DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Utx and Ifit1

DIOPT Version :9

Sequence 1:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_064481.1	Gene:	Ifit1 / 56824	RGDID:	620599	Length:	463	Species:	Rattus norvegicus

Alignment Length:	327	Identity:	60/327 - (18%)
Similarity:	109/327 - (33%)	Gaps:	96/327 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 IQKFEPSTQAGEHMENTSSRNNDDTKPFEQDAK---EKVSIIEEKHQDEHYVNALCKLGHLHLLL 127
            :|......:|..|:|...|..:..:..|...||   .|..|.|..|.....:......|:||
  Rat   218 LQDLGEQDEAETHIEEALSSTSCQSYVFRYAAKYFRRKGDINEALHLLHRALQTSPSSGYLH--- 279

  Fly   128 GEYSEALSAYQKYL----------RFRENNYWTNHAFIYGIGVAYFKLRCFKWAIKSFQELLYLS 182
              |.:.|...|:.:          |.:||.....|.                 ||..|||.|.|.
  Rat   280 --YQKGLCYKQQMIQLKTSGNRQARRQENIQELAHQ-----------------AICEFQETLNLR 325

  Fly   183 PNFTCANEVHLRLGLMLKHCGEFHIALKHLQLALLYTYPSTFSELQVKFQIAHLYEVQNKHKAAK 247
            |.|..|                 ::.:..:|..:                        .:::.|:
  Rat   326 PTFEMA-----------------YVCMAEMQAEI------------------------GQYEEAE 349

  Fly   248 DGYEFLLNEKNISLELKADVYRQLG--WMYHCVECLGEKKEREANALNFLQKSIEADPKSGQSLY 310
            ..::..||..|:...::.|::.:.|  ..:|        |:.|..|:....|.::.:.||    :
  Rat   350 GNFQEALNLNNLVAHIEQDIHFRYGRSQQFH--------KKSEDKAITHYLKGLKLEEKS----F 402

  Fly   311 LLGRCYAGINKVHDAFLAYRNSVEKSEGNADTWCSIGVLYQQQNQPTDALQAYICAVQLDKDHKA 375
            ...:....:.||  |....|.:|...|..:    .:|::::.:.|...||..|..|::|..:...
  Rat   403 AWRKLLTALEKV--AERRVRQNVRLVESTS----LLGLVFKLKGQEMKALLYYEKALRLSGEMNP 461

  Fly   376 AW 377
            |:
  Rat   462 AF 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809	7/33 (21%)
		TPR_11	156..216	CDD:290150	11/59 (19%)
		TPR repeat	186..216	CDD:276809	2/29 (7%)
		TPR repeat	228..255	CDD:276809	1/26 (4%)
		TPR_11	264..337	CDD:290150	14/74 (19%)
		TPR repeat	265..300	CDD:276809	7/36 (19%)
		TPR repeat	307..334	CDD:276809	4/26 (15%)
		TPR_11	339..402	CDD:290150	8/39 (21%)
		TPR repeat	339..369	CDD:276809	6/29 (21%)
		TPR_1	340..373	CDD:278916	7/32 (22%)
		TPR repeat	374..402	CDD:276809	1/4 (25%)
		JmjC	870..978	CDD:202224
Ifit1	NP_064481.1	TPR repeat	136..166	CDD:276809
		Coatomer_E	158..421	CDD:252768	49/279 (18%)
		TPR repeat	171..203	CDD:276809
		TPR repeat	208..236	CDD:276809	4/17 (24%)
		TPR repeat	242..270	CDD:276809	7/27 (26%)
		TPR repeat	275..324	CDD:276809	16/70 (23%)
		TPR repeat	329..356	CDD:276809	3/67 (4%)
		TPR repeat	363..396	CDD:276809	7/40 (18%)
		TPR repeat	426..454	CDD:276809	7/31 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900