DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ufd4 and HUWE1

DIOPT Version :9

Sequence 1:NP_609369.1 Gene:Ufd4 / 34378 FlyBaseID:FBgn0032208 Length:2727 Species:Drosophila melanogaster
Sequence 2:XP_016884680.1 Gene:HUWE1 / 10075 HGNCID:30892 Length:4501 Species:Homo sapiens


Alignment Length:3200 Identity:610/3200 - (19%)
Similarity:1027/3200 - (32%) Gaps:1139/3200 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   112 SSRTSRDLAEQCIKVLELICTREAGAVFEGGGLNCVLSFIRDC----GSQVHKDTLHSAMSVVSR 172
            |:.|.::.:.:..|:.|::        .:|...:.|...||.|    |..|..||||:.:    |
Human  1855 STNTEKETSLEETKIGEIL--------IQGLTEDMVTVLIRACVSMLGVPVDPDTLHATL----R 1907

  Fly   173 LCTKVE------------PNTPCIQNCVES---------LSTLLQH--EDPMVSDGALKCFASVA 214
            ||.::.            .:|..|.|..:|         ::.||:|  |||......::      
Human  1908 LCLRLTRDHKYAMMFAELKSTRMILNLTQSSGFNGFTPLVTLLLRHIIEDPCTLRHTME------ 1966

  Fly   215 DRFTRKWVDPAPLAEYGLTTELLKRLQSVGGNTHSS-----LTAAGTQPTSSSQPAATTNSDAIN 274
                 |.|..|..:..|.||..:     |.|:..|.     |...|        |||..|.|...
Human  1967 -----KVVRSAATSGAGSTTSGV-----VSGSLGSREINYILRVLG--------PAACRNPDIFT 2013

  Fly   275 E------NVA-----GTATISN----STKVKSSDAAASPQSISTTISLLSTLCRGSPSITHDILR 324
            |      .:|     |:.|.|:    :.::|..:|.   |.:.||....|.|     .:..|.::
Human  2014 EVANCCIRIALPAPRGSGTASDDEFENLRIKGPNAV---QLVKTTPLKPSPL-----PVIPDTIK 2070

  Fly   325 SQLADALERALQGDERCVLDCMRFADLLLLLLFEGRQALNRGSNNPNQGQLAPRPRRNNTNTDRT 389
            ..:.|.|.                    .|..:...:..::  ::|..|.:              
Human  2071 EVIYDMLN--------------------ALAAYHAPEEADK--SDPKPGVM-------------- 2099

  Fly   390 HRQLIDCIRSKDSEALREAIESGGIDVNCMDDVGQ---TLLNWASAFGTLEMVEYLCEKGADVNK 451
                        ::.:.:.::..|      |||.|   :|...:|.|.|        :.|..:| 
Human  2100 ------------TQEVGQLLQDMG------DDVYQQYRSLTRQSSDFDT--------QSGFSIN- 2137

  Fly   452 GQRSSSLHYAACFGRPAIAKILLKFGAYPDLRDEDGKTPLDKARERLDDGHREVAAILQSPGEWM 516
                 |..:||                                    |....|.:|...|.||..
Human  2138 -----SQVFAA------------------------------------DGASTETSASGTSQGEAS 2161

  Fly   517 SPDHSLLNKDGKKYTLMEPRGD--PEMAPIYLKVLLPIFCRTFLGSMLGSVRRASLALIKKIVQY 579
            :|:.|   :||||    :..||  .|......|...|:...:.:..:|..:.|:.:.:...|..|
Human  2162 TPEES---RDGKK----DKEGDRASEEGKQKGKGSKPLMPTSTILRLLAELVRSYVGIATLIANY 2219

  Fly   580 AYPTVLQS-----------------LSETSFSED--------------AASTSGQNGGNLLIEVI 613
            :| ||.||                 |..|..:||              ||:.||.:....|:..:
Human  2220 SY-TVGQSELIKEDCSVLAFVLDHLLPHTQNAEDKDTPALARLFLASLAAAGSGTDAQVALVNEV 2283

