DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Utx and tmtc4

DIOPT Version :9

Sequence 1:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_001166973.1	Gene:	tmtc4 / 560605	ZFINID:	ZDB-GENE-070912-148	Length:	739	Species:	Danio rerio

Alignment Length:	383	Identity:	79/383 - (20%)
Similarity:	134/383 - (34%)	Gaps:	110/383 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 YWTNHAFIYGIGVAYFKLRCF----------KWAIKSFQELLYLSPNFTCA-------NEVHLRL 195
            :|..|..:  :..|...|.|.          :|  :|.|.|      ||.|       .:||..:
Zfish   432 HWRKHKRL--LRAATLTLLCVNVTRSAQRSQQW--RSEQSL------FTSALSVCPLNAKVHYNV 486

  Fly   196 GLMLKHCGEFHIALKHLQLALLYTYPSTFSELQVKFQIAHLYEVQNKHKAAKDGYEFLLNEKNIS 260
            |..|...|....|:::.:.|:                     .:..|:..|.:....:|.|:|
Zfish   487 GKNLADRGNQSAAVQYYREAV---------------------RLHPKYVHAMNNLGNILKERN-- 528

  Fly   261 LELKADVYRQLGWMYHCVECLGEKKEREANALNFLQKSIEADPKSGQSLYLLGRCYAGINKVHDA 325
                                  |.||.|    ..|..::...|....:...||.....:.|.:.|
Zfish   529 ----------------------ELKEAE----ELLSAAVHIQPDFAAAWMNLGIVQNSLKKFNKA 567

  Fly   326 FLAYRNSVEKSEGNADTWCSIGVLYQQQNQPTDALQAYICAVQLDKDHKAAWTNLGILYESCGQL 390
            ..:|.|::...:...|.:.::|.||...|:..|||.|:..|..|..||..||.|:.||.::.|.|
Zfish   568 EQSYWNAIRFRKKYPDCYYNLGRLYADLNRSIDALNAWRNATMLKPDHSLAWNNMVILLDNTGNL 632

  Fly   391 RDAYACYLNATKQISFQKSSLIRKKQAIRMKKD-TI--GLSKGLSQRITFLEGQ---LSQAPL-P 448
            ..|                .||.|:....:.|| ||  .|:..|.::..:.|.:   |:...: |
Zfish   633 AQA----------------ELIGKEALKILPKDHTIMFSLANVLGKQEKYKESEGFFLNALKINP 681

  Fly   449 SITSKRRQLCSIEEAW--------NLPISLEMNSRQQQTAQ---MLPRQVTKQSPVQG 495
            ::.|....|..:...|        :..:||.::.....|.:   ||.|::.::....|
Zfish   682 NVASCHGNLAVLYHRWGKLDLAKRHYELSLRLDPSAPGTKENYNMLKRKLEQRQRTVG 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809	9/42 (21%)
		TPR_11	156..216	CDD:290150	16/76 (21%)
		TPR repeat	186..216	CDD:276809	8/36 (22%)
		TPR repeat	228..255	CDD:276809	2/26 (8%)
		TPR_11	264..337	CDD:290150	12/72 (17%)
		TPR repeat	265..300	CDD:276809	5/34 (15%)
		TPR repeat	307..334	CDD:276809	6/26 (23%)
		TPR_11	339..402	CDD:290150	21/62 (34%)
		TPR repeat	339..369	CDD:276809	10/29 (34%)
		TPR_1	340..373	CDD:278916	11/32 (34%)
		TPR repeat	374..402	CDD:276809	8/27 (30%)
		JmjC	870..978	CDD:202224
tmtc4	NP_001166973.1	DUF1736	291..363	CDD:312047
		TPR	479..716	CDD:223533	62/301 (21%)
		TPR repeat	480..508	CDD:276809	7/48 (15%)
		TPR repeat	513..543	CDD:276809	9/57 (16%)
		TPR repeat	548..576	CDD:276809	6/27 (22%)
		TPR repeat	582..608	CDD:276809	9/25 (36%)
		TPR repeat	618..644	CDD:276809	11/41 (27%)
		TPR repeat	649..679	CDD:276809	7/29 (24%)
		TPR repeat	684..712	CDD:276809	4/27 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900