DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Utx and TMTC1

DIOPT Version :9

Sequence 1:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_001354804.1	Gene:	TMTC1 / 83857	HGNCID:	24099	Length:	944	Species:	Homo sapiens

Alignment Length:	472	Identity:	97/472 - (20%)
Similarity:	167/472 - (35%)	Gaps:	152/472 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 TNLQNYIANGQVHES-----KNSSDNKNAIQ------KFEPSTQAGEHMENTSSRNNDDTKPFEQ 95
            :.:|....|.:||.:     |:...||.||.      |..|...:..:...|.:|:..:.|.:.|
Human   536 SGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTAEAKMYYQ 600

  Fly    96 DAKEKVSIIEEKHQDEHYVNALCKLGHL----------------HLLLG-EYSEALSAYQKYL-- 141
            .|.:    :..:|.     .||..||:|                .:..| |:::|.|:....|
Human   601 RALQ----LHPQHN-----RALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAE 656

  Fly   142 --RFRE-------------------NNYWTNHAFIYGIGVAYFKLRCFKWAIKSFQELLYLSPNF 185
              ||:|                   |||   ..|:...|:.       :.|:..:|:.:.|||:.
Human   657 QERFKEAEEIYQTGIKNCPDSSDLHNNY---GVFLVDTGLP-------EKAVAHYQQAIKLSPSH 711

  Fly   186 TCANEVHLRLGLMLKHCGEFHIALKHLQLAL--------------LYTYPSTFSE-LQV------ 229
            ..|   .:.||.:.:..||..:|.:..:.||              ||.....:.| ||:
Human   712 HVA---MVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQEAAA 773

  Fly   230 --------KFQIAHLYEVQNKHKAAKDGYEFLLNEKNISLELKADVYRQLGWMYHCVECLGEKKE 286
                    :..:|.:..|..:.|.|:.....:::|:...||    .||.|..:|       .|:|
Human   774 LQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLE----CYRLLSAIY-------SKQE 827

  Fly   287 REANALNFLQKSIEADPKSGQSLYLLGRCYAGINKVHDAFLAYRNSVEKSEGNADTWCSIGVLYQ 351
            ....||:.:.|:::..||..:             .:.:.|....|.:                 :
Human   828 NHDKALDAIDKALQLKPKDPK-------------VISELFFTKGNQL-----------------R 862

  Fly   352 QQNQPTDALQAYICAVQLDKDHKAAWTNLGILYESCGQLRDAYACYLNATKQISFQK-------- 408
            :||....|.::|..||||:.|...||.|:|.:....|:...|.|.|..|.:.:...|
Human   863 EQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPDSKLLKENLAK 927

  Fly   409 -SSLIRKKQAIRMKKDT 424
             ..|.::.|.:|.|..|
Human   928 LDRLEKRLQEVREKDQT 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809	6/33 (18%)
		TPR_11	156..216	CDD:290150	12/59 (20%)
		TPR repeat	186..216	CDD:276809	6/29 (21%)
		TPR repeat	228..255	CDD:276809	5/40 (13%)
		TPR_11	264..337	CDD:290150	13/72 (18%)
		TPR repeat	265..300	CDD:276809	9/34 (26%)
		TPR repeat	307..334	CDD:276809	2/26 (8%)
		TPR_11	339..402	CDD:290150	18/62 (29%)
		TPR repeat	339..369	CDD:276809	6/29 (21%)
		TPR_1	340..373	CDD:278916	8/32 (25%)
		TPR repeat	374..402	CDD:276809	9/27 (33%)
		JmjC	870..978	CDD:202224
TMTC1	NP_001354804.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900