Protein Alignment Ufd4 and WWP1

DIOPT Version :9

• Sequence 1: NP_609369.1
• Gene: Ufd4 / 34378
• FlyBaseID: FBgn0032208
• Length: 2727
• Species: Drosophila melanogaster
• Sequence 2: NP_008944.1
• Gene: WWP1 / 11059
• HGNCID: 17004
• Length: 922
• Species: Homo sapiens
• Alignment Length: 1127
• Identity: 234/1127 - (20%)
• Similarity: 384/1127 - (34%)
• Gaps: 323/1127 - (28%)

  Fly  1672 TNVPVGGK--KTPKAQALINPDNANQKQIIVTSE---EFPTKSSKKPSVTLKPAQQPNAVL--SI 1729
            |.|.|.|:  ||.|:.:..||....|..:.||.:   ||...|.:    |||    .:|:|  :.
Human    42 TEVVVDGEITKTAKSSSSSNPKWDEQLTVNVTPQTTLEFQVWSHR----TLK----ADALLGKAT 98

  Fly  1730 VDIKEQ-PISNENVS-VPSQMSISVPNLTTTSASEVPSTSEVATHTGLLETFAAIARRRTSQGTN 1792
            :|:|:. .|.|..:. |..|:.:|:.|     .:.:..|.|:   |.:|:            |..
Human    99 IDLKQALLIHNRKLERVKEQLKLSLEN-----KNGIAQTGEL---TVVLD------------GLV 143

  Fly  1793 IQDNQIMNAEAN----VNEHGDQNASGSFLGHSVTSLVKLALSSNFHSGLLSTAQSYPSLSSNNS 1853
            |:...|.|..::    :.|:||                  ||..|......:||:    |:...:
Human   144 IEQENITNCSSSPTIEIQENGD------------------ALHENGEPSARTTAR----LAVEGT 186

  Fly  1854 ENIAPSNPSNTSAGQQSASTINHTLTMSLTSTSSDSEQVSLEDFLESCRAPALLGDLDDEDDMDE 1918
            ..|....|::|.......|.:     ::..:|.|...||:...  ::..||..|.....:|.::.
Human   187 NGIDNHVPTSTLVQNSCCSYV-----VNGDNTPSSPSQVAARP--KNTPAPKPLASEPADDTVNG 244

  Fly  1919 DNDEEENEDEYEEVGNTLLQVMVSRNLLTFMDDEAMENRLVGVTKRKSWDDEFVLKRQFSALIPA 1983
            ::......|.....|..::.           ::.|:.......|.......|.:...:.:..||:
Human   245 ESSSFAPTDNASVTGTPVVS-----------EENALSPNCTSTTVEDPPVQEILTSSENNECIPS 298

  Fly  1984 FDP----------RPGRTNVNQTSDLEIS----PLGAELPKPQQSGGPETIEQPLLGLKLRGPGI 2034
            ...          .|..:|...:|..|.:    |.|...|..||||...|...| .|.:.|....
Human   299 TSAELESEARSILEPDTSNSRSSSAFEAAKSRQPDGCMDPVRQQSGNANTETLP-SGWEQRKDPH 362

  Fly  2035 GGIPEVEIDLSNTDWTIFRAVQELLQCSQLNKLDKFRKI-----------WE-PTYTIVYREVSP 2087
            |....|:.:...|.|    ...:.|......::|..|::           |: ||...|......
Human   363 GRTYYVDHNTRTTTW----ERPQPLPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQW 423

  Fly  2088 EAQESTCLES-EEFPQTPDVSSKSGASTLSPNSPMHIGFNVADNNLCSVDDVLELLTQINGLNQS 2151
            ::|.:....: ::|.|....|:...|:...|..|:..|:                        :.
Human   424 QSQRNQLQGAMQQFNQRYLYSASMLAAENDPYGPLPPGW------------------------EK 464

