DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ufd4 and Y92H12A.2

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	NP_001293292.1	Gene:	Y92H12A.2 / 171719	WormBaseID:	WBGene00022358	Length:	724	Species:	Caenorhabditis elegans

Alignment Length:	1155	Identity:	218/1155 - (18%)
Similarity:	333/1155 - (28%)	Gaps:	511/1155 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly  1627 IAGCPPVTQLSTEALEMIDKMRDGVDMIRNMSNSILSTDTFPVPCTNVPVGGKKTPKAQAL---- 1687
            :.|.||.|...||.|.        |.::|                      |.|..|...|
Worm     7 VHGYPPNTDNETELLR--------VRLLR----------------------GTKLGKRDLLGVCS 41

  Fly  1688 ----INPDNANQKQIIVTSEEFPTKSSKKPSVTLKPAQQPNAVLSIVDIKEQPISNENVSVPSQM 1748
                |..:|:|..    |.:|...::.||   |..|..  |:|.:.           .|:...||
Worm    42 PYCMIRLENSNGD----TVDEVQVETKKK---TRNPTW--NSVFTF-----------RVTRACQM 86

  Fly  1749 SISVPNLTTTSASEVPSTSEVATHTGLLETFAAIARRRTSQGTNIQDNQIMNAEANVNEHGDQNA 1813
            .|.|             ..|......:|..|.:    ||     :.|..|.....|..|:..|:.
Worm    87 KILV-------------YDENRLRKDVLMGFVS----RT-----LNDGLITTQAPNPEEYALQSG 129

  Fly  1814 SGSFLGHSVTSLVKLALSSNFHSGLLSTAQSYPSLSSNNSENIAPSNPSNTSAGQQSAST----- 1873
            :.| .|.|:.||.   ||.:|          .|| ||:||       ||:::|..|..|:
Worm   130 TAS-KGKSIGSLF---LSFHF----------MPS-SSDNS-------PSDSTADLQQTSSGMPQG 172

  Fly  1874 -------------INHTLTMSLTSTSSDSEQVSLEDFLESCRAPALLGDLD---DEDDMDEDNDE 1922
                         :||.|.   |:..:..|.||             .|::|   ::..::|....
Worm   173 WEEREDGNGRTVYVNHALR---TTQFTPPESVS-------------NGNVDAITEQSVIEETRRR 221

  Fly  1923 EENEDEYEEVGNTLLQVMVSRNLLTFMDDEAMENRLVGVTKRKSWDDEFVLKRQFSALIPAFDPR 1987
            .:|.:...:|.:......:..|.||.:||....|...|....:..:||..|...:
Worm   222 RDNYEHRSQVTDEPSDTTIVSNELTAIDDAMRANFERGGGHVEEEEDELRLPDGW---------- 276

  Fly  1988 PGRTNVNQTSDLEISPLGAELPKPQQSGGPETIEQPLLGLKLRGPGIGGIPEVEIDLSNTDWTIF 2052
                      |::::|.|...                              .::.....|.||
Worm   277 ----------DMQVAPNGRTF------------------------------FIDHRTKTTTWT-- 299

  Fly  2053 RAVQELLQCSQLNKLDKFRKIWEPTYTIVYREVSPEAQESTCLESEEFPQTPDVSSKSGASTLSP 2117
                                  :|                                :.||:|..|
Worm   300 ----------------------DP--------------------------------RPGAATRVP 310

  Fly  2118 NSPMHIGFNVADNNLCSVDDVLELLTQINGLNQSEIDSDVK------EHGVSVLSEDLFISKKIT 2176
                                          |.:.:.|.::.      |..|.......||..
Worm   311 ------------------------------LLRGKTDDEIGALPAGWEQRVHADGRVFFIDH--- 342

  Fly  2177 NKLQQQIQDPLVLASNALPNWCENLNQSCPFLFPFETRQLYFNCTSFGASRSIVCLQSQRDVTVE 2241
            |:.:.|.:||..          ||.|.:.|.: |:              ||..     :|.|...
Worm   343 NRRRTQWEDPRF----------ENENIAGPAV-PY--------------SRDY-----KRKVEYL 377

