DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ufd4 and Ubr5

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	XP_038936091.1	Gene:	Ubr5 / 117060	RGDID:	621236	Length:	2798	Species:	Rattus norvegicus

Alignment Length:	2957	Identity:	508/2957 - (17%)
Similarity:	876/2957 - (29%)	Gaps:	1123/2957 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   558 LGSMLGSVRRASLALIKKIVQYAYPTVLQSLSETSFSEDAASTSGQNGGNLLIEVIASVL---DN 619
            |||....|..||: :.::::..| ..|||..|.:....:...|      ||.:.:..:.|   |:
  Rat   172 LGSQPQPVIPASV-IPEELISQA-QVVLQGKSRSVIIRELQRT------NLDVNLAVNNLLSRDD 228

  Fly   620 EDDGDGHLIVLNII---EEIMCKTQEEFLD---HFARLGVFAKVQALMDTDAEELYVQLPGTVEE 678
            ||..||........   |::|     ..||   |.|...|.....|:...|..  |...| :...
  Rat   229 EDGDDGDDTASESYLPGEDLM-----SLLDADIHSAHPSVIIDADAMFSEDIS--YFGYP-SFRR 285

  Fly   679 PAAAQRSSTSVVVAPRPTSDDPMEDAKEILQGKPYHWREWS------------------------ 719
            .:.::..|:.|::.|.....:.:.:.:.:|:.:...|.:.:
  Rat   286 SSLSRLGSSRVLLLPLERDSELLRERESVLRLRERRWLDGASFDNERGSTSKEGEPNPDKKNTPV 350

  Fly   720 ---ICRGRDCLYVWSDSVALELSNGSNGWFRFIIDG----KLATMYSSGS--PENGNDSSENRGE 775
               :..|.| |..|.|      .:|:    :|...|    :|..:.|.|.  .....:|...|..
  Rat   351 QSPVSLGED-LQWWPD------KDGT----KFTCIGALYSELVAVSSKGELYQWKWTESEPYRNA 404

  Fly   776 FLEKLMRARSCVIAGVVSQPILPTASALRLVVGNWVLQSQKTNQLQIHNTEGHQVTVLQDDLPGF 840
            ....|...|:..:.....:.:|.:|:::|..|.                ||.::|....|:....
  Rat   405 QNPSLHHPRATFLGLTNEKIVLLSANSIRATVA----------------TENNKVATWVDETLSS 453

  Fly   841 IFESNRGTKHTFS---AETVLGPDFASGWSTAKKKRN----------KSKTEGQKFQVRNLSREI 892
            :......|..|:|   .|.::.....:.::.|:.:.|          :.|...:|.:.:|..
  Rat   454 VASKLEHTAQTYSELQGERIVSLHCCALYTCAQLENNLYWWGVVPFSQRKKMLEKARAKNKK--- 515

  Fly   893 YNKYFKSAQIIPRGAVAILTDIVKQIELSFEEQHMAPNGNWETTLTDALMKLSQLIHEDGVVSAY 957
                       |:.:..|.:               .||   .|..|...::.:.|.|...|  |:
  Rat   516 -----------PKSSAGISS---------------MPN---ITVGTQVCLRNNPLYHAGAV--AF 549

  Fly   958 EMHSSGLVQALVAVLSVNHWETN--------SPRCKRNKMQKQRVSVFKK--------------- 999
            .: |:|:.:  |.||..:.|..|        ||...:: |:|...::..|
  Rat   550 SI-SAGIPK--VGVLMESVWNMNDSCRFQLRSPESLKS-MEKASKTIETKPESKQEPVKTEMGPP 610

  Fly  1000 ------CILEDNVESATNKP--RTKSTASILIQKLVS----------VLESTEKLPV-------- 1038
                  |....::.|:.:.|  |.:||.:...::.|:          .:|..:.:||
  Rat   611 PSPASTCSDASSIASSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGKVLKVDG 675

  Fly  1039 -YL--------YDSPCTGYS------LQILQKRLRFRLERAECEST--------LFDRSGRTL-- 1078
             |:        .::.|...|      ..:||.....|::..:...|        .|.|:.:.|
  Rat   676 AYVAVKFPGTSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCI 740

