DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ufd4 and hecw2b

DIOPT Version :9

Sequence 1:NP_609369.1 Gene:Ufd4 / 34378 FlyBaseID:FBgn0032208 Length:2727 Species:Drosophila melanogaster
Sequence 2:XP_003197660.3 Gene:hecw2b / 100331355 ZFINID:ZDB-GENE-101001-3 Length:1472 Species:Danio rerio


Alignment Length:1769 Identity:346/1769 - (19%)
Similarity:576/1769 - (32%) Gaps:557/1769 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  1161 SSEGKTLPYGKLEDILSRDSISLNCHTKDNKKAWFAIDLGVYIIPTAYTLRHARGYGRSALRNWL 1225
            |..|...|.|     |.|.:...:..|.|::.:.           ||.|.:...|.|::.:.:|.
Zfish    46 SRGGAPEPMG-----LQRANSDTDLVTSDSRSSL-----------TASTYQFTLGRGQNLVISWD 94

  Fly  1226 LQGSKDGSTWTTLSTHVDDKSLVEPGSTATWPINCATDDSVWYRHIRIQQNGRNASGQTHYLSLS 1290
            ::...|.:.|..| .|:|:          |.|.|      ||      ....|..:|...     
Zfish    95 IKEEVDATDWIGL-YHIDE----------TCPAN------VW------DSKNRGVNGTQR----- 131

  Fly  1291 GFEIYGRVVGVADDIGKSVKEAEAKTRRERRQIRAQLKHMTTGARVIRGVDWRWEEQDGCAEGTI 1355
                 |::|...:. |....|.|.|                                        
Zfish   132 -----GQIVWRLEP-GPYFMEPETK---------------------------------------- 150

  Fly  1356 TGEIHNGWIDVKWDHGVRNSYR--------------MGAEGKYDLK--LADCEYLSAFDGNQSMG 1404
                    |..|:.|||..:.|              :||||:.|.:  ...|..|.:|.      
Zfish   151 --------ICFKYYHGVSGALRATTPCITVKNPGVTVGAEGQVDGQSVTEHCRKLVSFT------ 201

  Fly  1405 SASTAAKPSEKG--GNTLTSRKSSSTP----SLPEATEKNQNPEGA--SNQTVSADNLAWKQTVE 1461
            .:...|:..:||  .|.....|.|..|    ..|..:...|....:  ||.|    |..|.....
Zfish   202 LSDIRAQGLKKGMFFNPDPYLKMSIQPGKRNGFPTFSHHGQERRTSIISNTT----NPVWHGEKY 262

  Fly  1462 TIAENVFASAKTQIISNQLAMNTSSSRE-------------ARAKHKESGTNQ---------MHK 1504
            |     |.:..|.::..::....:.||.             .|...:.:..:|         :..
Zfish   263 T-----FVALMTDVLEIEVKDKFAKSRPIIKRFLGQLIIPVQRLLERHTAGDQHVSYTLCRRLPT 322

  Fly  1505 DNISGPSPLSRELEHISDLSAINNSMPAINSSNVSDLATISENLSLTELSKENICRVLTPSYKPA 1569
            :::||......|:.......|:.:.:.|  |:...|..:.|::        |::.:.::...: .
Zfish   323 EHVSGQLHFRVEITFNGHEDAMGSLLGA--SAMNGDPGSPSDD--------EDVLQPVSRMVR-G 376

  Fly  1570 ESVTASQSSSH-----PDVQSSSPREN--------DIKNISNIEENNKMNANNSVNKI------- 1614
            .|.|.|:.|.|     ||.....|.|:        |:...:....:.:.:.|:.::.|       
Zfish   377 PSPTGSEGSLHGDAFRPDECMMDPEEDRLLRDGAPDLAEGAPAHTHRQSSLNDYLDAIEAPKPPG 441

  Fly  1615 SKDLLAN---LRTSNIAGCPPVTQLSTEALEMIDKMRDGVDMIRNMSNSILSTDTFPVPCTNVPV 1676
            .:.|.|:   ||:|    .|..|:|:  |:..||...|        .....|.||........|.
Zfish   442 DRPLGASSPKLRSS----FPTDTRLN--AMLHIDSDED--------EEGHASRDTALTNGMPRPE 492

