DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Utx and Lonrf3

DIOPT Version :9

Sequence 1:NP_609368.3 Gene:Utx / 34377 FlyBaseID:FBgn0260749 Length:1136 Species:Drosophila melanogaster
Sequence 2:XP_006541467.1 Gene:Lonrf3 / 74365 MGIID:1921615 Length:805 Species:Mus musculus


Alignment Length:422 Identity:95/422 - (22%)
Similarity:148/422 - (35%) Gaps:119/422 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   311 LLGRCYAGINKVHDAFLAYRNSVEKSEGNADTWCSIGVLYQQQNQPTDALQAYICAVQLDKDHKA 375
            |||:.:.|         ..|.|..:.|||.        |: :::|...||..|..||:|..:...
Mouse   233 LLGKLFPG---------PARASQLRHEGNR--------LF-REHQVEAALLKYNEAVRLAPNDHL 279

  Fly   376 AWTNLGILYESCGQLRDA-----YACYLNATKQISFQKSSLIRKKQAIRMKKDTIGLSKGLSQRI 435
            .::|...:|.:.....||     .||.|   :.:.|:  :..||.||:.    |:|..|...:..
Mouse   280 LYSNRSQIYFTLESHEDALHDAEIACKL---RPMGFK--AHFRKAQALA----TLGKVKEALKEF 335

  Fly   436 TF---LEGQLSQAPLPSITSKRRQLCSIEEAWNLPISLEMNSRQQQTAQMLPRQVTKQSPVQGPP 497
            .:   |:|:...|.              .||..|..|....|        :|.:..:.||     
Mouse   336 LYCVSLDGKNKSAR--------------SEAQRLLFSFFSPS--------VPGESQEHSP----- 373

  Fly   498 PPYPHSQLSQSPIPSKRIKEDGTSQ-QEVTQNNSQTSAQNLINISESLNQRNFNAMPESNK--SS 559
                  .:.:...|..|:||...|. .|.|.:|....:|..:.:....||....|..||:.  :|
Mouse   374 ------DILKLLAPHPRLKEHVESMATEGTSHNLPKLSQENLELPHCSNQEGAAAAEESSSLANS 432

  Fly   560 EQSVLDTFDDISND----------------IYKQNESIKLERLSQDALSNNEDSRHDFIG--GDN 606
            .|..:.:.:|...|                ..|:....::| ..:|....|:.|:.||..  |..
Mouse   433 AQGKVSSKEDRKKDQEGEDRDAASVRTGKCQEKKRNRCQIE-TQEDTELPNKVSKQDFPAEQGAK 496

  Fly   607 ADISTTFKIQMDSKQL--MVAVKLL--PIDEPPVHCTILQV-------NAPPPSPPDCPPQKLTR 660
            .|:|.... ..|:..|  .:.::|.  |:..|..|...|:.       ||      .||   |.:
Mouse   497 PDLSNPLG-SFDASDLECSLCMRLFYEPVTTPCGHTFCLKCLERCLDHNA------KCP---LCK 551

  Fly   661 DQLLPPTPS------VHLENKKHAFSPQLQEF 686
            |.||...||      |.||.....|.|  :||
Mouse   552 DVLLQCLPSRKYSKNVILEELIATFLP--EEF 581

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
UtxNP_609368.3 TPR repeat 147..181 CDD:276809
TPR_11 156..216 CDD:290150
TPR repeat 186..216 CDD:276809
TPR repeat 228..255 CDD:276809
TPR_11 264..337 CDD:290150 6/25 (24%)
TPR repeat 265..300 CDD:276809
TPR repeat 307..334 CDD:276809 6/22 (27%)
TPR_11 339..402 CDD:290150 16/67 (24%)
TPR repeat 339..369 CDD:276809 8/29 (28%)
TPR_1 340..373 CDD:278916 8/32 (25%)
TPR repeat 374..402 CDD:276809 7/32 (22%)
JmjC 870..978 CDD:202224
Lonrf3XP_006541467.1 RING1-HC_LONFs 159..197 CDD:319427
3a0801s09 <244..>359 CDD:273380 33/146 (23%)
TPR repeat 244..272 CDD:276809 10/36 (28%)
TPR repeat 277..307 CDD:276809 6/29 (21%)
TPR repeat 312..335 CDD:276809 8/28 (29%)
PEX10 <456..551 CDD:227861 22/105 (21%)
RING2-HC_LONFs 510..551 CDD:319428 11/49 (22%)
LON_substr_bdg 601..802 CDD:366967
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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