DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ufd4 and Trip12

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	XP_011236956.1	Gene:	Trip12 / 14897	MGIID:	1309481	Length:	2074	Species:	Mus musculus

Alignment Length:	2130	Identity:	462/2130 - (21%)
Similarity:	769/2130 - (36%)	Gaps:	702/2130 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   843 ESNRGTKHTFSAETVLGPDFAS---------GWSTAKKKRNKSKTEGQ---KFQVRNLSREIYNK 895
            |||:.|.::.:|.|...|..|:         |.:|:.:..:.....|:   ..:.|.|...::..
Mouse   402 ESNQETVNSSAARTDEAPQGAAASSSVAGAVGMTTSGESESDDSEMGRLQALLEARGLPPHLFGP 466

  Fly   896 YF-KSAQIIPR----GAVAILTDIVKQIELSFEEQHMAP---------NGNWET-------TLTD 939
            .. :.:|:..|    ||.:....:::.::.|.|.|.:..         .||.||       ::..
Mouse   467 LGPRMSQLFHRTIGSGASSKAQQLLQGLQASDESQQLQAVIEMCQLLVMGNEETLGGFPVKSVVP 531

  Fly   940 ALMKLSQLIHE---------------------------------------------DGVVSAYEM 959
            ||:.|.|:.|.                                             :..::|.||
Mouse   532 ALITLLQMEHNFDIMNHACRALTYMMEALPRSSAVVVDAIPVFLEKLQVIQCIDVAEQALTALEM 596

  Fly   960 ----HSSGLVQA--------LVAVLSVN---------------------HWETNS-PRCKRNKMQ 990
                ||..::||        .:...|:|                     |:..:| |...:....
Mouse   597 LSRRHSKAILQAGGLADCLLYLEFFSINAQRNALAIAANCCQSITPDEFHFVADSLPLLTQRLTH 661

  Fly   991 KQRVSVFKKCI----LEDNVESATNKPRTKSTASILIQKLVS--VLESTEKLPVYLYDSPCTGYS 1049
            :.:.||...|:    |.||.:...|          |:|::.|  :|.:.::|.|  ...|.....
Mouse   662 QDKKSVESTCLCFARLVDNFQHEEN----------LLQQVASKDLLTNVQQLLV--VTPPILSSG 714

  Fly  1050 LQILQKRLRFRLERAECESTLFDRSGRTLKMEPLATIGQLSKYLLKMVAKQWYDLDRSTYFYLKK 1114
            :.|:..|: |.|..:.|.:                    |:..|:|   :.:.|:..:.:|.|
Mouse   715 MFIMVVRM-FSLMCSNCPT--------------------LAVQLMK---QSFTDIAETLHFLL-- 753

  Fly  1115 IREHRTATVFTHSFDFDEEGLLFYIGSNAKTC----DWVNPAQYGLVQVTSSEGKTLPYGKLEDI 1175
                                    .|::..:|    |.|..:...|.::||...:.:|
Mouse   754 ------------------------CGASNGSCQEQIDLVPRSPQELYELTSLICELMP------- 787

  Fly  1176 LSRDSISLNCHTKDNKKAWFAIDLGVYIIPTAYTLRHARGYGRSALRNWLLQGSKDGSTWTTLST 1240
                     |..|:          |::.:.|.....:|:              :.||:.|...
Mouse   788 ---------CLPKE----------GIFAVDTMLKKGNAQ--------------NTDGAIWQWR-- 817

  Fly  1241 HVDDKSLVEPGSTATWPINCATDDSVWYRHI--RIQQNGRNASGQTHYLSLSGFEIYGRVVGVAD 1303
              ||:.|..|                 |..|  ||.:...:..|:.. :|||   ..|||..:..
Mouse   818 --DDRGLWHP-----------------YNRIDSRIIEVAAHQVGEDE-ISLS---TLGRVYTIDF 859

  Fly  1304 DIGKSVKEAEAKTRRERRQIRAQLKHMTTGARVIRGVDWR---WEEQDGCAEG---TITGEIHNG 1362
            :..:.:.|.....|..:|:........|:|...::..|.|   .:|....|:.   |:.|.::..
Mouse   860 NSMQQINEDTGTARAIQRKPNPLANSNTSGYSELKKDDARAQLMKEDPELAKSFIKTLFGVLYEV 924

  Fly  1363 WI----------------------------DVKWDHGVRNSYRMGAEGKYDLKLADCEYLSAFDG 1399
            :.                            ||..:|.| :|:........|||:.
Mouse   925 YSSSAGPAVRHKCLRAILRIIYFADAELLKDVLKNHAV-SSHIASMLSSQDLKIV---------- 978