  Fly   614 ASVLDN----EDDGDGHL---IVLNIIEEIM--------------CKTQEEFLDHFARLGV---- 653
            .:.|..    .:..:.|.   .|:.||..||              .|||...:::..||.:    
Human  2284 KAALGRALAMAESTEKHARLQAVMCIISTIMESCPSTSSFYSSATAKTQHNGMNNIIRLFLKKGL 2348

  Fly   654 ---FAKVQALMDTDAEEL----------------YVQLPGTV------------EEPA--AAQRS 685
               .|:|...:|..:..:                .|..|.::            |:.|  |:|.|
Human  2349 VNDLARVPHSLDLSSPNMANTVNAALKPLETLSRIVNQPSSLFGSKSASSKNKSEQDAQGASQDS 2413

  Fly   686 STSVVVAPRPTSDDPMEDAKEILQGKPYHWREWSICRGRDCL--YVWSDSVAL------------ 736
            |::        ..||.|..:..:|.:.:...:..:..| |.:  ...:|||.:            
Human  2414 SSN--------QQDPGEPGEAEVQEEDHDVTQTEVADG-DIMDGEAETDSVVIAGQPEVLSSQEM 2469

  Fly   737 ----ELS---------NGSNGWFRFIID--------------------GKLATMY---------- 758
                ||.         :|.:|....|:.                    .:.:|:.          
Human  2470 QVENELEDLIDELLERDGGSGNSTIIVSRSGEDESQEDVLMDEAPSNLSQASTLQANREDSMNIL 2534

  Fly   759 -------------SSGSPENGNDSSENRGE----------------------------------- 775
                         ||||.|:.:||.:...|                                   
Human  2535 DPEDEEEHTQEEDSSGSNEDEDDSQDEEEEEEEDEEDDQEDDEGEEGDEDDDDDGSEMELDEDYP 2599

  Fly   776 --------FLEKLMRARSCVI---------AGVVSQP-ILPT-------------------ASAL 803
                    ..|:..|....:|         ..:...| .:||                   :|..
Human  2600 DMNASPLVRFERFDREDDLIIEFDNMFSSATDIPPSPGNIPTTHPLMVRHADHSSLTLGSGSSTT 2664

  Fly   804 RLVVGNWVLQSQKTNQLQIHNTEGHQVTVLQDDLPGFIFESNRGTKHTFSAETVLGPDFASGWST 868
            ||..|  :.:||:|.:....|| ||.:.|   ..||     ||........:.:|||..|:.   
Human  2665 RLTQG--IGRSQRTLRQLTANT-GHTIHV---HYPG-----NRQPNPPLILQRLLGPSAAAD--- 2715

  Fly   869 AKKKRNKSKTEGQKFQVRNLSREIYNKYFKSAQIIPRGAVAILTDIVKQIELSFEEQHMAPNGNW 933
                 ....:.....|.|..:|.:...  ....||.|....:|.|.       |.:|..|.  :.
Human  2716 -----ILQLSSSLPLQSRGRARLLVGN--DDVHIIARSDDELLDDF-------FHDQSTAT--SQ 2764

  Fly   934 ETTLTDALMKLSQLIHEDGVVSAYEMHSSGLVQALVAVLSVNHWE---TNSPRCKRNKMQKQRVS 995
            ..||:.....|::...|..|:.|..||.   ..::|.|..|||.|   ......:|.|.:||...
Human  2765 AGTLSSIPTALTRWTEECKVLDAESMHD---CVSVVKVSIVNHLEFLRDEELEERREKRRKQLAE 2826

  Fly   996 VFKKCILEDNVESATNKPRT-KSTASILIQKLVSVLESTEKLPVYLYDS-PCTGYSLQILQKRLR 1058
            ...| |.:...|...|:.:: :.|||.........|.....:|    || |.|..|......   
Human  2827 EETK-ITDKGKEDKENRDQSAQCTASKSNDSTEQNLSDGTPMP----DSYPTTPSSTDAATS--- 2883

  Fly  1059 FRLERAECESTL-FDRSGRTLKMEPLATIGQLSKYLLKMVAKQWYDLDRSTYFYLKKIREHRTAT 1122
               |..|...|| ..:...||...|  .:|::.:.|.....                        
Human  2884 ---ESKETLGTLQSSQQQPTLPTPP--ALGEVPQELQSPAG------------------------ 2919