  Fly  1677 GGKKTPKAQALINPDNANQKQIIVTSEEFPTK--SSKKPSVTLKPAQ-------QPNAVLS---- 1728
            |...:.:.:..::..|..:.:....|....|:  :|...|.|.|...       |..|.:|    
Zfish   493 GHASSERGKGEVHVKNRERLESEAASSATDTEATASVSSSGTTKSQNGGGAEGGQEGAAISGGLT 557

  Fly  1729 -IVDIKEQP---ISNENVSVP-----SQMSISVPNLTTTSASEVPSTSEV--ATHTGLLETFAAI 1782
             .:...:||   |.:|..:.|     ::.|...|.::..|||.:.:.:||  ||.|...|     
Zfish   558 QSISSFQQPALRIQDEEGAAPQASSRTEGSSEAPAVSEASASAIYTVNEVGGATATNQPE----- 617

  Fly  1783 ARRRTSQGTN--IQDNQIMNAEANVNEHGDQN-ASGSFLGHSV---TSLVKLALSSNFHSGLLST 1841
             |..:|:.||  .:|.:|.....::...|::: |....||:.|   ....:.||.::..:|..:.
Zfish   618 -RMNSSEMTNQEEEDEEIWQRRRSLQASGNESQAEAMELGNEVRRTADEAQAALITDGETGACAQ 681

  Fly  1842 A------QSYPSLSSNNS--ENIAPSNPSNTSAGQQS------ASTINHTLTMS----------L 1882
            .      :|.||:..:.|  :.:....|.|..|...|      ...:|.|.|..          |
Zfish   682 VNGHQPMRSLPSVRHDISRYQRVDEPLPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVL 746

  Fly  1883 TSTSSDSEQVSLEDFLESCRAPALLGDLDDEDDMDEDNDEEENED-------EYEEVG------- 1933
            ..::|..:...|....:|.|. .:..:..:|...:...|:....|       ||...|       
Zfish   747 QRSNSIQQMEQLNRRYQSIRR-TITNERTEEQAAEMPPDDLTTSDLLHHSIPEYRRDGVVGPASS 810

  Fly  1934 ---NTLLQVMVSRNLLT-----------------FMDDEAMENRLVGVTKRKSWDDEFVLKRQFS 1978
               .|||....|...||                 |..:..:::.:..|.:.....:.:...|...
Zfish   811 RSRLTLLLQSPSAKFLTSPDFFTVLHSNPSAYRMFTSNTCLKHMISKVRRDAHHFERYQHNRDLV 875

  Fly  1979 ALIPAFDPRPGRTNVNQTSDLEISPLGAELPKPQQSGGP---------ETIEQPLLGL------- 2027
            |.:..|        .|:..||   |.|.|: |...:|.|         .|...|.|.|       
Zfish   876 AFLNMF--------ANKQLDL---PRGWEM-KHDHTGKPFFVDHNCRATTFIDPRLPLQSARPSS 928

  Fly  2028 ---------KLRGPGIGGI--------PEVEIDLSNTDWTIFRAVQELLQCSQLNKLDKFRKIWE 2075
                     :.|....|.:        |.|....|||........|:|:..:...|:..|.:  :
Zfish   929 LLAHRQHLSRQRSHSAGEVGDDPRHAGPAVLPRPSNTFTANRNQCQDLVPVAYNEKIVAFLR--Q 991

  Fly  2076 PTYTIVYREVSPEAQESTCL-ESEEFPQTPDVSSKSGASTLSPNSPMHIGFNVADNNLCSVDDVL 2139
            |....:.:|..||...:..| |..:|.:      ..|||.|:              .|.|..|::
Zfish   992 PNIFDILQERQPELIRNHSLREKVQFIR------NEGASGLA--------------RLSSDADLV 1036

  Fly  2140 ELLTQINGLNQSEIDSDVKEHGVSVLSEDLFISKKITNKLQQQIQDPLVLASNALPNWCENLNQS 2204
            .||:    |.:.|:.|.|..|.:...|           ..|.....|:....|:......|....
Zfish  1037 ILLS----LFEEEVMSYVPPHALLHPS-----------YCQSPRGSPVSSPQNSPGTQRANARAP 1086