  Fly  1400 NQSMGSASTAAKPSEKGGNTLTSRKSSSTPSLPEATEKNQNPEGASNQTVSADNLAWKQTVETIA 1464
               :|:...|....:|               ||:........||..:|   ..:||..:::.|..
Mouse   979 ---VGALQMAEILMQK---------------LPDIFSVYFRREGVMHQ---VKHLAESESLLTSP 1022

  Fly  1465 ENVFASAKTQIISNQLAMNT-SSSREARAKHKESGTNQMHKDNISGPSPLSRELEHISDLSAINN 1528
            .....:.     |..|...| :||..|.|....|.       ::..||     |:|..|
Mouse  1023 PKACTNG-----SGSLGSTTPASSGTATAATNASA-------DLGSPS-----LQHSRD------ 1064

  Fly  1529 SMPAINSSNVSDLATISENLSLTELSKENICRVLTPSYKP----------AESVTASQSSSHPDV 1583
                 :|.::|....:|:.|....|.|....|   |.|.|          |:|.|.:||.....:
Mouse  1065 -----DSLDLSPQGRLSDVLKRKRLPKRGPRR---PKYSPPRDDDKVDNQAKSPTTTQSPKSSFL 1121

  Fly  1584 QSSSP----RENDIKNISNIEENNKMNANNSVNKISKDLLANLRTSNIAGCPPVTQLSTEALEMI 1644
            .|.:|    |.:...|.:|||.......:......|||.::|.| ..|.|     .:..:|.:.:
Mouse  1122 ASLNPKTWGRLSAQSNSNNIEPARTAGVSGLARAASKDTISNNR-EKIKG-----WIKEQAHKFV 1180

  Fly  1645 DKMRDGVDMIRNMSNSILSTDTFPVPCTNVPVGGKKTPKAQALINPDNANQKQIIVTSEEFPTKS 1709
            ::....    .||..|        .|..||                    .:::...:|:.
Mouse  1181 ERYFSS----ENMDGS--------NPALNV--------------------LQRLCAATEQL---- 1209

  Fly  1710 SKKPSVTLKPAQQPNAVLSIVDIKEQPISNENVSVPSQMSISVPNLTTTSASEVPSTSEVATHTG 1774
                                           |:.|.......|...:..|.|:| |:.|: .|:|
Mouse  1210 -------------------------------NLQVDGGAECLVEIRSIVSESDV-SSFEI-QHSG 1241

  Fly  1775 LLE---TFAAIARRRTSQGTNIQDNQIMNAEANVNEHGDQNASG-SFLGHSVTSLVKLALSSNFH 1835
            .::   .:......:.:.|..|:..:.::...:....|::.... ..:||:  .|:.|....|
Mouse  1242 FVKQLLLYLTSKNEKDAVGREIRLKRFLHVFFSSPLPGEEPVGRVEPVGHA--PLLALVHKMN-- 1302

  Fly  1836 SGLLSTAQSYPSLSSNNSENIAPSNPSNTSAGQQSASTIN-HTLTMSLTSTSSDSEQV------- 1892
             ..||..:.:|....:...........:.:.|.|:....| |.|...| ....|...|
Mouse  1303 -NCLSQMEQFPVKVHDFPSGNGAGGSFSLNRGSQALKFFNTHQLKCQL-QRHPDCANVKQWKGGP 1365

  Fly  1893 ----------SLEDFLESCRAPALLGDL--DDEDDMDEDNDEEENED---EYEEVGNT--LLQVM 1940
                      ::|.:| ..|.....|.:  ||||..|:.:|||.:|.   ::...||.  .||..
Mouse  1366 VKIDPLALVQAIERYL-VVRGIFRYGRVREDDEDSDDDGSDEEIDESLAAQFLNSGNVRHRLQFY 1429

  Fly  1941 VSRNLLTFMDDEAMENRLVGVTKRKSWDDEFVLKRQFSALIPAFDPRPGRTNVNQTSDLEISPLG 2005
            :..:||.:       |..|           :...||||  :.|.|.|       :::|.|.:|||
Mouse  1430 IGEHLLPY-------NMTV-----------YQAVRQFS--VQAEDER-------ESTDDESNPLG 1467

  Fly  2006 AELPKPQQSGGPETIEQPLLGLKLRGPGIGGIPEVEIDLSNTDWTIFRAVQELLQCSQLNKLDKF 2070
                   ::|
Mouse  1468 -------RAG------------------------------------------------------- 1470

  Fly  2071 RKIWEPTYTIVYREVSPEAQEST--CLESEE-FPQT-PDVSSKSGAST----------------- 2114
              ||..|:||.|:.|. |.:|||  |:..:. ..|| |..:|...|..
Mouse  1471 --IWTKTHTIWYKPVR-EDEESTKDCVGGKRGRAQTAPTKTSPRNAKKHDELWHDGVCPSVANPL 1532

