DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ufd4 and Ube3c

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	NP_598668.1	Gene:	Ube3c / 100763	MGIID:	2140998	Length:	1083	Species:	Mus musculus

Alignment Length:	926	Identity:	187/926 - (20%)
Similarity:	321/926 - (34%)	Gaps:	279/926 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1894 LEDFLESCRA-PALLGDLDDEDDMDEDNDEEENEDEYEEVGNTLLQVMVSRNLLTFMDDEAMENR 1957
            |:.||....| |...|..|...|.::||:|.:..:..|:  ..:....::...|..:|.:...|.
Mouse   345 LQTFLSQLPASPTGTGCPDSTSDSEDDNEETDQPNSPED--GRVSAPYITEECLRKLDTKQQTNT 407

  Fly  1958 LVGVTKRKSWDDE---------FVLKRQFSALIP--------AFDPR------------------ 1987
            |:.:..|.|..:|         ..|..|...::|        ||:.|
Mouse   408 LLNLVWRDSASEEVFTRMASICHTLMVQHRMMVPKVRLLYSLAFNARFLRHLWFLISSMTTQMIT 472

  Fly  1988 ----PGRTNVNQTSDLEISPLGAELP------------------------------KPQQSGGPE 2018
                |....:::.|.:........:|                              :.|.|..|.
Mouse   473 GSMVPLLQLISRGSPMSFEDSSRIIPLFYLFSSLFSHSLISIHDNEFFGDPIEVVGQRQSSMMPF 537

  Fly  2019 TIEQ-PLLGLKLRGPGIGGI----PEVEIDLSNTDWTIFRAV-----QELLQCSQLNKLDKFRKI 2073
            |:|: .||...||...:|.|    ||.:.::.....|.|:::     .|:.||.|:.     :|.
Mouse   538 TLEELILLSRCLRDACLGIIKLAYPETKPEVREEYVTAFQSIGVTTNSEMQQCIQME-----QKR 597

  Fly  2074 WEPTYTIVYREV----SPEAQESTCLESEEFPQTPDVSSKSGASTLSPNSPMHIGFNVADNNLCS 2134
            |...:.::...|    |.:.:.:.|..:....:..|:.:........|.| .|:........:..
Mouse   598 WVQLFKVITNLVKMLKSRDTRRNFCPPNHWLSEQEDIKADKVTQLYVPAS-RHVWRFRRMGRIGP 661

  Fly  2135 VDDVLELLTQINGLNQSEIDSDVKEHGVSVLSEDLFISKKITNKLQQQIQDPLVLASNALPNWCE 2199
            :...||:..:...|:.||      |..:::|:|
Mouse   662 LQSTLEVGLESLPLSVSE------ERQLAILTE-------------------------------- 688

  Fly  2200 NLNQSCPFLFPFETRQLYFNCTSFGASRSIVCLQSQRDVTVERQRIPIMSPRRDDHEFRIGRL-- 2262
                 .||:.|||.|...|                ||.:..::|.:....|..|.....|.|.
Mouse   689 -----LPFVVPFEERVKIF----------------QRLIYADKQEVQGDGPFLDGINVTIRRNYI 732

  Fly  2263 ---KHERVKVPRNEDLLMWAMQVMKTHCNRKSVLEVEFLDEEG-TGLGPTLEFYALVAAEIQRSD 2323
               .::::. |.||..|...::|        .:|....|||.| .|.|...||.
Mouse   733 YEDAYDKLS-PENEPDLKKRIRV--------HLLNAHGLDEAGIDGGGIFREFL----------- 777

  Fly  2324 LCMWLCDDDLGEDTENSTQSAEGNSKPVGYYVNRREHGIFPAPLPQNSEICENVLKYFWFFGVFV 2388
                   ::|.:...|..|         |::....|..::|.|..| ..:.::..::::|.|..:
Mouse   778 -------NELLKSGFNPNQ---------GFFKTTNEGLLYPNPAAQ-MLVGDSFARHYYFLGRML 825

  Fly  2389 AKVLQDMRLVDIPLSTSFLQLLCHNKVLSRNLQKVISDRRNGDLSVVSEDSDIVETCTKLLRTDS 2453
            .|.|.:..||::|.:..||                                      :|||.|.:
Mouse   826 GKALYENMLVELPFAGFFL--------------------------------------SKLLGTSA 852

  Fly  2454 NKSNAFGGILSLENLKEIDPTRYQFLQEMQNLLLRKQSIEFDDTISAEKKHELINELKLQTQNGL 2518
            :        :.:.:|..:||..|      :|||..|                           ..
Mouse   853 D--------VDIHHLASLDPEVY------RNLLFLK---------------------------SY 876

  Fly  2519 EVSLEDLALTFTYLPSSSIYGYTQ-AELLPNGSSVNVTIDNLEAYCELLMNFILQDGIAQQMKAF 2582
            |..:|:|.|.||.:  ::..|..| .||...|..:.||..|..||..|:.::.|...|.....||
Mouse   877 EEDVEELGLNFTVV--NNDLGEAQVVELKFGGKDIPVTGANRIAYIHLVADYRLNKQIRPHCLAF 939

  Fly  2583 SDGFNEVFPLKKLAAFTPSEARMMICGEQFPHWSREDIISYTEPKLGYNKDSPGFQRFVNVLLSM 2647
            ..|...|..|:.|..|...|.:::|.|.|.| .|.||:.|:|....||:.|.|..:.|..|:...
Mouse   940 RQGLANVVSLEWLRMFDQQEIQVLISGAQVP-VSLEDLKSFTNYSGGYSADHPVIKIFWRVVEGF 1003

  Fly  2648 SGDERKAFLQFTTGCSSLPPGGLANLHPRLTVVRKVDAGVGSYPSVNTCVHYLKLPDYPTEEIMK 2712
            :.:|::..|:|.|.||..|..|...|:|.. .:....:.:...|:.:||::.||||::..|.:::
Mouse  1004 TDEEKRKLLKFVTSCSRPPLLGFKELYPAF-CIHNGGSDLERLPTASTCMNLLKLPEFYDEALLR 1067

  Fly  2713 ERLLTATK-EKGFHLN 2727
            .:||.|.: ..||.|:
Mouse  1068 SKLLYAIECAAGFELS 1083

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041
		MIB_HERC2	1333..1389	CDD:310955
		DamX	1576..>1725	CDD:330571
		HECTc	2265..2725	CDD:238033	107/462 (23%)
Ube3c	NP_598668.1	Cis-determinant of acceptor ubiquitin-binding. /evidence=ECO:0000250	1..60
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..386		9/33 (27%)
		HECTc	723..1081	CDD:238033	109/477 (23%)
		HECTc	747..1080	CDD:214523	103/451 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900