DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Utx and Spag1

DIOPT Version :9

Sequence 1:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_001012116.1	Gene:	Spag1 / 315033	RGDID:	1310702	Length:	893	Species:	Rattus norvegicus

Alignment Length:	996	Identity:	182/996 - (18%)
Similarity:	310/996 - (31%)	Gaps:	339/996 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 CLIRELDSRYYGFLDLSNSKNAELRNLVQQTITNL----------------QNYIANGQVHESKN 58
            |::|..:..||          .||....::.:|.|                .::.|.   ...|.
  Rat    46 CVLRSGEEGYY----------PELTEFCEKRLTGLAPRSRALRKDKPAATASSFSAE---EWEKI 97

  Fly    59 SSDNKNAIQ--KFEPSTQAGEHME---------------NTSSRNNDDTKPFEQDAKEKV----- 101
            .||.|:.:.  |.|.:|:.....|               |:..|...:|....:.||:::
  Rat    98 DSDLKSWVSEIKREENTRHFHDPEKHPGVEDPLPPVRGSNSCPRGGKETSSKSKTAKKRIPRDYA 162

  Fly   102 -----------SIIEEKHQDEHYVNALCKLGHLHLLL---------------------------G 128
                       |.|:|.::::..:|....|..:...:                           |
  Rat   163 EWDKFDVEKECSKIDEDYKEKTVINNKAHLSKIETKIDTAGLTEKEKNFLANREKGKGNEAFYSG 227

  Fly   129 EYSEALSAYQKYL-RFRENNYWTNHAFIYGIGVAYFKLRCFKWAIKSFQELLYLSPNFTCANEVH 192
            :|.||:..|.:.| .......:.|.|      .|..||:.:..|::..::.|.|.|...   :..
  Rat   228 DYEEAVMYYTRSLSALPTATAYNNRA------QAEIKLQRWSSALEDCEKALELEPGNI---KAL 283

  Fly   193 LRLGLMLKHCGEFHIALKHLQLALLYTYPST-------------------FSELQVKFQIAHLYE 238
            ||.....||..:|..|:..|: .:|...|..                   .||||.|.:...:.|
  Rat   284 LRRATTYKHQNKFLEAVDDLR-KVLQAEPDNDLAKKTLSEVERELKNSEPASELQTKGKRMVIEE 347

  Fly   239 VQNKHKAAKDGYEFLLNEKNISLELKADVYRQLGWMYHCVECLGEKKEREANALNFLQKSIEADP 303
            |:|.......|.|....:..:.:....::.::|     .|...|.::.|.|.......:..|..|
  Rat   348 VENSGDEGGKGDEDDHEDDGVDMAAMGNIQKKL-----MVRSQGGRRSRRARTPMPGAEQQEGQP 407

  Fly   304 KSGQSLYLLGRCYAGINKVHDAFLAYRNSVE-----KSEGNADTWCSIGVLYQQQNQPTDALQAY 363
            ::|.         |..:..||  |..|.:.:     ||.||.        |::.......|:|..
  Rat   408 ETGT---------ASTSDNHD--LEERRAADSPGDLKSRGNE--------LFRGGQFAEAAVQYS 453

  Fly   364 ICAVQLDKDHKAAWTNLGILYESCGQLRDAYACYL-------------NATKQISFQKSSLIRKK 415
            ....||:.........|.|||.      :..||||             .|.:...|....|:|:.
  Rat   454 GAIAQLEPTGSENADELSILYS------NRAACYLKEGNCRGCIQDCDRALELQPFAVKPLLRRA 512

  Fly   416 QAIRMKKDTIGLSKGLSQRITFLEGQLSQAPLPSITSKRRQLCSIEEAWNLPISLEMNSRQQQTA 480
            .|...                 || |...|.:..||                 .|:::.|.|..:
  Rat   513 MAYET-----------------LE-QYRSAYVDYIT-----------------VLKIDCRIQLAS 542

  Fly   481 QMLPRQVTKQSPVQGPP-----PPYPHSQLSQSPI----PSKRIKEDGTSQQEVTQNNSQTSAQN 536
            ..:.|.....:.:.||.     ||.|....|: |:    |:..     |..|:...|:...:.
  Rat   543 DSVNRITRILTELDGPKWRERLPPIPAVPASE-PLRVWHPAAE-----TPDQDPCPNSCTPTI-- 599

