DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Utx and ifit10

DIOPT Version :9

Sequence 1:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_001287801.1	Gene:	ifit10 / 567441	ZFINID:	ZDB-GENE-121214-248	Length:	482	Species:	Danio rerio

Alignment Length:	366	Identity:	68/366 - (18%)
Similarity:	126/366 - (34%)	Gaps:	117/366 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 FEQDAKEKVSIIE------EKHQDEHYVNALCKLGHLHLLLGEYSEALSAYQKYLRFRENNYWTN 151
            ||....|..:.::      |.:.|:..:..|..|  ..::...|.||.|..:|.|   |.:....
Zfish   193 FESTVLEDSATVKQLRLAIEMNPDDDVLKVLLSL--RLIVYKRYGEAESWVEKAL---EKSPDHP 252

  Fly   152 HAFIYGIGVAYFKLRCFKWAIKSFQELLYLSPNFTCANEVHLRLGLMLKH------CGEFHIA-- 208
            |...| :|..:....|...:|...:..|..|||   ::.:|.:|.|..|:      ..:.|.|
Zfish   253 HVMRY-VGKFFRNKGCVDRSIDLLKRALERSPN---SSFIHHQLALCYKYKKIQVLQEQSHHARG 313

  Fly   209 ----------LKHLQLA--LLYTYPSTFSELQVKF-------QIAHLYEVQNKHKAAKDGYEFLL 254
                      :.||:.|  |..::.|..|:|.:::       :...|::|..|          :.
Zfish   314 SRVQQLRDQCIFHLEKATSLTTSFISAMSDLALQYGENGDIPRAEELFQVTFK----------IA 368

  Fly   255 NEKNISLELKADVYRQLGWMYHCVECLGEKKEREANALNFLQKSIEADPKSGQSLYLLGRCYAGI 319
            .|||..|.:....|.:  :..:|..|       |..|:....:.::..|||.:.
Zfish   369 KEKNDGLHVVNYYYAE--YQLYCHRC-------EPLAVQHYMECLKMCPKSVEG----------- 413

  Fly   320 NKVHDAFLAYRNSVEKSEGNADTWCSIGVLYQQQNQPTDALQAYICAVQLDKDHKA----AWTNL 380
                      |.|..:.:..|:.|.                           |.|:    |:..|
Zfish   414 ----------RISSTRMKKTAEKWI---------------------------DRKSQEGKAYGML 441

  Fly   381 GILYESCGQLRDAYACYLNATKQISFQ-KSSLIRKKQAIRM 420
            ..|::..|::..|..||   .|.:|:: .:..:|..:.:|:
Zfish   442 AFLHKVKGEIAQAIECY---EKALSYEDNNEFLRNLRELRL 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809	6/33 (18%)
		TPR_11	156..216	CDD:290150	17/79 (22%)
		TPR repeat	186..216	CDD:276809	9/49 (18%)
		TPR repeat	228..255	CDD:276809	3/33 (9%)
		TPR_11	264..337	CDD:290150	10/72 (14%)
		TPR repeat	265..300	CDD:276809	5/34 (15%)
		TPR repeat	307..334	CDD:276809	2/26 (8%)
		TPR_11	339..402	CDD:290150	11/66 (17%)
		TPR repeat	339..369	CDD:276809	2/29 (7%)
		TPR_1	340..373	CDD:278916	2/32 (6%)
		TPR repeat	374..402	CDD:276809	8/31 (26%)
		JmjC	870..978	CDD:202224
ifit10	NP_001287801.1	TPR repeat	58..86	CDD:276809
		TPR repeat	91..130	CDD:276809
		TPR repeat	142..172	CDD:276809
		TPR repeat	177..213	CDD:276809	3/19 (16%)
		TPR repeat	251..281	CDD:276809	6/30 (20%)
		TPR repeat	338..362	CDD:276809	4/23 (17%)
		TPR repeat	375..406	CDD:276809	6/39 (15%)
		TPR repeat	411..463	CDD:276809	14/102 (14%)
		TPR_1	436..468	CDD:278916	9/34 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900