DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ufd4 and Magi2

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	NP_446073.2	Gene:	Magi2 / 113970	RGDID:	621855	Length:	1277	Species:	Rattus norvegicus

Alignment Length:	1274	Identity:	220/1274 - (17%)
Similarity:	387/1274 - (30%)	Gaps:	461/1274 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  1265 SVWYRHIRIQQNGRNASGQTHYLSLSGFEIYGRV-------VGVADDIGKSVKEAEAKTRRER-- 1320
            |.|...:.....|||..||.      |||:.|..       :|.... ||...|:.:|...|.
  Rat     9 SHWTSKVHESVIGRNPEGQL------GFELKGGAENGQFPYLGEVKP-GKVAYESGSKLVSEELL 66

  Fly  1321 -------------RQIRAQLKHMTTGARVIRGVDWRWEEQDGCAEGTITGEIHNGWIDVKWDHGV 1372
                         |.:.|.:||.....|:            .|.:       ..|.:|....|.:
  Rat    67 LEVNETPVAGLTIRDVLAVIKHCKDPLRL------------KCVK-------QGGIVDKDLRHYL 112

  Fly  1373 RNSYRMGAEGKYDLKLADCEYLSAFDGNQSMGSASTAAKPSEKGGNTLTSRKSSSTP-------S 1430
            ...::.|:        .|.|.......|..:.:.....:|.::|          ..|       :
  Rat   113 NLRFQKGS--------VDHELQQIIRDNLYLRTVPCTTRPHKEG----------EVPGVDYIFIT 159

  Fly  1431 LPEATEKNQNPEGASNQTVSADNLAWKQTVETIAENVFASAKTQI--------ISNQLAMNTSSS 1487
            :.:..|..::  ||..::            .|..:|.:.:.|...        :::|:....:.|
  Rat   160 VEDFMELEKS--GALLES------------GTYEDNYYGTPKPPAEPAPLLLNVTDQILPGATPS 210

  Fly  1488 REARAKHKESGTNQMHKDNISGPSPLSRELEHISDLSAINNSMPAINSSNVSDLATISENLSLTE 1552
            .|.:.|..:|.|| |.|.:|..|.....|             .|.:|.:.|
  Rat   211 AEGKRKRNKSVTN-MEKASIEPPEEEEEE-------------RPVVNGNGV-------------- 247

  Fly  1553 LSKENICRVLTPSYKPAESVTASQSSSHP--------------------DVQSSSPRENDIKN-- 1595
                    |:||.....|..:|..|...|                    |.:|:.|.||:..:
  Rat   248 --------VITPESSEHEDKSAGASGETPSQPYPAPVYSQPEELKDQMDDTKSTKPEENEDSDPL 304

  Fly  1596 -------------ISNIEENNKMNA-----------------NNSV----NKISKDLLANLRTSN 1626
                         :..|:.|.|..:                 .|.:    .||...:.......:
  Rat   305 PDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPAEECKENELPYGWEKIDDPIYGTYYVDH 369

  Fly  1627 IAGCPPVTQLSTEALEMIDKMRDGVDMIRNMSNSILSTDTFPVPCTNVPVGGKKTPKAQALINPD 1691
            |   ...||.....||...|::.     .||.::.|.|.....|      |.::.|    |...|
  Rat   370 I---NRRTQFENPVLEAKRKLQQ-----HNMPHTELGTKPLQAP------GFREKP----LFTRD 416

  Fly  1692 NANQKQIIVTSEEFPTKSSKKPSVTLKPAQQPNAVLSIVD-IKEQPISNENVSVPSQMSISVPNL 1755
            .:..|...:::.  ..||:.....|:....:|:..|.:.. |.:.|.:.:.......:.:.:
  Rat   417 ASQLKGTFLSTT--LKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYI--- 476

  Fly  1756 TTTSASEVPSTSEVA----THTGLLETFAAIARRRTSQGTNI------------QDN-------- 1796
                       :||.    ||..:::.|.::.   ..|..|:            :|.
  Rat   477 -----------NEVCVLGHTHADVVKLFQSVP---IGQSVNLVLCRGYPLPFDPEDPANSMVPPL 527

  Fly  1797 QIMNAEANVNEHGDQNASGSFLGHSVTSLVKLALSSNFHSGLLSTAQSYPSLSSN---------- 1851
            .||.....|..:|..|.. ::|.:                 :..|:||.|.::..
  Rat   528 AIMERPPPVMVNGRHNYE-TYLEY-----------------ISRTSQSVPDITDRPPHSLHSMPA 574

