DRSC/TRiP Functional Genomics Resources

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Protein Alignment Utx and IFIT1

DIOPT Version :9

Sequence 1:NP_609368.3 Gene:Utx / 34377 FlyBaseID:FBgn0260749 Length:1136 Species:Drosophila melanogaster
Sequence 2:NP_001257856.1 Gene:IFIT1 / 3434 HGNCID:5407 Length:478 Species:Homo sapiens


Alignment Length:538 Identity:100/538 - (18%)
Similarity:185/538 - (34%) Gaps:176/538 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 NGQVHESKNS---------------------SDNK--NAIQKFEPSTQAGEH-----MENTSSRN 86
            ||..|:.|:|                     .:|:  :.|:..:.....|.|     :::...:|
Human     4 NGDDHQVKDSLEQLRCHFTWELSIDDDEMPDLENRVLDQIEFLDTKYSVGIHNLLAYVKHLKGQN 68

  Fly    87 NDDTKPFEQDAKEKVSIIEEKHQDEHYVNALCKLGH---LHLLLGEYSEALSAYQKYLRFREN-N 147
            .:..|    ..||..::::|:|.::..|.:|...|:   ::..:|..:||    |.||...|| .
Human    69 EEALK----SLKEAENLMQEEHDNQANVRSLVTWGNFAWMYYHMGRLAEA----QTYLDKVENIC 125

  Fly   148 YWTNHAFIYGIGV-------AYFKLRC----FKWAIKSFQELLYLSPNFTCANEVHLRLGLMLKH 201
            ...::.|.|.:..       .:..|:|    ::.|...|:::|.:.|.   ..|......:....
Human   126 KKLSNPFRYRMECPEIDCEEGWALLKCGGKNYERAKACFEKVLEVDPE---NPESSAGYAISAYR 187

  Fly   202 CGEFHIALKHLQLALLYTYPSTFSELQVK-----------FQIAHLYEVQNKHKAAKDGYEFLLN 255
            ...|.:|.|:         ...||.|.::           .::....::|::.:.|:.  |..:.
Human   188 LDGFKLATKN---------HKPFSLLPLRQAVRLNPDNGYIKVLLALKLQDEGQEAEG--EKYIE 241

  Fly   256 EKNISLELKADVYRQLGWMYHCVECLGEKKEREANALNFLQKSIEADPKSGQSLYLLGRCY---- 316
            |...::..:..|:|.....|       .:|.....||..|:|:::..|.|....:.:|.||    
Human   242 EALANMSSQTYVFRYAAKFY-------RRKGSVDKALELLKKALQETPTSVLLHHQIGLCYKAQM 299

  Fly   317 -----------AGINK------VHDAFLAYRNSVEKSEGNADTWCSIGVLYQQQNQPT------D 358
                       .|.|:      :..|...:.::|||                   :||      |
Human   300 IQIKEATKGQPRGQNREKLDKMIRSAIFHFESAVEK-------------------KPTFEVAHLD 345

  Fly   359 ALQAYICAVQLDKDHKAAWTNL-------GILYESCGQLRDAYACY--------LNA----TKQI 404
            ..:.||.|    .:|:.|..|.       .::.|:...:...|..:        :||    .|.|
Human   346 LARMYIEA----GNHRKAEENFQKLLCMKPVVEETMQDIHFHYGRFQEFQKKSDVNAIIHYLKAI 406

  Fly   405 SFQKSSLIRKKQAIRMKK-----------DTIGLSKGLSQRITFLEGQLSQAPLPSITSKRRQLC 458
            ..:::||.|.|....:||           |...||  |...:..|||.:::|           |.
Human   407 KIEQASLTRDKSINSLKKLVLRKLRRKALDLESLS--LLGFVYKLEGNMNEA-----------LE 458

  Fly   459 SIEEAWNLPISLEMNSRQ 476
            ..|.|..|....|.:.||
Human   459 YYERALRLAADFENSVRQ 476

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
UtxNP_609368.3 TPR repeat 147..181 CDD:276809 7/44 (16%)
TPR_11 156..216 CDD:290150 11/70 (16%)
TPR repeat 186..216 CDD:276809 4/29 (14%)
TPR repeat 228..255 CDD:276809 3/37 (8%)
TPR_11 264..337 CDD:290150 19/93 (20%)
TPR repeat 265..300 CDD:276809 8/34 (24%)
TPR repeat 307..334 CDD:276809 6/47 (13%)
TPR_11 339..402 CDD:290150 13/87 (15%)
TPR repeat 339..369 CDD:276809 6/35 (17%)
TPR_1 340..373 CDD:278916 6/38 (16%)
TPR repeat 374..402 CDD:276809 6/46 (13%)
JmjC 870..978 CDD:202224
IFIT1NP_001257856.1 TPR 1 52..85 6/36 (17%)
TPR_12 54..127 CDD:290160 18/80 (23%)
TPR repeat 54..80 CDD:276809 5/29 (17%)
TPR 2 95..128 10/36 (28%)
TPR repeat 97..123 CDD:276809 7/29 (24%)
TPR repeat 128..170 CDD:276809 7/41 (17%)
TPR 3 139..174 6/37 (16%)
TPR 4 183..216 6/41 (15%)
TPR repeat 216..246 CDD:276809 4/31 (13%)
TPR 5 218..249 4/32 (13%)
TPR 6 251..284 9/39 (23%)
TPR repeat 252..279 CDD:276809 8/33 (24%)
Interaction with the 5'-triphosphate group of PPP-RNA. /evidence=ECO:0000250 256..262 1/12 (8%)
TPR repeat 284..335 CDD:276809 8/50 (16%)
TPR 7 305..339 7/52 (13%)
TPR 8 340..373 7/36 (19%)
TPR repeat 340..367 CDD:276809 7/30 (23%)
TPR 9 378..412 5/33 (15%)
TPR repeat 378..407 CDD:276809 4/28 (14%)
TPR 10 437..470 11/45 (24%)
TPR repeat 437..465 CDD:276809 10/40 (25%)
TPR_1 438..470 CDD:278916 11/44 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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