DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Utx and CYC8

DIOPT Version :9

Sequence 1:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_009670.3	Gene:	CYC8 / 852410	SGDID:	S000000316	Length:	966	Species:	Saccharomyces cerevisiae

Alignment Length:	859	Identity:	194/859 - (22%)
Similarity:	332/859 - (38%)	Gaps:	183/859 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 TITNLQNYIANGQVHESKNSSDNK----NAIQKFEPSTQAG----EHMENTSSRNNDDTKPFEQD 96
            |.:..:.:::...:.|:....|..    :|..:|.||:...    .|:    .|:.|   .|::.
Yeast    42 TQSTAETWLSIASLAETLGDGDRAAMAYDATLQFNPSSAKALTSLAHL----YRSRD---MFQRA 99

  Fly    97 AK--EKVSIIEEKHQDEHYVNALCKLGHLHLLLGEYSEALSAYQKYLRFREN----NYWTNHAFI 155
            |:  |:..::..:..|     ....|||.:|:|.:...|.:|||:.|....|    ..|
Yeast   100 AELYERALLVNPELSD-----VWATLGHCYLMLDDLQRAYNAYQQALYHLSNPNVPKLW------ 153

  Fly   156 YGIGVAYFKLRCFKWAIKSFQELLYLSPNFTCANEVHLRLGLMLKHCGEFHIALKHLQLALLYTY 220
            :|||:.|.:.....:|.::|.::|.|.|:|..|||::.|||::.||.|::..||:..:. :|...
Yeast   154 HGIGILYDRYGSLDYAEEAFAKVLELDPHFEKANEIYFRLGIIYKHQGKWSQALECFRY-ILPQP 217

  Fly   221 PSTFSELQVKFQIAHLYEVQNKHKAAKDGYEFLLNEKNISLELKADVYRQLGWMYHC--VECLGE 283
            |:...|..:.||:..:.|...:.:.||:.||.:|.:.    :..|.|.:|||.:|..  |:....
Yeast   218 PAPLQEWDIWFQLGSVLESMGEWQGAKEAYEHVLAQN----QHHAKVLQQLGCLYGMSNVQFYDP 278

  Fly   284 KKEREANALNFLQKSIEADPKSGQSLYLLGRCYAGINKVHDAFLAYRNSVEKSEGNADTWCSIGV 348
            :|     ||::|.||:||||....:.|.|||.:........|:.|::.:|.:...|...||||||
Yeast   279 QK-----ALDYLLKSLEADPSDATTWYHLGRVHMIRTDYTAAYDAFQQAVNRDSRNPIFWCSIGV 338

  Fly   349 LYQQQNQPTDALQAYICAVQLDKDHKAAWTNLGILYESC-GQLRDAYACYLNATKQISFQKSSLI 412
            ||.|.:|..|||.||..|::|:......|.:||.|||:| .||.||...|
Yeast   339 LYYQISQYRDALDAYTRAIRLNPYISEVWYDLGTLYETCNNQLSDALDAY--------------- 388

  Fly   413 RKKQAIRMKKDTIGLSKGLSQRITFLEG------------QLSQAPLPSITSKRRQLCSIEEAWN 465
              |||.|:..:.:.:.:.|......||.            ..|.||.|.|.....|........|
Yeast   389 --KQAARLDVNNVHIRERLEALTKQLENPGNINKSNGAPTNASPAPPPVILQPTLQPNDQGNPLN 451

  Fly   466 LPISLEMNSRQQQTAQMLPRQVTKQSPVQGPPPPYPHSQLSQSPIPSKRIKEDGTSQ-------Q 523
            ..||       .|:|......|.:|.|.|..|.....:..|....|..:.:....:|       |
Yeast   452 TRIS-------AQSANATASMVQQQHPAQQTPINSSATMYSNGASPQLQAQAQAQAQAQAQAQAQ 509