  Fly  1852 ------------NSENIAPSNPSNTSAGQQSASTINHTLTMSLTSTSSDSEQVSLEDFLESCRAP 1904
                        :.:|::.::...|.|...:.:.:........|...|.:.| .::..|:....|
  Rat   575 DGQLDGTYPPPVHDDNVSVASSGATQAELMTLTIVKGAQGFGFTIADSPTGQ-RVKQILDIQGCP 638

  Fly  1905 ALL-GDLDDEDDMDEDNDEEENEDEYEEV-------GNTLLQVMVSRNLLTFMDDEAMENRLVGV 1961
            .|. |||..|  :::.|.:..:..|..::       ..|.|.:........:...:.|.:|
  Rat   639 GLCEGDLIVE--INQQNVQNLSHTEVVDILKDCPVGSETSLIIHRGGFFSPWKTPKPMVDR---- 697

  Fly  1962 TKRKSWDDEFVLKRQFSA-LIP-------------------AFDPR------------------- 1987
                 |:::...:...|| .:|                   |||||
  Rat   698 -----WENQGSPQTSLSAPAVPQSLPFPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQ 757

  Fly  1988 --PGRTNVN-QTSDLEISPLGAELPKPQQS------GGPETIEQPLLGLKLR----------GPG 2033
              |.||:.. .:|..:...|...|.:.:..      ||.|..:..|:|..:.          .||
  Rat   758 QVPPRTSFRMDSSGPDYKELDVHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPG 822

  Fly  2034 -----IGGIPEVEIDLSNTDWTIFRAVQELLQCSQLNKLDKFRKI---WEP-------TYTIVYR 2083
                 :.|||..    ..|...:...:....:..|:| |...||:   .||       ..::...
  Rat   823 DELVYVDGIPVA----GKTHRYVIDLMHHAARNGQVN-LTVRRKVLCGGEPCPENGRSPGSVSTH 882

  Fly  2084 EVSPEAQESTCLES------------EEFP----QTPDV---------------SS----KSGAS 2113
            ..||.:..:|...|            |.|.    ||.||               ||    :|||:
  Rat   883 HSSPRSDYATYANSNHAAPSSNASPPEGFASHSLQTSDVIIHRKENEGFGFVIISSLNRPESGAT 947

  Fly  2114 TLSPNSPMHIGFNVADN---NLCSVDDVLELLTQING-----LNQSEIDSDVKEHGVSVL----- 2165
            ...|:.   || .:.|.   :.|:...|.:.:..:||     :..::|...:|:.|:||.
  Rat   948 ITVPHK---IG-RIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIP 1008

  Fly  2166 SEDLF------ISKKITNKLQQ-----QIQDPLVLASNALPNWCENLNQSCPFLFPFETRQLYFN 2219
            .|:|.      .|:|.:...||     |...||...|.|.||  ..:.|..|   | :..||..:
  Rat  1009 QEELNSPTSAPSSEKQSPMAQQHSPLAQQHSPLAQPSPATPN--SPVAQPAP---P-QPLQLQGH 1067

  Fly  2220 CTSFGASRSIVCLQSQRDVTVERQRIPIMSPRRDDHEFR 2258
            ..|:   ||.|  ::::||..:.::.|....|:...::|
  Rat  1068 ENSY---RSEV--KARQDVKPDIRQPPFTDYRQPPLDYR 1101

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041	11/32 (34%)
		MIB_HERC2	1333..1389	CDD:310955	6/55 (11%)
		DamX	1576..>1725	CDD:330571	33/204 (16%)
		HECTc	2265..2725	CDD:238033
Magi2	NP_446073.2	PDZ_signaling	22..96	CDD:238492	19/92 (21%)
		GuKc	118..291	CDD:214504	36/240 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	205..308		26/138 (19%)
		Interaction with DDN. /evidence=ECO:0000250	302..381		9/81 (11%)
		WW	304..333	CDD:395320	3/28 (11%)
		WW	350..381	CDD:197736	5/33 (15%)
		PDZ	428..509	CDD:214570	14/99 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	556..575		3/18 (17%)
		PDZ	602..683	CDD:214570	14/83 (17%)
		MAGI_u5	687..758	CDD:406953	11/79 (14%)
		PDZ	775..861	CDD:214570	16/90 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	869..913		6/43 (14%)
		PDZ_signaling	920..1007	CDD:238492	20/90 (22%)
		PRK10263	<1007..>1135	CDD:236669	27/106 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1011..1130		26/102 (25%)
		PDZ_signaling	1140..1220	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900