DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Utx and ATP2

DIOPT Version :9

Sequence 1:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_012655.3	Gene:	ATP2 / 853585	SGDID:	S000003882	Length:	511	Species:	Saccharomyces cerevisiae

Alignment Length:	464	Identity:	82/464 - (17%)
Similarity:	159/464 - (34%)	Gaps:	112/464 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 PSTFSELQVK-------FQIA-HLYEVQNKHKAAKDGYEFLLNEKNISLELKADVYRQLG--WMY 275
            |:..:.|::|       .::| ||.| ......|.||.|.|:..:.: |:....:...:|  .:.
Yeast    64 PAILNALEIKTPQGKLVLEVAQHLGE-NTVRTIAMDGTEGLVRGEKV-LDTGGPISVPVGRETLG 126

  Fly   276 HCVECLGEKKEREANALNFLQKSIEADPKS--------------------------GQSLYLLGR 314
            ..:..:||..:......:.|:|.|.|||.|                          |..:.|.|.
Yeast   127 RIINVIGEPIDERGPIKSKLRKPIHADPPSFAEQSTSAEILETGIKVVDLLAPYARGGKIGLFGG 191

  Fly   315 CYAG-----------INKVHDAFLA--------------YRNSVEKSEGNADTWCSIGVLYQQQN 354
            ...|           |.|.|..|..              ||...|....|.:....:.:::.|.|
Yeast   192 AGVGKTVFIQELINNIAKAHGGFSVFTGVGERTREGNDLYREMKETGVINLEGESKVALVFGQMN 256

  Fly   355 QPTDALQAYICAVQLDKDHKAAWTNLGIL-YESCGQLRDAYACYLNATK--QISFQKSSLIRKKQ 416
            :|..|..            :.|.|.|.|. |....:.:|......|..:  |...:.|:|:.:..
Yeast   257 EPPGARA------------RVALTGLTIAEYFRDEEGQDVLLFIDNIFRFTQAGSEVSALLGRIP 309

  Fly   417 AIRMKKDTIGLSKGLSQ-RITFLEGQLSQAPLPSITSKRRQLCSIEEAWNLPISLEMNSRQQQT- 479
            :....:.|:....||.| |||              |:|:..:.|::..: :|.. ::......|
Yeast   310 SAVGYQPTLATDMGLLQERIT--------------TTKKGSVTSVQAVY-VPAD-DLTDPAPATT 358

  Fly   480 ------AQMLPRQVTKQSPVQGPPPPYPHSQLSQSPIPSKRIKEDGTSQQEVTQNNSQTSAQNLI 538
                  ..:|.|.:::........|....|:|..:.:..:...:..:..||..|  :..|.|::|
Yeast   359 FAHLDATTVLSRGISELGIYPAVDPLDSKSRLLDAAVVGQEHYDVASKVQETLQ--TYKSLQDII 421

  Fly   539 NI--SESLNQRNFNAMPESNK-----SSEQSVLDTFDDISNDIYKQNESI-KLERLSQDALSNNE 595
            .|  .:.|::::...:..:.|     |...:|.:.|..|...:.:..::: ..:.:.:....|..
Yeast   422 AILGMDELSEQDKLTVERARKIQRFLSQPFAVAEVFTGIPGKLVRLKDTVASFKAVLEGKYDNIP 486

  Fly   596 DSRHDFIGG 604
            :.....:||
Yeast   487 EHAFYMVGG 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809
		TPR_11	156..216	CDD:290150
		TPR repeat	186..216	CDD:276809
		TPR repeat	228..255	CDD:276809	10/34 (29%)
		TPR_11	264..337	CDD:290150	21/125 (17%)
		TPR repeat	265..300	CDD:276809	5/36 (14%)
		TPR repeat	307..334	CDD:276809	9/51 (18%)
		TPR_11	339..402	CDD:290150	12/63 (19%)
		TPR repeat	339..369	CDD:276809	5/29 (17%)
		TPR_1	340..373	CDD:278916	4/32 (13%)
		TPR repeat	374..402	CDD:276809	7/28 (25%)
		JmjC	870..978	CDD:202224
ATP2	NP_012655.3	PRK09280	41..500	CDD:236447	82/464 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900