DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Utx and kdm6b

DIOPT Version :9

Sequence 1:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	XP_031753875.1	Gene:	kdm6b / 779446	XenbaseID:	XB-GENE-6067077	Length:	1740	Species:	Xenopus tropicalis

Alignment Length:	972	Identity:	370/972 - (38%)
Similarity:	512/972 - (52%)	Gaps:	224/972 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   239 VQNKHKAAKDGYEFLLNEKNISLELKADVYR---------QLGWMYHCV-ECLGEKKEREANALN 293
            |:.||.|.|.  ...::.|..:|: ||||..         ..|.:.|.| |.|....|||:
Frog   902 VEKKHGADKP--RVPVDRKPETLQ-KADVQEGVAEIKQETSYGTIRHEVAERLEAALERES---- 959

  Fly   294 FLQKSIEADPKSGQSLYLLGRCYAG------------INKVHDAFL--------AYR----NSVE 334
              :||::...|         :|..|            .:|:|.|.:        |.|    |..|
Frog   960 --KKSVKGAEK---------KCLPGPADSPSGTAREDPSKIHGANVKEAVKEATAKRLQGVNDRE 1013

  Fly   335 KSEGNADTWCSIGVLYQQQNQPTDALQAYICAVQLD-KDHKAA-----------------WTNLG 381
            ..:.|.|:....||        :..:.|.:.....| ||.|::                 |
Frog  1014 SPKKNTDSLAQGGV--------SKNVAAEVAKPNADSKDTKSSEEAPMPTMEAGDNGTKGW---- 1066

  Fly   382 ILYESCGQLRDAYACYLNA---TKQISFQKSSLIRKKQAIRMKKDTIGLSKGLSQRITFLEGQLS 443
                ..|:..:.....|.|   :|:.|.::....||.:....||.|       .:|
Frog  1067 ----EAGKPIERLTISLPAPARSKEESRRRERKHRKSRRDCSKKST-------DRR--------- 1111

  Fly   444 QAPLPSITSKRRQLCSIEEAWNLPI----------SLEMNSRQQQTA-----QMLPRQVTKQSPV 493
                 |:..|.||:..     ||.:          :|:.:||:.:|.     :....|.|..:|.
Frog  1112 -----SLKDKERQVLG-----NLDLQSQCRDTSNSTLKQSSRKSETGRRGCEEAHHHQPTPPTPP 1166

  Fly   494 QGPPPPYPHSQLSQSPIPSKRIKEDGTSQQEVTQNNSQTSAQNLINISESLNQRNFNAMPESNKS 558
            ...|||..|...:...:..:...|....:.::          .||.: ||.::..|.|.....:.
Frog  1167 TSAPPPTSHGTANSDLLKMRPFTEGPPKELKI----------RLIKV-ESGDRETFIASEVEERR 1220

  Fly   559 SEQSVLDTFDDISNDIYKQNESIKLERLSQDALSNNEDSRHDFIGGDNADISTTFKIQMDSKQLM 623
            .:.|.| |.::.:.:|.:...|:.|:...:::.
Frog  1221 LQASEL-TINNTAAEIVRATRSMVLKGKFKESY-------------------------------- 1252

  Fly   624 VAVKLLPIDEPPVHCTILQVNAPPPSPPDCPPQKLTRDQLLPPTPSVHLENKKHAFSPQLQEFCL 688
                |||           .::..||...:   |.|.|::|.|||||::||:|:.||||.|.:||.
Frog  1253 ----LLP-----------SMSVKPPLGTE---QNLPREKLNPPTPSIYLESKRDAFSPILLQFCT 1299

  Fly   689 --KHPIAVVRGLAGVLKLDLGLFSTKTLVEANPDHSVEVRTQVHQSPDENWDTSQGKRVWACISH 751
              |:||.|:|||||.|:|:||||||||||:||.:|.|||||||.|..|||||.|..:::|.|.|.
Frog  1300 DPKNPITVIRGLAGSLRLNLGLFSTKTLVDANGEHMVEVRTQVQQPSDENWDPSGTRQIWHCESS 1364