  Fly  1079 --KMEPLAT------------IGQLSKY----LLKMVAKQWYDLDRSTYFYLKKIREHRTATVFT 1125
              |.|.||.            .|...:|    |....|:|..:...|:..:|.  :..|:..:||
  Rat   741 PEKTEILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQENNFPTSSVAFLG--QNERSVAIFT 803

  Fly  1126 HSFDF-----DEEGLLFYIGSNAKTC-------DWVNPAQYGLVQVTSSEGKTLPYGKLEDILSR 1178
            ...:.     |..|.::.:   ||.|       ||:                        |:...
  Rat   804 AGQESPIILRDGNGTIYPM---AKDCMGGIRDPDWL------------------------DLPPI 841

  Fly  1179 DSISLNCHTKDNKKAWFAIDLGVYIIPTAY----TLRHARGYGRSALRNWL-------------- 1225
            .|:.:..|:..|..|...|.....||..|.    .::|.......|.|.:|
  Rat   842 SSLGMGVHSLINLPANSTIKKKAAIIIMAVEKQTLMQHILRCDYEACRQYLVNLEQAVVLEQNLQ 906

  Fly  1226 -LQGSKDGSTWTTLSTHVD-DKSLVEPGSTATWPINCATDDSVWYRHIRIQQNGRNASGQTHYLS 1288
             ||        |.:|...| :::::....:..:|.:        .:..:.::....:...|....
  Rat   907 MLQ--------TFISHRCDGNRNILHACVSVCFPTS--------NKETKEEEEAERSERNTFAER 955

  Fly  1289 LSGFEIYGRVVGVADDIGKSVKEAEAKTR--RERRQIRAQLKHMTTGARVIRGVDWRWEEQDGCA 1351
            ||..|.....:.|....|...:...:.:|  |.|..:|..|:....|           ..:.|.:
  Rat   956 LSAVEAIANAISVVSSNGPGNRAGSSSSRSLRLREMMRRSLRAAGLG-----------RHEAGAS 1009

  Fly  1352 EGTITGEIHNGWIDVKWDHGVRNSYRMGAEGKYDLKLADCEYLSAFDGNQSMGSASTAAKPSEKG 1416
            .......:........|   |.:...|..:|..|..||           .::||.:|||....:|
  Rat  1010 SSDHQDPVSPPIAPPSW---VPDPPSMDPDGDIDFILA-----------PAVGSLTTAATGGGQG 1060

  Fly  1417 GNTLTSRKSSSTPSLPEATEKNQNP--------EGASNQTVSADNLAWKQT------VETIAENV 1467
            .:|.|....|:.||:.|:.::..|.        :.|..|....:.|:.|..      :..::...
  Rat  1061 PSTSTIPGPSTEPSVVESKDRKANAHFILKLLCDSAVLQPYLRELLSAKDARGMTPFMSAVSGRA 1125

  Fly  1468 FASAKTQIISNQLAMNTSSSREARAKHKE----------SGTNQMHKDNISGPSPLS-------- 1514
            :.:|.|.:.:.|    ..:..|.....||          ||||       ...|||.
  Rat  1126 YPAAITILETAQ----KIAKAEVSGSEKEEDVFMGMVCPSGTN-------PDDSPLYVLCCNDTC 1179

  Fly  1515 ----RELEHIS-------------DLSAINNSMPAINSSNVSDLATISENLSLTELSKENICRVL 1562
                ...|||:             .|..........:..:...|...|.. :..:..::..|:.|
  Rat  1180 SFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPT-AYCDCWEKCKCKTL 1243

  Fly  1563 TPSYKPAE-----------------------------SVTASQSSSHPDVQSSSPRENDIKNISN 1598
            ....|.|.                             ...|.|:..|...:....||:..:..::
  Rat  1244 IAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIREDRNRKTAS 1308

  Fly  1599 IEENNKMN--------ANNSVNKISKDLLANLRTSNIAGC----PPVTQLSTEALEMIDKMRDGV 1651
            .::::..:        |..::.::.:|..| ||:..:.|.    .|::     |...|..:....
  Rat  1309 PDDSDMPDHDLEPPRFAQLALERVLQDWNA-LRSMIMFGSQENKDPLS-----ASSRIGHLLPEE 1367

  Fly  1652 DMIRNMSNSILSTDTFP----VPCT------------------NVPVGGKKTPKAQALINPDNAN 1694
            .:..|..:..:..|.|.    |.||                  |....|::.......:....:.
  Rat  1368 QVYLNQQSGTIRLDCFTHCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSV 1432

