DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ufd4 and herc-1

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	NP_490834.1	Gene:	herc-1 / 171700	WormBaseID:	WBGene00021685	Length:	1019	Species:	Caenorhabditis elegans

Alignment Length:	725	Identity:	160/725 - (22%)
Similarity:	268/725 - (36%)	Gaps:	190/725 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  2115 LSPNSPMHIGFNVADNNLCSV---DDVLELLTQIN-------GLNQSEIDSDVKEHGVSVLSED- 2168
            :.|:.||.....:...:|..:   .|.||:::.|.       .:|.|.:..|.:.:.|....|.
Worm   371 VGPSCPMQYPIKLDHESLKKLLDEGDALEVMSLIESVFSSLASMNMSFLYKDERRYNVGFCFERS 435

  Fly  2169 -------------LFISKKITNKLQQQIQDPLVLASNALPNWCENLNQ-SC-------PFLFPFE 2212
                         ||....:..:..:.|.|.|.:   |...|.|||.. .|       |:| |..
Worm   436 HGIDMDQVMEAFMLFDEYPMKRQYMELIVDSLKI---AFQEWSENLKGIECLRVLLMLPWL-PIF 496

  Fly  2213 TRQLYFN-------------CTSFGASRS--------IVCLQSQRDVTVERQRIPIM-----SPR 2251
            |..:...             |...|..|:        :.....:|.|||.:..|..|     .|
Worm   497 TENVNVQTIKNVHTPFVDAMCLITGDLRAALEKWWTQLSTRHFRRMVTVFKTAIKAMLKAKKGP- 560

  Fly  2252 RDDHEFRIGRLKHERVKVPRNEDLLMWAMQVM-KTHCNRKSVLEVEFLDEEGTGLGPTLEFYALV 2315
            ||.|:|                .|:|..:.:: ||:  ....||..::||..|.:...||:
Worm   561 RDCHKF----------------ILIMQKLSLINKTY--HIIPLETFYIDELNTSVDLKLEY---- 603

  Fly  2316 AAEIQRSDLCMWLCDDDLGEDTENSTQSAEGNSKPVGYYVNRREHGIFPAPLPQNSEICENVLKY 2380
            ..|:.|.|              .|.|:        :.|:.:      ||..|   :.:.:..|
Worm   604 VLELTRQD--------------PNKTE--------LDYWTH------FPFLL---NGVAKGEL-- 635

  Fly  2381 FWFFGVFV-AKVLQDMRLVDIPLSTSFLQLLCHNKVLSRNLQK--VISDRRN-------GDL--- 2432
                 :|| |.::|.:|......:|:...::.....|...:::  ::||..|       .||
Worm   636 -----IFVEAWLMQTLRRQSSLFNTAHGTIIFELPHLELTVRREFIVSDTMNQMAGLSESDLQKP 695

  Fly  2433 ---SVVSEDSD---------IVETCTKLLRTD------SNKSNA--FGGILSLENLKEIDPTRYQ 2477
               ::..||:|         .:....|:|::|      ..:|:.  |.|:.|    :..|..::.
Worm   696 LKVNIAGEDADDAGGVRKEFFILVMRKILQSDYGMFSEDEESHLVWFSGLPS----EFCDREQFH 756

  Fly  2478 FLQEMQNLLLRKQSIE--------FDDTISAEKKHELINELKLQTQNGLEVSL----EDLALTF- 2529
            .|..:..|.:...||.        :...:......|.:.||......||::.|    :|:...|
Worm   757 QLGRLVGLSIYNHSIVPFPFPLALYKYLLDTPPDLEDLCELSPSEGKGLKMLLSYEEDDVEDVFG 821

  Fly  2530 -TYLPSSSIYGYTQ-AELLPNGSSVNVTIDNLEAYCELLMNFILQDG----IAQQMKAFSDGFNE 2588
             .:..|.:|.|.|. .|||..|:...||..|.:.|..|.::..|:.|    ||||...|..||:|
Worm   822 LNFCISFNILGETHTTELLSGGTEKPVTNANRDEYVRLYVHHRLELGYNGEIAQQALLFRKGFSE 886

  Fly  2589 VFPLKKLAAFTPSEARMMICGEQFPHWSR-EDIISYTEPKLGYNKDSPGFQRFVNVLLSMSGDER 2652
            ....:.|..|.|.|.:.||.|.:...|:. .||:.|   :..|:...|..|.|.....:::.|||
Worm   887 SLHSRTLRFFQPCELKEMIVGNENYDWNEFRDILMY---RGEYSSSHPTIQAFWKAFFALTDDER 948

  Fly  2653 KAFLQFTTGCSSLPPGGLANLHPRLTVVRKVDAGVGSYPSVNTCVHYLKLPDYPTE-EIMKERLL 2716
            :.||||.||.:.:|..|...||..:.     .:...|.|..:||.:.|.||:...: |:::...:
Worm   949 RKFLQFLTGSTRIPVSGWEELHAAIQ-----PSAPESLPVAHTCFNLLDLPNIADDVELLRRLRI 1008

  Fly  2717 TATKEKGFHL 2726
            :....:||.|
Worm  1009 SIEHTEGFTL 1018

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041
		MIB_HERC2	1333..1389	CDD:310955
		DamX	1576..>1725	CDD:330571
		HECTc	2265..2725	CDD:238033	116/514 (23%)
herc-1	NP_490834.1	ATS1	2..359	CDD:227511
herc-1	NP_490834.1	HECTc	667..1016	CDD:238033	88/360 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900