DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ufd4 and herc3

DIOPT Version :9

Sequence 1:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster
Sequence 2:	NP_001139096.1	Gene:	herc3 / 100003587	ZFINID:	ZDB-GENE-090313-139	Length:	1046	Species:	Danio rerio

Alignment Length:	1154	Identity:	223/1154 - (19%)
Similarity:	380/1154 - (32%)	Gaps:	394/1154 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1669 VPCTNVPVGGK---------------KTPKAQALINPDN-----------ANQKQIIVTSEEFPT 1707
            :|.|.:..||.               |....|..:|.:.           .:||.:.::..|..|
Zfish   190 IPLTQISAGGDHSFALSFSGAVFGWGKNSAGQLGLNDEQDRAVPCHIKFLRSQKVVYISCGEEHT 254

  Fly  1708 KSSKKPSVTLKPAQQPNAVLSIVDIKEQPISNENVSVPSQMSISVPNLTTTSASEVP----STSE 1768
            .:..|..............|.....:.:|:...           |..|..|..|::.    .|..
Zfish   255 AALTKEGGLFTFGNGSKGQLGHDSTRNEPLPRR-----------VMELMGTEVSQIACGRNHTLA 308

  Fly  1769 VATHTGLLETFAAIARRRTSQG-----------TNIQDNQIMNAE--------ANVNEHGDQNAS 1814
            ....|||:..|....:.:...|           :|||...|.||.        |.::..||.|
Zfish   309 FVPSTGLIYAFGCNTQGQLGTGIRGSAKSPVPVSNIQPLCIGNAYTRTEHCTIAKIHSGGDHN-- 371

  Fly  1815 GSFLGHSVTSLVKLALSSNFHSGLLSTAQSYPSLSSNNSENIAPSNPSNTSAGQQSASTINHTLT 1879
              ||  .::::..|:...:|.  :|:|.:|...::|.:.::.......|      |.|:|.:.:.
Zfish   372 --FL--LLSTVEGLSCPDDFR--ILNTTKSIALINSESLDSWRMKLHDN------SDSSITNDII 424

  Fly  1880 MSLTSTSSDSEQVSLEDFLESCRAPALLGDLDDEDDMDEDNDEEENEDEYEEVG---NTLLQVMV 1941
            :.|:||              :|...:.   ||..||.....:.:....::..|.   .||::...
Zfish   425 LLLSST--------------ACWNASF---LDQSDDGHFKTNPKVPGIDFNAVRLLFETLMKPAF 472

  Fly  1942 SRNLLTFMDDEAMENRLVGVTKRKSWDDEFVLKRQFSALIPAFDPRPGRTNVNQTSDLE---ISP 2003
            :|.|                        |.:.|...|.|||.....|        .|:|   |..
Zfish   473 ARLL------------------------EQITKSFESLLIPQLPCSP--------PDVEAMRIYL 505

  Fly  2004 LGAELPKPQQSGGPETIEQPLLGLKLRGPGIGGIPEVEID--LSNTDWTIFRAVQELLQ------ 2060
            :.:|.|..|.|....|:..||....||   :...|...:|  .|..|.|:|..:.|:.:
Zfish   506 ILSECPAFQDSKNYITLTIPLAMAILR---LDANPSKVLDNWWSLMDCTVFTRLVEMYKSIVVFL 567

  Fly  2061 -----------------CSQLNKLDKFRKIWEPTYTIVYRE-VSPEAQESTCLESEE-----FPQ 2102
                             .:.|..|:|..|:....:.:.|.. ..|:.  :|.::.:|     |.:
Zfish   568 LTGGKALLMPVFLESYTSAALRLLEKLHKVNLKAHRVEYNHFYIPDI--ATLVDIQEDYLKWFLR 630

  Fly  2103 TPDVSSK----SGASTLSPNSPMHIGFNVADNNLCSVDDVLELLTQINGLNQSEIDSDVKEHGVS 2163
            ..|:..:    .|:.||.. .|..:... |...:...|..|::...::|.|.         |.|.
Zfish   631 KADIKMRYPPVQGSVTLCA-YPFILNAQ-AKTTVLQTDAELQMQMAVSGANL---------HNVF 684