  Fly  1695 QKQIIVTSEEFPTKSSKKPSVTLKP---------AQQPNAVLSIVDIKEQPISNENVSVPSQMSI 1750
            .:..::.|.|. ..|.||.:...:|         |..|.||..:.::.|..|      ||.:|.|
  Rat  1433 ARVFVILSVEM-ASSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAESLI------VPVRMGI 1490

  Fly  1751 SVPNLTTTSASEV-------------------PSTSEVATHTGLLETFAAIAR----RRTSQ--- 1789
            :.|....|.||..                   ||:.:.::.:....::  |.|    ||.||
  Rat  1491 ARPTAPFTLASTSIDAMQGSEELFSVEPLPPRPSSDQSSSSSQSQSSY--IIRNPQQRRISQSQP 1553

  Fly  1790 --GTNIQDNQIMNAEA-----------------NVNEHGDQNASGSFLGHSVTSLVKLALSSNFH 1835
              |...:.:.|::|:.                 ...|||::||...  ||.......   .|:..
  Rat  1554 VRGREEEQDDIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAE--GHHDEHDED---GSDME 1613

  Fly  1836 SGLLSTAQSYPSLSSNNSENIAPSNPSNTSAGQQSASTINHTLTMSLTSTSSDSEQVSLEDFLES 1900
            ..||:.|::.....||:      ||..|.| |::|.          :|:.::.||       ..:
  Rat  1614 LDLLAAAETESDSESNH------SNQDNAS-GRRSV----------VTAATAGSE-------AGA 1654

  Fly  1901 CRAPALLGDLDDE--DDMDEDNDEEENEDEYEEVGNTLLQVMVSRNLLTFMDDEAMENRLVGVTK 1963
            ...||...:.|.:  |..|.|:...:::|..:|               |||.||.:|.
  Rat  1655 SSVPAFFSEDDSQSNDSSDSDSSSSQSDDIEQE---------------TFMLDEPLER------- 1697

  Fly  1964 RKSWDDEFVLKRQFSALIPAFDPRPGRTNVNQTSDLEISPLGAELPKPQQ------------SGG 2016
                                      .||.:..:.      .|:.|:..|            |..
  Rat  1698 --------------------------TTNSSHANG------AAQAPRSMQWAVRNTQHQRAASTA 1730

  Fly  2017 PETIEQPLLGLKLRGPGIGGIPEVEIDLSNTDWTIFRAVQELLQCSQLNKLDKFRKIWEPTYTIV 2081
            |.:...|...    ..|:..|....:..|.|..|...|....|:.|..:............|:||
  Rat  1731 PSSTSTPAAS----SAGLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSASSLARAYSIV 1791

  Fly  2082 YREVS-----------------PEAQEST---------CLESEEFP---------QTPDVSSKSG 2111
            .|::|                 |.|.:.|         .:|.:..|         .:.:...:.|
  Rat  1792 IRQISDLMGLIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYG 1856

  Fly  2112 ASTLS------PNSPMHIGFNVADN---------------------------------------- 2130
            ::..|      ||.|:|...|.|..
  Rat  1857 SALASAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRRATLLSARQGMMSARGDFLNYA 1921

  Fly  2131 ------------------NLCSVDDVL----ELLTQINGLNQSE-------------------ID 2154
                              ::||:..|.    .|:..|..:||..                   ||
  Rat  1922 LSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTRELLELGID 1986

  Fly  2155 SDVKEHGVSVLSEDLFISKKITNKLQQQI------QDPLVLASNAL-------PNWCE-NLNQSC 2205
            ::..||   ...:|...|..:.:|..:.:      ..|....|:::       ||..| .|.::.
  Rat  1987 NEDSEH---ENDDDTSQSATLNDKDDESLPAETGQNHPFFRRSDSMTFLGCIPPNPFEVPLAEAI 2048

  Fly  2206 PF---------------LFPFETRQLYFNCTSFGASRSIV-------CLQ--------------- 2233
            |.               ||...::.||  .:|.|:.:.:|       ||:
  Rat  2049 PLADQPHLLQPNARKEDLFGRPSQGLY--SSSAGSGKCLVEVTMDRNCLEVLPTKMSYAANLKNV 2111

