DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Utx and kdm6ba

DIOPT Version :9

Sequence 1:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	XP_005172296.1	Gene:	kdm6ba / 556678	ZFINID:	ZDB-GENE-091005-1	Length:	1996	Species:	Danio rerio

Alignment Length:	784	Identity:	338/784 - (43%)
Similarity:	465/784 - (59%)	Gaps:	122/784 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   439 EGQLSQAP--------LPSITSKRRQLCSIEEA--WNLPISLEMNS-----RQQQTAQMLPRQVT 488
            |..:|:.|        :..:..:|.:|.:|.|:  ..|..|||:|.     :....|:  .|::.
Zfish  1232 EKDISEEPKVKVDSGNMKDLLERRPKLTTISESSLAELGQSLEVNKHIIPFKDHSKAE--AREIC 1294

  Fly   489 KQSPVQGP--------PPPYPHSQLSQSPIPSKRIKEDGTSQQEVTQNNSQTSAQNLINISESLN 545
            |  ||:..        ...:.||..|:.....|..|:....:.:....:|.:|:        |.:
Zfish  1295 K--PVEEKERHRDRERERKHKHSSSSKKHEDKKERKKKHRERHDDASLSSSSSS--------SSS 1349

  Fly   546 QRNFNAMPESNKSSEQSVLDTFDDISNDI---YKQNESIKLERLSQDALSNNE------------ 595
            :|:.:......|.|.| ||...|..|.::   .::.:..|..|..:.....||
Zfish  1350 RRHRDGKSHKEKKSRQ-VLGNLDLQSKELREKEQERDGDKKRRKEESGRPQNEGEAWTQIREKGS 1413

  Fly   596 DSRH--DFIGGDNADISTTF-------------------KIQMDSKQLMVA----VKLLPIDEPP 635
            .|.|  |...|.:|..|..|                   |::...::..:|    .|.:|:.:..
Zfish  1414 SSGHSSDLPSGSSALCSDDFQKLKALTDGPPKELKIRLIKVESGDRETFIASEVEEKRIPLKDIT 1478

  Fly   636 VH---------CTILQV-------------NAPPPSPPDCPPQKLTRDQLLPPTPSVHLENKKHA 678
            :.         |...:|             :..|....:.|   :.|::|.|||||::||:|:.|
Zfish  1479 IKNSASEIIRACKAARVKGKFKESYLLDAFSVKPVVRTELP---IPREKLNPPTPSIYLESKRDA 1540

  Fly   679 FSPQLQEFCL--KHPIAVVRGLAGVLKLDLGLFSTKTLVEANPDHSVEVRTQVHQSPDENWDTSQ 741
            |||.|.:||.  |:||.|:|||||.|:|:|||||||:|||||.:|:|||||||.|..|||||.|.
Zfish  1541 FSPVLLQFCTDPKNPITVIRGLAGSLRLNLGLFSTKSLVEANSEHAVEVRTQVQQPADENWDASG 1605

  Fly   742 GKRVWACISHRSHTTIAKYAQYQASSFQDSLKLILPQDESDKGFPGSQAMSDSDSK------DSV 800
            ..:.|.|.|.||||||||||||||||||:||     |:|.     ||.|..|:|.|      .:.
Zfish  1606 TGQTWPCESSRSHTTIAKYAQYQASSFQESL-----QEEK-----GSDAEEDNDEKPTTKAESTT 1660

  Fly   801 SNSNIVLKRKKHKINSKMLRFGTNVDLSDEKKWKPQLTELQKLPAFARVISAANMLSHVGHVILG 865
            |||:......:.|...|:::||||:||||.|:|||||.||||||||.||.|:.||||||||.|||
Zfish  1661 SNSSAPNSSSEQKTVGKIIKFGTNIDLSDPKRWKPQLQELQKLPAFMRVSSSGNMLSHVGHTILG 1725

  Fly   866 MNTVQLYMKVPGSRTPGHQENNNFCSININIGPGDCEWFAVPDAYWGGVHNLCEKNNISYLHGSW 930
            |||||||||:||.|||||||||||||:||||||||||||||.|.||..:.:.|:|:.:.||.|||
Zfish  1726 MNTVQLYMKIPGCRTPGHQENNNFCSVNINIGPGDCEWFAVHDDYWEAISDFCQKHGVDYLTGSW 1790

  Fly   931 WPVLEDLYKENIPVYRFIQKPGDLVWVNAGCVHWVQSIGWCNNIAWNVGPLTARQYSLAIERYEW 995
            ||||:|||:.|||||||||:||||||:|||.|||||::||||||||||||:.|.||.:|:||:||
Zfish  1791 WPVLDDLYRANIPVYRFIQRPGDLVWINAGTVHWVQAVGWCNNIAWNVGPVNAYQYQVALERFEW 1855

  Fly   996 NKVQAFKSIVPMVHLSWNLARNIKVSDTKLFELIKMCLLQTLKNVLHIQEYVKSKGVEIRFNGRG 1060
            |:|:..||||||:|:|||:||.:||:|...:.:||.||||::|::..:::.:.:.|::|.:..|.
Zfish  1856 NEVKKVKSIVPMIHVSWNVARTVKVTDPDAYNMIKHCLLQSIKHIQILRDQLVAAGMKISYQSRV 1920

  Fly  1061 KNEASHYCGQCEVEVFNVLFIKEQ---EKRHVVHCLSCALKLSPSLQGIVCLEEYRLSELQRVYD 1122
            |:|.::||.:|:|||||:||:..:   .|.:||||..||.:.||:|..:|.||:||:.||..:||
Zfish  1921 KDEPAYYCNECDVEVFNLLFVTSENGSRKMYVVHCEDCARQRSPNLSNVVVLEQYRMEELMNMYD 1985

  Fly  1123 SFTL 1126
            ||:|
Zfish  1986 SFSL 1989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809
		TPR_11	156..216	CDD:290150
		TPR repeat	186..216	CDD:276809
		TPR repeat	228..255	CDD:276809
		TPR_11	264..337	CDD:290150
		TPR repeat	265..300	CDD:276809
		TPR repeat	307..334	CDD:276809
		TPR_11	339..402	CDD:290150
		TPR repeat	339..369	CDD:276809
		TPR_1	340..373	CDD:278916
		TPR repeat	374..402	CDD:276809
		JmjC	870..978	CDD:202224	82/107 (77%)
kdm6ba	XP_005172296.1	Atrophin-1	<128..507	CDD:331285
		Herpes_BLLF1	478..>693	CDD:330317
		JmjC	1696..1760	CDD:214721	54/63 (86%)
		JmjC	1730..1838	CDD:202224	82/107 (77%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593769
Domainoid	1	1.000	184	1.000	Domainoid score	I3342
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141383at33208
OrthoFinder	1	1.000	-	-		FOG0001095
OrthoInspector	1	1.000	-	-		otm24903
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14017
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X932
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.950