  Fly  2115 ---LSPNSPMHIGFNVADNNLCSVDDVLELLTQINGLNQSEI----DSDVKEHGVSVLSEDLFIS 2172
               |.|..|.:|.|.  |.:|    ||:.||..::.:::...    ::..||    ::....||:
Mouse  1533 EVYLIPTPPENITFE--DPSL----DVILLLRVLHAISRYWYYLYDNAMCKE----IIPTSEFIN 1587

  Fly  2173 KKITNKLQQQIQDPLVLASNALPNWCENLNQSCPFLFPFETRQLYFNCTSFGASRSIVCLQSQRD 2237
            .|:|.|..:|:|||||:.:..:|.|...|.::|||.|||:|||:.|..|:|...|::
Mouse  1588 SKLTAKANRQLQDPLVIMTGNIPTWLTELGKTCPFFFPFDTRQMLFYVTAFDRDRAM-------- 1644

  Fly  2238 VTVERQRIPIMSP---RRDDHEFRIG-RLKHERVKVPRNEDLLMWAMQVMKTHCNRKSVLEVEFL 2298
                 ||:...:|   :.|..:.|:. ||..::..|.| |:||..|..||:...:.:::||:::.
Mouse  1645 -----QRLLDTNPEINQSDSQDSRVAPRLDRKKRTVNR-EELLKQAESVMQDLGSSRAMLEIQYE 1703

  Fly  2299 DEEGTGLGPTLEFYALVAAEIQRSDLCMWLCDDDLGEDT--ENSTQSAEGNSKPVGYYVNRREHG 2361
            :|.||||||||||||||:.|:||:|||:|     .||:.  .|...|.||..     |:...: |
Mouse  1704 NEVGTGLGPTLEFYALVSQELQRADLCLW-----RGEEVTLSNPKGSQEGTK-----YIQNLQ-G 1757

  Fly  2362 IFPAPLPQNSE---ICENVLKYFWFFGVFVAKVLQDMRLVDIPLSTSFLQLLCHNKVLSRNLQKV 2423
            :|..|..:.::   |.:..:| |.|.|..:||.:.|.||||:||...|.:.
Mouse  1758 LFALPFGRTAKPAHIAKVKMK-FRFLGKLMAKAIMDFRLVDLPLGLPFYKW-------------- 1807

  Fly  2424 ISDRRNGDLSVVSEDSDIVETCTKLLRTDSNKSNAFGGILSLENLKEIDPTRYQFLQEMQNLLLR 2488
                                    :||.:::        |:..:|.:|||...:.:..:::::.:
Mouse  1808 ------------------------MLRQETS--------LTSHDLFDIDPVVARSVYHLEDIVRQ 1840

  Fly  2489 KQSIEFDDTISAEKKHELINELKLQTQNGLEVSLEDLALTFTYLPSSSIYGYTQAELLPNGSSVN 2553
            |:.:|.|   .::.|..|...|:..|.||  .|:|||.|.|| ||     |:...||...|..:.
Mouse  1841 KKRLEQD---KSQTKESLQYALETLTMNG--CSVEDLGLDFT-LP-----GFPNIELKKGGKDIP 1894

  Fly  2554 VTIDNLEAYCELLMNFILQDGIAQQMKAFSDGFNEVFPLKKLAAFTPSEARMMICGEQFPHWSRE 2618
            |||.|||.|..|::.:.|.:|:.:|..:|.|||..||||..|..|.|.|...::||.:...|..:
Mouse  1895 VTIHNLEEYLRLVIFWALNEGVCRQFDSFRDGFESVFPLCHLQYFYPEELDQLLCGSKADTWDAK 1959

  Fly  2619 DIISYTEPKLGYNKDSPGFQRFVNVLLSMSGDERKAFLQFTTGCSSLPPGGLANLHPRLTVVRKV 2683
            .::....|..||..||...:....:|.|...::::.||||.||...||.||..:|:|.||:|||.
Mouse  1960 TLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKT 2024

  Fly  2684 DAGVGS----YPSVNTCVHYLKLPDYPTEEIMKERLLTATKE--KGFHLN 2727
            .....:    .|||.|||:|||||||.:.:||:::||.|.:|  :.|||:
Mouse  2025 FESTENPDDFLPSVMTCVNYLKLPDYSSIDIMRDKLLIAAREGQQSFHLS 2074

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041	21/126 (17%)
		MIB_HERC2	1333..1389	CDD:310955	15/89 (17%)
		DamX	1576..>1725	CDD:330571	24/152 (16%)
		HECTc	2265..2725	CDD:238033	155/470 (33%)
Trip12	XP_011236956.1	SRP1	489..>714	CDD:227396	38/236 (16%)
		WWE	814..876	CDD:397111	18/86 (21%)
		HECTc	1672..2072	CDD:238033	155/469 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3704
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840