DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Utx and CG5038

DIOPT Version :9

Sequence 1:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_650451.1	Gene:	CG5038 / 41867	FlyBaseID:	FBgn0038324	Length:	705	Species:	Drosophila melanogaster

Alignment Length:	361	Identity:	86/361 - (23%)
Similarity:	143/361 - (39%)	Gaps:	84/361 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 CLIRELDSRYYGFL---DLSNSKNAELRNLVQQTITNLQNYIANGQVHESKNSSDNKNAIQKFEP 71
            ||:     ..||||   | |:::|...|..::..:..|.:.:   .|...:.::|..|..|.|:.
  Fly   380 CLL-----SIYGFLYWYD-SSTENTHWRTALRILLMLLFSVM---MVRTRQRATDWLNEEQLFKS 435

  Fly    72 STQ-----AGEHME----NTSSRNNDDTKPFEQDAKEKVSIIEEKHQDEHYVNALCKLGHLHLLL 127
            :.|     |..|..    .|...||  ||.| |.....:.:.      .:|.:||..||:|:...
  Fly   436 ALQVCPDNAKVHYNIARLATDMGNN--TKAF-QHYHRAIELY------PNYESALMNLGNLYREH 491

  Fly   128 GEYSEALSAYQKYLRFRENNY------WTNHAFIYGIGVAYFKLRCFKWAIKSFQELLYLSPNFT 186
            |:    ||..::|:|.....|      |.|...:......|.|      |:.|:::.|....||.
  Fly   492 GQ----LSTAEEYIRLALQAYPAFPAAWMNLGIVQSAQGKYDK------ALASYEKALKYRANFA 546

  Fly   187 CANEVHLRLGLMLKHCGEFHIALKHLQ--LALLYTYPSTFSELQVKFQIAHLYEVQNKH------ 243
            ..   :..:|.:......:..||.|.|  :||....|..::.:        |..:.||.
  Fly   547 VC---YYNMGNLYLEQKRYAEALHHWQHAVALNPRQPKAWANI--------LTMLDNKGLQDDAL 600

  Fly   244 KAAKDGYEFLLNEKNISLELKADVYRQLGWMYHCVECLGEKKEREANALNFLQKSIEADPKSGQS 308
            :.:....:.|.|:.:| |.::|:|   ||.:.|..         ||.|:  .::.||.:|.:  :
  Fly   601 RISNQALQHLPNDVSI-LFIRANV---LGKLKHYT---------EAEAI--YKRVIELEPHN--T 648

  Fly   309 LY--LLGRCYAGINKVHDAFLAYRNSVEKSEGNADT 342
            ||  .||..|...:|..:|..|||.::..|...|.|
  Fly   649 LYHTNLGVLYHRWDKTQEAIEAYRTAISISAARATT 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809	8/39 (21%)
		TPR_11	156..216	CDD:290150	12/61 (20%)
		TPR repeat	186..216	CDD:276809	5/31 (16%)
		TPR repeat	228..255	CDD:276809	4/32 (13%)
		TPR_11	264..337	CDD:290150	21/74 (28%)
		TPR repeat	265..300	CDD:276809	8/34 (24%)
		TPR repeat	307..334	CDD:276809	10/28 (36%)
		TPR_11	339..402	CDD:290150	2/4 (50%)
		TPR repeat	339..369	CDD:276809	2/4 (50%)
		TPR_1	340..373	CDD:278916	2/3 (67%)
		TPR repeat	374..402	CDD:276809
		JmjC	870..978	CDD:202224
CG5038	NP_650451.1	DUF1736	258..331	CDD:285594
		TPR	442..701	CDD:223533	69/290 (24%)
		TPR_1	444..477	CDD:278916	9/41 (22%)
		TPR repeat	444..472	CDD:276809	9/30 (30%)
		TPR_17	466..499	CDD:290167	9/42 (21%)
		TPR repeat	480..506	CDD:276809	10/29 (34%)
		TPR repeat	511..541	CDD:276809	7/35 (20%)
		TPR_1	512..545	CDD:278916	7/38 (18%)
		TPR_1	546..577	CDD:278916	7/33 (21%)
		TPR repeat	546..574	CDD:276809	5/30 (17%)
		TPR repeat	580..608	CDD:276809	4/35 (11%)
		TPR repeat	614..642	CDD:276809	10/42 (24%)
		TPR repeat	647..677	CDD:276809	10/31 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900