DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Utx and Bbs4

DIOPT Version :9

Sequence 1:NP_609368.3 Gene:Utx / 34377 FlyBaseID:FBgn0260749 Length:1136 Species:Drosophila melanogaster
Sequence 2:XP_038937022.1 Gene:Bbs4 / 300754 RGDID:1309134 Length:529 Species:Rattus norvegicus


Alignment Length:446 Identity:95/446 - (21%)
Similarity:170/446 - (38%) Gaps:94/446 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    91 KPFEQDAKEKVSIIEEKHQDEHYVNALCKLGHLHLLLGEYSEALSAYQKYLRFRENNYWTNHAFI 155
            |.|.:...:..|.::....|..|:    .||.:|||.|:..:|:..|:|.:.|...    |...:
  Rat   158 KQFSKAQDQLHSALQLNKHDLTYI----MLGKIHLLQGDLDKAIEIYKKAVEFSPE----NTELL 214

  Fly   156 YGIGVAYFKLRCFKWAIKSFQELLYLSPNFTCAN-EVHLRLGLMLKHCGEFHIALKHLQL--ALL 217
            ..:|:.|.:|..::.|.:.....|...|    || :..|..|.|::..|:|.:||...::  ..:
  Rat   215 TTLGLLYLQLGVYQKAFEHLGNALTYDP----ANYKAILAAGSMMQTHGDFDVALTKYRVVACAI 275

  Fly   218 YTYPSTFSELQVKFQIAHLYEVQNKHKAAKDGYEFLLNEKNISLELKADVYRQLGW--MYHCVEC 280
            ...|..::      .|...:..:.|:.||            ||...:|:......|  :|:    
  Rat   276 PESPPLWN------NIGMCFFGKKKYVAA------------ISCLKRANYLAPFDWKILYN---- 318

  Fly   281 LG---EKKEREANALNFLQKSIEADPKSGQSLYLLGRCYAGINKVHDAFLAYRNSVEKSEGNADT 342
            ||   ...::.|:|.:||..:|...||.|: ||:|                              
  Rat   319 LGLVHLTMQQYASAFHFLSAAINFQPKMGE-LYML------------------------------ 352

  Fly   343 WCSIGVLYQQQNQPTDALQAYICAVQLDKDHKAAWTNLGILYESCGQLRDAYACYLNATKQISFQ 407
               :.|.........:|.:||:.||:|||.:.....|..:|..:.|:.:.|.|.|....|::.|.
  Rat   353 ---LAVALTNLEDIENAKRAYVEAVRLDKCNPLVNLNYAVLLYNQGEKKGALAQYQEMEKKVHFL 414

  Fly   408 KSSLIRKKQAIRMKKDTIGLSKGLSQRITFLEGQLSQAPLPSITSKRRQLCSIEEA-WNLPI-SL 470
            |.:     ..:....:.:.:::.|...:...|..:...|:....||.|.....:.| ...|: |.
  Rat   415 KDN-----NPLEFDSEMVEMAQKLGAALQVGEALVWTKPVKDPKSKHRTNSGSKSATLQQPLGSF 474

  Fly   471 EMNSRQQQTA---QMLP-----RQVTKQSPVQGPPPPYPHSQLSQSPI-PSKRIKE 517
            :...:...:|   :.:|     .|:||  |...|..|.|...:..||. .|::.||
  Rat   475 QALGQAMSSAAAHRKIPSGAVGAQLTK--PPSLPLEPEPEPTVEASPTEASEQNKE 528

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
UtxNP_609368.3 TPR repeat 147..181 CDD:276809 6/33 (18%)
TPR_11 156..216 CDD:290150 15/62 (24%)
TPR repeat 186..216 CDD:276809 9/32 (28%)
TPR repeat 228..255 CDD:276809 4/26 (15%)
TPR_11 264..337 CDD:290150 16/77 (21%)
TPR repeat 265..300 CDD:276809 9/39 (23%)
TPR repeat 307..334 CDD:276809 3/26 (12%)
TPR_11 339..402 CDD:290150 15/62 (24%)
TPR repeat 339..369 CDD:276809 6/29 (21%)
TPR_1 340..373 CDD:278916 9/32 (28%)
TPR repeat 374..402 CDD:276809 6/27 (22%)
JmjC 870..978 CDD:202224
Bbs4XP_038937022.1 PEP_TPR_lipo <31..442 CDD:274350 73/356 (21%)
TPR repeat 77..104 CDD:276809
TPR repeat 110..138 CDD:276809
TPR repeat 143..173 CDD:276809 3/14 (21%)
TPR repeat 178..205 CDD:276809 10/30 (33%)
TPR repeat 211..238 CDD:276809 4/26 (15%)
TPR repeat 245..273 CDD:276809 7/27 (26%)
TPR repeat 279..307 CDD:276809 8/45 (18%)
TPR repeat 312..342 CDD:276809 9/33 (27%)
TPR repeat 347..375 CDD:276809 9/61 (15%)
TPR repeat 381..406 CDD:276809 6/24 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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