DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Utx and spag1b

DIOPT Version :9

Sequence 1:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_001070789.1	Gene:	spag1b / 768178	ZFINID:	ZDB-GENE-061013-512	Length:	591	Species:	Danio rerio

Alignment Length:	256	Identity:	45/256 - (17%)
Similarity:	85/256 - (33%)	Gaps:	66/256 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LIRELDSRYYGFLDLSNSKNAELRNLVQQTITNLQNYIANGQVHESKNSSDNKNAIQKFEPSTQA 75
            ||:|::....|   ..:..:.|.|.::..|.::..   |.|..|...::.:..:.....|.:...
Zfish   321 LIQEVEEEEEG---AHSEHSGESRGIMGNTHSSSS---AGGAAHGDAHTENTPSGHTHTEDTPSG 379

  Fly    76 GEHMENTSS------------RNNDDTKPFE---QDAKEKVSIIEEKHQDE-------------- 111
            ..|.|:|:|            .:::||.|..   :|.....:.||:....:
Zfish   380 HTHTEDTTSGHTHTEDTPLGHTHDEDTPPGHIQTEDTPRGHTHIEDTSSGQMETTPPGHIHNEAT 444

  Fly   112 ---HYVNALCKLGHLHLLLGEYSEALSAYQKYLRFRENN--YWTNHAFIYGIGVAYFKLRCFKWA 171
               |........||.|::..|:.|....:.:.|:...:.  .:||.|      :.|.||..|..|
Zfish   445 PPGHTPTKDTPPGHTHMMDEEHKETAERHTQSLQLDTHTCAAYTNRA------LCYIKLERFTEA 503

  Fly   172 IKSFQELLYLSPN------------------FTCANEVH--LRLGLMLKHCGEFHIALKHL 212
            .:.....|.:.|.                  .:|.:::.  |||...:.......:.|.||
Zfish   504 RQDCDSALQIEPTNKKAFYRRALANKGLKDYLSCRSDLQQVLRLDASVTEAQRLLMELTHL 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809	9/35 (26%)
		TPR_11	156..216	CDD:290150	14/77 (18%)
		TPR repeat	186..216	CDD:276809	7/29 (24%)
		TPR repeat	228..255	CDD:276809
		TPR_11	264..337	CDD:290150
		TPR repeat	265..300	CDD:276809
		TPR repeat	307..334	CDD:276809
		TPR_11	339..402	CDD:290150
		TPR repeat	339..369	CDD:276809
		TPR_1	340..373	CDD:278916
		TPR repeat	374..402	CDD:276809
		JmjC	870..978	CDD:202224
spag1b	NP_001070789.1	TPR_11	194..258	CDD:290150
		TPR repeat	198..222	CDD:276809
		TPR repeat	226..256	CDD:276809
		TPR_16	233..294	CDD:290168
		TPR repeat	261..289	CDD:276809
		TPR repeat	483..513	CDD:276809	9/35 (26%)
		TPR_11	486..548	CDD:290150	13/67 (19%)
		TPR_1	486..517	CDD:278916	10/36 (28%)
		TPR repeat	518..546	CDD:276809	1/27 (4%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900