DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Utx and Ifit3

DIOPT Version :9

Sequence 1:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_001007695.1	Gene:	Ifit3 / 309526	RGDID:	1359681	Length:	411	Species:	Rattus norvegicus

Alignment Length:	422	Identity:	84/422 - (19%)
Similarity:	156/422 - (36%)	Gaps:	130/422 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   257 KNISLELKADVYRQLGWMYH-------CVECLGEKKEREANALNFLQKSIEADPKSGQSLYLLGR 314
            :|::.|.||.:|..|.::.|       .:||||:.::        |:||..:|....:.|...|.
  Rat    43 ENLNSEHKATMYDLLAYIKHLDGENEAALECLGQAED--------LRKSERSDRAEIKCLVTWGN 99

  Fly   315 ---CYAGINKVHDAFLAYRNSV---------------------------------------EKS- 336
               .|..|.::.:| .||.:.|                                       ||:
  Rat   100 YAWIYYRIGQLSEA-QAYADKVRQVCQKFANPYSMECPELDCEEGWTRLKCGRNERAKMCFEKAL 163

  Fly   337 -EGNADTWCSIGV---LYQQQNQP-----TDALQAYICAVQLDKDHKAAWTNLGILYESCGQLRD 392
             |...|..|..|:   :|:.|.:|     .|||:.   |::|:..::.....|.:..:..|:..:
  Rat   164 EEKPEDPECRAGMAIAMYRLQEKPEKQFSVDALKQ---AMELNSQNQYEKVLLALKLQKMGEEAE 225

  Fly   393 AYACYLNATKQISFQKSSLIRKKQAIRMKKDTIGLSKGLSQRITFLEGQL----SQAPLPSIT-- 451
            |.....:|.::...|...|.:..|..|.|.:       |.:.|.||...|    :.:||.|:.
  Rat   226 AERLVEDALEKGPNQTDVLQKAAQFYRKKGN-------LDRAIEFLGKALRSTANNSPLYSLVMC 283

  Fly   452 ---SKRRQLCSIEEAWNLPISLEMNSRQQQTAQMLPRQVTKQSPVQGPPPPYPHSQLSQSPIPSK 513
               .|.:||.:..||        ..|.::||.:.| |::|.:         |.:..|.:.|.|
  Rat   284 RYREKLKQLQNTGEA--------DKSERRQTMEEL-RRLTME---------YMNKALQRRPSP-- 328

  Fly   514 RIKEDGTSQQEVTQNNSQTSAQNLINISESLNQRNFNAMPESNKSSEQSVLDTFDDISNDIYKQN 578
                             ..|..:||:..|...........||.::.:|.:.:.:.:: .:.::::
  Rat   329 -----------------LNSYSDLIDFPEVEKCYQMVFSEESPRAEDQELFERYCNL-QEYHRKS 375

  Fly   579 ESIK-LERLSQ----DALSNNEDSRHDFIGGD 605
            |.:| |:.|.|    :..:..|:.:.....||
  Rat   376 EGLKALKDLMQFPRPEKSTEKEEVKQQTQNGD 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809
		TPR_11	156..216	CDD:290150
		TPR repeat	186..216	CDD:276809
		TPR repeat	228..255	CDD:276809
		TPR_11	264..337	CDD:290150	23/123 (19%)
		TPR repeat	265..300	CDD:276809	11/41 (27%)
		TPR repeat	307..334	CDD:276809	8/68 (12%)
		TPR_11	339..402	CDD:290150	15/70 (21%)
		TPR repeat	339..369	CDD:276809	10/37 (27%)
		TPR_1	340..373	CDD:278916	11/40 (28%)
		TPR repeat	374..402	CDD:276809	4/27 (15%)
		JmjC	870..978	CDD:202224
Ifit3	NP_001007695.1	TPR_12	51..126	CDD:290160	20/83 (24%)
		TPR repeat	51..79	CDD:276809	8/27 (30%)
		TPR repeat	93..123	CDD:276809	8/30 (27%)
		TPR_12	94..164	CDD:290160	10/70 (14%)
		TPR repeat	136..164	CDD:276809	2/27 (7%)
		TPR repeat	206..236	CDD:276809	4/29 (14%)
		TPR_19	217..281	CDD:291240	16/70 (23%)
		TPR repeat	241..269	CDD:276809	8/34 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900