DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ufd4 and trip12

DIOPT Version :9

Sequence 1:NP_609369.1 Gene:Ufd4 / 34378 FlyBaseID:FBgn0032208 Length:2727 Species:Drosophila melanogaster
Sequence 2:NP_001136384.1 Gene:trip12 / 100158539 XenbaseID:XB-GENE-6071044 Length:2056 Species:Xenopus tropicalis


Alignment Length:2720 Identity:582/2720 - (21%)
Similarity:929/2720 - (34%) Gaps:910/2720 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   244 GGNTHSSLTAAGTQPTSSSQPAATTNSDAINE-------------------NVAGTATISNSTK- 288
            |....|....||.||...:....:....|.|:                   |.....:..:|:| 
 Frog    11 GSLRRSQRNTAGAQPQEDTAGGRSNLEQAENKTHSLPESRKSHFKTPKVQSNTTSGPSKGHSSKR 75

  Fly   289 -VKSSDAAASPQS---ISTTISL--LSTLCRG---SPSITHDILRSQLADALERALQGDERCVLD 344
             ..||:...:|:.   |:||.:.  .....||   |.|..|....|..:....:|||..|.    
 Frog    76 GCSSSNLLPNPEDTERINTTDTQRPKKDHVRGVKRSASPDHSRTNSPSSAKKPKALQHPEP---- 136

  Fly   345 CMRFADLLLLLLFEGRQALNRGSNNPN------QG-QLAPRPRRNNTNTDRTH------------ 390
                               :.|...||      || |..|.|..:..:|.:.|            
 Frog   137 -------------------SSGPRRPNNKPKKRQGSQEQPFPSASLPSTSKAHSRKGGSQGTSPL 182

  Fly   391 -----RQLIDCIRSKDSEALREAIESGGIDVNCMDDVGQTLLNWASAFGTLEMVEYLCEKGADVN 450
                 .:|..|::|..:     |:.|.|     .:|....|...||...|  ..:..|....|.:
 Frog   183 PKRKRTELSPCVKSSSA-----AVISTG-----AEDRPPKLSKLASKSAT--SAKAGCSNITDSS 235

  Fly   451 KGQRSSSLHYAACFGRPAIAKILLKFGAYPDLRDEDGKTPLDKARERLDDGHREVAAILQSPGEW 515
            ....:||       ...|:|.:   ..|.|..|.:.||.. :|||       |..:|  .||   
 Frog   236 SSASTSS-------SSSAVASV---SAAPPGARVKQGKDQ-NKAR-------RSRSA--SSP--- 277

  Fly   516 MSPDHSLLNKDGKKYTLME-----PRGDPEMAPIYLKVLLPIFCRTFLGSMLGSVRRASLALIKK 575
             ||..|...|:..|.:...     .|..|:::....|:.||...:|.......|..:|.||.::|
 Frog   278 -SPRRSSREKEQTKTSSSSKFDWAARFSPKVSLPKTKLSLPGSSKTETSKPGPSGLQAKLANLRK 341

  Fly   576 IVQ---YAYPTVLQSLSETSFSE---DAASTSGQNGGNLLIEVIASVLDNEDDGDGHLIVLNIIE 634
            ..:   .:.|..|.||..::..:   ..||||.:..|                            
 Frog   342 STKKRSESPPAELPSLRRSTRQKTTGSCASTSRRGSG---------------------------- 378

  Fly   635 EIMCKTQEEFLDHFARLGVFAKVQA-----LMDTDAEELYVQLPGTVEEPAAAQRSSTSVVVA-P 693
                            ||..|..:|     :.|.|.:|.........:|.|....:|:||..| .
 Frog   379 ----------------LGKRAAAEARRQEKMADPDNQEGANSSAARTDETAQGAAASSSVAGAVG 427

  Fly   694 RPTSDDPMEDAKEI--------LQGKPYHWREWSICRGRDCLY-----VWSDSVALELSNGSNGW 745
            ..||.:...|..|:        .:|.|.|            |:     ..|......:.:|::..
 Frog   428 MTTSGESESDDSEMGRLQALLEARGLPPH------------LFGPLGPRMSQLFHRTIGSGASSK 480

  Fly   746 FRFIIDGKLATMYSSGSPENGNDSSENRG--EFLEKLMRARSCVIAGVVSQPILPTASALRLVVG 808
            .:.::.|..||          ::|.:.:.  |..:.|:......:.|...:.::|....|..:..
 Frog   481 AQQLLQGLQAT----------DESQQLQAVIEMCQLLVMGNEETLGGFPVKSVVPALITLLQMEH 535

