DRSC/TRiP Functional Genomics Resources

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Protein Alignment Utx and Kdm6b

DIOPT Version :10

Sequence 1:NP_609368.3 Gene:Utx / 34377 FlyBaseID:FBgn0260749 Length:1136 Species:Drosophila melanogaster
Sequence 2:XP_038942397.1 Gene:Kdm6b / 363630 RGDID:1307629 Length:1636 Species:Rattus norvegicus


Alignment Length:728 Identity:335/728 - (46%)
Similarity:449/728 - (61%) Gaps:82/728 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   413 RKKQAIRMKKDTIGLSKGLSQRITFLEGQL-SQAPLPSITSKRRQLCSIEEAWNLPI-SLEMNSR 475
            |:::..|..:.|...|.|...|    ||:. ::|..|...|:|       ...||.: |.|:..|
  Rat   970 RRQKEHRRHRRTCRDSVGRRPR----EGRAKAKAKAPKEKSRR-------VLGNLDLQSEEIQGR 1023

  Fly   476 QQQTAQMLPRQVTKQSPVQGPPP-PYPHSQLS--QSPIPSKRIKEDGTSQQEVTQNNSQTSAQNL 537
            ::....:......|......||| |.|.:|.:  .:|:|.|:.:|:......|    |:.....|
  Rat  1024 EKARPDVGGASKVKTPTTPAPPPAPAPSAQPTPPSAPVPGKKTREEAPGPPGV----SRADMLKL 1084

  Fly   538 INISESLNQRNFNAMPESNK----SSEQSVLDTFDDISNDIYKQNESIKLERLSQDALSNNEDSR 598
            .::||        ..|:..|    ..|....:||  |::::.::       ||....|:.:..:.
  Rat  1085 RSLSE--------GPPKELKIRLIKVESGDKETF--IASEVEER-------RLRMADLTISHCAA 1132

  Fly   599 HDFIGGDNADISTTFKIQMDSKQLMVAVKLLPIDEPPVHCTILQVNAPPPSPPDCPPQKLTRDQL 663
            .......||.:...|:    ...|..|..:.|           ::|.         .:||.|::|
  Rat  1133 DVMRASKNAKVKGKFR----ESYLSPAQSVKP-----------KINT---------EEKLPREKL 1173

  Fly   664 LPPTPSVHLENKKHAFSPQLQEFCL--KHPIAVVRGLAGVLKLDLGLFSTKTLVEANPDHSVEVR 726
            .|||||::||:|:.||||.|.:||.  ::||.|:|||||.|:|:||||||||||||:.:|:||||
  Rat  1174 NPPTPSIYLESKRDAFSPVLLQFCTDPRNPITVIRGLAGSLRLNLGLFSTKTLVEASGEHTVEVR 1238

  Fly   727 TQVHQSPDENWDTSQGKRVWACISHRSHTTIAKYAQYQASSFQDSLKLILPQDESDKGFPGSQAM 791
            |||.|..|||||.:..:::|.|.|.||||||||||||||||||:||     |:|.:.   ..:..
  Rat  1239 TQVQQPSDENWDLTGTRQIWPCESSRSHTTIAKYAQYQASSFQESL-----QEEKES---EDEES 1295

  Fly   792 SDSDSKDSVSNSNIVLKRKKHKINSKMLRFGTNVDLSDEKKWKPQLTELQKLPAFARVISAANML 856
            .:.||....|.|:.....|.|.|    ::||||:||||.|:|||||.||.|||||.||.|..|||
  Rat  1296 EEPDSTTGTSPSSSAPDPKNHHI----IKFGTNIDLSDAKRWKPQLQELLKLPAFMRVTSTGNML 1356

  Fly   857 SHVGHVILGMNTVQLYMKVPGSRTPGHQENNNFCSININIGPGDCEWFAVPDAYWGGVHNLCEKN 921
            |||||.|||||||||||||||||||||||||||||:||||||||||||||.:.||..:...|:::
  Rat  1357 SHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFAVHEHYWETISAFCDRH 1421

  Fly   922 NISYLHGSWWPVLEDLYKENIPVYRFIQKPGDLVWVNAGCVHWVQSIGWCNNIAWNVGPLTARQY 986
            .:.||.|||||:|:|||..|||||||:|:||||||:|||.|||||:.|||||||||||||||.||
  Rat  1422 GVDYLTGSWWPILDDLYASNIPVYRFVQRPGDLVWINAGTVHWVQATGWCNNIAWNVGPLTAYQY 1486

  Fly   987 SLAIERYEWNKVQAFKSIVPMVHLSWNLARNIKVSDTKLFELIKMCLLQTLKNVLHIQEYVKSKG 1051
            .||:||||||:|:..||||||:|:|||:||.:|:||..||::||.||||::|:....:|.:...|
  Rat  1487 QLALERYEWNEVKNVKSIVPMIHVSWNVARTVKISDPDLFKMIKFCLLQSMKHCQVQRESLVRAG 1551

  Fly  1052 VEIRFNGRGKNEASHYCGQCEVEVFNVLFIKEQ---EKRHVVHCLSCALKLSPSLQGIVCLEEYR 1113
            .:|.:.||.|:|.::||.:|:|||||:||:..:   ...::|||..||.:.|..|||:|.||:||
  Rat  1552 KKIAYQGRVKDEPAYYCNECDVEVFNILFVTSENGSRNTYLVHCEGCARRRSAGLQGVVVLEQYR 1616

  Fly  1114 LSELQRVYDSFTL 1126
            ..||.:.||:|||
  Rat  1617 TEELAQAYDAFTL 1629

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
UtxNP_609368.3 TPR repeat 147..181 CDD:276809
LapB 171..444 CDD:442196 8/31 (26%)
TPR repeat 186..216 CDD:276809
TPR repeat 228..255 CDD:276809
TPR repeat 265..300 CDD:276809
TPR repeat 307..334 CDD:276809
TPR repeat 339..369 CDD:276809
TPR repeat 374..402 CDD:276809
JmjC 870..978 CDD:396791 80/107 (75%)
Kdm6bXP_038942397.1 BepA <90..154 CDD:443813
TPR repeat 106..136 CDD:276809
JmjC 1336..1400 CDD:214721 55/63 (87%)
JmjC 1370..1478 CDD:396791 80/107 (75%)
Blue background indicates that the domain is not in the aligned region.

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