  Fly  1123 VFTHSFDFDEEGLLFYIGSNAKTCDWVNPAQYGLVQVTSSEGKTLPYGKLEDILSRDSISLNCHT 1187
                      ||     ||:.:....|.|.:.         |.|.|.|:.|              
Human  2920 ----------EG-----GSSTQLLMPVEPEEL---------GPTRPSGEAE-------------- 2946

  Fly  1188 KDNKKAWFAIDLGVYIIPTAYTLRHARGYGRSALRNWLLQGSKDGSTWTTLSTHVDDKSLVEPGS 1252
                    ...:.:...||..:|...|              ::|....|.:|:.::. |.::..|
Human  2947 --------TTQMELSPAPTITSLSPER--------------AEDSDALTAVSSQLEG-SPMDTSS 2988

  Fly  1253 TATWPINCATDDSVWYRHIRIQQNGRNASGQTHY----LSLSG------FEIYGRVVGVADDIGK 1307
            .|    :|..:::|         ...:|:|.:..    .|..|      .|:.||    :|..|:
Human  2989 LA----SCTLEEAV---------GDTSAAGSSEQPRAGSSTPGDAPPAVAEVQGR----SDGSGE 3036

  Fly  1308 SVK---------EAEAKTRRERRQIRAQLKHMTTGARVIRGVDWRW-----------EEQDGCAE 1352
            |.:         .:|:.:.|:             .|..|.|.|.|.           ||:|..|.
Human  3037 SAQPPEDSSPPASSESSSTRD-------------SAVAISGADSRGILEEPLPSTSSEEEDPLAG 3088

  Fly  1353 GTITGEIHNGWI-----DVKWD-----HGVR---------NSYRMGAEGKYDLKLADCEYLSAFD 1398
            .::...:...::     |::.:     .|:|         ||......|...:.....|:|:|..
Human  3089 ISLPEGVDPSFLAALPDDIRREVLQNQLGIRPPTRTAPSTNSSAPAVVGNPGVTEVSPEFLAALP 3153

  Fly  1399 GNQSMGSASTAAKPSEKGGNTLTSRKSSSTP--------SLPEATEKN--QNPEGASNQTVSADN 1453
              .::.....|.:.:|:....|....||.||        :||....::  ::.|.:....:..|.
Human  3154 --PAIQEEVLAQQRAEQQRRELAQNASSDTPMDPVTFIQTLPSDLRRSVLEDMEDSVLAVMPPDI 3216

  Fly  1454 LAWKQTV---------ETIAENVFASAKTQIISNQLAMNTSSSR--------EARAKHKESGTNQ 1501
            .|..|.:         :.:.|.:|..:.|..:|..|.....:||        ..|...:..||.|
Human  3217 AAEAQALRREQEARQRQLMHERLFGHSSTSALSAILRSPAFTSRLSGNRGVQYTRLAVQRGGTFQ 3281

  Fly  1502 MHKDNISGPSPLSRE----------------LEHISDLSAINNSM----PAINSSNVSDLA---- 1542
            |     .|.|..:|.                |:| ..||.:...:    |.:|:|.:..:.    
Human  3282 M-----GGSSSHNRPSGSNVDTLLRLRGRLLLDH-EALSCLLVLLFVDEPKLNTSRLHRVLRNLC 3340

  Fly  1543 --------TISENLSLTELSKEN-IC----RVLTPSYKPAESVTASQSSSHPDVQSSSPRENDIK 1594
                    .|...||:.:.|.|: :|    ::.|...|..:|..:..||||.:      |..|:.
Human  3341 YHAQTRHWVIRSLLSILQRSSESELCIETPKLTTSEEKGKKSSKSCGSSSHEN------RPLDLL 3399

  Fly  1595 NISNIEENNKMNANNSVNKISKDLLANLRTSNIAGCPPVTQLS-TEALEMIDKMRDGVDMIRNMS 1658
            :....:.:|::    |...:|.|.....||:       :.|:. :...:..:|...|...:.   
Human  3400 HKMESKSSNQL----SWLSVSMDAALGCRTN-------IFQIQRSGGRKHTEKHASGGSTVH--- 3450