  Fly   809 NWVLQSQKTNQL-QIHNTEGHQVTVLQDDLPGFIFESNRGTKHTFSAETVLGPDFASGWSTAKK- 871
            |:.:.:.....| .:.........|:.|.:|.|:.:          .:.:...|.|....||.: 
 Frog   536 NFDIMNHACRALTYMMEALPRSSAVVVDAIPVFLEK----------LQVIQCIDVAEQALTALEM 590

  Fly   872 -KRNKSKTEGQKFQVRNLSREIYNKYFK-SAQIIPRGAVAILTDIVKQIELSFEEQHMAPNGNWE 934
             .|..||...|...:.:..  :|.::|. :||   |.|:||..:..:.|  |.:|.|.       
 Frog   591 LSRRHSKAILQAGGLADCL--LYLEFFSINAQ---RNALAIAANCCQSI--SPDEFHF------- 641

  Fly   935 TTLTDALMKLSQ-LIHEDGVVSAYEMHSSGLVQALVAVLSVNHWETNSPRCKRNKMQKQRVSVFK 998
              :.|:|..|:| |.|:|                                         :.||..
 Frog   642 --VADSLPLLTQRLTHQD-----------------------------------------KKSVES 663

  Fly   999 KCI----LEDNVESATNKPRTKSTASILIQKLVS--VLESTEKLPVYLYDSPCTGYSLQILQKRL 1057
            .|:    |.||.:...|          |:|::.|  :|.:.::|.|  ...|.....:.|:..|:
 Frog   664 TCLCFARLVDNFQHEEN----------LLQQVASRDLLTNIQQLLV--VTPPILSSGMFIMVVRM 716

  Fly  1058 RFRLERAECESTLFDRSGRTLKMEPLATIGQLSKYLLKMVAKQWYDLDRSTYFYLKKIREHRTAT 1122
             |.|..:.|.:                    |:..|:|.      ::..:.:|.|          
 Frog   717 -FSLMCSNCPT--------------------LAVQLMKQ------NIAETLHFLL---------- 744

  Fly  1123 VFTHSFDFDEEGLLFYIGSNAKTC----DWVNPAQYGLVQVTSSEGKTLPYGKLEDILSRDSISL 1183
                            .|::..:|    |.|..:...|.::||...:.:|               
 Frog   745 ----------------CGASNGSCLEQIDLVPRSPQELYELTSLICELMP--------------- 778

  Fly  1184 NCHTKDNKKAWFAIDLGVYIIPTAYTLRHARGYGRSALRNWLLQGSKDGSTWTTLSTHVDDKSLV 1248
             |..|:          |::.:.|.....:|:              :.||:.|             
 Frog   779 -CLPKE----------GIFAVDTMLKKGNAQ--------------NTDGAIW------------- 805

  Fly  1249 EPGSTATWPINCATDDSVWYRHIRIQQNGRNASGQT--HYLSLSGFEIYGRVVGVADDIGKSVKE 1311
                  .|    ..|..:|:.:.||......|:.|.  ..:|||   ..|||..:..:..:.:.|
 Frog   806 ------QW----RDDRGLWHPYSRIDSRIIEAAHQVGEDEISLS---TLGRVYTIDFNSMQQINE 857

  Fly  1312 AEAKTRRERRQIRAQLKHMTTGARVIRGVDWR---WEEQDGCAEG---TITGEIHNGWI------ 1364
            .....|..:|:........|||...::..|.|   .:|....|:.   |:.|.::..:.      
 Frog   858 DTGTARAIQRKPNPVANANTTGHSELKRDDARAQLMKEDPELAKSFIKTLFGVLYEVYSSSAGPA 922

  Fly  1365 ----------------------DVKWDHGVRNSYRMGAEGKYDLKLADCEYLSAFDGNQSMGSAS 1407
                                  ||..:|.| :|:........|||:.             :|:..
 Frog   923 VRHKCLRAILRIIYFADAELLKDVLKNHAV-SSHIASMLSSQDLKIV-------------VGALQ 973

  Fly  1408 TAAKPSEKGGNTLTSRKSSSTPSLPEATEKNQNPEGASNQTVSADNLAWKQTVETIAENVFASAK 1472
            .|....:|               ||:........||..:|   ..|||..:.:.|....|..:. 
 Frog   974 MAEILMQK---------------LPDIFSVYFRREGVMHQ---VKNLAESEALLTSPPKVCTNG- 1019

  Fly  1473 TQIISNQLAMNTSSSREARAKHKESGTNQMHKDNISGPSPL---SRELEHISDLSAINNSMPAIN 1534
                |..||..|:.|       ..|||       .||.|..   |..|:|..|            
 Frog  1020 ----SGSLASTTTIS-------TGSGT-------ASGNSAADLGSPSLQHRDD------------ 1054

