RLQLPSYNTKQQLKSKLQQA 1237

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ufd4NP_609369.1 ANK repeat 393..420 CDD:293786
ANK 396..509 CDD:238125
ANK repeat 422..453 CDD:293786
ANK repeat 455..484 CDD:293786
F5_F8_type_C 1173..1298 CDD:329041 22/124 (18%)
MIB_HERC2 1333..1389 CDD:310955 5/58 (9%)
DamX 1576..>1725 CDD:330571 19/165 (12%)
HECTc 2265..2725 CDD:238033 99/466 (21%)
hecw-1NP_001317872.1 FBA_2 230..285 CDD:311601 19/109 (17%)
WW 603..634 CDD:197736 9/82 (11%)
WW 746..777 CDD:197736 9/88 (10%)
HECTc 918..1244 CDD:214523 96/448 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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