DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Utx and Odad4

DIOPT Version :9

Sequence 1:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_083194.2	Gene:	Odad4 / 74407	MGIID:	1921657	Length:	624	Species:	Mus musculus

Alignment Length:	588	Identity:	112/588 - (19%)
Similarity:	209/588 - (35%)	Gaps:	134/588 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 QQTITN---------LQNYIANGQVHESKNSSDNKNAIQKFEPSTQAGEHMENTSSRNNDDTKPF 93
            |:.|.|         |:|   .|.:......:::|.|.||..|..|.     :.|:::....|..
Mouse   122 QEAINNSVGSPSSIKLEN---KGDLSFLSKQAESKKAQQKHLPIKQL-----SYSTKHEIKRKGS 178

  Fly    94 EQDAKEKVSIIEEKHQDEHYVNALCKLGHLHLLLGEYSEALSAYQ------KYLRFRENNYWTNH 152
            .:..|....::.|.:.|:.|:..|  |....|:.|.....|:...      .||..| :|:|...
Mouse   179 LKSEKTVRQLLGELYVDKEYLEKL--LLDEDLIKGTIKSGLTVEDLIMTGINYLDTR-SNFWRQQ 240

  Fly   153 AFIYGIGVAYFKLRCFKWAIKSFQELLYLSPNFTCANEVHLRLGLMLKHCGEFHIALKHLQ-LAL 216
            ..||. .....||...|| ::..:.    ||:.|.                  |..||.|: :.:
Mouse   241 KPIYA-RERDRKLMQEKW-LRDRKR----SPSQTA------------------HYILKSLEDIDM 281

  Fly   217 LYTYPSTFSELQVKFQIA------HLYEVQNKHKAAKDGYEFLLNEKNISLELKADVYRQLGWMY 275
            |.|..|....||...::.      :..||.||.:...:.|..:.|         |.:  :||.|.
Mouse   282 LLTSGSADGSLQKAEKVLKKVLEWNQEEVPNKDELVGNLYSCIGN---------AQI--ELGQMV 335

  Fly   276 HCVECLGEKKEREANALNFLQKSIEADPKSGQSLYLLGRCYAGINKVHDAFLAYRNSVEKSEGNA 340
            ..::  ..:|:.|      :.|..:......::|..:||.:|.:.|...|...:...:..::...
Mouse   336 AALQ--SHRKDLE------IAKEHDLPDAKSRALDNIGRVFARVGKFQQAIDTWEEKIPLAKTTL 392

  Fly   341 D-TWCSIGVLYQQQNQPTDALQAYICAVQLDKDHKAAWTNLGILYESCGQLRDAYA-------CY 397
            : ||     |:.:..:         |.::||:    ||.     .:|.|:....||       ..
Mouse   393 EKTW-----LFHEIGR---------CYLELDQ----AWQ-----AQSYGEKSQQYAEEEGDLEWQ 434

  Fly   398 LNATKQISFQKSSLIRKKQAIRMKKDTIGLSKGLSQRITFLEGQLSQAPLPSITSKRRQLCSIEE 462
            |||:..::..:..|...:.|:.      ...|.|.:.......:..||.:.::....:.:  |||
Mouse   435 LNASVLVAQAQVKLRDFESAVN------NFEKALERAKLVHNNEAQQAIISALDDANKGI--IEE 491

  Fly   463 AWNLPISLEMNSRQQQTAQMLPRQ-VTKQSPVQGPPPPYPHSQLSQSPIPSKRIKEDGTSQQEVT 526
                   |:..:.::...:...|| :..|..:||.....|.....:.....|:.:.|..|::|.|
Mouse   492 -------LKKTNYREILREKAERQDIMSQMDLQGASEKEPLRGREEQERVVKQWERDQESEREAT 549

  Fly   527 QNNSQTSAQNLINISESL----NQRNFNAMPESNKSSEQSVLDTFDDISNDIYKQNESIKLERLS 587
            .:.....:..  .:|:.|    :..|.....||     :.:.....|.|:.:..::.|.|.|:..
Mouse   550 DDEQDRKSSG--GLSKKLLGDGHSSNLGIRRES-----REIYRRLSDYSSHLPSEDGSQKQEKKQ 607

  Fly   588 QDA 590
            .:|
Mouse   608 AEA 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809	8/33 (24%)
		TPR_11	156..216	CDD:290150	12/60 (20%)
		TPR repeat	186..216	CDD:276809	5/30 (17%)
		TPR repeat	228..255	CDD:276809	6/32 (19%)
		TPR_11	264..337	CDD:290150	13/72 (18%)
		TPR repeat	265..300	CDD:276809	7/34 (21%)
		TPR repeat	307..334	CDD:276809	6/26 (23%)
		TPR_11	339..402	CDD:290150	15/70 (21%)
		TPR repeat	339..369	CDD:276809	4/30 (13%)
		TPR_1	340..373	CDD:278916	6/33 (18%)
		TPR repeat	374..402	CDD:276809	9/34 (26%)
		JmjC	870..978	CDD:202224
Odad4	NP_083194.2	TPR 1. /evidence=ECO:0000255	11..44
		TPR_11	14..76	CDD:290150
		TPR repeat	14..39	CDD:276809
		TPR repeat	44..74	CDD:276809
		TPR 2. /evidence=ECO:0000255	46..78
		TPR_11	47..110	CDD:290150
		TPR 3. /evidence=ECO:0000255	79..112
		TPR repeat	79..107	CDD:276809
		TPR 4. /evidence=ECO:0000255	273..309		8/35 (23%)
		TPR repeat	309..347	CDD:276809	12/56 (21%)
		TPR_12	314..383	CDD:290160	15/87 (17%)
		TPR 5. /evidence=ECO:0000255	318..351		9/51 (18%)
		TPR 6. /evidence=ECO:0000255	358..391		6/32 (19%)
		TPR repeat	358..383	CDD:276809	6/24 (25%)
		TPR_12	359..427	CDD:290160	18/90 (20%)
		TPR 7. /evidence=ECO:0000255	395..428		12/55 (22%)
		TPR_12	396..466	CDD:290160	18/98 (18%)
		TPR repeat	429..463	CDD:276809	6/39 (15%)
		TPR 8. /evidence=ECO:0000255	435..468		7/38 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	511..624		20/107 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900