  Fly   752 RSHTTIAKYAQYQASSFQDSLKLILPQDESDKGFPGSQAMSDSDSKDSV------SNSNIVLKRK 810
            ||||||||||||||||||:||:   ...|||         .||:..||.      |::|     .
Frog  1365 RSHTTIAKYAQYQASSFQESLQ---EDKESD---------DDSNEPDSTTETPPPSSTN-----P 1412

  Fly   811 KHKINSKMLRFGTNVDLSDEKKWKPQLTELQKLPAFARVISAANMLSHVGHVILGMNTVQLYMKV 875
            :|| ..::::||||:||||.|:|||||.||||||:|.||.|.|||||||||.|||||||||||||
Frog  1413 EHK-TPQIIKFGTNIDLSDPKRWKPQLQELQKLPSFMRVTSNANMLSHVGHTILGMNTVQLYMKV 1476

  Fly   876 PGSRTPGHQENNNFCSININIGPGDCEWFAVPDAYWGGVHNLCEKNNISYLHGSWWPVLEDLYKE 940
            ||||||||||||||||:||||||||||||||.:.||..:...|:|:|:.||.|||||||||||:.
Frog  1477 PGSRTPGHQENNNFCSVNINIGPGDCEWFAVHENYWEKISAFCDKHNLDYLTGSWWPVLEDLYRA 1541

  Fly   941 NIPVYRFIQKPGDLVWVNAGCVHWVQSIGWCNNIAWNVGPLTARQYSLAIERYEWNKVQAFKSIV 1005
            :||||||:|:||||||:|||.|||||:.||||||||||||||..||.||:||:|||:|:..||||
Frog  1542 DIPVYRFVQRPGDLVWINAGTVHWVQATGWCNNIAWNVGPLTPYQYQLALERFEWNEVKNVKSIV 1606

  Fly  1006 PMVHLSWNLARNIKVSDTKLFELIKMCLLQTLKNVLHIQEYVKSKGVEIRFNGRGKNEASHYCGQ 1070
            ||:|:|||:||.:|:||..|:.:||.||:|::|..:..::.:...|.:|.:..|.|:|.::||.:
Frog  1607 PMIHVSWNVARTVKISDPDLYRMIKYCLMQSMKRCVLQRDSLIRGGKKIAYQSRVKDEPAYYCNE 1671

  Fly  1071 CEVEVFNVLFIKEQ---EKRHVVHCLSC---ALKLSPSLQGIVCLEEYRLSELQRVYDSFTL 1126
            |:|||||:||:..:   :..::|||.||   |...|.:...:|.||:::..||..:||:|.|
Frog  1672 CDVEVFNILFVTSESGGKNTYLVHCESCSRSASSASSASSNVVILEQFKTEELMHIYDNFHL 1733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809
		TPR_11	156..216	CDD:290150
		TPR repeat	186..216	CDD:276809
		TPR repeat	228..255	CDD:276809	5/15 (33%)
		TPR_11	264..337	CDD:290150	24/106 (23%)
		TPR repeat	265..300	CDD:276809	13/44 (30%)
		TPR repeat	307..334	CDD:276809	8/50 (16%)
		TPR_11	339..402	CDD:290150	13/83 (16%)
		TPR repeat	339..369	CDD:276809	5/29 (17%)
		TPR_1	340..373	CDD:278916	6/33 (18%)
		TPR repeat	374..402	CDD:276809	5/47 (11%)
		JmjC	870..978	CDD:202224	83/107 (78%)
kdm6b	XP_031753875.1	TPR repeat	98..126	CDD:276809
		PHA03247	<188..571	CDD:223021
		PTZ00121	<784..1259	CDD:173412	85/475 (18%)
		JmjC	1437..1501	CDD:214721	56/63 (89%)
		JmjC	1471..1579	CDD:396791	83/107 (78%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141383at33208
OrthoFinder	1	1.000	-	-		FOG0001095
OrthoInspector	1	1.000	-	-		otm49532
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X932
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010