  Fly  1659 NSILSTDTFPVPCTNVPVGGKKTPKAQALINPDNANQKQIIVTSEEFPTKSSKKPSVTLKPAQQP 1723
               :.....||.|.:|    ..|....|.:.|.:..|::...|:.|...:...|   ...|....
Human  3451 ---IHPQAAPVVCRHV----LDTLIQLAKVFPSHFTQQRTKETNCESDRERGNK---ACSPCSSQ 3505

  Fly  1724 NAVLSI-VDIKEQPISNENVSVPSQMSISVPNLTTTSASE---VPSTSEVATHTGLLETFAAIAR 1784
            ::...| .|..:..:..:|::|..:...||.::..::..|   .|.:.|.:....|:...:....
Human  3506 SSSSGICTDFWDLLVKLDNMNVSRKGKNSVKSVPVSAGGEGETSPYSLEASPLGQLMNMLSHPVI 3570

  Fly  1785 RRTSQGTN------------IQDNQIMNAEANVNEHGDQNASGSFLGHSVTSLVKLALSSNFHSG 1837
            ||:|..|.            :.:|::..|:||         |||  |.|.|              
Human  3571 RRSSLLTEKLLRLLSLISIALPENKVSEAQAN---------SGS--GASST-------------- 3610

  Fly  1838 LLSTAQSYPSLSSNNSENIAPSNPSN----TSAGQQSASTINHTLTM----SLTSTSSDSEQVSL 1894
              :||.|..|.::..:.:..|:.|:.    |||....|:|...|:.:    ::|:.::.:..||:
Human  3611 --TTATSTTSTTTTTAASTTPTPPTAPTPVTSAPALVAATAISTIVVAASTTVTTPTTATTTVSI 3673

  Fly  1895 EDFLESCRAPALLGDLDDEDDMDEDNDEEENEDEYEEVGNTLLQVMVSRNLLT--FMDDEAME-- 1955
            ....:..::||.:          .|......:.:....|.|..|:.:|..:||  ...:|.:|  
Human  3674 SPTTKGSKSPAKV----------SDGGSSSTDFKMVSSGLTENQLQLSVEVLTSHSCSEEGLEDA 3728

  Fly  1956 -NRLVGVTKRKSWDDEFVLKRQFSALIPAFDPRPGRTNVNQTSDLEISPLGAELPK---PQQ--- 2013
             |.|:.:::..|...:.|||...:          |..::..|...:|..|.|||.:   .||   
Human  3729 ANVLLQLSRGDSGTRDTVLKLLLN----------GARHLGYTLCKQIGTLLAELREYNLEQQRRA 3783

  Fly  2014 -------SGGPETIEQPLLGLKLRGP-------------------GIGG----IPEVEIDLSNTD 2048
                   .|.||  |||.. .||:|.                   .:||    :|.:.:..|.|.
Human  3784 QCETLSPDGLPE--EQPQT-TKLKGKMQSRFDMAENVVIVASQKRPLGGRELQLPSMSMLTSKTS 3845

  Fly  2049 WTIF--RAVQELLQ----CSQLNKLDK-------------------FRKIWEPTYTIV--YRE-- 2084
            ...|  |.:|.::|    ..:.||..|                   .|::......|:  .||  
Human  3846 TQKFFLRVLQVIIQLRDDTRRANKKAKQTGRLGSSGLGSASSIQAAVRQLEAEADAIIQMVREGQ 3910

  Fly  2085 ---------VSPEAQESTCLESEEFPQTPDVSSKSGASTLS-----------------PNSPMHI 2123
                     .|..:|....:..||.|...|..|.|...|.|                 |..|:. 
Human  3911 RARRQQQAATSESSQSEASVRREESPMDVDQPSPSAQDTQSIASDGTPQGEKEKEERPPELPLL- 3974

  Fly  2124 GFNVADNNLCSVDDVLELLTQINGLNQSEIDSDVKEHGVSVLS---EDLFISKKITNKLQQQIQD 2185
                  :...|:|::.::|    |....|::....:|.|.||.   |..|:......:.:..::|
Human  3975 ------SEQLSLDELWDML----GECLKELEESHDQHAVLVLQPAVEAFFLVHATERESKPPVRD 4029

