DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Utx and ATP5F1B

DIOPT Version :9

Sequence 1:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_001677.2	Gene:	ATP5F1B / 506	HGNCID:	830	Length:	529	Species:	Homo sapiens

Alignment Length:	476	Identity:	88/476 - (18%)
Similarity:	150/476 - (31%)	Gaps:	149/476 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 ELQVKFQIA-HLYEVQNKHKAAKDGYEFLLNEKNISLELKADVYRQLG--WMYHCVECLGEK-KE 286
            |.::..::| ||.| ......|.||.|.|:..:.: |:..|.:...:|  .:...:..:||. .|
Human    92 ETRLVLEVAQHLGE-STVRTIAMDGTEGLVRGQKV-LDSGAPIKIPVGPETLGRIMNVIGEPIDE 154

  Fly   287 R-----------EANALNFLQKSIE--------------ADPKSGQSLYLLGRCYAG-------- 318
            |           .|.|..|::.|:|              |....|..:.|.|....|
Human   155 RGPIKTKQFAPIHAEAPEFMEMSVEQEILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMEL 219

  Fly   319 ---INKVHDAFLAYRNSVEKS-EGN--------------ADTWCSIGVLYQQQNQPTDALQAYIC 365
               :.|.|..:..:....|:: |||              .|....:.::|.|.|:|..|..
Human   220 INNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVINLKDATSKVALVYGQMNEPPGARA---- 280

  Fly   366 AVQLDKDHKAAWTNLGIL-YESCGQLRDAYACYLNATK--QISFQKSSLIRKKQAIRMKKDTIGL 427
                    :.|.|.|.:. |....:.:|......|..:  |...:.|:|:.:..:....:.|:..
Human   281 --------RVALTGLTVAEYFRDQEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLAT 337

  Fly   428 SKG-LSQRITFLEGQLSQAPLPSITSKRRQLCSIEEAWNLPISLEMNSRQQQTAQMLPRQVTKQS 491
            ..| :.:|||              |:|:..:.|::..:                       ....
Human   338 DMGTMQERIT--------------TTKKGSITSVQAIY-----------------------VPAD 365

  Fly   492 PVQGPPPPYPHSQLSQSPIPSKRIKEDGT-SQQEVTQNNSQTSAQNLINISESLNQRNFNAMPES 555
            .:..|.|....:.|..:.:.|:.|.|.|. ...:...:.|:....|::.
Human   366 DLTDPAPATTFAHLDATTVLSRAIAELGIYPAVDPLDSTSRIMDPNIVG---------------- 414

  Fly   556 NKSSEQSVLDTFDDISNDIYKQNESIKLERLSQDALSNNEDSRHDFIGGDNADISTTFKIQ-MDS 619
              |....|......|..| ||..:.| :..|..|.||..          |...:|...||| ..|
Human   415 --SEHYDVARGVQKILQD-YKSLQDI-IAILGMDELSEE----------DKLTVSRARKIQRFLS 465

  Fly   620 KQLMVAV-------KLLPIDE 633
            :...||.       ||:|:.|
Human   466 QPFQVAEVFTGHMGKLVPLKE 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809
		TPR_11	156..216	CDD:290150
		TPR repeat	186..216	CDD:276809
		TPR repeat	228..255	CDD:276809	9/27 (33%)
		TPR_11	264..337	CDD:290150	19/112 (17%)
		TPR repeat	265..300	CDD:276809	10/48 (21%)
		TPR repeat	307..334	CDD:276809	5/37 (14%)
		TPR_11	339..402	CDD:290150	13/77 (17%)
		TPR repeat	339..369	CDD:276809	7/43 (16%)
		TPR_1	340..373	CDD:278916	6/32 (19%)
		TPR repeat	374..402	CDD:276809	6/28 (21%)
		JmjC	870..978	CDD:202224
ATP5F1B	NP_001677.2	PRK09280	58..524	CDD:236447	88/476 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900