DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ufd4 and Ube3b

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	NP_473434.2	Gene:	Ube3b / 117146	MGIID:	1891295	Length:	1070	Species:	Mus musculus

Alignment Length:	984	Identity:	184/984 - (18%)
Similarity:	328/984 - (33%)	Gaps:	343/984 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1903 APALLGDLDDED----------DMDEDNDEEENEDEYEE---VGNTLLQVMVSRNLLTFMDDEAM 1954
            ||..||.|:..|          |.|...|..|:.:....   :||.|....:|..||    :|.|
Mouse   271 APERLGVLESHDMLRKFIVFLRDRDRCRDACESLEGCHTLCLMGNLLHLGSLSLRLL----EEEM 331

  Fly  1955 ENRLVGVT-----------KRKS----------W----------DDEFVLKRQFSAL--IPAF-- 1984
            :..:..:|           ::||          |          |..:::.:|...|  :|..
Mouse   332 DGFVSALTQMLCYCQKYVAQKKSNLTHWHPVLGWFSQPVDYGLNDSMYLITKQLQFLWAVPLIRI 396

  Fly  1985 --------------DPRPGRTNVNQTSDLEISPLGAELPKP-QQSGGPETIEQPLLGLKLRGPGI 2034
                          :|.|  .....:|...:.|:.:.|.:. |:|.....|.:|:.|.::....:
Mouse   397 LFSDILSRKLLEHAEPAP--VQPQPSSPQTVLPVKSLLKRAFQKSASVRNILRPVGGRRVDSAEV 459

  Fly  2035 GGIPEVEI--DLSNTDWTIFRAVQELLQCSQLNKLDKFRKIWEPTYTIVYREVSPEAQESTCLES 2097
            ..:..:.:  ..|.|..|..| :|.|...:.|:  |...|:|
Mouse   460 RKVCNICVLYQTSLTTLTQIR-LQILTGLTYLD--DLLPKLW----------------------- 498

  Fly  2098 EEFPQTPDVSSKSGASTLSPNSPMHIGFNVADNNLCSVDDVLELLTQINGLNQSEIDSDVKEHGV 2162
                        :....|.|:..:.:.....:|:......:|.:|.         :..|...|.:
Mouse   499 ------------AFICELGPHGGLKLFLECLNNDTGESKQLLAMLM---------LFCDCSRHLI 542

  Fly  2163 SVLSEDLFISKKITNKLQQQIQDPLVLASNALPNWCENLNQSCPFLFPFETRQLYFNCTSFGASR 2227
            ::|.:.....::|:.||::     ||..|:              ||..|..:.::..........
Mouse   543 TILDDIEVYEEQISFKLEE-----LVTISS--------------FLNSFVFKMIWDGIVENAKGE 588

  Fly  2228 SIVCLQSQRD---VTVERQRIPIMSP-----RRD----------DHEFRIGR--LKHERVKVPRN 2272
            ::...||...   |..||......:|     |||          |.:.|..:  |:|....||..
Mouse   589 TLELFQSVHGWLMVLYERDCRRRFAPEDHWLRRDLKPGVLFQELDKDRRRAQLVLQHIPHVVPHK 653

  Fly  2273 EDLLMWAMQVMK-----------------THCN---------------------RKSVLEVEFLD 2299
            ..:|::...|:|                 ||..                     .|.|:.|:|::
Mouse   654 NRVLLFRNMVIKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVN 718

  Fly  2300 EEG---TGLGPTLEFYALVAAEIQRSDLCMWLCDDDLGEDTENSTQSAEGNSKPVGYYVNRREHG 2361
            :.|   .|:.....|...:...|:|      :.|..|     |..::..|:.:
Mouse   719 DLGVDEAGIDQDGVFKEFLEEIIKR------VFDPAL-----NLFKTTSGDER------------ 760

  Fly  2362 IFPAPLPQNSEICENVLKYFWFFGVFVAKVLQDMRLVDIPLSTSFLQLLC--HNKVLSRNLQKVI 2424
            ::|:|   .|.|.||.|:.|.|.|..:.|.:.:..:||:|.::.||..:.  |:.|...::.:
Mouse   761 LYPSP---TSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQMLGHHHSVFYSSVDE-- 820

  Fly  2425 SDRRNGDLSVVSEDSDIVETCTKLLRTDSNKSNAFGGILSLENLKEIDPTRYQFLQEMQNLLLRK 2489
                     :.|.||:..:..|.:.|.|.:
Mouse   821 ---------LPSLDSEFYKNLTSIKRYDGD----------------------------------- 841

  Fly  2490 QSIEFDDTISAEKKHELINELKLQTQNGLEVSLEDLALTFTYLPSSSIYGYTQA-ELLPNGSSVN 2553
                                            :.||.||.:|  ...:.|.... ||:|.|.::.
Mouse   842 --------------------------------IADLGLTLSY--DEDVMGQLVCHELVPGGKTIP 872

  Fly  2554 VTIDNLEAYCELLMNFILQDGIAQQMKAFSDGFNEVFPLKKLAAFTPSEARMMICGEQFPHWSRE 2618
            ||.:|..:|..|:.:|.:...|..|..|...||..:...:.:..|:..|.:.:|.|:. .....|
Mouse   873 VTDENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDN-AEIDLE 936

  Fly  2619 DIISYTEPKLGYNKDSPGFQRFV----NVLLS-MSGDERKAFLQFTTGCSSLPPGGLANLHPRLT 2678
            |:..:|....|::    |..|.:    ::|.| .:.:||..||:|.|.||..|..|.|.|.|..:
Mouse   937 DLKKHTVYYGGFH----GSHRVIIWLWDILASDFTPEERAMFLKFVTSCSRPPLLGFAYLKPPFS 997

  Fly  2679 V------------------------VRKVDAGVGSYPSVNTCVHYLKLPDYPTEEIMKERLLTA- 2718
            :                        :||.:.| |..|:.:||.:.||||:|..:.:::|:|..|
Mouse   998 IRCVEVSDDQDTGDTLGSVLRGFFTIRKREPG-GRLPTSSTCFNLLKLPNYSKKSVLREKLRYAI 1061

  Fly  2719 TKEKGFHLN 2727
            :...||.|:
Mouse  1062 SMNTGFELS 1070

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041
		MIB_HERC2	1333..1389	CDD:310955
		DamX	1576..>1725	CDD:330571
		HECTc	2265..2725	CDD:238033	106/533 (20%)
Ube3b	NP_473434.2	HECTc	684..1068	CDD:238033	100/495 (20%)
Ube3b	NP_473434.2	HECTc	709..1067	CDD:214523	98/469 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900