  Fly  2164 VLSEDLFISKKITNKLQQQIQDPLVLASNALPNWCENLNQSCPFLFPFETRQLYFNCTSFGASRS 2228
            :|         :|       .:|| ||.|             |||.             ....|:
Zfish   685 ML---------LT-------MEPL-LARN-------------PFLV-------------LHVRRN 706

  Fly  2229 IVCLQSQRDVTVERQRIPIMSPRRDDHEFRIGRLKHERVKVPRNEDLLMWAMQVMKTHCNRKSVL 2293
            .:...:.|::|:.                             .:.||              |..|
Zfish   707 HLVSDALRELTIY-----------------------------NDVDL--------------KKPL 728

  Fly  2294 EVEFLDEEGTGL-GPTLEFYALVAAEIQRSDLCMWLCDDDLGEDTENSTQSAEGNSKPVGYYVNR 2357
            :|.|..||.... |.|.||:.|:..|:......|:             ||.:|.|
Zfish   729 KVIFDGEEAVDAGGVTKEFFLLLLKELMNPIYGMF-------------TQYSESN---------- 770

  Fly  2358 REHGIFPAPLPQNSEICENVLKYFWF--FGVFVAKVLQDMRLVDIPLSTSFLQLLCHNKVLSRNL 2420
                     |...|:.|  .:::.||  .|:.....:.:..:||:     ...|:.:.|:|.
Zfish   771 ---------LLWFSDKC--FVEHNWFHLIGIICGLAIYNSTVVDL-----HFPLVLYKKLLE--- 816

  Fly  2421 QKVISDRRNGDLSVVSEDSDIVETCTKLLRTDSNKSNAFGGILSLENLKEIDPTRYQFLQEMQNL 2485
               ||.                                     :|::|||:.||..:.||::
Zfish   817 ---ISP-------------------------------------TLDDLKELSPTEGRSLQQL--- 838

  Fly  2486 LLRKQSIEFDDTISAEKKHELINELKLQTQNGLEVSLEDLALTFTYLPSSSIYGYTQA-ELLPNG 2549
                  :||:..:.                   |....:.|:|..|      ||.|:. ||:..|
Zfish   839 ------LEFEGDVE-------------------ETFCLNFAITREY------YGITEVKELVQGG 872

  Fly  2550 SSVNVTIDNLEAYCELLMNFILQDGIAQQMKAFSDGFNEVFPLKKLAAFTPSEARMMICGEQFPH 2614
            .::.|...|.:.:.:..:.::..|.:.:|..|||.||.:|...:.|:.|.|||...|:.|....:
Zfish   873 KTIAVDKTNRKEFVQAYLQYVFSDAVQEQYSAFSSGFLKVCGGEILSLFQPSELMAMVVGNNNYN 937

  Fly  2615 WSR-EDIISYTEPKLGYNKDSPGFQRFVNVLLSMSGDERKAFLQFTTGCSSLPPGGLANLHPRLT 2678
            |.. |...||   |..::...|..:.|..|....|.:::|.||.|.||...:|..|:|:|.   .
Zfish   938 WEEMEKNASY---KGEFSATHPTVKMFWEVFHEFSLEKKKQFLLFLTGSDRIPIHGMASLR---I 996

  Fly  2679 VVRKVDAGVGSYPSVNTCVHYLKLPDYPTEEIMKERLLTATKE-KGFHL 2726
            |::...|.....|..:||.:.|.:|.|.|:|.:::||..|.:: :||.|
Zfish   997 VIQSTAAEEHYLPVAHTCYNMLDMPCYQTKETLRQRLTQAVEQYEGFSL 1045

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041
		MIB_HERC2	1333..1389	CDD:310955
		DamX	1576..>1725	CDD:330571	12/81 (15%)
		HECTc	2265..2725	CDD:238033	102/465 (22%)
herc3	NP_001139096.1	RCC1	4..49	CDD:278826
		RCC1_2	37..65	CDD:290274
		RCC1	52..99	CDD:278826
		RCC1	103..152	CDD:278826
		RCC1	155..205	CDD:278826	4/14 (29%)
		RCC1	208..257	CDD:278826	7/48 (15%)
		RCC1	260..308	CDD:278826	7/58 (12%)
		RCC1	314..374	CDD:278826	16/65 (25%)
		HECTc	699..1044	CDD:238033	106/522 (20%)
		HECTc	723..1043	CDD:214523	101/455 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900