  Fly  1535 SSNVSDLATISENLSLTELSKENICRVLTPSYKP----------AESVTASQS------SSHPDV 1583
            |.::|....:|:.|....|.|....|   |.|.|          |:|.|.:||      |.:|..
 Frog  1055 SLDLSPPGRLSDVLKRKRLPKRGPRR---PKYSPPRDEDKVDNQAKSPTTTQSPKSFLASLNPKT 1116

  Fly  1584 QSSSPRENDIKNISNIEENNKMNANNSVNKISKDLLANLRTSNIAGCPPVTQLSTEALEMIDKMR 1648
            ..   |.:...|.:|||.......:......|||.::|.| ..|.|     .:..:|.:.:::..
 Frog  1117 WG---RLSTQSNSNNIEPARTAGVSGLARAASKDTISNNR-ERIRG-----WIKEQAHKFVERYF 1172

  Fly  1649 DGVDMIRNMSNSILSTDTFPVPCTNVPVGGKKTPKAQALINPDNANQKQIIVTSEEFPTKSSKKP 1713
            ..    .||..|        .|..||         .|.|.|.......|:               
 Frog  1173 SS----ENMDGS--------NPALNV---------LQRLCNATEQLNLQV--------------- 1201

  Fly  1714 SVTLKPAQQPNAVLSIVDIKEQPISNENVSVPSQMSISVPNLTTTSASEVPSTSEVATHTGLLET 1778
                     ...|..:|:|:         |:.|:..:|               |....|:|.::.
 Frog  1202 ---------DGGVECLVEIR---------SIVSESDVS---------------SFEIQHSGFVKQ 1233

  Fly  1779 FAAIARRRTSQGTNIQDNQIMNAEANVNE--HGDQNASGSFLGHSVTS---LVKLALSSNFH--- 1835
            .....       |:..|..|::.:..:..  |       .|.|..:..   |.||..:.|.|   
 Frog  1234 LLLYL-------TSKSDKDIVSRDIRLKRFLH-------VFFGTPLPGEEPLAKLDPTENRHLLA 1284

  Fly  1836 -----SGLLSTAQSYPSLSSNNSENIAPSNPSNTSAGQQSASTIN-HTLTMSL------TSTSS- 1887
                 :..||..:.:|.     ..:..||.....|.|.|:....| |.|...|      |:... 
 Frog  1285 LVHKMNNCLSQMEQFPV-----KVHDFPSGNGTGSRGSQALKFFNTHQLKCQLQRHPDCTNVKQW 1344

  Fly  1888 -----DSEQVSLEDFLESCRAPALLGDL--DDEDDMDEDNDEEENED---EYEEVGNT--LLQVM 1940
                 ..:.::|...:|........|.:  ||||..|:.:|||.:|.   ::...||.  .||..
 Frog  1345 KGGPVKIDPLALVQAIERYLVVRGYGRVREDDEDSDDDGSDEEIDESLAAQFLNSGNVRHRLQFY 1409

  Fly  1941 VSRNLLTFMDDEAMENRLVGVTKRKSWDDEFVLKRQFSALIPAFDPRPGRTNVNQTSDLEISPLG 2005
            :..:||.:       |..|           :...||:|  |...:.|       :::|.|.:|||
 Frog  1410 IGDHLLPY-------NMTV-----------YQAVRQYS--IQTEEER-------ESTDDESNPLG 1447

  Fly  2006 AELPKPQQSGGPETIEQPLLGLKLRGPGIGGIPEVEIDLSNTDWTIFRAVQELLQCSQLNKLDKF 2070
                   ::|                                                       
 Frog  1448 -------RAG------------------------------------------------------- 1450

  Fly  2071 RKIWEPTYTIVYREVSPEAQESTCLESEEFPQTPDVSSKSGASTLSP------NSPMHIGFNVAD 2129
              ||..|:||.|:.|          ..||......|..|.|.:..:|      ||..|.......
 Frog  1451 --IWTKTHTIWYKPV----------REEEESAKDTVGGKRGRAQTAPTKTSPRNSKKHDELWHGK 1503

  Fly  2130 NNLC-------------------SVD----DVLELLTQINGLNQ---SEIDSDV-KEHGVSVLSE 2167
            :.:|                   :.|    ||:.||..::.:::   ...|:.| ||    ::..
 Frog  1504 DGVCPRILNPLEVYLISGPPENITFDDPSLDVVILLRVLHAISRYWYYLYDNAVCKE----IIPT 1564

  Fly  2168 DLFISKKITNKLQQQIQDPLVLASNALPNWCENLNQSCPFLFPFETRQLYFNCTSFGASRSIVCL 2232
            ..|.:.|:|.|..:|:|||||:.:..:|.|...|.:||||.|||:|||:.|..|:|...|::   
 Frog  1565 SEFNNSKLTAKANRQLQDPLVIMTGNIPTWLTELGKSCPFFFPFDTRQMLFYVTAFDRDRAM--- 1626

