DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Utx and IFIT3

DIOPT Version :9

Sequence 1:NP_609368.3 Gene:Utx / 34377 FlyBaseID:FBgn0260749 Length:1136 Species:Drosophila melanogaster
Sequence 2:NP_001026853.1 Gene:IFIT3 / 3437 HGNCID:5411 Length:490 Species:Homo sapiens


Alignment Length:664 Identity:115/664 - (17%)
Similarity:211/664 - (31%) Gaps:246/664 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 FEDDCLIRELDSRYYGFLDLSNSKNAELRNLVQQTITNLQNYIANGQVHESKNSSDNKNAIQKFE 70
            |::|.:.|:|:.|....::..|::       .:.|:.||..||                      
Human    25 FKEDSVSRDLEDRVCNQIEFLNTE-------FKATMYNLLAYI---------------------- 60

  Fly    71 PSTQAGEHMENTSSRNNDDTKPFEQDAKEKVSIIEEKHQDEHYVNALCKLGHLHLLLGEYSEALS 135
                  :|::.    ||:......:.|:|   :|:::|.|:..:.:|..                
Human    61 ------KHLDG----NNEAALECLRQAEE---LIQQEHADQAEIRSLVT---------------- 96

  Fly   136 AYQKYLRFRENNYWTNHAFIY---------GIGVAYFKLRCFKWAIKSFQELLYLSPNFTCANEV 191
                         |.|:|::|         .|.|...|..|.|::          :|.....:|:
Human    97 -------------WGNYAWVYYHLGRLSDAQIYVDKVKQTCKKFS----------NPYSIEYSEL 138

  Fly   192 HLRLGLMLKHCGEFHIALKHLQLALLYTYPSTFSELQVKFQIAHLYEVQNKHKAAKDGYEFLLNE 256
            ....|.....||                                      :::.||..:|..|.|
Human   139 DCEEGWTQLKCG--------------------------------------RNERAKVCFEKALEE 165

  Fly   257 KNISLELKADVYRQLGWMYHCVECLGEKKEREANALNFLQKSIEADPKSGQSLYLLGRCYAGINK 321
            |..:.|..:.:...   |||    |....|::.:. :.|:::||..|.:.....|||.....:||
Human   166 KPNNPEFSSGLAIA---MYH----LDNHPEKQFST-DVLKQAIELSPDNQYVKVLLGLKLQKMNK 222

  Fly   322 VHDAFLAYRNSVEKSEGNADTWCSIGVLYQQQNQPTDALQAYICAVQLDKDHKAAWTNLGILYES 386
            ..:.......::|||....|...|....|:::.....|::.:...::       :..|.|.||..
Human   223 EAEGEQFVEEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLE-------STPNNGYLYHQ 280

  Fly   387 CGQLRDAYACYLNATKQISFQKSS-------LIRKKQAIRMKKDTIGLSKGL------SQRITFL 438
            .|      .||....:|:.....|       :|...:...|......|.|||      |....||
Human   281 IG------CCYKAKVRQMQNTGESEASGNKEMIEALKQYAMDYSNKALEKGLNPLNAYSDLAEFL 339

  Fly   439 EGQLSQAP----LPSITSKR--RQLCSIEEAWNLPISLEMNSRQQQTAQMLPRQVTKQSPVQGPP 497
            |.:..|.|    :|....::  ::.|:::         :.|.:.:.||                 
Human   340 ETECYQTPFNKEVPDAEKQQSHQRYCNLQ---------KYNGKSEDTA----------------- 378

  Fly   498 PPYPHSQLSQSPIPSKRIKEDGTSQQEVTQNNSQTSAQNLINISESLNQRNFNAMPESNKSSEQS 562
                    .|..:....|.:..|.::|:.....        |:||:|..:|              
Human   379 --------VQHGLEGLSISKKSTDKEEIKDQPQ--------NVSENLLPQN-------------- 413

  Fly   563 VLDTFDDISNDIYKQNESI---------KLERLSQDA----------LSNNEDSRHDFIGGDNAD 608
             ...:..:...|:|||..:         :|.||.:||          .|..||...:.  |..|.
Human   414 -APNYWYLQGLIHKQNGDLLQAAKCYEKELGRLLRDAPSGIGSIFLSASELEDGSEEM--GQGAV 475

  Fly   609 ISTTFKIQMDSKQL 622
            .|:..::..:|:||
Human   476 SSSPRELLSNSEQL 489

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
UtxNP_609368.3 TPR repeat 147..181 CDD:276809 9/42 (21%)
TPR_11 156..216 CDD:290150 11/68 (16%)
TPR repeat 186..216 CDD:276809 4/29 (14%)
TPR repeat 228..255 CDD:276809 3/26 (12%)
TPR_11 264..337 CDD:290150 16/72 (22%)
TPR repeat 265..300 CDD:276809 6/34 (18%)
TPR repeat 307..334 CDD:276809 5/26 (19%)
TPR_11 339..402 CDD:290150 11/62 (18%)
TPR repeat 339..369 CDD:276809 4/29 (14%)
TPR_1 340..373 CDD:278916 4/32 (13%)
TPR repeat 374..402 CDD:276809 7/27 (26%)
JmjC 870..978 CDD:202224
IFIT3NP_001026853.1 TPR_12 51..126 CDD:290160 22/138 (16%)
TPR 1 51..84 11/67 (16%)
TPR repeat 51..79 CDD:276809 9/59 (15%)
TPR repeat 84..123 CDD:276809 10/67 (15%)
TPR 2 94..127 9/61 (15%)
TPR 3 136..169 10/70 (14%)
TPR repeat 136..164 CDD:276809 7/65 (11%)
TPR_19 150..213 CDD:291240 17/108 (16%)
TPR 4 172..206 9/41 (22%)
PRK02603 184..341 CDD:179448 35/170 (21%)
TPR repeat 206..236 CDD:276809 5/29 (17%)
TPR 5 207..240 8/32 (25%)
TPR 6 241..274 4/39 (10%)
TPR repeat 241..269 CDD:276809 4/27 (15%)
TPR 7 415..448 7/32 (22%)
TPR 8 450..481 6/32 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 467..490 6/25 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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