DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Utx and Kdm6b

DIOPT Version :9

Sequence 1:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	XP_038942397.1	Gene:	Kdm6b / 363630	RGDID:	1307629	Length:	1636	Species:	Rattus norvegicus

Alignment Length:	728	Identity:	335/728 - (46%)
Similarity:	449/728 - (61%)	Gaps:	82/728 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   413 RKKQAIRMKKDTIGLSKGLSQRITFLEGQL-SQAPLPSITSKRRQLCSIEEAWNLPI-SLEMNSR 475
            |:::..|..:.|...|.|...|    ||:. ::|..|...|:|       ...||.: |.|:..|
  Rat   970 RRQKEHRRHRRTCRDSVGRRPR----EGRAKAKAKAPKEKSRR-------VLGNLDLQSEEIQGR 1023

  Fly   476 QQQTAQMLPRQVTKQSPVQGPPP-PYPHSQLS--QSPIPSKRIKEDGTSQQEVTQNNSQTSAQNL 537
            ::....:......|......||| |.|.:|.:  .:|:|.|:.:|:......|    |:.....|
  Rat  1024 EKARPDVGGASKVKTPTTPAPPPAPAPSAQPTPPSAPVPGKKTREEAPGPPGV----SRADMLKL 1084

  Fly   538 INISESLNQRNFNAMPESNK----SSEQSVLDTFDDISNDIYKQNESIKLERLSQDALSNNEDSR 598
            .::||        ..|:..|    ..|....:||  |::::.::       ||....|:.:..:.
  Rat  1085 RSLSE--------GPPKELKIRLIKVESGDKETF--IASEVEER-------RLRMADLTISHCAA 1132

  Fly   599 HDFIGGDNADISTTFKIQMDSKQLMVAVKLLPIDEPPVHCTILQVNAPPPSPPDCPPQKLTRDQL 663
            .......||.:...|:    ...|..|..:.|           ::|.         .:||.|::|
  Rat  1133 DVMRASKNAKVKGKFR----ESYLSPAQSVKP-----------KINT---------EEKLPREKL 1173

  Fly   664 LPPTPSVHLENKKHAFSPQLQEFCL--KHPIAVVRGLAGVLKLDLGLFSTKTLVEANPDHSVEVR 726
            .|||||::||:|:.||||.|.:||.  ::||.|:|||||.|:|:||||||||||||:.:|:||||
  Rat  1174 NPPTPSIYLESKRDAFSPVLLQFCTDPRNPITVIRGLAGSLRLNLGLFSTKTLVEASGEHTVEVR 1238

  Fly   727 TQVHQSPDENWDTSQGKRVWACISHRSHTTIAKYAQYQASSFQDSLKLILPQDESDKGFPGSQAM 791
            |||.|..|||||.:..:::|.|.|.||||||||||||||||||:||     |:|.:.   ..:..
  Rat  1239 TQVQQPSDENWDLTGTRQIWPCESSRSHTTIAKYAQYQASSFQESL-----QEEKES---EDEES 1295

  Fly   792 SDSDSKDSVSNSNIVLKRKKHKINSKMLRFGTNVDLSDEKKWKPQLTELQKLPAFARVISAANML 856
            .:.||....|.|:.....|.|.|    ::||||:||||.|:|||||.||.|||||.||.|..|||
  Rat  1296 EEPDSTTGTSPSSSAPDPKNHHI----IKFGTNIDLSDAKRWKPQLQELLKLPAFMRVTSTGNML 1356

  Fly   857 SHVGHVILGMNTVQLYMKVPGSRTPGHQENNNFCSININIGPGDCEWFAVPDAYWGGVHNLCEKN 921
            |||||.|||||||||||||||||||||||||||||:||||||||||||||.:.||..:...|:::
  Rat  1357 SHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFAVHEHYWETISAFCDRH 1421

  Fly   922 NISYLHGSWWPVLEDLYKENIPVYRFIQKPGDLVWVNAGCVHWVQSIGWCNNIAWNVGPLTARQY 986
            .:.||.|||||:|:|||..|||||||:|:||||||:|||.|||||:.|||||||||||||||.||
  Rat  1422 GVDYLTGSWWPILDDLYASNIPVYRFVQRPGDLVWINAGTVHWVQATGWCNNIAWNVGPLTAYQY 1486

  Fly   987 SLAIERYEWNKVQAFKSIVPMVHLSWNLARNIKVSDTKLFELIKMCLLQTLKNVLHIQEYVKSKG 1051
            .||:||||||:|:..||||||:|:|||:||.:|:||..||::||.||||::|:....:|.:...|
  Rat  1487 QLALERYEWNEVKNVKSIVPMIHVSWNVARTVKISDPDLFKMIKFCLLQSMKHCQVQRESLVRAG 1551

  Fly  1052 VEIRFNGRGKNEASHYCGQCEVEVFNVLFIKEQ---EKRHVVHCLSCALKLSPSLQGIVCLEEYR 1113
            .:|.:.||.|:|.::||.:|:|||||:||:..:   ...::|||..||.:.|..|||:|.||:||
  Rat  1552 KKIAYQGRVKDEPAYYCNECDVEVFNILFVTSENGSRNTYLVHCEGCARRRSAGLQGVVVLEQYR 1616

  Fly  1114 LSELQRVYDSFTL 1126
            ..||.:.||:|||
  Rat  1617 TEELAQAYDAFTL 1629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809
		TPR_11	156..216	CDD:290150
		TPR repeat	186..216	CDD:276809
		TPR repeat	228..255	CDD:276809
		TPR_11	264..337	CDD:290150
		TPR repeat	265..300	CDD:276809
		TPR repeat	307..334	CDD:276809
		TPR_11	339..402	CDD:290150
		TPR repeat	339..369	CDD:276809
		TPR_1	340..373	CDD:278916
		TPR repeat	374..402	CDD:276809
		JmjC	870..978	CDD:202224	80/107 (75%)
Kdm6b	XP_038942397.1	TPR repeat	106..136	CDD:276809
		JmjC	1336..1400	CDD:214721	55/63 (87%)
		JmjC	1370..1478	CDD:396791	80/107 (75%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351953
Domainoid	1	1.000	183	1.000	Domainoid score	I3348
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141383at33208
OrthoFinder	1	1.000	-	-		FOG0001095
OrthoInspector	1	1.000	-	-		otm46453
orthoMCL	1	0.900	-	-		OOG6_101645
Panther	1	1.100	-	-	O	PTHR14017
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X932
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.750