DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ufd4 and Magi1

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	XP_006505643.1	Gene:	Magi1 / 14924	MGIID:	1203522	Length:	1484	Species:	Mus musculus

Alignment Length:	1611	Identity:	305/1611 - (18%)
Similarity:	502/1611 - (31%)	Gaps:	535/1611 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 AVFEGGGLNCVL-SFIR---DCGSQVH--KDTLHSAMSVVSRLCTKVEPNTPCIQNCVESLSTLL 195
            ||.:||.||..| .|:.   ..||..|  :.|:...:...:..||...|....:.....|..|:.
Mouse   101 AVRQGGRLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYSFLTVK 165

  Fly   196 QHEDPMVSDGALKCFASVADRFTRKWVDPAPLAEYGLTTELLKRLQSVGGNTHSSLTAAGTQPTS 260
            :..|...|...|:......:.:........|::...:||:.|..|||  |:..|  |...|:..:
Mouse   166 EFLDLEQSGTLLEVGTYEGNYYGTPKPPSQPVSGKVITTDALHSLQS--GSKQS--TPKRTKSYN 226

  Fly   261 SSQPAATTNSDAINENVAGTATISNSTKVKSSDAAASPQSISTTISLLSTLCRGSPSITHDILRS 325
            ..|.|...:.:  ||.......:::|....|.|........:|.           |.:...||.:
Mouse   227 DMQNAGIVHPE--NEEEEDVPEMNSSFTADSGDQDEHTLQEATL-----------PPVNSSILAA 278

  Fly   326 QLADALERALQGDERCVLDCMRFADLLLLLLFEGRQALNRGSNNPNQGQLAPRPRR--------- 381
            .:.|..:              :|...|.|               ..:..|.|.|..
Mouse   279 PITDPSQ--------------KFPQYLPL---------------SAEDNLGPLPENWEMAYTENG 314

  Fly   382 ------NNTNTDRTHRQLID--CIRSKDSEALREAIESGGIDVNCMDDVGQTLLNWASAFGTLEM 438
                  :||.|    ...:|  |: :|..:.|.|          |.||
Mouse   315 EVYFIDHNTKT----TSWLDPRCL-NKQQKPLEE----------CEDD----------------- 347

  Fly   439 VEYLCEKGADVNKGQRSSSLHYAACFGR---PAIAKILLKFGAYPDLRDEDGKTPLD------KA 494
                 |:|  |:..:..|.|...|.:.:   |.       :|.| .:...:.||..:      |.
Mouse   348 -----EEG--VHTEELDSELELPAGWEKIEDPV-------YGVY-YVDHINRKTQYENPVLEAKR 397

  Fly   495 RERLDDGHREVAAILQSPGEW----------MSPDHSLLNKDGKKYTLME-----PRGDPEMAPI 544
            :::|:...::.......|.||          ::|.|...|.:..:.|.::     .|...|:...
Mouse   398 KKQLEQQQQQQQPQPPQPEEWTEDHASVVPPVAPSHPPSNPEPARETPLQGKPFFTRNPSELKGK 462

  Fly   545 YLKVLLPIFCRTFLGSMLGSVRRASLALIKKIVQYAYPTVLQSLSETSFSEDAASTSGQNGGNLL 609
            ::...|....|.|..:::|.........||.:|... |..|....||.
Mouse   463 FIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDG-PAALDGKMETG----------------- 509

  Fly   610 IEVIASVLDNEDDGDGHLIVLNIIEEI---------MCKTQE-EFLDHFARLGVFAKVQALMDTD 664
             :||.||.|....|..|..|:.|.:.|         :|:... .|........:...|..|   |
Mouse   510 -DVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAIL---D 570

  Fly   665 AEELYVQLPGTVEEPA--AAQRSSTSVVVAPRPTSDDPMEDAKEILQGKPYHWREWSICRGRDCL 727
            .|.:.|....|.:.||  :::....|.:...||:|  |.:.|.....|.|
Mouse   571 KEPIIVNGQETYDSPASHSSKTGKVSSMKDARPSS--PADVASNSSHGYP--------------- 618

  Fly   728 YVWSDSVALELS-------------NGSNGWFRFIIDGKLATMYSSGSPENGN-------DSSEN 772
               :|:|:|..|             .|..| |.|.|         :.||..|.       ||...
Mouse   619 ---NDTVSLASSIATQPELITVHIVKGPMG-FGFTI---------ADSPGGGGQRVKQIVDSPRC 670

  Fly   773 RG--------EFLEKLMRA--RSCVIAGVVSQPILPTASALRLVVGNWVL-------QSQKTNQL 820
            ||        |..:|.::|  .:.|:..::.   .|..|.:.|:|....|       :||...:.
Mouse   671 RGLKEGDLIVEVNKKNVQALTHNQVVDMLIE---CPKGSEVTLLVQRGGLPVPKKSPKSQPLERK 732

  Fly   821 QIHNTEGHQVTVLQDDLPGFIFESNRGTKHTFSAE---TVLGPDFASGWSTAKKKRNKSKTEGQK 882
            ...|:..|.|             |:..:.||.|..   .|| |::....:.|..:.:.|   |||
Mouse   733 DSQNSSQHSV-------------SSHRSLHTASPSHGIQVL-PEYLPADAPAPDQTDSS---GQK 780