  Fly  2234 ----------------------------SQRDVT-------------VERQRIPIMSPRRD---- 2253
                                        |..||.             .|.:..|:.|.|..
  Rat  2112 MNMQNRQKKAGEDQSMLAEEADSSKPGPSAHDVAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFM 2176

  Fly  2254 ----DHEFRIGR-------------------------------------------LKHER----- 2266
                .|:..:||                                           |::::
  Rat  2177 GMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLS 2241

  Fly  2267 VKVPRNEDLLM-WAMQVMKTHCNRKSV--------LEVEFLDEEGTGLGPTLEFYALVA------ 2316
            ::|.|:.|||: ..|:.:..|..|:..        ::|.|.||.|.|.|....||..:|
  Rat  2242 LEVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSN 2306

  Fly  2317 -------------------------------------AEIQRS---------DLCMWLCDDD--- 2332
                                                 .|::||         |.     |.|
  Rat  2307 EKLPNLDCIQNANKGTHTSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDR-----DRDFRR 2366

  Fly  2333 -LGEDTENSTQSAEGNSKPVGYYVNRREHGIFPAPLPQNSE-ICENVLKYFWFFGVFVAKVLQDM 2395
             |..||.....::|||...            .|.|||.:.: :.|.:...........|..:..|
  Rat  2367 QLSIDTRPFRPASEGNPSD------------DPDPLPAHRQALGERLYPRVQAMQPAFASKITGM 2419

  Fly  2396 RLVDIPLSTSFLQLLCHNKVLSRNLQK-----VISDRRNG-----DLSVVSEDSDIVETCTK--- 2447
            .|...|  ...|.||.....|...:::     |...|.||     ||.::.....:.|...:
  Rat  2420 LLELSP--AQLLLLLASEDSLRARVEEAMELIVAHGRENGADSILDLGLLDSSEKVQENRKRHGS 2482

  Fly  2448 --------LLRTDSNKSNA-----------------------------FGGILSLENLKE----- 2470
                    |..||....||                             .|.||.|..|:.
  Rat  2483 SRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPI 2547

  Fly  2471 ----------------------IDPTRYQFLQEMQNLLLRKQSIEFDDTISAEKKHELINELKLQ 2513
                                  .||..|:.|::   |:|..||.:.|...||
  Rat  2548 TLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQ---LILASQSSDADAVFSA------------- 2596

  Fly  2514 TQNGLEVSLEDLALTFTYLPSSSIYGYTQAELLPNGSSVNVTIDN----LEAYCELLMNFILQDG 2574
                     .|||.........   |..|.||:|||.::.||..|    :..|.|..|..:.:
  Rat  2597 ---------MDLAFAVDLCKEE---GGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAE-- 2647

  Fly  2575 IAQQMKAFSDGFNEVFPLKKLAAFTPSEARMMI--CGEQFPHWSREDIISYTEPKLGYNKDSP-- 2635
              |.:.|...|..:|.|...|...|..:.|:::  |||.    :.:.:||:|    .:|.:|.
  Rat  2648 --QPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEV----NVQMLISFT----SFNDESGEN 2702

  Fly  2636 -----GFQR-FVNVLLSMSGDERKAFLQFTTGCSSLPPG--GLANLHPRLTVVRKVDAGVGSYPS 2692
                 .|:| |.:::..||..||:..:.|.|...|||..  |...: |.:|:....|..:   |:
  Rat  2703 AEKLLQFKRWFWSIVERMSMTERQDLVYFWTSSPSLPASEEGFQPM-PSITIRPPDDQHL---PT 2763

  Fly  2693 VNTCVHYLKLPDYPTEEIMKERLLTATKEKGF 2724
            .|||:..|.:|.|.:::|:|::||.|.|.|.|
  Rat  2764 ANTCISRLYVPLYSSKQILKQKLLLAIKTKNF 2795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041	23/144 (16%)
		MIB_HERC2	1333..1389	CDD:310955	7/55 (13%)
		DamX	1576..>1725	CDD:330571	29/191 (15%)
		HECTc	2265..2725	CDD:238033	134/624 (21%)
Ubr5	XP_038936091.1	CUE_UBR5	184..230	CDD:270606	10/53 (19%)
		ZnF_UBR1	1177..1244	CDD:197698	7/67 (10%)
		PolyA	2389..2452	CDD:197769	13/64 (20%)
		HECTc	2500..2795	CDD:214523	80/338 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000