DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Utx and Tmtc3

DIOPT Version :9

Sequence 1:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_477246.2	Gene:	Tmtc3 / 37401	FlyBaseID:	FBgn0020312	Length:	926	Species:	Drosophila melanogaster

Alignment Length:	362	Identity:	75/362 - (20%)
Similarity:	139/362 - (38%)	Gaps:	92/362 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 HMENTSSRNNDDTKPFEQDAKEKVSI-IEEKHQDEHYVNALCKLGHLHLLLGEYSEALSAYQKYL 141
            |...|..||        .|.:.:.|: :...|.::........:||.....|::.|||..:|:.:
  Fly   485 HALKTHQRN--------LDWRTEYSLFMSGVHVNQRNAKLYNNVGHALENEGKFEEALLYFQQAV 541

  Fly   142 RFRENNYWTNHAFIYGIGVAYFKLRCFKWAIKSFQELLYLSPNFTCANEVHLRLGLMLKHCGEFH 206
            |.:.::...:    ..:|..:..|:.:..|.:::.:...|.|........|.|
  Fly   542 RIQTDDIGAH----INVGRTFNNLKRYAEAEQAYVQAKALFPQAKPGVSYHAR------------ 590

  Fly   207 IALKHLQLALLYTYPSTFSELQVKFQIA-HLYE---------VQ------------NKHKAAKDG 249
            ||..||.:.:  ...:..::.|.:.:.| |||.         ||            |:...|::.
  Fly   591 IAPNHLNVFI--NLANLIAKNQTRLEEADHLYRQAISMRSDYVQAYINRGDILMKLNRTAQAQEV 653

  Fly   250 YE--FLLNEKNISLELKADVYRQLGWMYHCVECLGEKKEREANALNFLQKSIEADPKSGQSLYLL 312
            ||  .|.:.:|      ||:|..||.::     |.:.|.::|..  :..|:||..|:..|:|
  Fly   654 YEQALLYDNEN------ADIYYNLGVVF-----LEQGKSQQAQV--YFNKAIELYPEHEQAL--- 702

  Fly   313 GRCYAGINKVHDAFL--------AYRNS-------VEKSEGNADTWCSIGVLYQQQNQPTDALQA 362
                     ::.|.|        |.|.|       :|..:.|...:.::|:|...::...:|.|.
  Fly   703 ---------LNSAILLQELGGEEARRVSRSRLYKVLENDDQNEKVYFNLGMLAMDESSFDEAEQF 758

  Fly   363 YICAVQLDKDHKAAWTNLGILYESCGQLRDAYACYLN 399
            :..|:.|..|.::|..||.:|.....:..||.. :||
  Fly   759 FKRAIHLKADFRSALFNLALLLADTKRPLDAVP-FLN 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809	3/33 (9%)
		TPR_11	156..216	CDD:290150	11/59 (19%)
		TPR repeat	186..216	CDD:276809	6/29 (21%)
		TPR repeat	228..255	CDD:276809	12/50 (24%)
		TPR_11	264..337	CDD:290150	20/87 (23%)
		TPR repeat	265..300	CDD:276809	9/34 (26%)
		TPR repeat	307..334	CDD:276809	7/41 (17%)
		TPR_11	339..402	CDD:290150	16/61 (26%)
		TPR repeat	339..369	CDD:276809	6/29 (21%)
		TPR_1	340..373	CDD:278916	6/32 (19%)
		TPR repeat	374..402	CDD:276809	8/26 (31%)
		JmjC	870..978	CDD:202224
Tmtc3	NP_477246.2	DUF1736	323..396	CDD:369859
		PEP_TPR_lipo	<513..871	CDD:274350	68/326 (21%)
		TPR repeat	514..542	CDD:276809	7/27 (26%)
		TPR repeat	547..591	CDD:276809	7/59 (12%)
		TPR repeat	598..625	CDD:276809	5/28 (18%)
		TPR repeat	630..660	CDD:276809	6/29 (21%)
		TPR repeat	665..693	CDD:276809	9/34 (26%)
		TPR repeat	737..764	CDD:276809	5/26 (19%)
		TPR repeat	803..834	CDD:276809
		TPR repeat	839..867	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900