DRSC/TRiP Functional Genomics Resources

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Protein Alignment Utx and IFIT1B

DIOPT Version :9

Sequence 1:NP_609368.3 Gene:Utx / 34377 FlyBaseID:FBgn0260749 Length:1136 Species:Drosophila melanogaster
Sequence 2:NP_001010987.1 Gene:IFIT1B / 439996 HGNCID:23442 Length:474 Species:Homo sapiens


Alignment Length:480 Identity:95/480 - (19%)
Similarity:159/480 - (33%) Gaps:180/480 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 IRELDSRYYGFLDLSNSK-NAELRNLVQQTITNLQNYIAN--GQVHES----KNSSDNKNAIQKF 69
            |.:|::|.:..:...::| |..:.||:.        |:.:  ||..|:    |.:.|   .||| 
Human    32 IPDLENRIWEEIQFLDTKYNVGIHNLLA--------YVKHLKGQNEEALVSLKKAED---LIQK- 84

  Fly    70 EPSTQAG---------------------------EHMENTSSRNNDDTKPFEQDAKEKVSIIEEK 107
            |.:.||.                           :.:|||       .|.|...::.::...|..
Human    85 EHANQADIRSLVTWGNFAWVYYHMGRLAEAQTYLDKVENT-------CKKFANPSRYRMECPEVD 142

  Fly   108 HQDEHYVNALCKLGHLHLLLGEYSEALSAYQKYLRFRENNYWTNHAFIYGIGVAYFKLRCFKWAI 172
            .::..   ||.|.|..:     |..|.:.::|.|   |.|. .|..|..|..:..::|..|..|.
Human   143 CEEGW---ALAKCGGKN-----YERAKTCFEKAL---EGNP-ENPEFNTGYAITVYRLDKFNTAS 195

  Fly   173 ---KSF-----QELLYLSPNFTCANEVHLRLGLMLKHCGEFHIALKHLQLALLYTYPSTFSELQV 229
               |:|     :..:.|:|     ::|::|:.|.||                             
Human   196 GRNKAFSLHVLKRAVRLNP-----DDVYIRVLLALK----------------------------- 226

  Fly   230 KFQIAHLYEVQNKHKAAKDGYEFLLNEKNISLELKADVYRQLGWMYHCVECLGEKKEREANALNF 294
                     :|::.:.|:.  |..:.|...|:..:|.|::.....|       .:|.....||..
Human   227 ---------LQDEGQEAEG--EKYIEEALTSISSQAYVFQYAAKFY-------RRKGSVDKALEL 273

  Fly   295 LQKSIEADPKSGQSLYLLGRCYAGINKVHDAFLAYRNSVEKSEGNADTWCSIGVLYQQQNQPTDA 359
            |:.::|..|.|....:.:|.||..            ..::..|  |..|...|    |..:..|.
Human   274 LKMALETTPTSAFLHHQMGLCYRA------------QMIQIKE--ATNWQPRG----QDRETVDR 320

  Fly   360 L-QAYIC----AVQLDKDHKAAWTNLGILYESCGQLRDAYACYLNATKQISFQKSSLIRKKQAIR 419
            | |..||    .:.|.:..:.|:.:|...|...|..|.|         :..|||        .:|
Human   321 LVQLAICKFEKTIMLKRTFEMAYVDLAETYAEIGHHRKA---------EEHFQK--------GLR 368

  Fly   420 MKKDTIGLSKGLSQRITFLEGQLSQ 444
            ||               ..|.||.|
Human   369 MK---------------IFEDQLKQ 378

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
UtxNP_609368.3 TPR repeat 147..181 CDD:276809 9/41 (22%)
TPR_11 156..216 CDD:290150 13/67 (19%)
TPR repeat 186..216 CDD:276809 5/29 (17%)
TPR repeat 228..255 CDD:276809 3/26 (12%)
TPR_11 264..337 CDD:290150 13/72 (18%)
TPR repeat 265..300 CDD:276809 7/34 (21%)
TPR repeat 307..334 CDD:276809 3/26 (12%)
TPR_11 339..402 CDD:290150 16/67 (24%)
TPR repeat 339..369 CDD:276809 9/34 (26%)
TPR_1 340..373 CDD:278916 10/37 (27%)
TPR repeat 374..402 CDD:276809 6/27 (22%)
JmjC 870..978 CDD:202224
IFIT1BNP_001010987.1 TPR_11 36..>298 CDD:330823 66/356 (19%)
TPR 1 52..85 11/44 (25%)
TPR repeat 54..80 CDD:276809 7/33 (21%)
TPR 2 95..128 4/39 (10%)
TPR repeat 97..123 CDD:276809 0/25 (0%)
TPR repeat 128..170 CDD:276809 10/52 (19%)
TPR 3 139..174 11/46 (24%)
TPR 4 182..216 7/38 (18%)
TPR repeat 216..246 CDD:276809 9/69 (13%)
TPR 5 251..284 9/39 (23%)
TPR repeat 251..279 CDD:276809 7/34 (21%)
TPR repeat 284..335 CDD:276809 14/68 (21%)
TPR_11 <323..469 CDD:330823 20/88 (23%)
TPR 6 340..373 12/64 (19%)
TPR repeat 340..368 CDD:276809 9/44 (20%)
TPR 7 378..412 1/1 (100%)
TPR repeat 378..407 CDD:276809 1/1 (100%)
TPR 8 437..470
TPR repeat 437..465 CDD:276809
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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