  Fly  2205 CPFLFPFET--RQLY--FNCTSFGASRSIVCLQSQRDVTVERQRIPIMSPRRDDHEFRIGRLKHE 2265
            .|:...||.  |..|  .....:|.....|.|..:||..:|.....||...|.|.:         
Zfish  1087 APYKRDFEAKLRNFYRKLETKGYGQGPGKVKLIIRRDHLLEDAFNQIMCYSRKDLQ--------- 1142

  Fly  2266 RVKVPRNEDLLMWAMQVMKTHCNRKSVLEVEFLDEEGTGL-GPTLEFYALVAAEIQRSDLCMWLC 2329
                                    :|.|.|.|:.|||... ||:.||:.||:.|:.....     
Zfish  1143 ------------------------RSKLYVSFVGEEGLDYSGPSREFFFLVSRELFNPYY----- 1178

  Fly  2330 DDDLGEDTENSTQSAEGNSKPVGYYVNRREHGIFPAPLPQNSEICENVLKYFWFFGVFVAKVLQD 2394
              .|.|.:.|.|.:.:  ..|:..:|                   :|..::|.|.|..:...|..
Zfish  1179 --GLFEYSANDTYTVQ--ISPMSAFV-------------------DNHHEWFRFSGRILGLALIH 1220

  Fly  2395 MRLVDI----PLSTSFLQLLCHNKVLSRNLQKVISDRRNGDLSVVSEDSDIVETCTKLLRTDSNK 2455
            ..|:|.    |.....|::.|                   |||                      
Zfish  1221 QYLLDAFFTRPFYKGLLRIPC-------------------DLS---------------------- 1244

  Fly  2456 SNAFGGILSLENLKEIDPTRYQFLQEMQNLLLRKQSIEFDDTISAEKKHELINELKLQTQNGLEV 2520
                       :|:.:|...:|.||.|::                               |.:|.
Zfish  1245 -----------DLEYLDEEFHQSLQWMKD-------------------------------NDIED 1267

  Fly  2521 SLEDLALTFTYLPSSSIYG-YTQAELLPNGSSVNVTIDNLEAYCELLMNFILQDGIAQQMKAFSD 2584
            .|:   ||||.  :..::| .|:.||.|.|:::.|:..|.:.|.|.::.:.::.|:.||.::...
Zfish  1268 MLD---LTFTV--NEEVFGQITERELKPGGANIPVSEKNKKEYIERMVKWRIERGVVQQTESLVR 1327

  Fly  2585 GFNEVFPLKKLAAFTPSEARMMICGE---QFPHWSREDIISYTEPKLGYNKDSPGFQRFVNVLLS 2646
            ||.||...:.::.|...|..::|.|.   ....|...     ||.:.||:.:....:.|...:..
Zfish  1328 GFYEVVDARLVSVFDARELELVIAGTAEIDLGDWRNN-----TEYRGGYHDNHIVIRWFWAAVER 1387

  Fly  2647 MSGDERKAFLQFTTGCSSLPPGGLANLH----PRLTVVRKVDAGVGSYPSVNTCVHYLKLPDYPT 2707
            .:.::|...|||.||.||:|..|.|:|.    ||...|.|. ..:.|.|..:||.:.|.||.||:
Zfish  1388 FNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKW-GKITSLPRAHTCFNRLDLPPYPS 1451

  Fly  2708 EEIMKERLLTATKE 2721
            ..::.|::|||.:|
Zfish  1452 FSMLYEKMLTAVEE 1465

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ufd4NP_609369.1 ANK repeat 393..420 CDD:293786
ANK 396..509 CDD:238125
ANK repeat 422..453 CDD:293786
ANK repeat 455..484 CDD:293786
F5_F8_type_C 1173..1298 CDD:329041 23/124 (19%)
MIB_HERC2 1333..1389 CDD:310955 11/71 (15%)
DamX 1576..>1725 CDD:330571 34/180 (19%)
HECTc 2265..2725 CDD:238033 103/470 (22%)
hecw2bXP_003197660.3 HECW_N 58..177 CDD:318711 33/211 (16%)
C2_NEDL1-like 198..334 CDD:176073 24/150 (16%)
LGT <491..633 CDD:320995 33/147 (22%)
WW 708..737 CDD:306827 7/28 (25%)
WW 887..919 CDD:197736 10/35 (29%)
HECTc 1117..1470 CDD:238033 111/504 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.000

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