  Fly   537 LINISESLNQRNFNAMPESNKSSEQSVLDTFDDISNDIYKQNESIKLERLSQDALSNN------- 594
                   .:::.|.|:.|   ...|.|.|  .:..:.|.|.||.:|:...:....:|.
  Rat   600 -------TDEKMFQALKE---EGNQLVKD--KNYKDAISKYNECLKINSKACAIYTNRALCYLKL 652

  Fly   595 ---EDSRHDFIGGDNADISTTFKIQMDSKQLMVAVKLLPIDEPPVHCTILQVNAPPPSPPDCPPQ 656
               |:::.|.   |.|       :|:|||.:..:.:|....:...:|   :.....||
  Rat   653 GQFEEAKLDC---DKA-------LQIDSKNVKASYRLELAQKGLENC---RERVADPS------- 697

  Fly   657 KLTRDQLLPPTPSV---HLENKKHAFSP---------QLQEFCLKHPIAVVRGLAGVLKLDLGLF 709
               :..||.|..|.   ||:.|.....|         ::||
  Rat   698 ---QVVLLSPDSSEAARHLDTKNDTAPPSRERERRRIEIQE------------------------ 735

  Fly   710 STKTLVEANPDHSVEVRTQVHQSPDENWDTSQGKRVWACISHRSH------TTIAKYAQYQASSF 768
                 |:.:.|...| |.....:.:|.|...:..::..|....::      :||:  |:....:.
  Rat   736 -----VDDSSDEEPE-RPAEASAVEEGWSAERAGKIEVCKPRNAYEFGQVLSTIS--ARKDEEAC 792

  Fly   769 QDSLKLILPQD---------ESDKGFPGSQAMSDSDSKDSVSNSNIVLKRK----KHKIN-SKML 819
            ...|....|||         |.|......|::          .|::|.|..    ||.:. ||..
  Rat   793 AQLLVFTAPQDLPVLLSNKLEGDMLLLIMQSL----------KSHLVAKDPSLVCKHLLYLSKAE 847

  Fly   820 RFGTNVDLSDEKKWKPQLTEL 840
            ||...:.|: .|..|.|:.:|
  Rat   848 RFEMMLALT-SKDQKEQMAQL 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809	7/33 (21%)
		TPR_11	156..216	CDD:290150	14/59 (24%)
		TPR repeat	186..216	CDD:276809	7/29 (24%)
		TPR repeat	228..255	CDD:276809	7/26 (27%)
		TPR_11	264..337	CDD:290150	14/77 (18%)
		TPR repeat	265..300	CDD:276809	5/34 (15%)
		TPR repeat	307..334	CDD:276809	5/26 (19%)
		TPR_11	339..402	CDD:290150	15/75 (20%)
		TPR repeat	339..369	CDD:276809	4/29 (14%)
		TPR_1	340..373	CDD:278916	5/32 (16%)
		TPR repeat	374..402	CDD:276809	9/40 (23%)
		JmjC	870..978	CDD:202224
Spag1	NP_001012116.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	112..155		6/42 (14%)
		3a0801s09	141..>303	CDD:273380	30/170 (18%)
		TPR 1	213..246		6/32 (19%)
		TPR repeat	217..241	CDD:276809	5/23 (22%)
		TPR repeat	246..275	CDD:276809	7/34 (21%)
		TPR 2	247..279		9/37 (24%)
		TPR 3	280..313		9/36 (25%)
		TPR repeat	280..308	CDD:276809	7/31 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..344		5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	349..368		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	373..437		15/79 (19%)
		TPR 4	429..463		9/41 (22%)
		3a0801s09	<432..>569	CDD:273380	36/185 (19%)
		TPR repeat	432..458	CDD:276809	7/33 (21%)
		TPR repeat	466..500	CDD:276809	9/39 (23%)
		TPR 5	471..504		8/38 (21%)
		TPR repeat	505..533	CDD:276809	9/62 (15%)
		TPR 6	506..538		10/66 (15%)
		3a0801s09	569..>695	CDD:273380	28/158 (18%)
		TPR 7	605..638		11/37 (30%)
		TPR repeat	606..633	CDD:276809	9/31 (29%)
		TPR repeat	638..668	CDD:276809	5/39 (13%)
		TPR 8	639..672		8/42 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	704..756		12/81 (15%)
		RPAP3_C	769..858	CDD:404718	20/101 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900