DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Utx and Kdm5b

DIOPT Version :9

Sequence 1:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_690855.2	Gene:	Kdm5b / 75605	MGIID:	1922855	Length:	1544	Species:	Mus musculus

Alignment Length:	834	Identity:	150/834 - (17%)
Similarity:	275/834 - (32%)	Gaps:	266/834 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 SIIEEKHQDEHYVNALCKLGHLHLLLGEYSEALSAYQKYL------RFR------ENNYWTN--H 152
            ::|||....:...|.|  |.||.|:..:..:..|..|:.|      |:|      :|....|  .
Mouse   781 ALIEESEMKKFPDNDL--LRHLRLVTQDAEKCASVAQQLLNGKRQTRYRSGGGKSQNQLTVNELR 843

  Fly   153 AFIYGIGVAYFKLRCFKWAIKSFQELL------------YLSPNFTCANEVHLRLGLMLKHCGEF 205
            .|:    ...:.|.|........::||            .||.....|.|:...|.:..    ||
Mouse   844 QFV----TQLYALPCVLSQTPLLKDLLNRVEDFQQQSQKLLSEEMPSAAELQELLDVSF----EF 900

  Fly   206 HIALKHLQLALLYTYPSTFSELQVKFQIAH-LYEVQNKHKAAKDGYEFLLNEKNISLELKADVYR 269
            .:.|..|            :|::::.:.|. |.|||          :..|:..::||:   |:.|
Mouse   901 DVELPQL------------TEMRIRLEQARWLEEVQ----------QACLDSSSLSLD---DMRR 940

  Fly   270 --QLG---WMYHCVE----------CLGEKKEREANALNFLQKSIEADPKSGQSLYLLGRCYAGI 319
              .||   ..|..||          .:.|..:.:|.:|      :.|.|:  .||..|......:
Mouse   941 LIDLGVGLAPYSAVEKAMARLQELLTVSEHWDDKAKSL------LRARPR--HSLSSLATAVKEM 997

  Fly   320 NKVHDAFLAYRNSVEKSEGNADTWCSIGVLYQQQNQPTDALQA---------------------- 362
            .:: .|:|.....::.|...|..|.          |..|||||
Mouse   998 EEI-PAYLPNGTVLKDSVQRARDWV----------QDVDALQAGGRVPVLETLIELVARGRSIPV 1051

  Fly   363 ------------------YICAVQLDKDHKAAWTNLGILYESCG-----------QLRDAYACYL 398
                              ..||.:......:.::.|.:|...|.           :|::.    |
Mouse  1052 HLNSLPRLEMLVAEVHAWKECAAKTFLPENSTYSLLEVLCPRCDIGLLGLKRKQRKLKEP----L 1112

  Fly   399 NATKQISFQKSSLIRKKQAIRMKKDTIGLSKGLS----------QRITFLEGQLSQAPLPSITSK 453
            .:.|:.|.:..||...::|:...|:|......|.          |.:.|...:...:|:..:..|
Mouse  1113 PSGKKRSTKLESLSDLERALMESKETAAAMATLGEARLREMEALQSLRFANEEKLLSPVQDLEMK 1177

  Fly   454 RRQLCSIEEAWNLP-ISLEMNSRQQQTAQMLPRQVTKQSPVQGPPPPYPHSQLSQSPIPSKRIKE 517
               :|..::....| |..|:......|:.:....:::.|.:.    ..||.:.|:.| |.::|..
Mouse  1178 ---VCLCQKTPATPMIQCELCRDAFHTSCVAAPSISQSSRIW----LCPHCRRSEKP-PLEKILP 1234

  Fly   518 DGTSQQEVTQNNSQTSA-QNLINISESLNQRNFNAMPESNKSSEQSVLDTFDDISNDIYKQ---- 577
            ...|.|.:.....:..| :.:|..:.:...|....:...|....|      |.:.:.:...
Mouse  1235 LLASLQRIRVRLPEGDALRYMIERTVNWQHRAQQLLSSGNLKLVQ------DQVGSGLLSSRWPA 1293

  Fly   578 --NESIKLERLSQD------ALSNNEDSRHDFIGGDNADIST------TFKIQMDSKQLMVAVKL 628
              .::...:::||.      :|.::.|:|..::   ::..||      ...:..:..:|::..:|
Mouse  1294 SAGQASATDKVSQPPGTTSFSLPDDWDNRTSYL---HSPFSTGQSCLPLHGLSPEVNELLMEAQL 1355

  Fly   629 LPIDEPPV---HCTIL----QVNAPPPSPP--------DC----------PPQKLTRDQLLPPTP 668
            |.:..|.:   :.|:|    .|.....|.|        ||          |.:||.|.......|
Mouse  1356 LQVSLPEIQELYQTLLTKPSSVQQADRSSPVRSSSEKNDCLRGKRDAINSPERKLKRRPEREGLP 1420

  Fly   669 SVHLENKKHAFSPQLQEFCLKHPIAVVRGLAGVLKLDLGLFSTKTLVEANPDHSVEVRTQVHQSP 733
            |...:..||..:||.::..|.||            .|:..|.    :|....:.:....:.|..|
Mouse  1421 SERWDRVKHMRTPQKKKIKLSHP------------KDMDSFK----LERERSYDLVRNAETHSLP 1469

  Fly   734 DENWDTSQGKRVWACISHRSHTTIAKYAQYQASSFQDSL----KLILPQ-DESD 782
            .   |||                   |::.:.|..:|::    ..:.|: ||.|
Mouse  1470 S---DTS-------------------YSEQEDSEDEDAICPAVSCLQPEGDEVD 1501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809	6/47 (13%)
		TPR_11	156..216	CDD:290150	13/71 (18%)
		TPR repeat	186..216	CDD:276809	7/29 (24%)
		TPR repeat	228..255	CDD:276809	5/27 (19%)
		TPR_11	264..337	CDD:290150	17/87 (20%)
		TPR repeat	265..300	CDD:276809	10/49 (20%)
		TPR repeat	307..334	CDD:276809	5/26 (19%)
		TPR_11	339..402	CDD:290150	15/113 (13%)
		TPR repeat	339..369	CDD:276809	10/69 (14%)
		TPR_1	340..373	CDD:278916	10/72 (14%)
		TPR repeat	374..402	CDD:276809	5/38 (13%)
		JmjC	870..978	CDD:202224
Kdm5b	NP_690855.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		JmjN	31..72	CDD:128818
		BRIGHT	98..188	CDD:128777
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	200..228
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	269..297
		PHD1_KDM5B	311..356	CDD:277076
		JmjC	486..602	CDD:202224
		zf-C5HC2	692..744	CDD:280996
		PLU-1	757..1086	CDD:285609	67/358 (19%)
		PHD_SF	1178..1221	CDD:304600	7/46 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1297..1318		3/20 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1374..1447		19/84 (23%)
		PHD3_KDM5B	1486..1535	CDD:277157	4/16 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900