DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Utx and kdm5bb

DIOPT Version :9

Sequence 1:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	XP_005167081.1	Gene:	kdm5bb / 415256	ZFINID:	ZDB-GENE-030424-1	Length:	1522	Species:	Danio rerio

Alignment Length:	808	Identity:	147/808 - (18%)
Similarity:	243/808 - (30%)	Gaps:	287/808 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   458 CSIEEAWNLPISLEMNSRQQQTAQMLP--RQVTKQSPVQGPPPPYPHSQ---------------- 504
            |.::.....|....:|..:.||...|.  .|:.|...:||.....||.:
Zfish    59 CDVDRLHFTPRIQRLNELEAQTRVKLNFLDQIAKFWDLQGCTLKIPHVERKILDLYQLNKLVADE 123

  Fly   505 ----------------LSQSPIPSKRIKEDGTSQQE--VTQNNSQTSAQNLINISESLNQRNFNA 551
                            ::....|.|.:.....:..|  :...|...|..||:....::....|..
Zfish   124 GGFDLVCRERRWTKIAMTMGFAPGKAVGSHLRAHYERILYPYNLFQSGTNLLAPEFAVKLTGFGE 188

  Fly   552 MPESNKSSEQSVLDTFDDISNDI---YK-----QNESIKLERLSQDALSNNEDSRHDFIG----- 603
            .|    ..|:.:....|:: |||   ||     |.:::.|:..:..|.:..........|
Zfish   189 PP----VLEECLQKPGDEV-NDIDKEYKPHDLLQRQNVPLQPSNTSAPARRAKRMKTESGCIKSE 248

  Fly   604 -GDNADISTTFKIQMDS--------KQLMVAVKLLPIDEPPVHCTILQVNAPP----PSPPDCPP 655
             |:..:.....:.:|.|        |::.:.||..|::       |.::|..|    |...:.||
Zfish   249 EGEGVENKPNLRRRMGSFVVKTEQKKEIPIQVKEEPVE-------IKELNPEPEKSKPKKKNIPP 306

  Fly   656 QKLTRDQLLPPTPSVHL---------------------ENKKHAFSPQLQEFCLKHPIAVVRGLA 699
                     ||...|.|                     ::..|.       |||..|      |.
Zfish   307 ---------PPVSMVDLYVCLVCGKGNDEDRLLLCDGCDDSYHT-------FCLIPP------LT 349

  Fly   700 GVLKLDLGLFSTKT-----------LVEANPDHSVEV-------------RTQVHQSPDENWDTS 740
            .|.|.|.......|           ..:|:.|::::.             ...||..|.|..:
Zfish   350 DVPKGDWRCPKCLTQECCKPQEAFGFEQAHRDYTLKAFGEMADSFKSDYFNMPVHMVPTELVE-- 412

  Fly   741 QGKRVWACISHRSHTTIAKYAQYQASSFQDSLKLILPQDESDKGFPGSQAMSDSDSKDSVSNSNI 805
              |..|..:.........:|....||.            |...|||
Zfish   413 --KEFWRLVGTIQEDVTVEYGADIASK------------EFGSGFP------------------- 444

  Fly   806 VLKRKKHKI---NSKMLRFGTNVDLSDEKKWKPQLTELQKLPAFARVISAANMLSHVGHVILGMN 867
             :|..:.||   :.|.|:.|.|::                    ...:...::|:||...|.||.
Zfish   445 -IKGGRFKIAPHDEKYLQCGWNLN--------------------NMAMMTPSVLTHVTADICGMT 488

  Fly   868 TVQLYMKVPGSRTPGHQENNNFCSININIGPGDCEWFAVP-------------------DAYWGG 913
            ...||:.:..|....|.|::...|||.........|:..|                   |:....
Zfish   489 LPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGAPGFAAEQLEAVMKKLAPELFDSQPDL 553

  Fly   914 VHNLCEKNNISYL--HGSWWPVLEDLYKENIPVYRFIQKPGDLV---------WVNAGCVHWVQS 967
            :|.|....|.:.|  ||             :|:||..|..|:.|         ..|.| .::.::
Zfish   554 LHQLVTIMNPNTLMAHG-------------VPIYRTNQCAGEFVITFPRSYHSGFNQG-FNFAEA 604

  Fly   968 IGWCNNIAWNVGPLTARQYSLAIERYEWNKVQAFKSIVPMVHLSWNLARNIKVSDTKLFELIKMC 1032
            :.:| .:.|.  || .||   .::.|.........|...||   .|:|......|..|...::..
Zfish   605 VNFC-TVDWM--PL-GRQ---CVDHYRQLHRYCVFSHDEMV---CNMAMKADCLDVVLASAVQKD 659

  Fly  1033 LLQTLKNVLHIQEYVKSKGVEIRFNGRGKNEASHYCGQCEVEVFNVLFIKEQEKRHVVHC----- 1092
            :...:|....::|.|:..||                .|||:..:::|   ..::|..|.|
Zfish   660 MQLMIKEERELREKVRKMGV----------------AQCELFQYDLL---ADDERQCVKCRTTCY 705

  Fly  1093 ---LSCALKLSPSLQGIVCLEEYRLSEL 1117
               |:|..:  |.:|  |||  |...:|
Zfish   706 LSALTCPCR--PGVQ--VCL--YHTHDL 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809
		TPR_11	156..216	CDD:290150
		TPR repeat	186..216	CDD:276809
		TPR repeat	228..255	CDD:276809
		TPR_11	264..337	CDD:290150
		TPR repeat	265..300	CDD:276809
		TPR repeat	307..334	CDD:276809
		TPR_11	339..402	CDD:290150
		TPR repeat	339..369	CDD:276809
		TPR_1	340..373	CDD:278916
		TPR repeat	374..402	CDD:276809
		JmjC	870..978	CDD:202224	27/137 (20%)
kdm5bb	XP_005167081.1	JmjN	14..55	CDD:128818
		BRIGHT	81..171	CDD:128777	11/89 (12%)
		PHD1_KDM5B	316..361	CDD:277076	9/57 (16%)
		JmjC	491..607	CDD:202224	25/129 (19%)
		zf-C5HC2	697..749	CDD:280996	11/37 (30%)
		PLU-1	762..1096	CDD:285609
		PHD2_KDM5B	1189..1232	CDD:277080
		PHD3_KDM5B	1465..1513	CDD:277157
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900