  Fly   883 ----FQVRNLSREIYNKYFKSAQIIPRGAVAILTDIVKQIELSFEEQHMAPNGNWETTLTDALMK 943
                |::...||.:|                             |.:.|:|:
Mouse   781 KPDPFKIWAQSRSMY-----------------------------ENRPMSPS------------- 803

  Fly   944 LSQLIHEDGVVSAYEMHSSGLVQALVAVLSVNHWETNSPRCKRNKMQKQRVSVFKK------CIL 1002
                            .:|||.:. .....:|  .||...|:....|:|.:.:::|      .||
Mouse   804 ----------------PASGLSKG-ERDREIN--STNFGECQIPDYQEQDIFLWRKETGFGFRIL 849

  Fly  1003 EDN-------------VESATNKPRTKSTASILIQKLVSVLESTEKLPVYLYDSPC-TGYSLQIL 1053
            ..|             :.:|....|.:|...::......|:..:.:|.|.|..... .|:....:
Mouse   850 GGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTV 914

  Fly  1054 QKRLRFRLERAECE-------------------------------STLFDRSGRTLKMEPLATIG 1087
            ::::.|.:.:||.|                               :|:...||.|      :.||
Mouse   915 RRKVVFAVPKAENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGST------SGIG 973

  Fly  1088 Q--------LSKYLLKMVAKQWYDLDRSTYFYLKKIREHRTATVFTHSFDFDEEGLLFYIGSNAK 1144
            .        :|..|      |.||::      :::........|...|....|.|..|  ..||.
Mouse   974 SGGGGGSGVVSAVL------QPYDVE------IRRGENEGFGFVIVSSVSRPEAGTTF--AGNAC 1024

  Fly  1145 TCDWVNPAQYGLVQVTSSEGKTLPYGKL---EDILSRDSISLNCHTKDN-----KKAWFAIDLGV 1201
            .   ..|.:.|.:...|...:.   |||   :.||:.:..|:...:..:     |:|...:.|
Mouse  1025 V---AMPHKIGRIIEGSPADRC---GKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTL-- 1081

  Fly  1202 YIIPTAYTLRHARGYGRSALRNWLLQGSKDGSTWTTLSTHVDDKSLVEPGSTATWPINCATDDSV 1266
            .|||           |..:....||..::..:|.||  ||...:...:...|.|.|    ..||
Mouse  1082 RIIP-----------GDESSNATLLTNAEKIATITT--THAPSQQGTQETRTTTKP----KQDS- 1128

  Fly  1267 WYRHIRIQQNGRNASGQTHYLSLS--------GFEIYG--------RVVGVADD----------I 1305
                 :.:..|..|:.:..:.::.        ||.:.|        .|:.:|:|          |
Mouse  1129 -----QFEFKGPQAAQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRI 1188

  Fly  1306 GKSVKEAEAKTRRERRQIRAQLKHMTTGARV---IRGVDWRWEEQDGCAE--GTITG-----EIH 1360
            |..:.|...:|.:..:..||.......|.||   :|..|....|.|..::  |..||     |:.
Mouse  1189 GDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLRRGDGSVPEYDPSSDRNGPSTGAQGVPEVR 1253

  Fly  1361 NGWIDVKWDHGVRNSY--RMGAEGKYDLKLADCEYLSAFDGNQSMGSASTAAKPSEKGGNTLTSR 1423
            .|..|.:....:.:||  .:....::..|.|..:        ...|:...:.:|:|......|||
Mouse  1254 PGPPDHRPHPALESSYPPELHKSSQHAEKRAHAK--------DPKGNREHSKQPNEHHTWNGTSR 1310

  Fly  1424 KSSS-------------TPSLPEAT----EKNQNPEGASNQTVSADNLAWKQTVETIAENVFASA 1471
            |..|             ..:.||.|    .|.::||.....|.||||     |:|...::
Mouse  1311 KQDSGACRPKDRPPDAWREAQPERTATNGSKRRSPEKRREGTRSADN-----TLERREKH----- 1365

  Fly  1472 KTQIISNQLAMNTSSSREARAKHKESGTNQMHKDNISGPSPLSRELEHISD 1522
                         ...||...:.|...:....||  |.||...|.||.:.|
Mouse  1366 -------------EKRREISPERKRERSPTRRKD--SSPSRRRRSLERLLD 1401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786	6/28 (21%)
		ANK	396..509	CDD:238125	20/121 (17%)
		ANK repeat	422..453	CDD:293786	3/30 (10%)
		ANK repeat	455..484	CDD:293786	6/31 (19%)
		F5_F8_type_C	1173..1298	CDD:329041	27/145 (19%)
		MIB_HERC2	1333..1389	CDD:310955	16/67 (24%)
		DamX	1576..>1725	CDD:330571
		HECTc	2265..2725	CDD:238033
Magi1	XP_006505643.1	PDZ_signaling	15..100	CDD:238492
		GuKc	122..293	CDD:214504	37/201 (18%)
		WW	302..331	CDD:366073	4/32 (13%)
		WW	362..393	CDD:197736	6/38 (16%)
		PDZ	462..548	CDD:214570	22/104 (21%)
		PDZ	633..716	CDD:214570	20/95 (21%)
		MAGI_u5	715..798	CDD:374709	23/128 (18%)
		PDZ_signaling	840..915	CDD:238492	12/74 (16%)
		PDZ_signaling	989..1084	CDD:238492	21/110 (19%)
		PDZ	1145..1227	CDD:214570	16/81 (20%)
		PRK12678	1203..>1452	CDD:237171	52/232 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900