Protein Alignment Utx and Tmtc1

DIOPT Version :10

• Sequence 1: NP_609368.3
• Gene: Utx / 34377
• FlyBaseID: FBgn0260749
• Length: 1136
• Species: Drosophila melanogaster
• Sequence 2: NP_945318.2
• Gene: Tmtc1 / 387314
• MGIID: 3039590
• Length: 942
• Species: Mus musculus
• Alignment Length: 471
• Identity: 98/471 - (20%)
• Similarity: 162/471 - (34%)
• Gaps: 150/471 - (31%)

  Fly    42 TNLQNYIANGQVHES-----KNSSDNKNAIQKFEPSTQAGEHMENTSSRNNDDTKPFEQ-DAK-- 98
            :.:|....|.:||.:     |:...||.||..:..:.:.  :..:.|:.||..|...:. :||
Mouse   534 SGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKL--YPRHASALNNLGTLTKDMAEAKMY 596

  Fly    99 -EKVSIIEEKHQDEHYVNALCKLGHL----------HLLLGE-----------YSEALSAYQKYL 141
             :|...:..:|.     .||..||:|          .:||.|           ||...|...:..
Mouse   597 YQKALQLHPQHN-----RALFNLGNLLKSQEKTEEAIMLLKESIKYGPDFADAYSSLASLLAEQE 656

  Fly   142 RFRE-------------------NNYWTNHAFIYGIGVAYFKLRCFKWAIKSFQELLYLSPNFTC 187
            ||:|                   |||   ..|:...|..       :.|:..:|:.:.|||:...
Mouse   657 RFKEAEDIYQAGIKNCPDSSDLHNNY---AVFLVDSGFP-------EKAVAHYQQAIQLSPSHHV 711

  Fly   188 ANEVHLRLGLMLKHCGE-------FHIALKHLQLALLYTYPSTFSELQVKFQIAHLYEVQNKHKA 245
            |   .:.||.:.:..||       :..|||..:.|            :|...:..||....:||.
Mouse   712 A---VVNLGRLYRSLGENSKAEEWYRRALKVARTA------------EVLSPLGALYYNTGRHKE 761

  Fly   246 AKDGYEFLLNEKNISLELKADVYRQLGWM-----------------YHCVEC------LGEKKER 287
            |.:.|...::.:....||:..:.:.|..|                 ..|:||      :..|:|.
Mouse   762 ALEVYREAVSLQPSQRELRLALAQVLAVMGQTKEAEKITSHIVSEEPRCLECYRLLSAIHSKQEH 826

  Fly   288 EANALNFLQKSIEADPKSGQSLYLLGRCYAGINKVHDAFLAYRNSVEKSEGNADTWCSIGVLYQQ 352
            ...||..::|:::..||..:             .:.:.|....|.:                 ::
Mouse   827 HGKALEAIEKALQLKPKDPK-------------VISELFFTKGNQL-----------------RE 861

  Fly   353 QNQPTDALQAYICAVQLDKDHKAAWTNLGILYESCGQLRDAYACYLNATKQISFQK--------- 408
            ||....|.::|..||.||.|...||.|:|.:....|....|.|.|..|.|.:...|
Mouse   862 QNLLDKAFESYEAAVTLDPDQAQAWMNMGGIRHIQGSYVSARAYYERALKLVPDSKLLKENLAKL 926

  Fly   409 SSLIRKKQAIRMKKDT 424
            ..|.|:.|.:|.:..|
Mouse   927 DRLERRLQEVRERDQT 942

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809	6/33 (18%)
		LapB	171..444	CDD:442196	62/293 (21%)
		TPR repeat	186..216	CDD:276809	8/36 (22%)
		TPR repeat	228..255	CDD:276809	7/26 (27%)
		TPR repeat	265..300	CDD:276809	10/57 (18%)
		TPR repeat	307..334	CDD:276809	2/26 (8%)
		TPR repeat	339..369	CDD:276809	6/29 (21%)
		TPR repeat	374..402	CDD:276809	9/27 (33%)
		JmjC	870..978	CDD:396791
Tmtc1	NP_945318.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	245..285
		TMTC_DUF1736	351..425	CDD:462468
		TPR 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	543..576		7/34 (21%)
		TPR repeat	543..571	CDD:276809	7/27 (26%)
		LapB	547..798	CDD:442196	57/282 (20%)
		TPR repeat	576..603	CDD:276809	7/26 (27%)
		TPR 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	577..607		7/29 (24%)
		TPR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	608..641		8/37 (22%)
		TPR repeat	608..636	CDD:276809	8/32 (25%)
		TPR 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	642..675		6/32 (19%)
		TPR repeat	642..670	CDD:276809	6/27 (22%)
		TPR repeat	675..705	CDD:276809	7/39 (18%)
		TPR 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	676..709		10/42 (24%)
		LapB	683..938	CDD:442196	62/306 (20%)
		TPR 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	710..742		8/34 (24%)
		TPR repeat	710..738	CDD:276809	6/30 (20%)
		TPR 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	743..776		8/44 (18%)
		TPR repeat	743..771	CDD:276809	8/39 (21%)
		TPR repeat	776..806	CDD:276809	4/29 (14%)
		TPR 8. /evidence=ECO:0000255	777..810		4/32 (13%)
		TPR 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	811..844		8/32 (25%)
		TPR repeat	812..839	CDD:276809	7/26 (27%)
		TPR repeat	844..878	CDD:276809	8/63 (13%)
		TPR 10. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	849..882		10/49 (20%)
		TPR 11. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	883..916		10/32 (31%)
		TPR repeat	883..911	CDD:276809	9/27 (33%)