DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ufd4 and Gas7

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	XP_006532265.1	Gene:	Gas7 / 14457	MGIID:	1202388	Length:	476	Species:	Mus musculus

Alignment Length:	647	Identity:	115/647 - (17%)
Similarity:	195/647 - (30%)	Gaps:	254/647 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly  1778 TFAAIARRRTSQGTNIQDNQIMNAEANVNEHG------DQNASGSFLGHSVTSLVK--------- 1827
            |....:..|.|||......:::.. ..|.:.|      |....|.|....|..|.|
Mouse     8 TLYPFSGERHSQGLRFSAGELLTL-LQVPDGGWWEGEKDDGLRGWFPASYVQLLEKPGMVPPPPG 71

  Fly  1828 -----LALSSNFHSGLLSTAQSY-------------PSLSSNNSENIAPSNPS--NTSAGQQSAS 1872
                 :.|...:||.|....:.|             ||.|...|.:..|...|  .|..|..::.
Mouse    72 EESQTVILPPGWHSYLSPQGRRYYVNTTTNETTWERPSSSPGISASPGPHRSSLPTTVNGYHASG 136

  Fly  1873 TINH---TLTMSLTSTSSDSEQVSLEDFLESCRAPALLGDLDDEDDMDEDNDEEENEDEYEEVGN 1934
            |..|   |..|||..::.||:.               ||.........::|
Mouse   137 TPAHPPETAHMSLRKSTGDSQN---------------LGSSSPGRKQSKEN-------------- 172

  Fly  1935 TLLQVMVSRNLLTFMDDEAM-ENRLVGVTKRKSWDDEFVLKRQFSALIPAFDPRPGRTNVNQTSD 1998
                 .::.|.:||...:.| |.:|:..|: .|:.|.|
Mouse   173 -----TITINCVTFPHPDTMPEQQLLKPTE-WSYCDYF--------------------------- 204

  Fly  1999 LEISPLGAELPKPQQSGGPETIEQPLLGLKLRGPGIGGIPEVEIDLSNTDWTIFRAVQELLQCSQ 2063
                  .|:...||.:|       .:.|.:|                        .:|:.|:..|
Mouse   205 ------WADKKDPQGNG-------TVAGFEL------------------------LLQKQLKGKQ 232

  Fly  2064 LNKLDKFRKIWEPTYTIVYREVSPEAQESTCLESEEFPQTPDVSSKSGASTLSPNSPMHIGFNVA 2128
            :.|                 |:|...:|...:| ||:.:        ..:.||.||
Mouse   233 MQK-----------------EMSEFIRERIKIE-EEYAK--------NLAKLSQNS--------- 262

  Fly  2129 DNNLCSVDDVLELLTQINGLNQSEIDSDVKEHGVSVLSEDLFISKKITNKLQQQIQDPLVLASNA 2193
                        |..|..| :..|..:.||:.    |:::..:..|.:.||..:::.||:
Mouse   263 ------------LAAQEEG-SLGEAWAQVKKS----LADEAEVHLKFSAKLHSEVEKPLM----- 305

  Fly  2194 LPNWCENLN---QSCPFLFPFETRQLYFNCTSFGASRSIVCLQSQRDVTVERQRIPIMSPRRDDH 2255
              |:.||..   :.|........:||.....|...:|..: .:.|:|:.::.|::.|....:.:.
Mouse   306 --NFRENFKKDMKKCDHHIADLRKQLASRYASVEKARKAL-TERQKDLEMKTQQLEIKLSNKTEE 367

  Fly  2256 EFRIGRLKHERVKVPRNEDLL-----------MWAMQVMKTHCNRKSVLEVEFLDEEGTGLGPTL 2309
            :.:    |..|......:||:           .|..:::.|      .||:|.|:.|
Mouse   368 DIK----KARRKSTQAGDDLMRCVDLYNQAQSKWFEEMVTT------TLELERLEVE-------- 414

  Fly  2310 EFYALVAAEIQRSDLCMWLCDDDLGEDTENSTQSAEGNSKPVGYYVNR-----------REH 2360
                  ..|:.|..||.:   ..|..:|:...||   ..:||...:.:           |||
Mouse   415 ------RVEMIRQHLCQY---TQLRHETDMFNQS---TVEPVDQLLRKVDPAKDRELWVREH 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041
		MIB_HERC2	1333..1389	CDD:310955
		DamX	1576..>1725	CDD:330571
		HECTc	2265..2725	CDD:238033	23/118 (19%)
Gas7	XP_006532265.1	SH3_GAS7	5..57	CDD:212763	10/49 (20%)
		WW_FCH_linker	109..201	CDD:374680	26/126 (21%)
		F-BAR_GAS7	214..446	CDD:153333	62/352 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900