  Fly  2186 --------------PLVLA--SNALPNWCENLNQSCPFLFPFETRQLYFNCT---------SFGA 2225
                          ||..|  :.|.|:..:      || |..|...::.:.:         .|..
Human  4030 TRESQLAHIKDEPPPLSPAPLTPATPSSLD------PF-FSREPSSMHISSSLPPDTQKFLRFAE 4087

  Fly  2226 SRSIVCLQSQRD-----------VTVERQRIPIMSPRRDDHEFRIGRLKHERVKVPRNEDLLMWA 2279
            :...|..|..|.           |.|:..|:.....:|......:.||....    |.||:   |
Human  4088 THRTVLNQILRQSTTHLADGPFAVLVDYIRVLDFDVKRKYFRQELERLDEGL----RKEDM---A 4145

  Fly  2280 MQVMKTH--------CNRKSVLEVE------FLDEEGTGLGPTL-EFYALVAAEIQRSDLCMWLC 2329
            :.|.:.|        .:|||..|::      |..|||...|..| |:|.:::.|:......::  
Human  4146 VHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALF-- 4208

  Fly  2330 DDDLGEDTENSTQSAEGNSKPVGYYVNRREHGIFPAPLPQNSEICE-NVLKYFWFFGVFVAKVLQ 2393
                        :::.|:.  |.|.:|...|             |. |.|.||.|.|..|||.:.
Human  4209 ------------RTSPGDR--VTYTINPSSH-------------CNPNHLSYFKFVGRIVAKAVY 4246

  Fly  2394 DMRLVDIPLSTSFLQLLCHNKVLSRNLQKVISDRRNGDLSVVSEDSDIVETCTKLLRTDSNKSNA 2458
            |.||::...:.||     :..:|.:::       |..|:.  |||                    
Human  4247 DNRLLECYFTRSF-----YKHILGKSV-------RYTDME--SED-------------------- 4277

  Fly  2459 FGGILSLENLKEIDPTRYQFLQEMQNLLLRKQS-IEFDDTISAEKKHELINELKLQTQNGLEVSL 2522
                             |.|.|.:..||....| :.:|.|.|.|.:...:.|::           
Human  4278 -----------------YHFYQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVR----------- 4314

  Fly  2523 EDLALTFTYLPSSSIYGYTQAELLPNGSSVNVTIDNLEAYCELLMNFILQDGIAQQMKAFSDGFN 2587
                                 :|.|||:::.||.:|.:.|..|:....:...|.:|:.||.:||.
Human  4315 ---------------------DLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFY 4358

  Fly  2588 EVFPLKKLAAFTPSEARMMICGEQFPHWSREDIISYTEPKLGYNKDSPGFQRFVNVLLSMSGDER 2652
            |:.|.:.::.||..|..::|.|  .|....:|:.|.||.. .|..:|...|.|...|.|....:|
Human  4359 EIIPKRLISIFTEQELELLISG--LPTIDIDDLKSNTEYH-KYQSNSIQIQWFWRALRSFDQADR 4420

  Fly  2653 KAFLQFTTGCSSLPPGGLANLHPRLTV----VRKVDAGVGSYPSVNTCVHYLKLPDYPTEEIMKE 2713
            ..||||.||.|.:|..|.|.|.....:    :.:.|......||.:||.:.|.||.|.:.|.::.
Human  4421 AKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRH 4485

  Fly  2714 RLLTATKE--KGFHL 2726
            .||.|.:|  :||.|
Human  4486 MLLLAIQECSEGFGL 4500

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ufd4NP_609369.1 ANK repeat 393..420 CDD:293786 1/26 (4%)
ANK 396..509 CDD:238125 17/115 (15%)
ANK repeat 422..453 CDD:293786 8/33 (24%)
ANK repeat 455..484 CDD:293786 3/28 (11%)
F5_F8_type_C 1173..1298 CDD:329041 19/134 (14%)
MIB_HERC2 1333..1389 CDD:310955 15/85 (18%)
DamX 1576..>1725 CDD:330571 27/149 (18%)
HECTc 2265..2725 CDD:238033 116/482 (24%)
HUWE1XP_016884680.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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