  Fly   524 EVTQNNSQTSAQNLINISESLNQRNFNAMPESNKSSE-QSVLDTFDDISNDIYKQNESIKLERLS 587
            ...|..:|..||     :::..|....|..:::..:: |:.............:|.:..:.::..
Yeast   510 AQAQAQAQAQAQ-----AQAQAQAQAQAQAQAHAQAQAQAQAQAQAQAQAQAQQQQQQQQQQQQQ 569

  Fly   588 QDALSNNEDSRHDFIGGDNADISTTFKIQMDSKQLM-----------VAVKLLP-------IDEP 634
            |......:..:.                |...:||.           |:|::|.       |.:|
Yeast   570 QQQQQQQQQQQQ----------------QQQQQQLQPLPRQQLQQKGVSVQMLNPQQGQPYITQP 618

  Fly   635 PVHCTILQVN---------APPPSPPDCPPQKLTRDQLLPPTPSVHLENKKHAFSPQ--LQEFCL 688
                |::|.:         ...|.....|||   :.||........|:.:..|.:||  :|....
Yeast   619 ----TVIQAHQLQPFSTQAMEHPQSSQLPPQ---QQQLQSVQHPQQLQGQPQAQAPQPLIQHNVE 676

  Fly   689 KHPIAVVRGLAGVLK--LDLGLFSTKTLVEAN------PDHSV--------------EVRTQVHQ 731
            ::.:...|.:.|.:.  :|..: |:.|..|.|      |.|::              :|:.|...
Yeast   677 QNVLPQKRYMEGAIHTLVDAAV-SSSTHTENNTKSPRQPTHAIPTQAPATGITNAEPQVKKQKLN 740

  Fly   732 SP--------------DENWDTSQGKRVWACISHRSHTTIAKYAQYQASSFQDSLKLILPQDESD 782
            ||              :||..:....:..|.:...::.|..:....:|:|....:....|..|:.
Yeast   741 SPNSNINKLVNTATSIEENAKSEVSNQSPAVVESNTNNTSQEEKPVKANSIPSVIGAQEPPQEAS 805

  Fly   783 KGFPGSQAMSDSDS 796
            .....::|.|.|.|
Yeast   806 PAEEATKAASVSPS 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809	8/33 (24%)
		TPR_11	156..216	CDD:290150	21/59 (36%)
		TPR repeat	186..216	CDD:276809	11/29 (38%)
		TPR repeat	228..255	CDD:276809	7/26 (27%)
		TPR_11	264..337	CDD:290150	24/74 (32%)
		TPR repeat	265..300	CDD:276809	13/36 (36%)
		TPR repeat	307..334	CDD:276809	6/26 (23%)
		TPR_11	339..402	CDD:290150	30/63 (48%)
		TPR repeat	339..369	CDD:276809	17/29 (59%)
		TPR_1	340..373	CDD:278916	17/32 (53%)
		TPR repeat	374..402	CDD:276809	12/28 (43%)
		JmjC	870..978	CDD:202224
CYC8	NP_009670.3	TPR	<38..142	CDD:223533	23/111 (21%)
		TPR repeat	46..74	CDD:276809	3/27 (11%)
		TPR repeat	80..108	CDD:276809	6/34 (18%)
		TPR	94..391	CDD:223533	104/337 (31%)
		TPR repeat	113..143	CDD:276809	11/34 (32%)
		TPR repeat	150..178	CDD:276809	7/33 (21%)
		TPR repeat	184..211	CDD:276809	11/26 (42%)
		TPR repeat	223..253	CDD:276809	9/29 (31%)
		TPR repeat	258..290	CDD:276809	13/36 (36%)
		TPR repeat	296..324	CDD:276809	6/27 (22%)
		TPR repeat	329..359	CDD:276809	17/29 (59%)
		TPR repeat	364..393	CDD:276809	15/45 (33%)
		Herpes_BLLF1	<697..944	CDD:282904	22/124 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344074
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001095
OrthoInspector	1	1.000	-	-		oto100386
orthoMCL	1	0.900	-	-		OOG6_101645
Panther	1	1.100	-	-	LDO	PTHR14017
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R281
SonicParanoid	1	1.000	-	-		X932
TreeFam	0	0.000	Not matched by this tool.
	8	7.860