Protein Alignment Utx and kdm6ba

DIOPT Version :10

• Sequence 1: NP_609368.3
• Gene: Utx / 34377
• FlyBaseID: FBgn0260749
• Length: 1136
• Species: Drosophila melanogaster
• Sequence 2: XP_005172296.1
• Gene: kdm6ba / 556678
• ZFINID: ZDB-GENE-091005-1
• Length: 1996
• Species: Danio rerio
• Alignment Length: 784
• Identity: 338/784 - (43%)
• Similarity: 465/784 - (59%)
• Gaps: 122/784 - (15%)

  Fly   439 EGQLSQAP--------LPSITSKRRQLCSIEEA--WNLPISLEMNS-----RQQQTAQMLPRQVT 488
            |..:|:.|        :..:..:|.:|.:|.|:  ..|..|||:|.     :....|:  .|::.
Zfish  1232 EKDISEEPKVKVDSGNMKDLLERRPKLTTISESSLAELGQSLEVNKHIIPFKDHSKAE--AREIC 1294

  Fly   489 KQSPVQGP--------PPPYPHSQLSQSPIPSKRIKEDGTSQQEVTQNNSQTSAQNLINISESLN 545
            |  ||:..        ...:.||..|:.....|..|:....:.:....:|.:|:        |.:
Zfish  1295 K--PVEEKERHRDRERERKHKHSSSSKKHEDKKERKKKHRERHDDASLSSSSSS--------SSS 1349

  Fly   546 QRNFNAMPESNKSSEQSVLDTFDDISNDI---YKQNESIKLERLSQDALSNNE------------ 595
            :|:.:......|.|.| ||...|..|.::   .::.:..|..|..:.....||
Zfish  1350 RRHRDGKSHKEKKSRQ-VLGNLDLQSKELREKEQERDGDKKRRKEESGRPQNEGEAWTQIREKGS 1413

  Fly   596 DSRH--DFIGGDNADISTTF-------------------KIQMDSKQLMVA----VKLLPIDEPP 635
            .|.|  |...|.:|..|..|                   |::...::..:|    .|.:|:.:..
Zfish  1414 SSGHSSDLPSGSSALCSDDFQKLKALTDGPPKELKIRLIKVESGDRETFIASEVEEKRIPLKDIT 1478

  Fly   636 VH---------CTILQV-------------NAPPPSPPDCPPQKLTRDQLLPPTPSVHLENKKHA 678
            :.         |...:|             :..|....:.|   :.|::|.|||||::||:|:.|
Zfish  1479 IKNSASEIIRACKAARVKGKFKESYLLDAFSVKPVVRTELP---IPREKLNPPTPSIYLESKRDA 1540

  Fly   679 FSPQLQEFCL--KHPIAVVRGLAGVLKLDLGLFSTKTLVEANPDHSVEVRTQVHQSPDENWDTSQ 741
            |||.|.:||.  |:||.|:|||||.|:|:|||||||:|||||.:|:|||||||.|..|||||.|.
Zfish  1541 FSPVLLQFCTDPKNPITVIRGLAGSLRLNLGLFSTKSLVEANSEHAVEVRTQVQQPADENWDASG 1605

  Fly   742 GKRVWACISHRSHTTIAKYAQYQASSFQDSLKLILPQDESDKGFPGSQAMSDSDSK------DSV 800
            ..:.|.|.|.||||||||||||||||||:||     |:|.     ||.|..|:|.|      .:.
Zfish  1606 TGQTWPCESSRSHTTIAKYAQYQASSFQESL-----QEEK-----GSDAEEDNDEKPTTKAESTT 1660

  Fly   801 SNSNIVLKRKKHKINSKMLRFGTNVDLSDEKKWKPQLTELQKLPAFARVISAANMLSHVGHVILG 865
            |||:......:.|...|:::||||:||||.|:|||||.||||||||.||.|:.||||||||.|||
Zfish  1661 SNSSAPNSSSEQKTVGKIIKFGTNIDLSDPKRWKPQLQELQKLPAFMRVSSSGNMLSHVGHTILG 1725

  Fly   866 MNTVQLYMKVPGSRTPGHQENNNFCSININIGPGDCEWFAVPDAYWGGVHNLCEKNNISYLHGSW 930
            |||||||||:||.|||||||||||||:||||||||||||||.|.||..:.:.|:|:.:.||.|||
Zfish  1726 MNTVQLYMKIPGCRTPGHQENNNFCSVNINIGPGDCEWFAVHDDYWEAISDFCQKHGVDYLTGSW 1790

  Fly   931 WPVLEDLYKENIPVYRFIQKPGDLVWVNAGCVHWVQSIGWCNNIAWNVGPLTARQYSLAIERYEW 995
            ||||:|||:.|||||||||:||||||:|||.|||||::||||||||||||:.|.||.:|:||:||
Zfish  1791 WPVLDDLYRANIPVYRFIQRPGDLVWINAGTVHWVQAVGWCNNIAWNVGPVNAYQYQVALERFEW 1855

  Fly   996 NKVQAFKSIVPMVHLSWNLARNIKVSDTKLFELIKMCLLQTLKNVLHIQEYVKSKGVEIRFNGRG 1060
            |:|:..||||||:|:|||:||.:||:|...:.:||.||||::|::..:::.:.:.|::|.:..|.
Zfish  1856 NEVKKVKSIVPMIHVSWNVARTVKVTDPDAYNMIKHCLLQSIKHIQILRDQLVAAGMKISYQSRV 1920

  Fly  1061 KNEASHYCGQCEVEVFNVLFIKEQ---EKRHVVHCLSCALKLSPSLQGIVCLEEYRLSELQRVYD 1122
            |:|.::||.:|:|||||:||:..:   .|.:||||..||.:.||:|..:|.||:||:.||..:||
Zfish  1921 KDEPAYYCNECDVEVFNLLFVTSENGSRKMYVVHCEDCARQRSPNLSNVVVLEQYRMEELMNMYD 1985

  Fly  1123 SFTL 1126
            ||:|
Zfish  1986 SFSL 1989

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809
		LapB	171..444	CDD:442196	1/4 (25%)
		TPR repeat	186..216	CDD:276809
		TPR repeat	228..255	CDD:276809
		TPR repeat	265..300	CDD:276809
		TPR repeat	307..334	CDD:276809
		TPR repeat	339..369	CDD:276809
		TPR repeat	374..402	CDD:276809
		JmjC	870..978	CDD:396791	82/107 (77%)
kdm6ba	XP_005172296.1	Atrophin-1	273..>657	CDD:460830
		JmjC	1696..1760	CDD:214721	54/63 (86%)
		JmjC	1730..1838	CDD:396791	82/107 (77%)