  Fly  2152 EIDSDVKEHGVSVLSEDLFISKKITNKLQQQIQDPLVLA---SNALPNWCE--NLNQSCPFLFPF 2211
            .:||..:.:.|:            .|....|.:||....   ...||...|  ...:...:....
Human   465 RVDSTDRVYFVN------------HNTKTTQWEDPRTQGLQNEEPLPEGWEIRYTREGVRYFVDH 517

  Fly  2212 ETRQLYFNCTSFGASRSIVCLQSQRDVTVERQRIPIMSPRRDDHEFRIGRLK----------HER 2266
            .||...|.....|.| |:.  :....:..||           ...:::...:          |.:
Human   518 NTRTTTFKDPRNGKS-SVT--KGGPQIAYER-----------GFRWKLAHFRYLCQSNALPSHVK 568

  Fly  2267 VKVPRN---EDLLMWAMQVMKTHCNRKSVLEVEFLDEEGTGLGP-TLEFYALVAAEIQRSDLCMW 2327
            :.|.|.   ||.....|.:......|:  |.|.|..|||...|. ..|::.|::.|:.....|::
Human   569 INVSRQTLFEDSFQQIMALKPYDLRRR--LYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLF 631

  Fly  2328 LCDDDLGEDTENSTQSAEGNSKPVGYYVNRREH--GIFPAPLPQNSEICENVLKYFWFFGVFVAK 2390
                                     .|..:..:  .|.||     |.|..:.|.||.|.|.|:|.
Human   632 -------------------------EYAGKNNYCLQINPA-----STINPDHLSYFCFIGRFIAM 666

  Fly  2391 VLQDMRLVDIPLSTSFLQLLCHNKVLSRNLQKVISDRRNGDLSVVSEDSDIVETCTKLLRTDSNK 2455
            .|...:.:|...|..|     :.::||:.
Human   667 ALFHGKFIDTGFSLPF-----YKRMLSKK------------------------------------ 690

  Fly  2456 SNAFGGILSLENLKEIDPTRYQFLQEMQNLLLRKQSIEFDDTISAEKKHELINELKLQTQNGLE- 2519
                   |::::|:.||...|..|     :.:|..:||                     :.|||
Human   691 -------LTIKDLESIDTEFYNSL-----IWIRDNNIE---------------------ECGLEM 722

  Fly  2520 ---VSLEDLALTFTYLPSSSIYGYTQAELLPNGSSVNVTIDNLEAYCELLMNFILQDGIAQQMKA 2581
               |.:|.|...            |..:|...||::.||.:|.:.|..|:..:....|:.:|.||
Human   723 YFSVDMEILGKV------------TSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKA 775

  Fly  2582 FSDGFNEVFPLKKLAAFTPSEARMMICGEQ---FPHWSREDIISYTEPKLGYNKDSPGFQRFVNV 2643
            |.||||||.||:.|..|...|..:|:||.|   ...|.|..:..:      |.::|.....|...
Human   776 FLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRH------YTRNSKQIIWFWQF 834

  Fly  2644 LLSMSGDERKAFLQFTTGCSSLPPGGLANL----HPRLTVVRKVDAGVGSY-PSVNTCVHYLKLP 2703
            :.....:.|...|||.||...||.||.|.|    .|:...:.||  |..:: |..:||.:.|.||
Human   835 VKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKV--GKDTWLPRSHTCFNRLDLP 897

  Fly  2704 DYPTEEIMKERLLTATKE-KGF 2724
            .|.:.|.:||:||.|.:| :||
Human   898 PYKSYEQLKEKLLFAIEETEGF 919

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041
		MIB_HERC2	1333..1389	CDD:310955
		DamX	1576..>1725	CDD:330571	18/57 (32%)
		HECTc	2265..2725	CDD:238033	117/479 (24%)
WWP1	NP_008944.1	C2_E3_ubiquitin_ligase	17..140	CDD:175988	31/113 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	210..388		35/195 (18%)
		HUL4	<307..922	CDD:227354	170/794 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900