  Fly  2242 RQRIPIMSPRRDD-------HEFRIGRLKHERVKVPRNEDLLMWAMQVMKTHCNRKSVLEVEFLD 2299
            |.|:|  .|..:.       |...:....:..:...::.||              ::.|.:||..
Worm   378 RSRLP--KPNSNSGKCDMVVHRDTLFEDSYRHIMDKKDYDL--------------RNKLWIEFFG 426

  Fly  2300 EEGTGL---GPTLEFYALVAAEIQRSDLCMWLCDDDLGEDTENSTQSAEGNSKPVGYYVNRREHG 2361
            |  |||   |.|.|::.|::.:|...                              ||      |
Worm   427 E--TGLDYGGVTREWFFLLSHQIFNP------------------------------YY------G 453

  Fly  2362 IFPAPLPQN--------SEICE-NVLKYFWFFGVFVAKVLQDMRLVDIPLSTSFLQLLCHNKVLS 2417
            :|......|        ||.|. ..|.||.|.|..:...:...:|:|......|.:::...|:..
Worm   454 LFEYSATDNYTLQINPHSEACNPEHLSYFHFIGRIIGMAIYHGKLLDAFFIRPFYKMMLGKKITL 518

  Fly  2418 RNLQKVISDRRNGDLSVVSEDSDIVETCTKLLRTDSNKSNAFGGILSLENLKEIDPTRYQFLQEM 2482
            .:::.|.::..|                                  ||..:|:.||.
Worm   519 FDMESVDNEYYN----------------------------------SLIYVKDNDPA-------- 541

  Fly  2483 QNLLLRKQSIEFDDTISAEKKHELINELKLQTQNGLEVSLEDLALTFTYLPSSSIYGYTQ-AELL 2546
                                                     ||.|||:.  ..||:|.|| .||:
Worm   542 -----------------------------------------DLELTFSL--DDSIFGETQNIELI 563

  Fly  2547 PNGSSVNVTIDNLEAYCELLMNFILQDGIAQQMKAFSDGFNEVFPLKKLAAFTPSEARMMICGEQ 2611
            |||::|.||.||.|.|.|                       .|.|...|..|..:|..:::||.|
Worm   564 PNGANVPVTEDNKEEYIE-----------------------AVVPSNLLRLFDANELELLMCGLQ 605

  Fly  2612 ---FPHWSREDIISYTEPKLGYNKDSPGFQRFVNVLLSMSGDERKAFLQFTTGCSSLPPGGLANL 2673
               ...|....|.     |.||...|.....|...:||...:.|...|||.:|.|.:|..|...|
Worm   606 KIDVKDWKANTIY-----KGGYGPSSQVVHNFWKCILSFDNEMRARVLQFVSGTSRVPMNGFREL 665

  Fly  2674 H-----PRLTVVRKVDAGVGSYPSVNTCVHYLKLPDYPTEEIMKERLLTA 2718
            :     .:.|:.|...|.:  .|..:||.:.|.||.|.|.:.:|.:||||
Worm   666 YGSNGLQKFTIERWGSADM--LPRAHTCFNRLDLPPYTTFKELKSKLLTA 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041
		MIB_HERC2	1333..1389	CDD:310955
		DamX	1576..>1725	CDD:330571	22/105 (21%)
		HECTc	2265..2725	CDD:238033	103/475 (22%)
Y92H12A.2	NP_001293292.1	C2	20..147	CDD:301316	41/212 (19%)
		WW	170..198	CDD:278809	4/30 (13%)
		WW	272..301	CDD:278809	7/102 (7%)
		WW	323..353	CDD:197736	7/32 (22%)
		HECTc	393..721	CDD:238033	104/488 (21%)
		HECTc	415..720	CDD:214523	103/466 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900