  Fly  2233 QSQRDVTVERQRIPIMSP---RRDDHEFRIG-RLKHERVKVPRNEDLLMWAMQVMKTHCNRKSVL 2293
                      ||:...:|   :.|..:.|:. ||..::..|.| ||||..|..||:...:.:::|
 Frog  1627 ----------QRLLDTNPEINQSDSQDSRVAPRLDRKKRTVNR-EDLLKQAESVMQDLGSSRAML 1680

  Fly  2294 EVEFLDEEGTGLGPTLEFYALVAAEIQRSDLCMWLCDDDLGEDT--ENSTQSAEGNSKPVGYYVN 2356
            |:::.:|.||||||||||||||:.|:||:||.:|     .||:.  .|...|.||..     |::
 Frog  1681 EIQYENEVGTGLGPTLEFYALVSQELQRADLGLW-----RGEEVTLPNPKGSQEGTK-----YIH 1735

  Fly  2357 RREHGIFPAPLPQNSE---ICENVLKYFWFFGVFVAKVLQDMRLVDIPLSTSFLQLLCHNKVLSR 2418
            ..: |:|..|..:.::   |.:..:| |.|.|..:||.:.|.|||||||...|.:.         
 Frog  1736 NLQ-GLFALPFGRTAKPAHIAKVKMK-FRFLGKLMAKAIMDFRLVDIPLGLPFYKW--------- 1789

  Fly  2419 NLQKVISDRRNGDLSVVSEDSDIVETCTKLLRTDSNKSNAFGGILSLENLKEIDPTRYQFLQEMQ 2483
                                         :||.:|:        |:..:|..|||...:.:..::
 Frog  1790 -----------------------------MLRQESS--------LATHDLVNIDPVVAKSVYHLE 1817

  Fly  2484 NLLLRKQSIEFDDTISAEKKHELINELKLQTQNGLEVSLEDLALTFTYLPSSSIYGYTQAELLPN 2548
            :::.:|:.:|.|   .|:.|..|...|:....||  .|:|||.|.|| ||     |:...||...
 Frog  1818 DIVRQKKRLEQD---KAQTKESLQFALESLNMNG--CSVEDLGLDFT-LP-----GFPNIELKKG 1871

  Fly  2549 GSSVNVTIDNLEAYCELLMNFILQDGIAQQMKAFSDGFNEVFPLKKLAAFTPSEARMMICGEQFP 2613
            |..|.|||.|||.|..|::.:.|.:|:::|:.:|.|||..||||..|..|.|.|...::||.:..
 Frog  1872 GKDVPVTIHNLEDYVRLVIYWALNEGVSRQLDSFRDGFESVFPLNHLQYFYPEELDQLLCGSRAD 1936

  Fly  2614 HWSREDIISYTEPKLGYNKDSPGFQRFVNVLLSMSGDERKAFLQFTTGCSSLPPGGLANLHPRLT 2678
            .|..:.::....|..||..||...:....:|.|...::::.||||.||...||.||..:|:|.||
 Frog  1937 PWDVKTLMECCRPDHGYTHDSRAVKFLFEILSSFDKEQQRLFLQFVTGSPRLPVGGFRSLNPPLT 2001

  Fly  2679 VVRKVDAGVGS----YPSVNTCVHYLKLPDYPTEEIMKERLLTATKE--KGFHLN 2727
            :|||......:    .|||.|||:|||||||.:.:.|:|:||.|.:|  :.|||:
 Frog  2002 IVRKTFEATENPDDFLPSVMTCVNYLKLPDYSSIDNMREKLLMAAREGQQSFHLS 2056

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ufd4NP_609369.1 ANK repeat 393..420 CDD:293786 6/26 (23%)
ANK 396..509 CDD:238125 26/112 (23%)
ANK repeat 422..453 CDD:293786 6/30 (20%)
ANK repeat 455..484 CDD:293786 6/28 (21%)
F5_F8_type_C 1173..1298 CDD:329041 19/126 (15%)
MIB_HERC2 1333..1389 CDD:310955 15/89 (17%)
DamX 1576..>1725 CDD:330571 27/154 (18%)
HECTc 2265..2725 CDD:238033 158/470 (34%)
trip12NP_001136384.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..440 107/531 (20%)
PHA03307 84..>462 CDD:223039 99/492 (20%)
SRP1 483..>708 CDD:227396 56/313 (18%)
WWE 805..866 CDD:397111 16/86 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1027..1147 35/151 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1465..1500 9/34 (26%)
K-box. /evidence=ECO:0000250 1560..1634 30/90 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1632..1651 4/18 (22%)
HECTc 1654..2054 CDD:238033 158/469 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D10145at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3704
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.950

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